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ANO4 Gene

protein-coding   GIFtS: 51
GCID: GC12P101111

Anoctamin 4

(Previous name: transmembrane protein 16D)
(Previous symbol: TMEM16D)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Anoctamin 41 2
TMEM16D1 2 3 5
Transmembrane Protein 16D1 2 3
anoctamin-42
FLJ342725

External Ids:    HGNC: 238371   Entrez Gene: 1216012   Ensembl: ENSG000001515727   OMIM: 6101115   UniProtKB: Q32M453   

Export aliases for ANO4 gene to outside databases

Previous GC identifers: GC12P099712 GC12P101188 GC12P098249


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANO4 Gene:
ANO4 (anoctamin 4) is a protein-coding gene. Diseases associated with ANO4 include alzheimer's disease. An important paralog of this gene is ANO10.

UniProtKB/Swiss-Prot: ANO4_HUMAN, Q32M45
Function: Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANO4 gene promoter:
         TBP   SREBP-1c   NF-AT   SREBP-1b   NF-AT4   SREBP-1a   NF-AT2   NF-AT3   Hlf   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANO4 promoter sequence
   Search Chromatin IP Primers for ANO4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.1   Ensembl cytogenetic band:  12q23.1   HGNC cytogenetic band: 12q23.3

ANO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANO4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P101111:  view genomic region     (about GC identifiers)

Start:
101,111,304 bp from pter      End:
101,522,419 bp from pter
Size:
411,116 bases      Orientation:
plus strand

1 alternative location:
Chr12-,NW_003315942 135,832-154,069     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ANO4_HUMAN, Q32M45 (See protein sequence)
Recommended Name: Anoctamin-4  
Size: 955 amino acids; 111462 Da
Miscellaneous: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT)
transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not
certain that all the members of this family are anion channels or have the 8-transmembrane topology
Sequence caution: Sequence=BAC03688.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q8NAJ0 Q8NB39 Q8NB53
Alternative splicing: 3 isoforms:  Q32M45-1   Q32M45-2   Q32M45-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANO4: NX_Q32M45

Explore proteomics data for ANO4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn83, Asn105, Asn257, Asn288
  • Modification sites at PhosphoSitePlus

  • See ANO4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273544.1  NP_001273545.1  NP_849148.2  

    ENSEMBL proteins: 
     ENSP00000449116   ENSP00000447867   ENSP00000376705   ENSP00000376703   ENSP00000450192  
     ENSP00000443751   ENSP00000299222  
    Reactome Protein details: Q32M45

    ANO4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ANO4

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    LSBio Antibodies in human, mouse, rat for ANO4

    ANO4 Assay Products:

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    Cloud-Clone Corp. CLIAs for ANO4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANO: Ion channels / Chloride channels : Calcium activated : Anoctamins

    1 InterPro protein domain:
     IPR007632 Anoctamin

    Graphical View of Domain Structure for InterPro Entry Q32M45

    ProtoNet protein and cluster: Q32M45

    UniProtKB/Swiss-Prot: ANO4_HUMAN, Q32M45
    Similarity: Belongs to the anoctamin family


    ANO4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANO4_HUMAN, Q32M45
    Function: Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for ANO4:

     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANO4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANO4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANO4

    miRNA
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    miRTarBase miRNAs that target ANO4:
    hsa-mir-378c (MIRT052833)

    Block miRNA regulation of human, mouse, rat ANO4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANO4 (see all 30):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-137 hsa-miR-300 hsa-miR-25 hsa-miR-30d hsa-miR-507 hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidANO4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ANO4

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ANO4 (NM_178826)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANO4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANO4_HUMAN, Q32M45: Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    peroxisome2
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ISS--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    ANO4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANO4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ANO4
        Stimuli-sensing channels



    ANO4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANO4
    Interactions:

        Search GeneGlobe Interaction Network for ANO4

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--

    ANO4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANO4

    2 HMDB Compounds for ANO4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANO4 gene (3 alternative transcripts): 
    NM_001286615.1  NM_001286616.1  NM_178826.3  

    Unigene Cluster for ANO4:

    Anoctamin 4
    Hs.58785  [show with all ESTs]
    Unigene Representative Sequence: NM_178826
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000549155 ENST00000551148 ENST00000546991 ENST00000392979(uc001thw.2 uc010svm.1 uc001thx.2)
    ENST00000392977 ENST00000549234 ENST00000548940 ENST00000550015(uc001thy.2)
    ENST00000538618(uc010svl.1) ENST00000299222
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ANO4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANO4 (see all 30):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-137 hsa-miR-300 hsa-miR-25 hsa-miR-30d hsa-miR-507 hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidANO4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ANO4
    Predesigned siRNA for gene silencing in human, mouse, rat ANO4
    Clone
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    OriGene clones in human, mouse for ANO4 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANO4 (NM_178826)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANO4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANO4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ANO4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANO4
      QuantiTect SYBR Green Assays in human, mouse, rat ANO4
      QuantiFast Probe-based Assays in human, mouse, rat ANO4

    Additional mRNA sequence: 

    AK091540.1 AK091591.1 AK092596.1 AK293810.1 AK302962.1 AK316105.1 BC109308.2 

    6 DOTS entries:

    DT.209412  DT.100748156  DT.121152386  DT.121152380  DT.121152420  DT.205807 

    Selected AceView cDNA sequences (see all 37):

    AI140598 BX105943 AK091540 AI093277 BX281248 AX747046 NM_178826 AX747079 
    BF589515 BF939628 BI915289 AK092596 AI796421 AK091591 AX747621 BE644980 
    W85930 AA669481 AI078428 AI949760 AA777662 AI669168 AA703373 AW006706 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ANO4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                    -     -                                                                             -                                                   
    SP2:                                                                                                                          -                                 
    SP3:                          -                                                                                                                                 
    SP4:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          


    ECgene alternative splicing isoforms for ANO4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANO4 expression in normal human tissues (normalized intensities)      ANO4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACCAAGAA
    ANO4 Expression
    About this image


    ANO4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
    ANO4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANO4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.58785
        Custom PCR Arrays for ANO4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANO4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ano41 , 5 anoctamin 41, 5 92.08(n)1
    98.32(a)1
      10 (44.42 cM)5
    3200911  NM_001277188.11  NP_001264117.11 
     889489945 
    chicken
    (Gallus gallus)
    Aves ANO41 anoctamin 4 86(n)
    93.3(a)
      427878  XM_425452.4  XP_425452.4 
    lizard
    (Anolis carolinensis)
    Reptilia ANO46
    anoctamin 4
    90(a)
    1 ↔ 1
    5(28385435-28443669)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ano41 anoctamin 4 79.06(n)
    88.01(a)
      100488512  XM_002936841.2  XP_002936887.2 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.99602 Oncorhynchus mykiss transcribed sequence with weak more 74.68(n)    BX313732.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69386
    --
    30(a)
    1 → many
    3L(11978006-11983605)


    ENSEMBL Gene Tree for ANO4 (if available)
    TreeFam Gene Tree for ANO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANO4 gene
    ANO102  ANO92  ANO32  ANO62  ANO82  ANO72  ANO22  ANO12  
    ANO52  
    7 SIMAP similar genes for ANO4 using alignment to 4 protein entries:     ANO4_HUMAN (see all proteins):
    ANO3    ANO2    ANO5    ANO1    ANO9    ANO7
    ANO6

    ANO4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANO4 (see all 6783)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342915391,2
    C--98301983(+) AGGTG-/A/GA  
            
    GTCTC
    1 -- int11NA 2
    rs58004411,2
    C--101166302(+) TTTTTT/-GCATT 1 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1817131751,2
    --101186409(+) TAACTA/GGAATA 1 -- us2k10--------
    rs731476381,2
    C,F--101186538(+) GAACCC/TGTTTC 1 -- us2k11Minor allele frequency- T:0.06NA 120
    rs796055531,2
    C--101186551(+) CAACAA/GTATTA 1 -- us2k10--------
    rs174802731,2
    C,F,H--101186553(+) ACAGTA/GTTAAT 1 -- us2k18Minor allele frequency- G:0.01NA NS EA 664
    rs779324721,2
    C--101186631(+) TTTTAC/GAGTGT 1 -- us2k10--------
    rs789608881,2
    C--101186632(+) TTTACA/GGTGTC 1 -- us2k10--------
    rs1846880311,2
    --101186699(+) TAATTC/TGATTT 1 -- us2k10--------
    rs1503164121,2
    --101186725(+) CATTTA/GTATTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANO4 (101111304 - 101361304 bp, first 250kb of ANO4)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ANO4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673176CNV Deletion23128226
    esv2666281CNV Deletion23128226
    esv2586099CNV Deletion19546169
    nsv856CNV Insertion18451855
    nsv899471CNV Loss21882294
    esv27167CNV Loss19812545
    nsv853CNV Loss18451855
    nsv518877CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANO4
    DNA2.0 Custom Variant and Variant Library Synthesis for ANO4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610111    OMIM disorders: --

    1 disease for ANO4:    About MalaCards
    alzheimer's disease


    ANO4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ANO4

    Export disorders for ANO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANO4 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ANO4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. (PubMed id 12739008)1, 2, 3 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Identification and characterization of TMEM16E and TMEM16F genes in silico. (PubMed id 15067359)1, 3 Katoh M. and Katoh M. (Int. J. Oncol. 2004)
    4. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)1 Sherva R....Green R.C. (amp 2014)
    5. Anoctamins are a family of Ca2+ activated Cl- channels. (PubMed id 22946059)2 Tian Y.... Kunzelmann K. (J. Cell Sci. 2012)
    6. The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age. (PubMed id 22302790)2 Winpenny J.P. and Gray M.A. (Exp. Physiol. 2012)
    7. Anoctamins. (PubMed id 21607626)2 Kunzelmann K.... Schreiber R. (Pflugers Arch. 2011)
    8. Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels? (PubMed id 21642943)2 Duran C. and Hartzell H.C. (Acta Pharmacol. Sin. 2011)
    9. Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels. (PubMed id 19015192)1 Hartzell H.C....Qu Z. (J. Physiol. (Lond.) 2009)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 121601 HGNC: 23837 AceView: TMEM16D Ensembl:ENSG00000151572 euGenes: HUgn121601
    ECgene: ANO4 H-InvDB: ANO4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANO4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANO4 gene:
    Search GeneIP for patents involving ANO4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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