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ANO3 Gene

protein-coding   GIFtS: 53
GCID: GC11P026310

Anoctamin 3

(Previous names: chromosome 11 open reading frame 25, transmembrane protein...)
(Previous symbols: C11orf25, TMEM16C)
  See ANO3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Anoctamin 31 2     DYT242 5
C11orf251 2 3 5     Chromosome 11 Open Reading Frame 251
TMEM16C1 2 3 5     DYT232
Transmembrane Protein 16C1 3     anoctamin-32
Transmembrane Protein 16C (Eight Membrane-Spanning Domains)1 2     

External Ids:    HGNC: 140041   Entrez Gene: 639822   Ensembl: ENSG000001343437   OMIM: 6101105   UniProtKB: Q9BYT93   

Export aliases for ANO3 gene to outside databases

Previous GC identifer: GC11P026049


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANO3 Gene:
ANO3 (anoctamin 3) is a protein-coding gene. Diseases associated with ANO3 include dystonia 24. GO annotations related to this gene include intracellular calcium activated chloride channel activity. An important paralog of this gene is ANO10.

UniProtKB/Swiss-Prot: ANO3_HUMAN, Q9BYT9
Function: Does not exhibit calcium-activated chloride channel (CaCC) activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANO3 gene promoter:
         FOXF2   Nkx2-2   NF-AT   NF-AT4   PPAR-gamma1   POU2F1   NF-AT2   NF-AT3   PPAR-gamma2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANO3 promoter sequence
   Search Chromatin IP Primers for ANO3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.2   Ensembl cytogenetic band:  11p14.2   HGNC cytogenetic band: 11p14.2

ANO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANO3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P026310:  view genomic region     (about GC identifiers)

Start:
26,210,829 bp from pter      End:
26,684,836 bp from pter
Size:
474,008 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANO3_HUMAN, Q9BYT9 (See protein sequence)
Recommended Name: Anoctamin-3  
Size: 981 amino acids; 114657 Da
Miscellaneous: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT)
transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not
certain that all the members of this family are anion channels or have the 8-transmembrane topology

Explore the universe of human proteins at neXtProt for ANO3: NX_Q9BYT9

Explore proteomics data for ANO3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn425, Asn448, Asn455, Asn866
  • Modification sites at PhosphoSitePlus

  • See ANO3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_113606.2  
    ENSEMBL proteins: 
     ENSP00000432576   ENSP00000256737   ENSP00000435275   ENSP00000432394   ENSP00000440737  
    Reactome Protein details: Q9BYT9

    ANO3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ANO3

     
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    Search eBioscience for ELISAs for ANO3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANO: Ion channels / Chloride channels : Calcium activated : Anoctamins

    1 InterPro protein domain:
     IPR007632 Anoctamin

    Graphical View of Domain Structure for InterPro Entry Q9BYT9

    ProtoNet protein and cluster: Q9BYT9

    UniProtKB/Swiss-Prot: ANO3_HUMAN, Q9BYT9
    Similarity: Belongs to the anoctamin family


    Find genes that share domains with ANO3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANO3_HUMAN, Q9BYT9
    Function: Does not exhibit calcium-activated chloride channel (CaCC) activity

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005229NOT intracellular calcium activated chloride channel activity IDA--
         
    Find genes that share ontologies with ANO3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ANO3:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANO3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANO3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANO3

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANO3:
    hsa-mir-18a-3p (MIRT040750), hsa-mir-26a-5p (MIRT050061), hsa-mir-186-5p (MIRT044970), hsa-mir-335-5p (MIRT017573)

    Block miRNA regulation of human, mouse, rat ANO3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANO3 (see all 28):
    hsa-miR-217 hsa-miR-19b-2* hsa-miR-4251 hsa-miR-15a hsa-miR-103a hsa-miR-374c hsa-miR-424 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidANO3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ANO3
    Predesigned siRNA for gene silencing in human, mouse, rat ANO3

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANO3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ANO3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANO3_HUMAN, Q9BYT9: Cell membrane; Multi-pass membrane protein (Potential). Note=Shows an intracellular
    localization (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ANO3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANO3 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with ANO3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ANO3
        Stimuli-sensing channels


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANO3
    Interactions:

        Search GeneGlobe Interaction Network for ANO3

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with ANO3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANO3

    2 HMDB Compounds for ANO3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANO3 gene: 
    NM_031418.2  

    Unigene Cluster for ANO3:

    Anoctamin 3
    Hs.91791  [show with all ESTs]
    Unigene Representative Sequence: AJ300461
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525139 ENST00000256737(uc010rdr.2 uc001mqt.4 uc010rds.2 uc010rdt.2)
    ENST00000531646 ENST00000531568 ENST00000529242 ENST00000537978
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ANO3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANO3 (see all 28):
    hsa-miR-217 hsa-miR-19b-2* hsa-miR-4251 hsa-miR-15a hsa-miR-103a hsa-miR-374c hsa-miR-424 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidANO3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANO3
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    GenScript: all cDNA clones in your preferred vector: ANO3 (NM_031418)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANO3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANO3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ANO3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ANO3
      QuantiTect SYBR Green Assays in human, mouse, rat ANO3
      QuantiFast Probe-based Assays in human, mouse, rat ANO3

    Additional mRNA sequence: 

    AJ300461.1 AK295143.1 AK295658.1 AK295816.1 AK302659.1 AK304781.1 AK316018.1 X81896.1 

    3 DOTS entries:

    DT.310398  DT.120684036  DT.214133 

    1 AceView cDNA sequence:

    AL120323 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANO3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAGATACA
    ANO3 Expression
    About this image


    ANO3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Pons
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Bone (Muscoskeletal System)
             Osteochondro Mesenchymal Cells Rib
     
     Mesoderm (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Cartilage (Muscoskeletal System)
             Osteochondro Mesenchymal Cells Rib
    ANO3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANO3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.91791

    UniProtKB/Swiss-Prot: ANO3_HUMAN, Q9BYT9
    Tissue specificity: Highly expressed in the forebrain striatum

        Custom PCR Arrays for ANO3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANO3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ano31 , 5 anoctamin 31, 5 89.19(n)1
    93.68(a)1
      2 (56.75 cM)5
    2284321  NM_001128103.21  NP_001121575.11 
     1106552015 
    chicken
    (Gallus gallus)
    Aves ANO31 anoctamin 3 75.15(n)
    77.3(a)
      422968  NM_001199465.1  NP_001186394.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANO36
    anoctamin 3
    75(a)
    1 ↔ 1
    GL343240.1(664048-863978)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.187782 Xenopus laevis transcribed sequence with weak similarity more 75.53(n)    BX851135.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ano31 anoctamin 3 67.57(n)
    72.36(a)
      553392  XM_005163184.1  XP_005163241.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69386
    --
    30(a)
    1 → many
    3L(11978006-11983605)


    ENSEMBL Gene Tree for ANO3 (if available)
    TreeFam Gene Tree for ANO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANO3 gene
    ANO102  ANO92  ANO42  ANO62  ANO82  ANO72  ANO22  ANO12  
    ANO52  
    7 SIMAP similar genes for ANO3 using alignment to 4 protein entries:     ANO3_HUMAN (see all proteins):
    ANO4    ANO6    ANO5    ANO1    ANO2    ANO9
    ANO7

    Find genes that share paralogs with ANO3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANO3 (see all 7281)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0697354
    Dystonia 24 (DYT24)4--see VAR_0697352 K N mis40--------
    VAR_0697334
    Dystonia 24 (DYT24)4--see VAR_0697332 R W mis40--------
    VAR_0697344
    Dystonia 24 (DYT24)4--see VAR_0697342 S G mis40--------
    VAR_0697324
    Dystonia 24 (DYT24)4--see VAR_0697322 W C mis40--------
    rs1861406161,2
    --26351723(+) CCTCAC/GGTAGG 1 -- us2k10--------
    rs110295241,2
    C,F--26351773(+) CAGAAT/CGATCT 1 -- us2k14Minor allele frequency- C:0.02NA WA 258
    rs1908051531,2
    --26351814(+) TGGATA/GAACAA 1 -- us2k10--------
    rs2017781091,2
    --26351824(+) AATTT-/AAAAAA 1 -- us2k10--------
    rs1496663241,2
    --26352007(+) CATACC/TGAGCT 1 -- us2k10--------
    rs169154801,2
    C,F,H--26352138(+) GACTTT/CAAGAC 1 -- us2k111Minor allele frequency- C:0.06NA NS EA 1112

    HapMap Linkage Disequilibrium report for ANO3 (26210829 - 26460829 bp, first 250kb of ANO3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ANO3 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422406CNV Deletion17116639
    esv1978126CNV Deletion18987734
    esv2744284CNV Deletion23290073
    esv2744283CNV Deletion23290073
    esv2744282CNV Deletion23290073
    esv2744279CNV Deletion23290073
    esv1774662CNV Deletion17803354
    esv2744280CNV Deletion23290073
    esv2744278CNV Deletion23290073
    esv2744281CNV Deletion23290073

    Human Gene Mutation Database (HGMD): ANO3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANO3
    DNA2.0 Custom Variant and Variant Library Synthesis for ANO3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610110   
    OMIM disorders: 615034  
    UniProtKB/Swiss-Prot: ANO3_HUMAN, Q9BYT9
  • Dystonia 24 (DYT24) [MIM:615034]: A form of dystonia, a disorder defined by the presence of sustained
    involuntary muscle contraction, often leading to abnormal postures. DYT24 is an autosomal dominant focal dystonia
    affecting the neck, laryngeal muscles, and muscles of the upper limbs. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 1 disease for ANO3:    
    About MalaCards
    dystonia 24


    Find genes that share disorders with ANO3           About GenesLikeMe

    Genetic Association Database (GAD): ANO3
    Human Genome Epidemiology (HuGE) Navigator: ANO3 (3 documents)

    Export disorders for ANO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANO3 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ANO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in ANO3 cause dominant craniocervical dystonia: ion channel implicated in pathogenesis. (PubMed id 23200863)1, 2, 3 Charlesworth G....Wood N.W. (Am. J. Hum. Genet. 2012)
    2. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. (PubMed id 12739008)1, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Common body mass index-associated variants confer risk of extreme obesity. (PubMed id 19553259)1, 4 Cotsapas C....Daly M.J. (Hum. Mol. Genet. 2009)
    5. Identification and characterization of TMEM16E and TMEM16F genes in silico. (PubMed id 15067359)1, 3 Katoh M. and Katoh M. (Int. J. Oncol. 2004)
    6. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PubMed id 21984732)2 Scudieri P.... Galietta L.J. (Exp. Physiol. 2012)
    7. The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma. (PubMed id 22657408)1 Dizier M.H....Demenais F. (J. Allergy Clin. Immunol. 2012)
    8. The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age. (PubMed id 22302790)2 Winpenny J.P. and Gray M.A. (Exp. Physiol. 2012)
    9. Anoctamins. (PubMed id 21607626)2 Kunzelmann K.... Schreiber R. (Pflugers Arch. 2011)
    10. Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels? (PubMed id 21642943)2 Duran C. and Hartzell H.C. (Acta Pharmacol. Sin. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63982 HGNC: 14004 AceView: TMEM16C.4 Ensembl:ENSG00000134343 euGenes: HUgn63982
    ECgene: ANO3 H-InvDB: ANO3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANO3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for ANO3 gene:
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