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Aliases for ANO4 Gene

Aliases for ANO4 Gene

  • Anoctamin 4 2 3
  • Transmembrane Protein 16D 2 3 4
  • TMEM16D 3 4 6
  • Anoctamin-4 3
  • FLJ34272 6

External Ids for ANO4 Gene

Previous Symbols for ANO4 Gene

  • TMEM16D

Summaries for ANO4 Gene

GeneCards Summary for ANO4 Gene

ANO4 (Anoctamin 4) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. An important paralog of this gene is ANO5.

UniProtKB/Swiss-Prot for ANO4 Gene

  • Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANO4 Gene

Genomics for ANO4 Gene

Genomic Location for ANO4 Gene

100,717,526 bp from pter
101,128,641 bp from pter
411,116 bases
Plus strand

Genomic View for ANO4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANO4 Gene

Regulatory Elements for ANO4 Gene

Proteins for ANO4 Gene

  • Protein details for ANO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8NAJ0
    • Q8NB39
    • Q8NB53

    Protein attributes for ANO4 Gene

    955 amino acids
    Molecular mass:
    111462 Da
    Quaternary structure:
    No Data Available
    • The term anoctamin was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology
    • Sequence=BAC03688.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANO4 Gene


neXtProt entry for ANO4 Gene

Proteomics data for ANO4 Gene at MOPED

Post-translational modifications for ANO4 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn83, Asn105, Asn257, and Asn288

Other Protein References for ANO4 Gene

No data available for DME Specific Peptides for ANO4 Gene

Domains for ANO4 Gene

Gene Families for ANO4 Gene

  • ANO :Ion channels / Chloride channels : Calcium activated : Anoctamins

Protein Domains for ANO4 Gene



  • Belongs to the anoctamin family.:
    • Q32M45
genes like me logo Genes that share domains with ANO4: view

Function for ANO4 Gene

Molecular function for ANO4 Gene

UniProtKB/Swiss-Prot Function: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity.

Gene Ontology (GO) - Molecular Function for ANO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005229 intracellular calcium activated chloride channel activity IDA 22946059
GO:0017128 phospholipid scramblase activity IEA --
genes like me logo Genes that share ontologies with ANO4: view

Phenotypes for ANO4 Gene

GenomeRNAi human phenotypes for ANO4:
genes like me logo Genes that share phenotypes with ANO4: view

miRNA for ANO4 Gene

miRTarBase miRNAs that target ANO4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANO4 Gene

Localization for ANO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANO4 Gene

Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization. {ECO:0000250 UniProtKB:Q8C5H1}.

Subcellular locations from

Jensen Localization Image for ANO4 Gene COMPARTMENTS Subcellular localization image for ANO4 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ANO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular ISS --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANO4: view

Pathways for ANO4 Gene

genes like me logo Genes that share pathways with ANO4: view

Pathways by source for ANO4 Gene

Interacting Proteins for ANO4 Gene

Gene Ontology (GO) - Biological Process for ANO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006821 chloride transport IDA 22946059
GO:0006869 lipid transport IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
GO:0061589 calcium activated phosphatidylserine scrambling IEA --
genes like me logo Genes that share ontologies with ANO4: view

Compounds for ANO4 Gene

(2) HMDB Compounds for ANO4 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • Cl2
genes like me logo Genes that share compounds with ANO4: view

Transcripts for ANO4 Gene

Unigene Clusters for ANO4 Gene

Anoctamin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANO4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - -
SP2: -
SP3: -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29

Relevant External Links for ANO4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANO4 Gene

mRNA expression in normal human tissues for ANO4 Gene

mRNA differential expression in normal tissues according to GTEx for ANO4 Gene

This gene is overexpressed in Brain - Hippocampus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ANO4 Gene

SOURCE GeneReport for Unigene cluster for ANO4 Gene Hs.58785

genes like me logo Genes that share expressions with ANO4: view

Orthologs for ANO4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANO4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANO4 36
  • 99.76 (n)
  • 99.9 (a)
ANO4 37
  • 96 (a)
(Bos Taurus)
Mammalia ANO4 36
  • 95.22 (n)
  • 98.59 (a)
ANO4 37
  • 99 (a)
(Canis familiaris)
Mammalia ANO4 36
  • 94.97 (n)
  • 99.27 (a)
ANO4 37
  • 95 (a)
(Mus musculus)
Mammalia Ano4 36
  • 92.08 (n)
  • 98.32 (a)
Ano4 16
Ano4 37
  • 98 (a)
(Monodelphis domestica)
Mammalia ANO4 37
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ANO4 37
  • 82 (a)
(Rattus norvegicus)
Mammalia Ano4 36
  • 91.42 (n)
  • 99.07 (a)
(Gallus gallus)
Aves ANO4 36
  • 86 (n)
  • 93.3 (a)
ANO4 37
  • 90 (a)
(Anolis carolinensis)
Reptilia ANO4 37
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ano4 36
  • 79.06 (n)
  • 88.01 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9960 36
fruit fly
(Drosophila melanogaster)
Insecta CG6938 37
  • 30 (a)
Species with no ortholog for ANO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANO4 Gene

Gene Tree for ANO4 (if available)
Gene Tree for ANO4 (if available)

Paralogs for ANO4 Gene

Paralogs for ANO4 Gene

Selected SIMAP similar genes for ANO4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ANO4: view

Variants for ANO4 Gene

Sequence variations from dbSNP and Humsavar for ANO4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs349661 -- 101,116,593(-) TGCAG(G/T)GACGT intron-variant
rs349662 -- 101,116,918(-) CAACA(A/G)TGCAT intron-variant
rs349663 -- 101,127,643(-) TCCCC(A/G)ATAGT intron-variant
rs473974 -- 101,054,902(+) atgca(A/G)attaa intron-variant
rs473988 -- 100,962,310(+) AACAT(C/G)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANO4 Gene

Variant ID Type Subtype PubMed ID
nsv853 CNV Loss 18451855
nsv518877 CNV Loss 19592680
esv27167 CNV Loss 19812545
esv2666281 CNV Deletion 23128226
esv2586099 CNV Deletion 19546169
nsv856 CNV Insertion 18451855
esv2673176 CNV Deletion 23128226
nsv899471 CNV Loss 21882294

Relevant External Links for ANO4 Gene

HapMap Linkage Disequilibrium report

Disorders for ANO4 Gene

Relevant External Links for ANO4

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ANO4: view

No data available for UniProtKB/Swiss-Prot for ANO4 Gene

Publications for ANO4 Gene

  1. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. (PMID: 12739008) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification and characterization of TMEM16E and TMEM16F genes in silico. (PMID: 15067359) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3
  4. Anoctamins are a family of Ca2+ activated Cl- channels. (PMID: 22946059) Tian Y. … Kunzelmann K. (J. Cell Sci. 2012) 3 4
  5. Structure and function of TMEM16 proteins (anoctamins). (PMID: 24692353) Pedemonte N. … Galietta L.J. (Physiol. Rev. 2014) 2 3

Products for ANO4 Gene

Sources for ANO4 Gene

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