Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANO6 Gene

protein-coding   GIFtS: 53
GCID: GC12P045609

Anoctamin 6

(Previous name: transmembrane protein 16F)
(Previous symbol: TMEM16F)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Anoctamin 61 2     SCAN Channel2 3
TMEM16F1 2 3 5     BDPLT72
Transmembrane Protein 16F1 2 3     SCTS2
Small-Conductance Calcium-Activated Nonselective Cation Channel2 3     anoctamin-62

External Ids:    HGNC: 252401   Entrez Gene: 1965272   Ensembl: ENSG000001771197   OMIM: 6086635   UniProtKB: Q4KMQ23   

Export aliases for ANO6 gene to outside databases

Previous GC identifers: GC12P043897 GC12P042639


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANO6 Gene:
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an
essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling
of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose
phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.(provided by
RefSeq, Mar 2011)

GeneCards Summary for ANO6 Gene: 
ANO6 (anoctamin 6) is a protein-coding gene. Diseases associated with ANO6 include scott syndrome, and ankylosing spondylitis, and among its related super-pathways are Stimuli-sensing channels and SLC-mediated transmembrane transport. GO annotations related to this gene include calcium activated cation channel activity and voltage-gated ion channel activity. An important paralog of this gene is ANO9.

UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2
Function: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of
phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of
phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is
essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying
chloride channel currents in airway epithelial cells and Jurkat T lymphocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANO6 gene promoter:
         LHX3b/Lhx3b   NF-AT2   NF-AT3   LHX3a/Lhx3a   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANO6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANO6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANO6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12-q13.11

ANO6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANO6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P045609:  view genomic region     (about GC identifiers)

Start:
45,609,770 bp from pter      End:
45,834,187 bp from pter
Size:
224,418 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2 (See protein sequence)
Recommended Name: Anoctamin-6  
Size: 910 amino acids; 106165 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization
according to PubMed:22075693
Miscellaneous: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT)
transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not
certain that all the members of this family are anion channels or have the 8-transmembrane topology
Secondary accessions: A6NNM6 B9EGG0 E7ENK4 E9PB30 E9PCT2 Q8N3Q2
Alternative splicing: 4 isoforms:  Q4KMQ2-1   Q4KMQ2-2   Q4KMQ2-3   Q4KMQ2-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ANO6: NX_Q4KMQ2

Explore proteomics data for ANO6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q4KMQ2

  • ANO6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANO6 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001020527.2  NP_001136150.1  NP_001136151.1  NP_001191732.1  

    ENSEMBL proteins: 
     ENSP00000391417   ENSP00000409126   ENSP00000449423   ENSP00000320087   ENSP00000413137  
     ENSP00000413840  
    Reactome Protein details: Q4KMQ2
    Human Recombinant Protein Products for ANO6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ANO6
    GenScript Custom Purified and Recombinant Proteins Services for ANO6
    Novus Biologicals ANO6 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANO6 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005886plasma membrane TAS--
    GO:0034707chloride channel complex IEA--

    ANO6 for ontologies           About GeneDecksing



    ANO6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ANO6
    GenScript Custom Superior Antibodies Services for ANO6
    Novus Biologicals ANO6 Antibodies
    Abcam antibodies for ANO6
    Cloud-Clone Corp. Antibodies for ANO6 
    Search ThermoFisher Antibodies for ANO6
    LSBio Antibodies in human, mouse, rat for ANO6 

    Assay Products for ANO6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ANO6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ANO6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ANO6 
    Cloud-Clone Corp. CLIAs for ANO6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANO: Ion channels / Chloride channels : Calcium activated : Anoctamins

    1 InterPro protein domain:
     IPR007632 Anoctamin

    Graphical View of Domain Structure for InterPro Entry Q4KMQ2

    ProtoNet protein and cluster: Q4KMQ2

    UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2
    Similarity: Belongs to the anoctamin family


    ANO6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANO6_HUMAN, Q4KMQ2
    Function: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of
    phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of
    phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is
    essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying
    chloride channel currents in airway epithelial cells and Jurkat T lymphocytes
    Enzyme regulation: Exhibits synergistic gating by Ca(2+) and voltage. Inhibited by some non-specific cation
    channel blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions (By
    similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005227calcium activated cation channel activity ISS--
    GO:0005229NOT intracellular calcium activated chloride channel activity IDA--
    GO:0005244voltage-gated ion channel activity ISS--
    GO:0005254chloride channel activity ----
         
    ANO6 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ano6):
     craniofacial  growth/size  hematopoietic system  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  no phenotypic analysis  skeleton 

    ANO6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ano6tm1.2Lyj for ANO6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ANO6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ANO6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANO6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANO6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANO6
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate ANO6 (see all 65):
    hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-429 hsa-miR-513a-5p hsa-miR-106a hsa-miR-485-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ANO6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANO6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ANO6
    Sirion Biotech Customized adenovirus for overexpression of ANO6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ANO6 (see all 21)
    OriGene ORF clones in mouse, rat for ANO6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): ANO6 (NM_001204803)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANO6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANO6
    Sirion Biotech Customized lentivirus for stable overexpression of ANO6 
                         Customized lentivirus expression plasmids for stable overexpression of ANO6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ANO6
    Search LifeMap BioReagents cell lines for ANO6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ANO6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.49
    Stimuli-sensing channels0.49
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for ANO6
        Transmembrane transport of small molecules
    Stimuli-sensing channels
    Ion channel transport



    ANO6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANO6

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ANO6 (ENSP000003914174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002543activation of blood coagulation via clotting cascade IMP--
    GO:0006821chloride transport ----
    GO:0007596blood coagulation ISS--
    GO:0017121phospholipid scrambling ISS--
    GO:0034220ion transmembrane transport TAS--

    ANO6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANO6

    2 HMDB Compounds for ANO6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--

    Search CenterWatch for drugs/clinical trials and news about ANO6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANO6 gene (5 alternative transcripts): 
    NM_001025356.2  NM_001142678.1  NM_001142679.1  NM_001204803.1  NM_001142680.1  

    Unigene Cluster for ANO6:

    Anoctamin 6
    Hs.505339  [show with all ESTs]
    Unigene Representative Sequence: NM_001204803
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426898 ENST00000425752(uc010sld.1) ENST00000423947 ENST00000550630
    ENST00000320560(uc001roo.3 uc010slf.2) ENST00000441606(uc010slg.2)
    ENST00000551667 ENST00000435642(uc010sle.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANO6
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate ANO6 (see all 65):
    hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-429 hsa-miR-513a-5p hsa-miR-106a hsa-miR-485-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ANO6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANO6
    Clone
    Products:
         
    OriGene clones in human, mouse for ANO6 (see all 21)
    OriGene ORF clones in mouse, rat for ANO6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): ANO6 (NM_001204803)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANO6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANO6
    Sirion Biotech Customized lentivirus for stable overexpression of ANO6 
                         Customized lentivirus expression plasmids for stable overexpression of ANO6 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ANO6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANO6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANO6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANO6

    Additional mRNA sequence: 

    AK095979.1 AK123755.1 AK126409.1 AK302819.1 AK303996.1 AK310641.1 AL832340.1 AL833405.1 
    BC042383.1 BC063576.1 BC073891.1 BC098410.1 BC136445.1 

    7 DOTS entries:

    DT.217550  DT.99929762  DT.40217443  DT.91740788  DT.308101  DT.91837716  DT.75152098 

    24/197 AceView cDNA sequences (see all 197):

    AA890008 N34238 BX507306 BG939600 BM854595 AA233026 BF445966 BQ024067 
    BX103594 AI770119 AI922307 BU674176 BM682581 BQ215211 BU619259 BU158799 
    BM664954 BC073891 AI082269 AI082758 AK126409 AL833405 AI150109 AA258062 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANO6 expression in normal human tissues (normalized intensities)      ANO6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCTTTTCA
    ANO6 Expression
    About this image


    ANO6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Osteochondro Mesenchymal Cells Thoracic Rib
     
     Cartilage (Muscoskeletal System)
             Osteochondro Mesenchymal Cells Thoracic Rib
     
     Somite (Muscoskeletal System)
             Thoracic Mesenchymal Sclerotome

    See ANO6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANO6

    SOURCE GeneReport for Unigene cluster: Hs.505339

    UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2
    Tissue specificity: Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and
    intestinal cancer

        SABiosciences Custom PCR Arrays for ANO6
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ANO6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANO6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANO6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANO6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ANO6 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ano61 , 5 anoctamin 61, 5 83.44(n)1
    90.32(a)1
      15 (50.66 cM)5
    1057221  NM_001253813.11  NP_001240742.11 
     957908435 
    chicken
    (Gallus gallus)
    Aves ANO61 anoctamin 6 75.35(n)
    77.69(a)
      417802  XM_416045.2  XP_416045.2 
    lizard
    (Anolis carolinensis)
    Reptilia ANO66
    Anoctamin
    75(a)
    1 ↔ 1
    5(53825559-53904175)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.94002 Xenopus laevis transcribed sequences 78.39(n)    BG486942.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005354371 anoctamin-6-like 65.1(n)
    65.75(a)
      100535437  XM_003198213.1  XP_003198261.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69386
    --
    28(a)
    1 → many
    3L(11978006-11983605)


    ENSEMBL Gene Tree for ANO6 (if available)
    TreeFam Gene Tree for ANO6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANO6 gene
    ANO92  ANO22  ANO12  ANO52  ANO102  ANO32  ANO42  ANO82  
    ANO72  
    7 SIMAP similar genes for ANO6 using alignment to 2 protein entries:     ANO6_HUMAN (see all proteins):
    ANO5    ANO3    ANO1    ANO4    ANO2    ANO9
    ANO7

    ANO6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4294 SNPs in ANO6 are shown (see all 4294)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104379401,2
    C,F,H--42660648(+) tgcttG/Agctga 3 -- int17Minor allele frequency- A:0.04NS EA NA WA 514
    rs2018430951,2
    C--42703079(+) ATATA-/ATA   
      G
    /TAGA
    GAGAG
    3 -- int10--------
    rs2001020301,2
    C--42731914(-) TAGTTG/TGGTTT 4 -- int10--------
    rs792038401,2
    C--42806307(+) ACTTGA/CTGCCA 4 -- int10--------
    rs1501609001,2
    --45448079(+) GAGGCA/CGGAGA 3 -- us2k10--------
    rs1853641441,2
    --45448122(+) GAGCCA/GAGATC 3 -- us2k10--------
    rs1173461941,2
    F--45448182(+) AAAAAA/GAGAGA 3 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1898343081,2
    --45448385(+) TGATTC/TTGGAC 3 -- us2k10--------
    rs1135319851,2
    C,F--45448407(+) GTTGCC/TTCACA 3 -- us2k12Minor allele frequency- T:0.02CSA WA 120
    rs1825260981,2
    --45448427(+) AAATGA/GTAACA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANO6 (45609770 - 45834187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ANO6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv689CNV Insertion18451855
    nsv826357CNV Loss20364138
    nsv690CNV Loss18451855


    Human Gene Mutation Database (HGMD): ANO6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ANO6
    DNA2.0 Custom Variant and Variant Library Synthesis for ANO6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608663   
    OMIM disorders: 262890  
    UniProtKB/Swiss-Prot: ANO6_HUMAN, Q4KMQ2
  • Scott syndrome (SCTS) [MIM:262890]: A mild bleeding disorder due to impaired surface exposure of
    procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with
    Ca(2+)-elevating agents. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for ANO6:    About MalaCards
    scott syndrome    ankylosing spondylitis    spondylitis    leukemia


    ANO6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ANO6
    Human Genome Epidemiology (HuGE) Navigator: ANO6 (1 document)

    Export disorders for ANO6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANO6 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with ANO6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of TMEM16E and TMEM16F genes in silico. (PubMed id 15067359)1, 2, 3, 9 Katoh M. and Katoh M. (2004)
    2. A genome-wide association study in Han Chinese identif ies new susceptibility loci for ankylosing spondylitis. (PubMed id 22138694)1, 4 Lin Z....Gu J. (2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Calcium-dependent phospholipid scrambling by TMEM16F. (PubMed id 21107324)1, 2 Suzuki J....Nagata S. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Association study of polymorphisms rs4552569 and rs170 95830 and the risk of ankylosing spondylitis in a Taiwanese population. (PubMed id 23308121)1 Wei J.C....Chang W.C. (2013)
    7. TMEM16F is a component of a Ca2+-activated Cl- channel but not a volume-sensitive outwardly rectifying Cl- channel. (PubMed id 23426967)1 Shimizu T....Okada Y. (2013)
    8. Anoctamins are a family of Ca2+ activated Cl- channels. (PubMed id 22946059)2 Tian Y.... Kunzelmann K. (2012)
    9. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PubMed id 21984732)2 Scudieri P.... Galietta L.J. (2012)
    10. ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. (PubMed id 22075693)2 Duran C.... Hartzell H.C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 196527 HGNC: 25240 AceView: TMEM16F Ensembl:ENSG00000177119 euGenes: HUgn196527
    ECgene: ANO6 H-InvDB: ANO6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANO6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANO6 gene:
    Search GeneIP for patents involving ANO6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ANO6  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ANO6  
     OriGene qSTAR qPCR primer pairs in human, mouse for ANO6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ANO6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ANO6   OriGene Custom Protein Services for ANO6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANO6
     QIAGEN SeqTarget long-range PCR primers for resequencing ANO6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANO6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANO6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANO6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANO6
     GenScript Custom Purified and Recombinant Proteins Services for ANO6 GenScript cDNA clones with any tag delivered in your preferred vector for ANO6
     GenScript Custom Assay Services for ANO6 GenScript Custom Superior Antibodies Services for ANO6
     GenScript Custom overexpressing Cell Line Services for ANO6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ANO6 promoter
     Search Chromatin IP Primers for ANO6
     RT2 qPCR Primer Assay in human, mouse, rat ANO6
     Search GNC Networks for ANO6
     SABiosciences Custom PCR Arrays for ANO6
     Search Tocris compounds for ANO6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ANO6 antibodies
     ANO6 proteins
     Antibodies for ANO6
     See all of Abcam's Antibodies, Kits and Proteins for ANO6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ANO6
     Antibodies for ANO6
     ELISAs for ANO6
     CLIAs for ANO6
     Search LifeMap BioReagents cell lines for ANO6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO6
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ANO6
     SwitchGear Promoter luciferase reporter plasmids for ANO6
     Search ThermoFisher Antibodies for ANO6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANO6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ANO6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ANO6
    Customized:
     lentivirus for stable overexpression of ANO6
     lentivirus expression plasmids for stable overexpression of ANO6
     adenovirus for overexpression of ANO6
     LSBio Antibodies in human, mouse, rat for ANO6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ANO6 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4