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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANO6 Gene

protein-coding   GIFtS: 49
GCID: GC12P045609

anoctamin 6

(Previous name: transmembrane protein 16F )
(Previous symbol: TMEM16F)
 Explore 3 diseases affiliated with
ANO6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ANO6    

Aliases
for ANO6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Anoctamin 61 2     DKFZp313M07201
TMEM16F1 2 3 5     BDPLT72
Transmembrane Protein 16F1 2 3     SCTS2
Small-Conductance Calcium-Activated Nonselective Cation Channel2 3     Anoctamin-61
SCAN Channel2 3     

External Ids:    HGNC: 252401   Entrez Gene: 1965272   Ensembl: ENSG000001771197   OMIM: 6086635   UniProtKB: Q4KMQ23   

Export aliases for ANO6 gene to outside databases

Previous GC identifers: GC12P043897 GC12P042639


Summaries
for ANO6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ANO6:
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential
component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid
occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to
trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2
Function: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of
phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of
phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential
for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel
currents in airway epithelial cells and Jurkat T lymphocytes




Genomic Views
for ANO6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANO6 gene promoter:
         LHX3b/Lhx3b   NF-AT2   NF-AT3   LHX3a/Lhx3a   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANO6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANO6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANO6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12-q13.11

ANO6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANO6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P045609:  view genomic region     (about GC identifiers)

Start:
 45,609,770 bp from pter      End:
 45,834,187 bp from pter
Size:
 224,418 bases      Orientation:
 plus strand

Proteins
for ANO6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2 (See protein sequence)
Recommended Name: Anoctamin-6  
Size: 910 amino acids; 106165 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization according to
PubMed:22075693
Miscellaneous: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT)
transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain
that all the members of this family are anion channels or have the 8-transmembrane topology
Secondary accessions: A6NNM6 B9EGG0 E7ENK4 Q8N3Q2
Alternative splicing: 2 isoforms:  Q4KMQ2-1   Q4KMQ2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANO6: NX_Q4KMQ2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q4KMQ2

    • ANO6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001020527.2  NP_001136150.1  NP_001136151.1  NP_001191732.1  

    ENSEMBL proteins: 
     ENSP00000391417   ENSP00000409126   ENSP00000449423   ENSP00000320087   ENSP00000413137  
     ENSP00000413840  
    Reactome Protein details: Q4KMQ2
    Human Recombinant Protein Products: 
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    Uscn Proteins for ANO6

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005886plasma membrane IDA--
    GO:0034707chloride channel complex IEA--


    ANO6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ANO6

    Protein Domains /
    Families
    for ANO6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ANO6 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007632 Anoctamin

    Graphical View of Domain Structure for InterPro Entry Q4KMQ2

    ProtoNet protein and cluster: Q4KMQ2

    UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2
    Similarity: Belongs to the anoctamin family


    Function
    for ANO6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2
    Function: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of
    phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of
    phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential
    for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel
    currents in airway epithelial cells and Jurkat T lymphocytes
    Enzyme regulation: Exhibits synergistic gating by Ca(2+) and voltage. Inhibited by some non-specific cation channel
    blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions (By similarity)

    miRNA
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    hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-429 hsa-miR-513a-5p hsa-miR-106a hsa-miR-485-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    OriGene shRNA RFP: ANO6
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005227calcium activated cation channel activity ISS--
    GO:0005229NOT intracellular calcium activated chloride channel activity IDA--
    GO:0005244voltage-gated ion channel activity ISS--
    GO:0005254chloride channel activity ----


    ANO6 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Ano6tm1.2Lyj for ANO6
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ano6):
     hematopoietic system  homeostasis/metabolism  no phenotypic analysis 

    ANO6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ANO6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ion channel transport
    		Ion channel transport1.00
    		Stimuli-sensing channels0.49
    2SLC-mediated transmembrane transport
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for ANO6
        Transmembrane transport of small molecules
    Stimuli-sensing channels
    Ion channel transport



    ANO6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANO6

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ANO6 (ENSP000003914174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002543activation of blood coagulation via clotting cascade IMP--
    GO:0006821chloride transport ----
    GO:0007596blood coagulation ISS--
    GO:0017121phospholipid scrambling ISS--
    GO:0097045phosphatidylserine exposure on blood platelet IMP--


    ANO6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ANO6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANO6

    2 HMDB Compounds for ANO6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--
    Search CenterWatch for drugs/clinical trials and news about ANO6 

    Transcripts
    for ANO6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ANO6 gene (5 alternative transcripts): 
    NM_001025356.2  NM_001142678.1  NM_001142679.1  NM_001204803.1  NM_001142680.1  

    Unigene Cluster for ANO6:

    Anoctamin 6
    Hs.505339  [show with all ESTs]
    Unigene Representative Sequence: NM_001204803
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426898 ENST00000425752(uc010sld.1) ENST00000423947 ENST00000550630
    ENST00000320560(uc001roo.3 uc010slf.2) ENST00000441606(uc010slg.2)
    ENST00000551667 ENST00000435642(uc010sle.1)

    miRNA
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    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate ANO6 (see all 65):
    hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-429 hsa-miR-513a-5p hsa-miR-106a hsa-miR-485-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANO6 (see all 4)
    OriGene shRNA RFP: ANO6
    OriGene siRNA: ANO6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANO6
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANO6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANO6

    Additional cDNA sequence: 

    AK095979.1 AK123755.1 AK126409.1 AK302819.1 AK303996.1 AK310641.1 AL832340.1 AL833405.1 
    BC042383.1 BC063576.1 BC073891.1 BC098410.1 BC136445.1 

    7 DOTS entries:

    DT.217550  DT.99929762  DT.40217443  DT.91740788  DT.308101  DT.91837716  DT.75152098 

    24/197 AceView cDNA sequences (see all 197):

    BI092690 AL599992 AA884389 BG741835 AI027376 CA426316 AL599991 AI027020 
    CA445259 AK095979 BQ006506 BU681802 AW103805 AW243674 BX103594 BQ215211 
    BC073891 AA994146 BQ068965 AA258062 AI150109 AL833405 AI082269 AI082758 

    GeneLoc Exon Structure


    Expression
    for ANO6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANO6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGCTTTTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ANO6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneThoracic RibOsteochondro Mesenchymal CellsBone, Cartilage
    SomiteThoracic Mesenchymal SclerotomeSomite
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ANO6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANO6

    SOURCE GeneReport for Unigene cluster: Hs.505339

    UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2
    Tissue specificity: Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal
    cancer

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    In Situ
    Assay Products:     
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    Orthologs
    for ANO6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANO6 gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ANO61 anoctamin 6 75.35(n)
    77.69(a)    		   417802  XM_416045.2  XP_416045.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ANO66
    		 --
    		 79(a)
    		 1 ↔ 1
    		 5(53825559-53868445)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.94002 Xenopus laevis transcribed sequences 78.39(n)    BG486942.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005354371 anoctamin-6-like 65.1(n)
    65.75(a)    		   100535437  XM_003198213.1  XP_003198261.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG69386
    		 --
    		 28(a)
    		 1 → many
    		 3L(11978006-11983605)
    worm
    (Caenorhabditis elegans)    		 Secernentea anoh-16
    		 --
    		 19(a)
    		 possible ortholog
    		 III(13246477-13253514)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G730206
    		 uncharacterized protein
    		 20(a)
    		 1 → many
    		 1(27469534-27473554)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 transmembrane protein 16K, putative, expressed
    		 20(a)
    		 1 → many
    		 1(29317147-29321524)


    ENSEMBL Gene Tree for ANO6 (if available)
    TreeFam Gene Tree for ANO6 (if available) 

    Paralogs
    for ANO6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANO6 gene
    ANO92  ANO22  ANO52  ANO12  ANO102  ANO42  ANO32  ANO82  
    ANO72  
    7 SIMAP similar genes for ANO6 using alignment to 4 protein entries:     ANO6_HUMAN (see all proteins):
    ANO5    ANO3    ANO1    ANO4    ANO2    ANO9
    ANO7

    ANO6 for paralogs           About GeneDecksing



    Genomic Variants
    for ANO6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3646 NCBI SNPs in ANO6 are shown (see all 3646)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs37590781,2
    		H--42640231(-) ATGAAT/CTTATA 3 -- int14Minor allele frequency- C:0.00NS EA 408
    rs125811911,2
    		H--42640360(+) ACCCTC/TTAGAA 3 -- int10--------
    rs1139862481,2
    		C,--42641013(+) TTTACG/CCTATT 3 -- int11Minor allele frequency- C:0.50CSA 2
    rs764154661,2
    		F,--42641114(+) CCCTCT/CATTAA 3 -- int11Minor allele frequency- C:0.02WA 118
    rs584300291,2
    		--42641429(+) ATATCA/GTAGAG 3 -- int10--------
    rs125781711,2
    		H--42641728(+) tttggG/Tagaga 3 -- int10--------
    rs123025691,2
    		C--42642126(+) GTGGAA/GATCAC 3 -- int10--------
    rs793557061,2
    		--42642724(+) CTTCTA/GTGCTA 3 -- int10--------
    rs740809741,2
    		C,--42642929(+) AATAAG/CTTGAC 3 -- int11Minor allele frequency- C:0.50WA 2
    rs768531971,2
    		F,--42643129(+) AAGAAC/TCCAAA 3 -- int11Minor allele frequency- T:0.02EA 120

    HapMap Linkage Disequilibrium report for ANO6 (45609770 - 45834187 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ANO6: --
    Human Gene Mutation Database (HGMD): ANO6

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    Disorders / Diseases
    for ANO6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ANO6 for disorders           About GeneDecksing

    OMIM gene information: 608663   
    OMIM disorders: 262890  
    UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2
  • Defects in ANO6 are the cause of Scott syndrome (SCTS) [MIM:262890]. A mild bleeding disorder due to impaired
    • surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with
    Ca(2+)-elevating agents

    3 diseases for ANO6:    About MalaCards
    scott syndrome    bleeding disorder    leukemia

    Human Genome Epidemiology (HuGE) Navigator: ANO6 (1 document)

    Export disorders for ANO6 gene to outside databases

    Publications
    for ANO6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANO6 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with ANO6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of TMEM16E and TMEM16F genes in silico. (PubMed id 15067359)1, 2, 3, 9 Katoh M. and Katoh M. (2004)
    2. Calcium-dependent phospholipid scrambling by TMEM16F. (PubMed id 21107324)1, 2 Suzuki J....Nagata S. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PubMed id 21984732)2 Scudieri P.... Galietta L.J. (2012)
    5. ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. (PubMed id 22075693)2 Duran C.... Hartzell H.C. (2012)
    6. A genome-wide association study in Han Chinese identif ies new susceptibility loci for ankylosing spondylitis. (PubMed id 22138694)1 Lin Z....Gu J. (2012)
    7. Anoctamins are a family of Ca2+ activated Cl- channels. (PubMed id 22946059)2 Tian Y.... Kunzelmann K. (2012)
    8. The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age. (PubMed id 22302790)2 Winpenny J.P. and Gray M.A. (2012)
    9. Expression and function of epithelial anoctamins. (PubMed id 21908539)2 Kunzelmann K.... Tian Y. (2012)
    10. Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome. (PubMed id 21511967)1 Castoldi E....Bevers E.M. (2011)

    External Searches for ANO6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ANO6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 196527 HGNC: 25240 AceView: TMEM16F Ensembl:ENSG00000177119 euGenes: HUgn196527
    ECgene: ANO6 H-InvDB: ANO6

    Other Databases showing ANO6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ANO6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANO6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ANO6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ANO6 gene:
    Search GeneIP for patents involving ANO6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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