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ANO6 Gene

protein-coding   GIFtS: 54
GCID: GC12P045609

Anoctamin 6

(Previous name: transmembrane protein 16F)
(Previous symbol: TMEM16F)
  See ANO6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Anoctamin 61 2     SCAN Channel2 3
TMEM16F1 2 3 5     BDPLT72 5
Transmembrane Protein 16F1 2 3     SCTS2 5
Small-Conductance Calcium-Activated Nonselective Cation Channel2 3     anoctamin-62

External Ids:    HGNC: 252401   Entrez Gene: 1965272   Ensembl: ENSG000001771197   OMIM: 6086635   UniProtKB: Q4KMQ23   

Export aliases for ANO6 gene to outside databases

Previous GC identifers: GC12P043897 GC12P042639


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANO6 Gene:
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an
essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling
of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose
phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.(provided by
RefSeq, Mar 2011)

GeneCards Summary for ANO6 Gene:
ANO6 (anoctamin 6) is a protein-coding gene. Diseases associated with ANO6 include scott syndrome. GO annotations related to this gene include calcium activated cation channel activity and voltage-gated ion channel activity. An important paralog of this gene is ANO9.

UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2
Function: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of
phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of
phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is
essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying
chloride channel currents in airway epithelial cells and Jurkat T lymphocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANO6 gene promoter:
         LHX3b/Lhx3b   NF-AT2   NF-AT3   LHX3a/Lhx3a   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANO6 promoter sequence
   Search Chromatin IP Primers for ANO6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANO6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12-q13.11

ANO6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANO6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P045609:  view genomic region     (about GC identifiers)

Start:
45,609,770 bp from pter      End:
45,834,187 bp from pter
Size:
224,418 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2 (See protein sequence)
Recommended Name: Anoctamin-6  
Size: 910 amino acids; 106165 Da
Miscellaneous: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT)
transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not
certain that all the members of this family are anion channels or have the 8-transmembrane topology
Secondary accessions: A6NNM6 B9EGG0 E7ENK4 E9PB30 E9PCT2 Q8N3Q2
Alternative splicing: 4 isoforms:  Q4KMQ2-1   Q4KMQ2-2   Q4KMQ2-3   Q4KMQ2-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ANO6: NX_Q4KMQ2

Explore proteomics data for ANO6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys876, Lys888
  • Glycosylation2 at Asn329, Asn361, Asn493, Asn777, Asn790, Asn802
  • Modification sites at PhosphoSitePlus

  • See ANO6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001020527.2  NP_001136150.1  NP_001136151.1  NP_001191732.1  

    ENSEMBL proteins: 
     ENSP00000391417   ENSP00000409126   ENSP00000449423   ENSP00000320087   ENSP00000413137  
     ENSP00000413840  
    Reactome Protein details: Q4KMQ2

    ANO6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ANO6

     
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    antibodies-online peptides for ANO6

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    antibodies-online antibodies for ANO6 (16 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANO: Ion channels / Chloride channels : Calcium activated : Anoctamins

    1 InterPro protein domain:
     IPR007632 Anoctamin

    Graphical View of Domain Structure for InterPro Entry Q4KMQ2

    ProtoNet protein and cluster: Q4KMQ2

    UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2
    Similarity: Belongs to the anoctamin family


    Find genes that share domains with ANO6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANO6_HUMAN, Q4KMQ2
    Function: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of
    phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of
    phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is
    essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying
    chloride channel currents in airway epithelial cells and Jurkat T lymphocytes
    Enzyme regulation: Exhibits synergistic gating by Ca(2+) and voltage. Inhibited by some non-specific cation
    channel blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions (By
    similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005227calcium activated cation channel activity ISS--
    GO:0005229NOT intracellular calcium activated chloride channel activity IDA--
    GO:0005244voltage-gated ion channel activity ISS--
    GO:0005254chloride channel activity ----
         
    Find genes that share ontologies with ANO6           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ano6):
     craniofacial  growth/size/body  hematopoietic system  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  no phenotypic analysis  skeleton 

    Find genes that share phenotypes with ANO6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ano6tm1.2Lyj for ANO6

       genOway: Develop your customized and physiologically relevant rodent model for ANO6

    miRNA
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    miRTarBase miRNAs that target ANO6:
    hsa-mir-615-3p (MIRT040178), hsa-mir-3620-3p (MIRT052862), hsa-mir-192-5p (MIRT026632), hsa-mir-182-5p (MIRT047212), hsa-mir-124-3p (MIRT022736), hsa-let-7a-5p (MIRT052405), hsa-mir-10a-5p (MIRT047637)

    Block miRNA regulation of human, mouse, rat ANO6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANO6 (see all 65):
    hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-429 hsa-miR-513a-5p hsa-miR-106a hsa-miR-485-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat ANO6

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    GenScript: all cDNA clones in your preferred vector (see all 5): ANO6 (NM_001204803)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANO6_HUMAN, Q4KMQ2: Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization
    according to PubMed:22075693
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005886plasma membrane TAS--
    GO:0034707chloride channel complex IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ANO6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANO6 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with ANO6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ANO6
        Stimuli-sensing channels


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANO6
    Interactions:

        Search GeneGlobe Interaction Network for ANO6

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ANO6 (ENSP000003914174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002543activation of blood coagulation via clotting cascade IMP--
    GO:0006812cation transport ISS--
    GO:0006821chloride transport ----
    GO:0007596blood coagulation ISS--
    GO:0017121phospholipid scrambling ISS--

    Find genes that share ontologies with ANO6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANO6

    2 HMDB Compounds for ANO6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANO6 gene (5 alternative transcripts): 
    NM_001025356.2  NM_001142678.1  NM_001142679.1  NM_001204803.1  NM_001142680.1  

    Unigene Cluster for ANO6:

    Anoctamin 6
    Hs.505339  [show with all ESTs]
    Unigene Representative Sequence: NM_001204803
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426898 ENST00000425752(uc010sld.1) ENST00000423947 ENST00000550630
    ENST00000320560(uc001roo.3 uc010slf.2) ENST00000441606(uc010slg.2)
    ENST00000551667 ENST00000435642(uc010sle.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat ANO6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANO6 (see all 65):
    hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-429 hsa-miR-513a-5p hsa-miR-106a hsa-miR-485-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ANO6
      QuantiFast Probe-based Assays in human, mouse, rat ANO6

    Additional mRNA sequence: 

    AK095979.1 AK123755.1 AK126409.1 AK302819.1 AK303996.1 AK310641.1 AL832340.1 AL833405.1 
    BC042383.1 BC063576.1 BC073891.1 BC098410.1 BC136445.1 

    7 DOTS entries:

    DT.217550  DT.99929762  DT.40217443  DT.91740788  DT.308101  DT.91837716  DT.75152098 

    Selected AceView cDNA sequences (see all 197):

    AA890008 N34238 BX507306 BG939600 BM854595 AA233026 BF445966 BQ024067 
    BX103594 AI770119 AI922307 BU674176 BM682581 BQ215211 BU619259 BU158799 
    BM664954 BC073891 AI082269 AI082758 AK126409 AL833405 AI150109 AA258062 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANO6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCTTTTCA
    ANO6 Expression
    About this image


    ANO6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)
             Osteochondro Mesenchymal Cells Rib
     
     Cartilage (Muscoskeletal System)
             Osteochondro Mesenchymal Cells Rib
     
     Somite (Muscoskeletal System)
             Thoracic Mesenchymal Sclerotome
     
     Ovary (Reproductive System)
     
     Adipose (Muscoskeletal System)
    ANO6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANO6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.505339

    UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2
    Tissue specificity: Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and
    intestinal cancer

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANO6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ano61 , 5 anoctamin 61, 5 83.26(n)1
    89.89(a)1
      15 (50.66 cM)5
    1057221  NM_001253813.11  NP_001240742.11 
     957908435 
    chicken
    (Gallus gallus)
    Aves ANO61 anoctamin 6 76.14(n)
    79.32(a)
      417802  XM_416045.3  XP_416045.2 
    lizard
    (Anolis carolinensis)
    Reptilia ANO66
    anoctamin 6
    76(a)
    1 ↔ 1
    5(53825559-53904175)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.94002 Xenopus laevis transcribed sequences 78.39(n)    BG486942.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005354371 anoctamin-6-like 65.1(n)
    65.75(a)
      100535437  XM_003198213.2  XP_003198261.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69386
    --
    29(a)
    1 → many
    3L(11978006-11983605)


    ENSEMBL Gene Tree for ANO6 (if available)
    TreeFam Gene Tree for ANO6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANO6 gene
    ANO92  ANO22  ANO12  ANO52  ANO102  ANO32  ANO42  ANO82  
    ANO72  
    7 SIMAP similar genes for ANO6 using alignment to 2 protein entries:     ANO6_HUMAN (see all proteins):
    ANO5    ANO3    ANO1    ANO4    ANO2    ANO9
    ANO7

    Find genes that share paralogs with ANO6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANO6 (see all 4294)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104379401,2
    C,F,H--42660648(+) tgcttG/Agctga 3 -- int17Minor allele frequency- A:0.04NS EA NA WA 514
    rs2018430951,2
    C--42703079(+) ATATA-/ATA   
      G
    /TAGA
    GAGAG
    3 -- int10--------
    rs2001020301,2
    C--42731914(-) TAGTTG/TGGTTT 4 -- int10--------
    rs792038401,2
    C--42806307(+) ACTTGA/CTGCCA 4 -- int10--------
    rs1501609001,2
    --45448079(+) GAGGCA/CGGAGA 3 -- us2k10--------
    rs1853641441,2
    --45448122(+) GAGCCA/GAGATC 3 -- us2k10--------
    rs1173461941,2
    F--45448182(+) AAAAAA/GAGAGA 3 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1898343081,2
    --45448385(+) TGATTC/TTGGAC 3 -- us2k10--------
    rs1135319851,2
    C,F--45448407(+) GTTGCC/TTCACA 3 -- us2k12Minor allele frequency- T:0.02CSA WA 120
    rs1825260981,2
    --45448427(+) AAATGA/GTAACA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANO6 (45609770 - 45834187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ANO6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv689CNV Insertion18451855
    nsv826357CNV Loss20364138
    nsv690CNV Loss18451855

    Human Gene Mutation Database (HGMD): ANO6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANO6
    DNA2.0 Custom Variant and Variant Library Synthesis for ANO6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 608663   
    OMIM disorders: 262890  
    UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2
  • Scott syndrome (SCTS) [MIM:262890]: A mild bleeding disorder due to impaired surface exposure of
    procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with
    Ca(2+)-elevating agents. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 1 disease for ANO6:    
    About MalaCards
    scott syndrome


    Find genes that share disorders with ANO6           About GenesLikeMe

    Genetic Association Database (GAD): ANO6
    Human Genome Epidemiology (HuGE) Navigator: ANO6 (1 document)

    Export disorders for ANO6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ANO6 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with ANO6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of TMEM16E and TMEM16F genes in silico. (PubMed id 15067359)1, 2, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2004)
    2. A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis. (PubMed id 22138694)1, 4 Lin Z....Gu J. (Nat. Genet. 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Calcium-dependent phospholipid scrambling by TMEM16F. (PubMed id 21107324)1, 2 Suzuki J.... Nagata S. (Nature 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents. (PubMed id 23618909)1 Kmit A....Kunzelmann K. (amp 2013)
    7. Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population. (PubMed id 23308121)1 Wei J.C....Chang W.C. (PLoS ONE 2013)
    8. TMEM16F is a component of a Ca2+-activated Cl- channel but not a volume-sensitive outwardly rectifying Cl- channel. (PubMed id 23426967)1 Shimizu T....Okada Y. (Am. J. Physiol., Cell Physiol. 2013)
    9. Anoctamins are a family of Ca2+ activated Cl- channels. (PubMed id 22946059)2 Tian Y.... Kunzelmann K. (J. Cell Sci. 2012)
    10. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PubMed id 21984732)2 Scudieri P.... Galietta L.J. (Exp. Physiol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 196527 HGNC: 25240 AceView: TMEM16F Ensembl:ENSG00000177119 euGenes: HUgn196527
    ECgene: ANO6 H-InvDB: ANO6

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ANO6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ANO6 gene:
    Search GeneIP for patents involving ANO6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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