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ANO2 Gene

protein-coding   GIFtS: 55
GCID: GC12M005671

Anoctamin 2

(Previous names: chromosome 12 open reading frame 3, transmembrane protein...)
(Previous symbols: C12orf3, TMEM16B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Anoctamin 21 2     Transmembrane Protein 16B (Eight Membrane-Spanning Domains)1 2
C12orf31 2 3 5     Chromosome 12 Open Reading Frame 31
TMEM16B1 2 3 5     anoctamin-22
Transmembrane Protein 16B1 3     

External Ids:    HGNC: 11831   Entrez Gene: 571012   Ensembl: ENSG000000476177   OMIM: 6101095   UniProtKB: Q9NQ903   

Export aliases for ANO2 gene to outside databases

Previous GC identifer: GC12M005543


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANO2 Gene:
ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 (PubMed
19015192)).(supplied by OMIM, Jan 2011)

GeneCards Summary for ANO2 Gene:
ANO2 (anoctamin 2) is a protein-coding gene. GO annotations related to this gene include intracellular calcium activated chloride channel activity. An important paralog of this gene is ANO9.

UniProtKB/Swiss-Prot: ANO2_HUMAN, Q9NQ90
Function: Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction.
Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates
CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride
channel involved in this process. May mediate light perception amplification in retina




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANO2 gene promoter:
         C/EBPbeta   NF-1   Pbx1a   MyoD   STAT5A   Nkx2-5   Nkx5-1   RORalpha2   GATA-1   RORalpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANO2 promoter sequence
   Search Chromatin IP Primers for ANO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.3

ANO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANO2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M005671:  view genomic region     (about GC identifiers)

Start:
5,641,035 bp from pter      End:
6,055,398 bp from pter
Size:
414,364 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANO2_HUMAN, Q9NQ90 (See protein sequence)
Recommended Name: Anoctamin-2  
Size: 1003 amino acids; 113969 Da
Subunit: Component of a presynaptic protein complex recruited to specialized plasma membrane domains of
photoreceptors. Interacts with DLG4 by its C-terminus region (By similarity)
Miscellaneous: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT)
transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not
certain that all the members of this family are anion channels or have the 8-transmembrane topology
Sequence caution: Sequence=BAB14773.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: C4N787 Q9H847
Alternative splicing: 3 isoforms:  Q9NQ90-1   Q9NQ90-2   Q9NQ90-3   (Splice site between exons 4 and 5 is non-canonical)

Explore the universe of human proteins at neXtProt for ANO2: NX_Q9NQ90

Explore proteomics data for ANO2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn422, Asn841, Asn849, Asn856
  • Modification sites at PhosphoSitePlus

  • See ANO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265525.1  NP_001265526.1  

    ENSEMBL proteins: 
     ENSP00000348453   ENSP00000443813   ENSP00000314048   ENSP00000440981  
    Reactome Protein details: Q9NQ90

    ANO2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANO: Ion channels / Chloride channels : Calcium activated : Anoctamins

    1 InterPro protein domain:
     IPR007632 Anoctamin

    Graphical View of Domain Structure for InterPro Entry Q9NQ90

    ProtoNet protein and cluster: Q9NQ90

    UniProtKB/Swiss-Prot: ANO2_HUMAN, Q9NQ90
    Similarity: Belongs to the anoctamin family


    Find genes that share domains with ANO2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANO2_HUMAN, Q9NQ90
    Function: Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction.
    Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates
    CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride
    channel involved in this process. May mediate light perception amplification in retina
    Enzyme regulation: Channel activity is repressed by chloride inhibitors; strongly by niflumic acid (NFA),
    partially by flufenamic acid (FFA), and only slightly by meclofenamic acid (MFA),
    5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), 4-acetamido-4'-isothiocyanato-stilben-2,2'-disulfonate
    (SITS), and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005229intracellular calcium activated chloride channel activity IDA19474308
    GO:0005254chloride channel activity ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ANO2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ANO2:
     Increased HPV18 LCR reporter a 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ano2):
     taste/olfaction 

    Find genes that share phenotypes with ANO2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ano2tm1.1Tjj for ANO2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANO2
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    miRTarBase miRNAs that target ANO2:
    hsa-mir-26b-5p (MIRT029442)

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    4 qRT-PCR Assays for microRNAs that regulate ANO2:
    hsa-miR-4303 hsa-miR-100* hsa-miR-186 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidANO2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANO2_HUMAN, Q9NQ90: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus4
    peroxisome2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane ----
    GO:0034707chloride channel complex IEA--

    Find genes that share ontologies with ANO2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANO2 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with ANO2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ANO2
        Stimuli-sensing channels


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANO2
    Interactions:

        Search GeneGlobe Interaction Network for ANO2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ANO2 (ENSP000003140484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006821chloride transport ----
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--
    GO:1902476chloride transmembrane transport IDA19474308

    Find genes that share ontologies with ANO2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANO2

    2 HMDB Compounds for ANO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANO2 gene (3 alternative transcripts): 
    NM_020373.2  NM_001278596.1  NM_001278597.1  

    Unigene Cluster for ANO2:

    Anoctamin 2
    Hs.148970  [show with all ESTs]
    Unigene Representative Sequence: AB593159
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536751 ENST00000356134 ENST00000541874 ENST00000545860 ENST00000542326
    ENST00000538154 ENST00000540543 ENST00000544988 ENST00000541487 ENST00000327087(uc001qnm.2 uc021qtt.1)
    ENST00000546188
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ANO2:
    hsa-miR-4303 hsa-miR-100* hsa-miR-186 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidANO2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ANO2
      QuantiFast Probe-based Assays in human, mouse, rat ANO2

    Additional mRNA sequence: 

    AB593159.1 AJ272204.1 AK024010.1 AL137419.1 FJ384095.1 

    5 DOTS entries:

    DT.109648  DT.100021042  DT.97799699  DT.97820884  DT.99998388 

    Selected AceView cDNA sequences (see all 31):

    BQ637458 BQ710148 BM723060 H85012 NM_020373 AA382811 AJ272204 BM710588 
    BU193509 BM725821 BM677940 BG721248 AU129076 AA018299 BI462450 BM930148 
    BQ640478 BQ317564 AK024010 AU142869 AU160072 BI056063 BQ317602 BI055442 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ANO2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                                                                                                        
    SP2:                                                                                                                        
    SP3:              -     -                                                                                                   
    SP4:                                                                                                                        


    ECgene alternative splicing isoforms for ANO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCCTGGGG
    ANO2 Expression
    About this image


    ANO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Brain (Nervous System)
             Medulla Oblongata
     
     Eye (Sensory Organs)
    ANO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANO2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.148970

    UniProtKB/Swiss-Prot: ANO2_HUMAN, Q9NQ90
    Tissue specificity: Retina, especially in the photoreceptor synaptic terminals

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANO2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ano21 , 5 anoctamin 21, 5 87.68(n)1
    92.01(a)1
      6 (59.58 cM)5
    2436341  NM_153589.21  NP_705817.21 
     1256904195 
    chicken
    (Gallus gallus)
    Aves ANO21 anoctamin 2 72.03(n)
    77.34(a)
      428100  XM_004938078.1  XP_004938135.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANO26
    anoctamin 2
    68(a)
    1 ↔ 1
    5(81613396-81763457)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.134902 Transcribed sequence with weak similarity to protein more 77.47(n)    BX733238.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ano26
    ANO2 (1 of 2)6
    anoctamin 2
    59(a)
    39(a)
    1 ↔ many
    1 ↔ many
    4(4145420-4231651) ENSDARG00000063524
    18(6728017-6768995) ENSDARG00000003210
    fruit fly
    (Drosophila melanogaster)
    Insecta CG103531 CG10353 49.13(n)
    39.98(a)
      32148  NM_167312.4  NP_727578.3 


    ENSEMBL Gene Tree for ANO2 (if available)
    TreeFam Gene Tree for ANO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANO2 gene
    ANO92  ANO62  ANO12  ANO52  ANO102  ANO32  ANO42  ANO82  
    ANO72  
    8 SIMAP similar genes for ANO2 using alignment to 4 protein entries:     ANO2_HUMAN (see all proteins):
    DKFZp434P102    ANO1    ANO4    ANO3    ANO5    ANO9
    ANO6    ANO7

    Find genes that share paralogs with ANO2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANO2 (see all 8558)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114202201,2
    C--5605531(+) ATTTT-/AC/ACACACA
    C
    /ACACACACAC
    ACACA
    1 -- int11CSA 2
    rs49308151,2
    C,F,A,H--5671327(+) TTACAA/TCATGA 1 -- int113Minor allele frequency- T:0.21NS EA NA WA CSA 548
    rs1385410451,2
    --5671406(+) ACCATC/TGGGGT 1 -- int10--------
    rs800434491,2
    C,F--5671449(+) CCTTAC/TCTCCT 1 -- int11Minor allele frequency- T:0.09WA 118
    rs73973801,2
    C,F,H--5671489(+) TACCTA/GATATT 1 -- int120Minor allele frequency- G:0.14NS EA WA NA CSA 1740
    rs1866350471,2
    --5671543(+) TTATCA/TTCTGT 1 -- int10--------
    rs1916851051,2
    --5671566(+) TGTAAG/TCTTCA 1 -- int10--------
    rs1488199371,2
    --5671640(+) ACATAC/GTAGAA 1 -- int10--------
    rs721833281,2
    C--5671694(+) GAGAG-/GAGAC 
            
    GAGAG
    1 -- int10--------
    rs780356721,2
    C,F--5671713(+) GGAGAG/CGAGAG 1 -- int11Minor allele frequency- C:0.50NA 4

    HapMap Linkage Disequilibrium report for ANO2 (5641035 - 5891035 bp, first 250kb of ANO2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ANO2 (see all 33):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1647797CNV Deletion17803354
    esv2745465CNV Deletion23290073
    esv2745467CNV Deletion23290073
    esv2745461CNV Deletion23290073
    esv2668238CNV Deletion23128226
    esv2745466CNV Deletion23290073
    esv2669204CNV Deletion23128226
    esv2745464CNV Deletion23290073
    esv2745462CNV Deletion23290073
    esv269170CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 610109    OMIM disorders: --


    Find genes that share disorders with ANO2           About GenesLikeMe

    Genetic Association Database (GAD): ANO2
    Human Genome Epidemiology (HuGE) Navigator: ANO2 (2 documents)

    Export disorders for ANO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANO2 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with ANO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. (PubMed id 12739008)1, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. (PubMed id 19474308)1, 2 Stoehr H.... Schulz H.L. (J. Neurosci. 2009)
    4. Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)1, 4 Otowa T....Okazaki Y. (J. Hum. Genet. 2009)
    5. Identification and characterization of TMEM16E and TMEM16F genes in silico. (PubMed id 15067359)1, 3 Katoh M. and Katoh M. (Int. J. Oncol. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    8. TMEM16A-TMEM16B chimaeras to investigate the structure-function relationship of calcium-activated chloride channels. (PubMed id 23570556)1 Scudieri P....Galietta L.J. (Biochem. J. 2013)
    9. Anoctamin 2/TMEM16B: a calcium-activated chloride channel in olfactory transduction. (PubMed id 21890523)2 Pifferi S.... Menini A. (Exp. Physiol. 2012)
    10. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PubMed id 21984732)2 Scudieri P.... Galietta L.J. (Exp. Physiol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57101 HGNC: 1183 AceView: TMEM16B Ensembl:ENSG00000047617 euGenes: HUgn57101
    ECgene: ANO2 H-InvDB: ANO2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ANO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ANO2 gene:
    Search GeneIP for patents involving ANO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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