ANO3 Gene
protein-coding GIFtS : 49
GCID: GC11 P026310
anoctamin 3 (Previous names: chromosome 11 open reading frame 25, transmembrane protein... ) (Previous symbols: C11orf25, TMEM16C )
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Aliasesfor ANO3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Anoctamin 3 1 2 Chromosome 11 Open Reading Frame 251 C11orf251 2 3 5 DYT242 TMEM16C1 2 3 5 Anoctamin-31 Transmembrane Protein 16C1 3 Transmembrane Protein 16C (Eight Membrane-Spanning Domains)2 GENX-39471
Export aliases for ANO3 gene to outside databases Previous GC identifer: GC11P026049
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Summariesfor ANO3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ANO3_HUMAN, Q9BYT9 Function : Does not exhibit calcium-activated chloride channel (CaCC) activity
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Genomic Viewsfor ANO3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_009237.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ANO3 gene promoter: FOXF2 Nkx2-2 NF-AT NF-AT4 PPAR-gamma1 POU2F1 NF-AT2 NF-AT3 PPAR-gamma2 NF-AT1 Other transcription factors Search SABiosciences Chromatin IP Primers for ANO3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANO3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p14.2 Ensembl cytogenetic band: 11p14.2 HGNC cytogenetic band: 11p14.1-p13 ANO3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P026310: view genomic region
(about GC identifiers )
Start:
26,210,829 bp from pter
End:
26,684,836 bp from pter
Size:
474,008 bases
Orientation:
plus strand
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Proteinsfor ANO3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ANO3_HUMAN, Q9BYT9 (See
protein sequence )Recommended Name: Anoctamin-3 Size : 981 amino acids; 114657 Da
Subcellular location : Cell membrane; Multi-pass membrane protein (Potential). Note=Shows an intracellular localization(By similarity)
Miscellaneous : The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT)transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology Explore the universe of human proteins at neXtProt for ANO3: NX_Q9BYT9 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BYT9 ANO3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_113606.2 ENSEMBL proteins: ENSP00000432576 ENSP00000256737 ENSP00000435275 ENSP00000432394 ENSP00000440737 Reactome Protein details: Q9BYT9 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
ANO3 for ontologies About GeneDecksing ANO3 Antibody Products: Assay Products for ANO3:
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Protein
Domains / Familiesfor ANO3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ANO3 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9BYT9 ProtoNet protein and cluster: Q9BYT9
UniProtKB/Swiss-Prot: ANO3_HUMAN, Q9BYT9 Similarity : Belongs to the anoctamin family
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Functionfor ANO3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ANO3_HUMAN, Q9BYT9 Function : Does not exhibit calcium-activated chloride channel (CaCC) activity
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANO3 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANO3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANO3 (NM_031418 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANO3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANO3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO3
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005229 NOT intracellular calcium activated chloride channel activity
IDA -- GO:0005254 chloride channel activity
-- --
ANO3 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for ANO3 :
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Pathways & Interactionsfor ANO3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Ion channel transport 2 SLC-mediated transmembrane transport
Pathway sources See GeneCards unified pathways Show all pathways 3
Reactome Pathways for ANO3
ANO3 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANO3
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Drugs & Compoundsfor ANO3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ANO3 2 HMDB Compounds for ANO3 About this table Search CenterWatch for drugs/clinical trials and news about ANO3
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Transcriptsfor ANO3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ANO3 gene: NM_031418.2 Unigene Cluster for ANO3:
Anoctamin 3 Hs.91791 [show with all ESTs ] Unigene Representative Sequence: AJ300461 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000525139 ENST00000256737 (uc010rdr.2 uc001mqt.4 uc010rds.2 uc010rdt.2 )ENST00000531646 ENST00000531568 ENST00000529242 ENST00000537978 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANO3 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANO3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANO3 (NM_031418 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANO3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANO3
Additional cDNA sequence: AJ300461.1 AK295143.1 AK295658.1 AK295816.1 AK302659.1 AK304781.1 AK316018.1 X81896.1
3 DOTS entries : DT.310398 DT.120684036
DT.214133 1 AceView cDNA sequence :
AL120323 GeneLoc Exon Structure
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Expression for ANO3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ANO3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATGAGATACA
About this image ANO3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ANO3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ANO3 SOURCE GeneReport for Unigene cluster: Hs.91791 SABiosciences Custom PCR Arrays for ANO3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ANO3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat ANO3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ANO3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ANO3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO3
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Orthologsfor ANO3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for ANO3 gene from 8/24 species (see all 24 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ANO31
anoctamin 3
75.15(n) 77.3(a)
 
422968 NM_001199465.1 NP_001186394.1
lizard (Anolis carolinensis)
Reptilia
ANO36
--
81(a)
1 ↔ 1
GL343240.1(781741-860166)
African clawed frog (Xenopus laevis)
Amphibia
Xl.187782
Xenopus laevis transcribed sequence with weak similarity more
75.53(n)
 
BX851135.1
zebrafish (Danio rerio)
Actinopterygii
ano31
anoctamin 3
67.92(n) 72.88(a)
 
553392 XM_003201470.1 XP_003201518.1
fruit fly (Drosophila melanogaster)
Insecta
CG69386
--
28(a)
1 → many
3L(11978006-11983605)
worm (Caenorhabditis elegans)
Secernentea
anoh-16
--
21(a)
possible ortholog
III(13246477-13253514)
thale cress (Arabidopsis thaliana)
eudicotyledons
AT1G730206
uncharacterized protein
21(a)
1 → many
1(27469534-27473554)
rice (Oryza sativa)
Liliopsida
--
transmembrane protein 16K, putative, expressed
19(a)
1 → many
1(29317147-29321524)
ENSEMBL Gene Tree for ANO3 (if available)TreeFam Gene Tree for ANO3 (if available)
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Paralogsfor ANO3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ANO3 gene ANO9 2 ANO6 2 ANO2 2 ANO5 2 ANO1 2 ANO10 2 ANO4 2 ANO8 2 ANO7 2 7 SIMAP similar genes for ANO3 using alignment to 4 protein entries: ANO3_HUMAN (see all proteins ):ANO4 ANO6 ANO5 ANO1 ANO2 ANO9 ANO7
ANO3 for paralogs About GeneDecksing
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Genomic Variantsfor ANO3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ANO3 (26210829 - 26460829 bp, first 250kb of ANO3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 8 variations for ANO3 6 CNVs : 39070 39069 71302 5620 65905 5419 2 Indels : 44871 24704
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ANO3
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Disorders
/ Diseasesfor ANO3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ANO3 for disorders About GeneDecksing
OMIM gene information: 610110
OMIM disorders : --1 disease for ANO3 : About MalaCards obesity Human Genome Epidemiology (HuGE) Navigator: ANO3 (3 documents) Export disorders for ANO3 gene to outside databases
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Publicationsfor ANO3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ANO3 gene, integrated from 9 sources (see all 16 ): (articles sorted by number of sources associating them with ANO3) Utopia : connect your pdf to the dynamic world of online information
FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. (PubMed id 12739008) 1 , 3, 9 Katoh M. and Katoh M. (2003) Identification and characterization of TMEM16E and TMEM16F genes in silico. (PubMed id 15067359) 1 , 3 Katoh M. and Katoh M. (2004) The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PubMed id 21984732) 2 Scudieri P.... Galietta L.J. (2012) The ANO3/MUC15 locus is associated with eczema in fami lies ascertained through asthma. (PubMed id 22657408) 1 Dizier M.H....Demenais F. (2012) The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age. (PubMed id 22302790) 2 Winpenny J.P. and Gray M.A. (2012) Mutations in ANO3 cause dominant craniocervical dyston ia: ion channel implicated in pathogenesis. (PubMed id 23200863) 1 Charlesworth G....Wood N.W. (2012) Anoctamins. (PubMed id 21607626) 2 Kunzelmann K.... Schreiber R. (2011) Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels? (PubMed id 21642943) 2 Duran C. and Hartzell H.C. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Common body mass index-associated variants confer ris k of extreme obesity. (PubMed id 19553259) 1 Cotsapas C....Daly M.J. (2009)
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External Searches for ANO3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ANO3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ANO3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ANO3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ANO3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ANO3 gene: Search GeneIP for patents involving ANO3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ANO3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ANO3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ANO3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ANO3 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ANO3 OriGene 3'-UTR Clone for ANO3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANO3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANO3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ANO3 OriGene Custom Protein Services for ANO3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANO3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ANO3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANO3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ANO3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ANO3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ANO3
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ANO3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO3
Search ThermoFisher Antibodies for ANO3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANO3
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Aliases for ANO3
Databases for ANO3
Disorders / Diseases for ANO3
Domains / Families for ANO3
Drugs / Compounds for ANO3
Expression for ANO3
Function for ANO3
Genomic Views for ANO3
Intellectual Property for ANO3
Orthologs for ANO3
Paralogs for ANO3
Pathways / Interactions for ANO3
Products for ANO3
Proteins for ANO3
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Summaries for ANO3
Transcripts for ANO3
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