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Aliases for ANO2 Gene

Aliases for ANO2 Gene

  • Anoctamin 2, Calcium Activated Chloride Channel 2 3
  • C12orf3 3 4 6
  • TMEM16B 3 4 6
  • Transmembrane Protein 16B (Eight Membrane-Spanning Domains) 2 3
  • Transmembrane Protein 16B 2 4
  • Chromosome 12 Open Reading Frame 3 2
  • Anoctamin 2 2
  • Anoctamin-2 3

External Ids for ANO2 Gene

Previous Symbols for ANO2 Gene

  • C12orf3
  • TMEM16B

Summaries for ANO2 Gene

Entrez Gene Summary for ANO2 Gene

  • ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011]

GeneCards Summary for ANO2 Gene

ANO2 (Anoctamin 2, Calcium Activated Chloride Channel) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include intracellular calcium activated chloride channel activity. An important paralog of this gene is ANO5.

UniProtKB/Swiss-Prot for ANO2 Gene

  • Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANO2 Gene

Genomics for ANO2 Gene

Genomic Location for ANO2 Gene

Start:
5,531,869 bp from pter
End:
5,946,232 bp from pter
Size:
414,364 bases
Orientation:
Minus strand

Genomic View for ANO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANO2 Gene

Regulatory Elements for ANO2 Gene

Proteins for ANO2 Gene

  • Protein details for ANO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ90-ANO2_HUMAN
    Recommended name:
    Anoctamin-2
    Protein Accession:
    Q9NQ90
    Secondary Accessions:
    • C4N787
    • Q9H847

    Protein attributes for ANO2 Gene

    Size:
    1003 amino acids
    Molecular mass:
    113969 Da
    Quaternary structure:
    • Component of a presynaptic protein complex recruited to specialized plasma membrane domains of photoreceptors. Interacts with DLG4 by its C-terminal region (By similarity).
    Miscellaneous:
    • The term anoctamin was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology
    SequenceCaution:
    • Sequence=BAB14773.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANO2 Gene

Proteomics data for ANO2 Gene at MOPED

Post-translational modifications for ANO2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn422, Asn841, Asn849, and Asn856

Other Protein References for ANO2 Gene

No data available for DME Specific Peptides for ANO2 Gene

Domains for ANO2 Gene

Gene Families for ANO2 Gene

HGNC:
  • ANO :Ion channels / Chloride channels : Calcium activated : Anoctamins

Protein Domains for ANO2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ANO2_HUMAN
Family:
  • Belongs to the anoctamin family.:
    • Q9NQ90
genes like me logo Genes that share domains with ANO2: view

Function for ANO2 Gene

Molecular function for ANO2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Channel activity is repressed by chloride inhibitors; strongly by niflumic acid (NFA), partially by flufenamic acid (FFA), and only slightly by meclofenamic acid (MFA), 5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), 4-acetamido-4-isothiocyanato-stilben-2,2-disulfonate (SITS), and 4,4-diisothiocyanatostilbene-2,2-disulfonic acid (DIDS).
UniProtKB/Swiss-Prot Function: Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.

Gene Ontology (GO) - Molecular Function for ANO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005229 intracellular calcium activated chloride channel activity IDA 19474308
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with ANO2: view

Phenotypes for ANO2 Gene

MGI mutant phenotypes for ANO2:
inferred from 1 alleles
GenomeRNAi human phenotypes for ANO2:
genes like me logo Genes that share phenotypes with ANO2: view

Animal Models for ANO2 Gene

MGI Knock Outs for ANO2:

miRNA for ANO2 Gene

miRTarBase miRNAs that target ANO2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ANO2 Gene

Localization for ANO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANO2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANO2 Gene COMPARTMENTS Subcellular localization image for ANO2 gene
Compartment Confidence
plasma membrane 5
nucleus 4
peroxisome 2

Gene Ontology (GO) - Cellular Components for ANO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane --
GO:0031513 nonmotile primary cilium IEA --
genes like me logo Genes that share ontologies with ANO2: view

Pathways for ANO2 Gene

genes like me logo Genes that share pathways with ANO2: view

Pathways by source for ANO2 Gene

Interacting Proteins for ANO2 Gene

Gene Ontology (GO) - Biological Process for ANO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006821 chloride transport --
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with ANO2: view

Compounds for ANO2 Gene

(2) HMDB Compounds for ANO2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Chlorine
  • Cl2
16887-00-6
genes like me logo Genes that share compounds with ANO2: view

Transcripts for ANO2 Gene

Unigene Clusters for ANO2 Gene

Anoctamin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANO2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3: - -
SP4:

Relevant External Links for ANO2 Gene

GeneLoc Exon Structure for
ANO2
ECgene alternative splicing isoforms for
ANO2

Expression for ANO2 Gene

mRNA expression in normal human tissues for ANO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANO2 Gene

SOURCE GeneReport for Unigene cluster for ANO2 Gene Hs.148970

mRNA Expression by UniProt/SwissProt for ANO2 Gene

Q9NQ90-ANO2_HUMAN
Tissue specificity: Retina, especially in the photoreceptor synaptic terminals.
genes like me logo Genes that share expressions with ANO2: view

Orthologs for ANO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANO2 36
  • 99.1 (n)
  • 99 (a)
ANO2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANO2 36
  • 87.82 (n)
  • 91.16 (a)
ANO2 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANO2 36
  • 90.4 (n)
  • 93.28 (a)
ANO2 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ano2 36
  • 87.68 (n)
  • 92.01 (a)
Ano2 16
Ano2 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANO2 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANO2 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100361584 36
  • 88.54 (n)
  • 94.93 (a)
chicken
(Gallus gallus)
Aves ANO2 36
  • 72.03 (n)
  • 77.34 (a)
ANO2 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANO2 37
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ano2 36
  • 67.96 (n)
  • 72.95 (a)
Str.13490 36
zebrafish
(Danio rerio)
Actinopterygii ano2 37
  • 59 (a)
OneToMany
ANO2 (1 of 2) 37
  • 39 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000095 36
  • 52.44 (n)
  • 43.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10353 36
  • 49.13 (n)
  • 39.98 (a)
CG10353 37
  • 30 (a)
ManyToMany
CG16718 37
  • 32 (a)
ManyToMany
Species with no ortholog for ANO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANO2 Gene

ENSEMBL:
Gene Tree for ANO2 (if available)
TreeFam:
Gene Tree for ANO2 (if available)

Paralogs for ANO2 Gene

Paralogs for ANO2 Gene

Selected SIMAP similar genes for ANO2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ANO2: view

Variants for ANO2 Gene

Sequence variations from dbSNP and Humsavar for ANO2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs96745 -- 5,665,043(+) AAATA(A/G)TGATT intron-variant
rs251755 -- 5,679,729(-) GAATC(A/G)CCACG intron-variant
rs251756 -- 5,679,421(-) aagtt(C/G)cttgt intron-variant
rs251757 -- 5,679,038(-) tgtca(C/T)acttt intron-variant
rs251758 -- 5,678,419(-) ACCCC(C/T)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANO2 Gene

Variant ID Type Subtype PubMed ID
nsv470262 CNV Gain 18288195
nsv468988 CNV Gain 19166990
nsv523152 CNV Gain 19592680
nsv898627 CNV Gain 21882294
esv2668238 CNV Deletion 23128226
esv268253 CNV Insertion 20981092
esv2585557 CNV Insertion 19546169
esv273463 CNV Insertion 20981092
esv269170 CNV Insertion 20981092
esv26915 CNV Gain 19812545
nsv826203 CNV Gain 20364138
esv1010714 CNV Loss 20482838
esv2669204 CNV Deletion 23128226
nsv528886 CNV Loss 19592680
esv267629 CNV Insertion 20981092
nsv507628 CNV Insertion 20534489
nsv521492 CNV Loss 19592680
nsv517527 CNV Loss 19592680
esv1098801 CNV Insertion 17803354
esv1061937 CNV Insertion 17803354
esv1270499 CNV Insertion 17803354
nsv53042 CNV Insertion 16902084
esv2745461 CNV Deletion 23290073
esv2745462 CNV Deletion 23290073
esv22765 CNV Gain+Loss 19812545
esv8531 CNV Loss 19470904
esv2745464 CNV Deletion 23290073
esv1647797 CNV Deletion 17803354
esv2745465 CNV Deletion 23290073
esv2745466 CNV Deletion 23290073
esv2745467 CNV Deletion 23290073
nsv898628 CNV Gain 21882294
nsv521996 CNV Loss 19592680

Relevant External Links for ANO2 Gene

HapMap Linkage Disequilibrium report
ANO2

Disorders for ANO2 Gene

Relevant External Links for ANO2

Genetic Association Database (GAD)
ANO2
Human Genome Epidemiology (HuGE) Navigator
ANO2
genes like me logo Genes that share disorders with ANO2: view

No data available for UniProtKB/Swiss-Prot for ANO2 Gene

Publications for ANO2 Gene

  1. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. (PMID: 12739008) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification and characterization of TMEM16E and TMEM16F genes in silico. (PMID: 15067359) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3
  4. Structure and function of TMEM16 proteins (anoctamins). (PMID: 24692353) Pedemonte N. … Galietta L.J. (Physiol. Rev. 2014) 2 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for ANO2 Gene

Sources for ANO2 Gene

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