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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANO2 Gene

protein-coding   GIFtS: 52
GCID: GC12M005671

anoctamin 2

(Previous names: chromosome 12 open reading frame 3, transmembrane protein...)
(Previous symbols: C12orf3, TMEM16B)
 Explore 3 diseases affiliated with
ANO2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ANO2    

Aliases
for ANO2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Anoctamin 21 2     Chromosome 12 Open Reading Frame 31
C12orf31 2 3 5     Anoctamin-21
TMEM16B1 2 3 5     Transmembrane Protein 16B (Eight Membrane-Spanning Domains)2
Transmembrane Protein 16B1 3     

External Ids:    HGNC: 11831   Entrez Gene: 571012   Ensembl: ENSG000000476177   OMIM: 6101095   UniProtKB: Q9NQ903   

Export aliases for ANO2 gene to outside databases

Previous GC identifer: GC12M005543


Summaries
for ANO2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ANO2:
ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 (PubMed
19015192)).(supplied by OMIM, Jan 2011)

UniProtKB/Swiss-Prot: ANO2_HUMAN, Q9NQ90
Function: Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant
molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current
which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this
process. May mediate light perception amplification in retina




Genomic Views
for ANO2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANO2 gene promoter:
         C/EBPbeta   NF-1   Pbx1a   MyoD   STAT5A   Nkx2-5   Nkx5-1   RORalpha2   GATA-1   RORalpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.3

ANO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANO2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M005671:  view genomic region     (about GC identifiers)

Start:
 5,641,035 bp from pter      End:
 6,055,398 bp from pter
Size:
 414,364 bases      Orientation:
 minus strand

Proteins
for ANO2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ANO2_HUMAN, Q9NQ90 (See protein sequence)
Recommended Name: Anoctamin-2  
Size: 1003 amino acids; 113969 Da
Subunit: Component of a presynaptic protein complex recruited to specialized plasma membrane domains of photoreceptors.
Interacts with DLG4 by its C-terminus region (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT)
transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain
that all the members of this family are anion channels or have the 8-transmembrane topology
Sequence caution: Sequence=BAB14773.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: C4N787 Q9H847
Alternative splicing: 3 isoforms:  Q9NQ90-1   Q9NQ90-2   Q9NQ90-3   (Splice site between exons 4 and 5 is non-canonical)

Explore the universe of human proteins at neXtProt for ANO2: NX_Q9NQ90

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NQ90

    • ANO2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065106.2  
    ENSEMBL proteins: 
     ENSP00000348453   ENSP00000443813   ENSP00000314048   ENSP00000440981  
    Reactome Protein details: Q9NQ90
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: ANO2
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    Uscn Proteins for ANO2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005886plasma membrane ISS--
    GO:0034707chloride channel complex IEA--


    ANO2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ANO2

    Protein Domains /
    Families
    for ANO2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ANO2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007632 Anoctamin

    Graphical View of Domain Structure for InterPro Entry Q9NQ90

    ProtoNet protein and cluster: Q9NQ90

    UniProtKB/Swiss-Prot: ANO2_HUMAN, Q9NQ90
    Similarity: Belongs to the anoctamin family


    Function
    for ANO2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ANO2_HUMAN, Q9NQ90
    Function: Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant
    molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current
    which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this
    process. May mediate light perception amplification in retina
    Enzyme regulation: Channel activity is repressed by chloride inhibitors; strongly by niflumic acid (NFA), partially by
    flufenamic acid (FFA), and only slightly by meclofenamic acid (MFA), 5-Nitro-2-(3-phenylpropylamino)benzoic acid
    (NPPB), 4-acetamido-4'-isothiocyanato-stilben-2,2'-disulfonate (SITS), and
    4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANO2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ANO2:
    hsa-miR-4303 hsa-miR-100* hsa-miR-186 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmid: ANO2 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: ANO2
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ANO2

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for ANO2

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005229intracellular calcium activated chloride channel activity IDA--
    GO:0005254chloride channel activity ----
    GO:0005515protein binding ----


    ANO2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ANO2:
     Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-out Ano2tm1.1Tjj for ANO2
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ano2):
     taste/olfaction 

    ANO2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ANO2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ion channel transport
    		Ion channel transport1.00
    		Stimuli-sensing channels0.49
    2SLC-mediated transmembrane transport
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for ANO2
        Transmembrane transport of small molecules
    Stimuli-sensing channels
    Ion channel transport



    ANO2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANO2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ANO2 (ENSP000003140484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006821chloride transport ----


    ANO2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ANO2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANO2

    2 HMDB Compounds for ANO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--
    Search CenterWatch for drugs/clinical trials and news about ANO2 

    Transcripts
    for ANO2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ANO2 gene: 
    NM_020373.2  

    Unigene Cluster for ANO2:

    Anoctamin 2
    Hs.148970  [show with all ESTs]
    Unigene Representative Sequence: AB593159
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536751 ENST00000356134 ENST00000541874 ENST00000545860 ENST00000542326
    ENST00000538154 ENST00000540543 ENST00000544988 ENST00000541487 ENST00000327087(uc001qnm.2 uc021qtt.1)
    ENST00000546188

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANO2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ANO2:
    hsa-miR-4303 hsa-miR-100* hsa-miR-186 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmid: ANO2 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: ANO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANO2
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANO2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANO2

    Additional cDNA sequence: 

    AB593159.1 AJ272204.1 AK024010.1 AL137419.1 FJ384095.1 

    5 DOTS entries:

    DT.109648  DT.100021042  DT.97799699  DT.97820884  DT.99998388 

    24/31 AceView cDNA sequences (see all 31):

    NM_020373 BU193509 BQ710148 BQ637458 H85012 AJ272204 BM723060 AA382811 
    BM677940 BM725821 BM710588 BI462450 AA018299 BM930148 AK024010 BG721248 
    BQ640478 AU142869 AU129076 BQ317564 AU160072 BQ317602 BI055442 BI056063 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ANO2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                                                                                                        
    SP2:                                                                                                                        
    SP3:              -     -                                                                                                   
    SP4:                                                                                                                        


    ECgene alternative splicing isoforms for ANO2

    Expression
    for ANO2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACCCTGGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ANO2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ANO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANO2

    SOURCE GeneReport for Unigene cluster: Hs.148970

    UniProtKB/Swiss-Prot: ANO2_HUMAN, Q9NQ90
    Tissue specificity: Retina, especially in the photoreceptor synaptic terminals

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO2

    Orthologs
    for ANO2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANO2 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ANO26
    		 Uncharacterized protein
    		 71(a)
    		 1 ↔ 1
    		 1(76361434-76540823)
    lizard
    (Anolis carolinensis)    		 Reptilia ANO26
    		 --
    		 68(a)
    		 1 ↔ 1
    		 5(81613396-81763457)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.134902 Transcribed sequence with weak similarity to protein more 77.47(n)    BX733238.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ano26
    si:ch73-86n2.16
    (see all 3)    		 si:ch73-86n2.1
    (see all 3)    		 58(a)
    39(a)
    (see all 3)    		 1 ↔ many
    1 ↔ many
    (see all 3)    		 4(4145420-4231651)
    18(6728017-6768995)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG103531 CG10353 50.35(n)
    40.57(a)    		   32148  NM_132534.3  NP_572762.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea anoh-16
    		 --
    		 19(a)
    		 possible ortholog
    		 III(13246477-13253514)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G730206
    		 uncharacterized protein
    		 19(a)
    		 1 → many
    		 1(27469534-27473554)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 transmembrane protein 16K, putative, expressed
    		 18(a)
    		 1 → many
    		 1(29317147-29321524)


    ENSEMBL Gene Tree for ANO2 (if available)
    TreeFam Gene Tree for ANO2 (if available) 

    Paralogs
    for ANO2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANO2 gene
    ANO92  ANO62  ANO52  ANO12  ANO102  ANO42  ANO32  ANO82  
    ANO72  
    8 SIMAP similar genes for ANO2 using alignment to 4 protein entries:     ANO2_HUMAN (see all proteins):
    DKFZp434P102    ANO1    ANO4    ANO3    ANO5    ANO9
    ANO6    ANO7

    ANO2 for paralogs           About GeneDecksing



    Genomic Variants
    for ANO2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7279 NCBI SNPs in ANO2 are shown (see all 7279)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs350867671,2
    		C,--5584324(+) AAGGA-/GGAAGA 1 -- int11Minor allele frequency- G:0.00NA 2
    rs49308151,2
    		C,F,A,H,--5671327(+) TTACAA/TCATGA 1 -- int113Minor allele frequency- T:0.21NS EA NA WA CSA 548
    rs1385410451,2
    		--5671406(+) ACCATC/TGGGGT 1 -- int10--------
    rs800434491,2
    		F,--5671449(+) CCTTAC/TCTCCT 1 -- int11Minor allele frequency- T:0.09WA 118
    rs73973801,2
    		C,F,H,--5671489(+) TACCTA/GATATT 1 -- int120Minor allele frequency- G:0.14NS EA WA NA CSA 1740
    rs1866350471,2
    		--5671543(+) TTATCA/TTCTGT 1 -- int10--------
    rs1916851051,2
    		--5671566(+) TGTAAG/TCTTCA 1 -- int10--------
    rs1488199371,2
    		--5671640(+) ACATAC/GTAGAA 1 -- int10--------
    rs721833281,2
    		C,--5671694(+) GAGAG-/GAGAC 
                GAGAG     		1 -- int10--------
    rs780356721,2
    		F,--5671713(+) GGAGAG/CGAGAG 1 -- int11Minor allele frequency- C:0.50NA 4

    HapMap Linkage Disequilibrium report for ANO2 (5641035 - 5891035 bp, first 250kb of ANO2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 31 variations for ANO2
         15/23 CNVs (see all 23): 86166 75916 75913 49102 75914 75919 86170 86163 86164 71445 75915 86165 61203 86169 75920
         8 Indels: 86159 75912 25044 86162 86158 101412 86161 86160

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    Disorders / Diseases
    for ANO2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ANO2 for disorders           About GeneDecksing

    OMIM gene information: 610109    OMIM disorders: --

    3 diseases for ANO2:    About MalaCards
    von willebrand's disease    panic disorder    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: ANO2 (2 documents)

    Export disorders for ANO2 gene to outside databases

    Publications
    for ANO2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANO2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ANO2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. (PubMed id 12739008)1, 3, 9 Katoh M. and Katoh M. (2003)
    2. TMEM16B, a novel protein with calcium-dependent chlor ide channel activity, associates with a presynaptic protein complex in photorec eptor terminals. (PubMed id 19474308)1, 2 StAPhr H....Schulz H.L. (2009)
    3. Identification and characterization of TMEM16E and TMEM16F genes in silico. (PubMed id 15067359)1, 3 Katoh M. and Katoh M. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Anoctamin 2/TMEM16B: a calcium-activated chloride channel in olfactory transduction. (PubMed id 21890523)2 Pifferi S.... Menini A. (2012)
    6. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PubMed id 21984732)2 Scudieri P.... Galietta L.J. (2012)
    7. The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age. (PubMed id 22302790)2 Winpenny J.P. and Gray M.A. (2012)
    8. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Anoctamins. (PubMed id 21607626)2 Kunzelmann K.... Schreiber R. (2011)

    External Searches for ANO2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ANO2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57101 HGNC: 1183 AceView: TMEM16B Ensembl:ENSG00000047617 euGenes: HUgn57101
    ECgene: ANO2 H-InvDB: ANO2

    Other Databases showing ANO2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ANO2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANO2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ANO2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ANO2 gene:
    Search GeneIP for patents involving ANO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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