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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANO5 Gene

protein-coding GIFtS: 52
GCID: GC11P022172

anoctamin 5

(Previous name: transmembrane protein 16E )
(Previous symbol: TMEM16E)

Explore 9 diseases affiliated with
ANO5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Anoctamin 5¹ ²		LGMD2L² ⁵
GDD1¹ ² ³ ⁵		Anoctamin-5¹
TMEM16E¹ ² ³ ⁵		Integral Membrane Protein GDD1²
Transmembrane Protein 16E¹ ² ³		Limb Girdle Muscular Dystrophy 2L (Autosomal Recessive)²
Gnathodiaphyseal Dysplasia 1 Protein² ³

External Ids:	HGNC: 27337¹	Entrez Gene: 203859²	Ensembl: ENSG00000171714⁷	OMIM: 608662⁵	UniProtKB: Q75V66³

Export aliases for ANO5 gene to outside databases

Previous GC identifer: GC11P021897

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANO5:

This gene encodes a member of the anoctamin family of transmembrane proteins. The encoded protein is likely a calcium

activated chloride channel. Mutations in this gene have been associated with gnathodiaphyseal dysplasia. Alternatively

spliced transcript variants have been described. (provided by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: ANO5_HUMAN, Q75V66

Function: Does not exhibit calcium-activated chloride channel (CaCC) activity

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANO5 gene promoter:
PPAR-gamma1 HSF2 Brachyury HSF1 (long) HSF1short Sox9 c-Myb PPAR-gamma2 Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANO5 promoter sequence

Search SABiosciences Chromatin IP Primers for ANO5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANO5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.3 Ensembl cytogenetic band: 11p14.3 HGNC cytogenetic band: 11p15.1

ANO5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANO5 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P022172: view genomic region (about GC identifiers)

Start:	22,214,722 bp from pter	End:	22,304,913 bp from pter
Size:	90,192 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANO5_HUMAN, Q75V66 (See protein sequence)

Recommended Name: Anoctamin-5

Size: 913 amino acids; 107188 Da

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane. Note=Co-localized

with CALR/calreticulin. Shows an intracellular localization according to PubMed:22075693

Miscellaneous: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT)

transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain

that all the members of this family are anion channels or have the 8-transmembrane topology

Explore the universe of human proteins at neXtProt for ANO5: NX_Q75V66

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q75V66

ANO5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001136121.1 NP_998764.1

ENSEMBL proteins:

ENSP00000315371

Reactome Protein details: Q75V66
Human Recombinant Protein Products for ANO5:

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	Uscn Proteins for ANO5

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0034707	chloride channel complex	--	--

ANO5 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANO5 for domains About GeneDecksing

1 InterPro domain/family:

IPR007632 Anoctamin

Graphical View of Domain Structure for InterPro Entry Q75V66

ProtoNet protein and cluster: Q75V66

UniProtKB/Swiss-Prot: ANO5_HUMAN, Q75V66

Similarity: Belongs to the anoctamin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ANO5_HUMAN, Q75V66

Function: Does not exhibit calcium-activated chloride channel (CaCC) activity

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005229	NOT intracellular calcium activated chloride channel activity	IDA	--
GO:0005254	chloride channel activity	--	--

ANO5 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ANO5:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ANO5

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		hsa-miR-579 hsa-miR-340 hsa-miR-4314 hsa-miR-374c hsa-miR-124 hsa-miR-506 hsa-miR-514b-3p hsa-miR-642b

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ion channel transport

Ion channel transport

1.00

Stimuli-sensing channels

0.49

SLC-mediated transmembrane transport

Transmembrane transport of small molecules

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for ANO5

	Transmembrane transport of small molecules
	Stimuli-sensing channels
	Ion channel transport

ANO5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ANO5

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for ANO5 (Q75V66³ ENSP00000315371⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK8	P45983³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ANO5

2 HMDB Compounds for ANO5 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Chlorine	Cl2 (see all 13)	16887-00-6	--

Search CenterWatch for drugs/clinical trials and news about ANO5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ANO5 gene (2 alternative transcripts):

NM_001142649.1 NM_213599.2

Unigene Cluster for ANO5:

Anoctamin 5

Hs.154329 [show with all ESTs]

Unigene Representative Sequence: AL833271

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000324559(uc001mqi.2 uc001mqj.2) ENST00000532043

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		hsa-miR-579 hsa-miR-340 hsa-miR-4314 hsa-miR-374c hsa-miR-124 hsa-miR-506 hsa-miR-514b-3p hsa-miR-642b

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Additional cDNA sequence:

AB125267.1 AK092680.1 AK125046.1 AL832374.1 AL833271.1

3 DOTS entries:

DT.309787 DT.99962279 DT.65285672

24/52 AceView cDNA sequences (see all 52):

BU742779 BQ086176 AI656017 NM_213599 BX096380 AI167890 F20661 AB125267

AI452416 H99734 BM728878 BG568450 BF055276 CD251010 CA773396 CA775403

AA332697 BQ102285 N89918 AK092680 W19512 CA773613 CA391883 AL832374

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANO5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGGTGATT

About this image

ANO5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Interscapular Brown Adipose Depot

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See ANO5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANO5

SOURCE GeneReport for Unigene cluster: Hs.154329

UniProtKB/Swiss-Prot: ANO5_HUMAN, Q75V66

Tissue specificity: Highly expressed in brain, heart, kidney, lung, and skeletal muscle. Weakly expressed in bone

marrow, fetal liver, placenta, spleen, thymus, osteoblasts and periodontal ligament cells

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANO5 gene from 8/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TMEM16E¹	transmembrane protein 16E	71.15(n) 71.43(a)		422973 NM_001168384.1 NP_001161856.1
lizard (Anolis carolinensis)	Reptilia	ANO5⁶	--	68(a)	1 ↔ 1	1(58576067-58611055)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.11223²	Transcribed sequence with weak similarity to protein more	76.17(n)		AL899430.2
zebrafish (Danio rerio)	Actinopterygii	ano5¹	anoctamin 5	63.42(n) 63.58(a)		100534737 XM_003201469.1 XP_003201517.1
fruit fly (Drosophila melanogaster)	Insecta	CG6938¹	CG6938	51(n) 43.59(a)		39362 NM_140278.2 NP_648535.2
worm (Caenorhabditis elegans)	Secernentea	anoh-1⁶	--	21(a)	possible ortholog	III(13246477-13253514)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G73020⁶	uncharacterized protein	19(a)	1 → many	1(27469534-27473554)
rice (Oryza sativa)	Liliopsida	--	transmembrane protein 16K, putative, expressed	18(a)	1 → many	1(29317147-29321524)

ENSEMBL Gene Tree for ANO5 (if available)
TreeFam Gene Tree for ANO5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANO5 gene

ANO9² ANO6² ANO2² ANO1² ANO10² ANO4² ANO3² ANO8²

ANO7²

7 SIMAP similar genes for ANO5 using alignment to 1 protein entry: ANO5_HUMAN:

ANO6 ANO4 ANO3 ANO1 ANO2 ANO7

ANO9

ANO5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs137854523^1,2	C,F	pathogenic	22257752(+)	`AGATGG/TGAAGA`	4	G V	mis¹		2		NA EU	5871
rs119103234^1,2	C	pathogenic	22272339(+)	`CACTCC/G/TGTGAT`	6	R G C	mis¹		0	--	--	--	--
rs137854529^1,2	C	pathogenic	22296151(+)	`TTCCCC/TGTCTA`	4	R C	mis¹		0	--	--	--	--
rs61879341^1,2	C	untested	22214877(+)	`AGGAGA/C/GAGGAG`	4	--	ut5¹		4		WA CSA	5
rs12792259^1,2	C	untested	22214903(+)	`AGCAGC/GCCCTT`	2	--	ut5¹ ese³		11		NA WA CSA EA	375
rs4922980^1,2	C,F,A,H	untested	22233029(+)	`TGGGGA/GGAAAA`	2	--	int¹ trp³		18		NS EA NA WA CSA	801
rs4922981^1,2	C,F,A,H	untested	22233066(+)	`CGCACC/TGAGTA`	2	--	int¹		34		NA NS EA WA CSA	2925
rs4312063^1,2	C,F,A,H	untested	22242729(+)	`GATGAC/TGTAAA`	4	D	syn¹		29		NS EA NA WA CSA EU	8268
rs4509753^1,2	C,F,A,H	untested	22247205(+)	`AGTGAA/GTCTTT`	2	--	int¹		22		NS EA NA WA CSA	1007
rs4534588^1,2	C,F,A,H	untested	22257543(+)	`ACTCCA/GTATAA`	2	--	int¹		20		NS EA NA WA CSA	2122

HapMap Linkage Disequilibrium report for ANO5 (22214722 - 22304913 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ANO5
2 CNVs: 85679 23405
2 Indels: 75572 44863
Human Gene Mutation Database (HGMD): ANO5

Locus Specific Mutation Databases (LSDB): ANO5

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANO5

DNA2.0 Custom Variant and Variant Library Synthesis for ANO5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ANO5 for disorders           About GeneDecksing

OMIM gene information: 608662
OMIM disorders: 166260  611307  613319
UniProtKB/Swiss-Prot: ANO5_HUMAN, Q75V66

Defects in ANO5 are the cause of gnathodiaphyseal dysplasia (GDD) [MIM:166260]; also known as osteogenesis

imperfecta with unusual skeletal lesions or gnathodiaphyseal sclerosis. GDD is a rare skeletal syndrome characterized

by bone fragility, sclerosis of tubular bones, and cemento-osseous lesions of the jawbone. Patients experience

frequent bone fractures caused by trivial accidents in childhood; however the fractures heal normally without bone

deformity. The jaw lesions replace the tooth-bearing segments of the maxilla and mandible with fibrous connective

tissues, including various amounts of cementum-like calcified mass, sometimes causing facial deformities. Patients

also have a propensity for jaw infection and often suffer from purulent osteomyelitis-like symptoms, such as swelling

of and pus discharge from the gums, mobility of the teeth, insufficient healing after tooth extraction and exposure of

the lesions into the oral cavity

Defects in ANO5 are the cause of limb-girdle muscular dystrophy type 2L (LGMD2L) [MIM:611307]. It is an

autosomal recessive degenerative myopathy characterized by proximal weakness, weakness of the hip and shoulder girdles

and prominent asymmetrical quadriceps femoris and biceps brachii atrophy

Defects in ANO5 are the cause of miyoshi muscular dystrophy type 3 (MMD3) [MIM:613319]. It is a late-onset

muscular dystrophy characterized by distal muscle weakness of the lower limbs, calf muscle discomfort and weakness,

quadriceps atrophy. Muscle weakness and atrophy may be asymmetric

9 diseases for ANO5: About MalaCards

limb-girdle muscular dystrophy gnathodiaphyseal dysplasia muscular dystrophy limb-girdle muscular dystrophy type 2l

miyoshi muscular dystrophy 3 osteogenesis imperfecta osteomyelitis periodontitis

myopathy

1 disease from the University of Copenhagen DISEASES database for ANO5:

Muscular dystrophy

1 Novoseek disease relationship for ANO5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dysplasia	63.6	5	20096397 (1), 20005074 (1), 15375614 (1), 15882990 (1)

Export disorders for ANO5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ANO5 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with ANO5)

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Identification and characterization of TMEM16E and TMEM16F genes in silico. (PubMed id 15067359)^{1, 2, 3, 9} Katoh M. and Katoh M. (2004)
The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD). (PubMed id 15124103)^{1, 2, 9} Tsutsumi S.... Itakura M. (2004)
Recessive mutations in the putative calcium-activated chloride channel Anoctamin 5 cause proximal LGMD2L and distal MMD3 muscular dy strophies. (PubMed id 20096397)^{1, 2, 9} Bolduc V....Brais B. (2010)
Novel ANO5 mutations causing hyper-CK-emia, limb girdle muscular weakness and Miyoshi type of muscular dystrophy. (PubMed id 22499103)^{1, 2} Schessl J.... Schoser B. (2012)
ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. (PubMed id 22075693)² Duran C.... Hartzell H.C. (2012)
Anoctamins are a family of Ca2+ activated Cl- channels. (PubMed id 22946059)² Tian Y.... Kunzelmann K. (2012)
The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age. (PubMed id 22302790)² Winpenny J.P. and Gray M.A. (2012)
LGMD2L with bone affection: overlapping phenotype of d ominant and recessive ANO5-induced disease. (PubMed id 23055322)¹ Witting N....Vissing J. (2012)
Eight new mutations and the expanding phenotype variab ility in muscular dystrophy caused by ANO5. (PubMed id 22402862)¹ Penttila S....Udd B. (2012)
Miyoshi-like distal myopathy with mutations in anoctam in 5 gene. (PubMed id 22336395)¹ Bouquet F....Eymard B. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 203859	HGNC: 27337	AceView: TMEM16E	Ensembl:ENSG00000171714	euGenes: HUgn203859
ECgene: ANO5	H-InvDB: ANO5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ANO5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANO5 gene
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Patent Information for ANO5 gene:
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