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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANO4 Gene

protein-coding GIFtS: 46
GCID: GC12P101111

anoctamin 4

(Previous name: transmembrane protein 16D )
(Previous symbol: TMEM16D)

Search for ANO4
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Anoctamin 4¹ ²		FLJ34221¹
TMEM16D¹ ² ³ ⁵		FLJ35277¹
Transmembrane Protein 16D¹ ² ³		Anoctamin-4¹
FLJ34272¹ ⁵

External Ids:	HGNC: 23837¹	Entrez Gene: 121601²	Ensembl: ENSG00000151572⁷	OMIM: 610111⁵	UniProtKB: Q32M45³

Export aliases for ANO4 gene to outside databases

Previous GC identifers: GC12P099712 GC12P101188 GC12P098249

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ANO4_HUMAN, Q32M45

Function: Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANO4 gene promoter:
TBP SREBP-1c NF-AT SREBP-1b NF-AT4 SREBP-1a NF-AT2 NF-AT3 Hlf NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANO4 promoter sequence

Search SABiosciences Chromatin IP Primers for ANO4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANO4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.1 Ensembl cytogenetic band: 12q23.1 HGNC cytogenetic band: 12q23.3

ANO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANO4 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P101111: view genomic region (about GC identifiers)

Start:	101,111,304 bp from pter	End:	101,522,419 bp from pter
Size:	411,116 bases	Orientation:	plus strand

1 alternative location:

Chr12-,PATCHES 101,636,113-101,654,350

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANO4_HUMAN, Q32M45 (See protein sequence)

Recommended Name: Anoctamin-4

Size: 955 amino acids; 111462 Da

Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization (By

similarity)

Miscellaneous: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT)

transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain

that all the members of this family are anion channels or have the 8-transmembrane topology

Sequence caution: Sequence=BAC03688.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q8NAJ0 Q8NB39 Q8NB53

Alternative splicing: 3 isoforms: Q32M45-1 Q32M45-2 Q32M45-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANO4: NX_Q32M45

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q32M45

ANO4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_849148.2

ENSEMBL proteins:

ENSP00000449116 ENSP00000447867 ENSP00000376705 ENSP00000376703 ENSP00000450192

ENSP00000443751 ENSP00000299222

Reactome Protein details: Q32M45
Human Recombinant Protein Products:

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	Uscn Proteins for ANO4

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	ISS	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0034707	chloride channel complex	--	--

ANO4 for ontologies About GeneDecksing

ANO4 Antibody Products:

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	Search for Antibodies for ANO4 at Abcam
	Uscn Antibodies for ANO4
	Search ThermoFisher Antibodies for ANO4

Assay Products for ANO4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for ANO4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ANO4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANO4 for domains About GeneDecksing

1 InterPro domain/family:

IPR007632 Anoctamin

Graphical View of Domain Structure for InterPro Entry Q32M45

ProtoNet protein and cluster: Q32M45

UniProtKB/Swiss-Prot: ANO4_HUMAN, Q32M45

Similarity: Belongs to the anoctamin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ANO4_HUMAN, Q32M45

Function: Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: ANO4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANO4
		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate ANO4 (see all 30):
		hsa-miR-30c hsa-miR-3607-3p hsa-miR-137 hsa-miR-300 hsa-miR-25 hsa-miR-30d hsa-miR-507 hsa-miR-548m

		SwitchGear 3'UTR luciferase reporter plasmid: ANO4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANO4 (see all 7) OriGene shRNA RFP: ANO4 OriGene siRNA: ANO4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANO4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ANO4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANO4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANO4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ANO4 (NM_178826)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ANO4
		Search LifeMap BioReagents cell lines for ANO4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO4

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005254	chloride channel activity	--	--

ANO4 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ANO4:

Decreased viability with pacli

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ion channel transport

Ion channel transport

1.00

Stimuli-sensing channels

0.49

SLC-mediated transmembrane transport

Transmembrane transport of small molecules

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for ANO4

	Transmembrane transport of small molecules
	Stimuli-sensing channels
	Ion channel transport

ANO4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ANO4

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ANO4

2 HMDB Compounds for ANO4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Chlorine	Cl2 (see all 13)	16887-00-6	--

Search CenterWatch for drugs/clinical trials and news about ANO4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ANO4 gene:

NM_178826.3

Unigene Cluster for ANO4:

Anoctamin 4

Hs.58785 [show with all ESTs]

Unigene Representative Sequence: NM_178826

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000549155 ENST00000551148 ENST00000546991 ENST00000392979(uc001thw.2 uc010svm.1 uc001thx.2)

ENST00000392977 ENST00000549234 ENST00000548940 ENST00000550015(uc001thy.2)

ENST00000538618(uc010svl.1) ENST00000299222

miRNA Products:		OriGene 3'-UTR Clone: ANO4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANO4
		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate ANO4 (see all 30):
		hsa-miR-30c hsa-miR-3607-3p hsa-miR-137 hsa-miR-300 hsa-miR-25 hsa-miR-30d hsa-miR-507 hsa-miR-548m

		SwitchGear 3'UTR luciferase reporter plasmid: ANO4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANO4 (see all 7) OriGene shRNA RFP: ANO4 OriGene siRNA: ANO4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANO4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANO4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANO4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ANO4 (NM_178826)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANO4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANO4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANO4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANO4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANO4

Additional cDNA sequence:

AK091540.1 AK091591.1 AK092596.1 AK293810.1 AK302962.1 AK316105.1 BC109308.2

6 DOTS entries:

DT.209412 DT.100748156 DT.121152386 DT.121152380 DT.121152420 DT.205807

24/37 AceView cDNA sequences (see all 37):

AI093277 AX747621 NM_178826 AX747079 AK091591 BX105943 AI796421 BX281248

AX747046 AK091540 BF589515 AK092596 AI140598 BF939628 BI915289 W85930

AI669168 AI949760 AI078428 AW006706 AA669481 AA777662 BE552129 BE501692

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ANO4 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^
SP1:							-		-																										-
SP2:																																									-
SP3:									-
SP4:

ExUns:	23	^	24	^	25	^	26	^	27	^	28	^	29
SP1:
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for ANO4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANO4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACCAAGAA

About this image

ANO4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Interstitial Stroma

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

See ANO4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANO4

SOURCE GeneReport for Unigene cluster: Hs.58785

SABiosciences Custom PCR Arrays for ANO4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANO4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANO4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANO4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANO4 gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ANO4¹	anoctamin 4	86.84(n) 95.01(a)		427878 XM_425452.3 XP_425452.3
lizard (Anolis carolinensis)	Reptilia	ANO4⁶	--	94(a)	1 ↔ 1	5(28389112-28431986)
rainbow trout (Oncorhynchus mykiss)	Actinopterygii	Omy.9960²	Oncorhynchus mykiss transcribed sequence with weak more	74.68(n)		BX313732.1
fruit fly (Drosophila melanogaster)	Insecta	CG6938⁶	--	28(a)	1 → many	3L(11978006-11983605)
worm (Caenorhabditis elegans)	Secernentea	anoh-1⁶	--	20(a)	possible ortholog	III(13246477-13253514)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G73020⁶	uncharacterized protein	21(a)	1 → many	1(27469534-27473554)
rice (Oryza sativa)	Liliopsida	--	transmembrane protein 16K, putative, expressed	20(a)	1 → many	1(29317147-29321524)

ENSEMBL Gene Tree for ANO4 (if available)
TreeFam Gene Tree for ANO4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANO4 gene

ANO9² ANO6² ANO2² ANO5² ANO1² ANO10² ANO3² ANO8²

ANO7²

7 SIMAP similar genes for ANO4 using alignment to 4 protein entries: ANO4_HUMAN (see all proteins):

ANO3 ANO2 ANO5 ANO1 ANO9 ANO6

ANO7

ANO4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181713175^1,2		--	101186409(+)	`TAACTA/GGAATA`	1	--	us2k¹		0	--	--	--	--
rs73147638^1,2	C,F,	--	101186538(+)	`GAACCC/TGTTTC`	1	--	us2k¹		1		NA	120
rs79605553^1,2		--	101186551(+)	`CAACAA/GTATTA`	1	--	us2k¹		0	--	--	--	--
rs17480273^1,2	C,F,H,	--	101186553(+)	`ACAGTA/GTTAAT`	1	--	us2k¹		8		NA NS EA	664
rs77932472^1,2	C	--	101186631(+)	`TTTTAC/GAGTGT`	1	--	us2k¹		0	--	--	--	--
rs78960888^1,2	C	--	101186632(+)	`TTTACA/GGTGTC`	1	--	us2k¹		0	--	--	--	--
rs184688031^1,2		--	101186699(+)	`TAATTC/TGATTT`	1	--	us2k¹		0	--	--	--	--
rs150316412^1,2		--	101186725(+)	`CATTTA/GTATTT`	1	--	us2k¹		0	--	--	--	--
rs74348682^1,2	C,F,	--	101186737(+)	`CTGAAT/GGGCTT`	1	--	us2k¹		1		WA	118
rs137892354^1,2		--	101186744(+)	`GCTTCA/GGTTAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ANO4 (101111304 - 101361304 bp, first 250kb of ANO4)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ANO4
1 CNV: 101603
1 Indel: 71548

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANO4

DNA2.0 Custom Variant and Variant Library Synthesis for ANO4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ANO4 for disorders About MalaCards

ANO4 for disorders About GeneDecksing

OMIM gene information: 610111 OMIM disorders: --

Export disorders for ANO4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ANO4 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ANO4)

Utopia: connect your pdf to the dynamic
world of online information

FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. (PubMed id 12739008)^{1, 2, 3} Katoh M. and Katoh M. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification and characterization of TMEM16E and TMEM16F genes in silico. (PubMed id 15067359)^{1, 3} Katoh M. and Katoh M. (2004)
Anoctamins are a family of Ca2+ activated Cl- channels. (PubMed id 22946059)² Tian Y.... Kunzelmann K. (2012)
The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age. (PubMed id 22302790)² Winpenny J.P. and Gray M.A. (2012)
Anoctamins. (PubMed id 21607626)² Kunzelmann K.... Schreiber R. (2011)
Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels? (PubMed id 21642943)² Duran C. and Hartzell H.C. (2011)
Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels. (PubMed id 19015192)¹ Hartzell H.C....Qu Z. (2009)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 121601	HGNC: 23837	AceView: TMEM16D	Ensembl:ENSG00000151572	euGenes: HUgn121601
ECgene: ANO4	H-InvDB: ANO4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANO4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANO4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ANO4 gene:
Search GeneIP for patents involving ANO4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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