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Aliases for ANO10 Gene

Aliases for ANO10 Gene

  • Anoctamin 10 2 3 5
  • Transmembrane Protein 16K 2 3 4
  • TMEM16K 3 4
  • SCAR10 3

External Ids for ANO10 Gene

Previous HGNC Symbols for ANO10 Gene

  • TMEM16K

Previous GeneCards Identifiers for ANO10 Gene

  • GC03M043385

Summaries for ANO10 Gene

Entrez Gene Summary for ANO10 Gene

  • The transmembrane protein encoded by this gene is a member of a family of calcium-activated chloride channels. Defects in this gene may be a cause of autosomal recessive spinocerebellar ataxia-10. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

GeneCards Summary for ANO10 Gene

ANO10 (Anoctamin 10) is a Protein Coding gene. Diseases associated with ANO10 include spinocerebellar ataxia, autosomal recessive 10 and adult-onset autosomal recessive cerebellar ataxia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include intracellular calcium activated chloride channel activity and calcium activated cation channel activity. An important paralog of this gene is ANO5.

UniProtKB/Swiss-Prot for ANO10 Gene

  • Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANO10 Gene

Genomics for ANO10 Gene

Regulatory Elements for ANO10 Gene

Genomic Location for ANO10 Gene

Chromosome:
3
Start:
43,354,859 bp from pter
End:
43,691,594 bp from pter
Size:
336,736 bases
Orientation:
Minus strand

Genomic View for ANO10 Gene

Genes around ANO10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANO10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANO10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANO10 Gene

Proteins for ANO10 Gene

  • Protein details for ANO10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NW15-ANO10_HUMAN
    Recommended name:
    Anoctamin-10
    Protein Accession:
    Q9NW15
    Secondary Accessions:
    • A8K8K3
    • A8MV74
    • B3KTZ1
    • B3KY93
    • B4DJ83
    • B4DNK2
    • B7WP12
    • C9JHS1
    • Q8IXX9

    Protein attributes for ANO10 Gene

    Size:
    660 amino acids
    Molecular mass:
    76329 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The term anoctamin was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
    SequenceCaution:
    • Sequence=BAA91573.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BC038855; Type=Frameshift; Positions=42; Evidence={ECO:0000305};

    Alternative splice isoforms for ANO10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANO10 Gene

Proteomics data for ANO10 Gene at MOPED

Post-translational modifications for ANO10 Gene

  • Ubiquitination at Lys 193
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ANO10 Gene

Domains & Families for ANO10 Gene

Gene Families for ANO10 Gene

Protein Domains for ANO10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANO10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NW15

UniProtKB/Swiss-Prot:

ANO10_HUMAN :
  • Belongs to the anoctamin family.
Family:
  • Belongs to the anoctamin family.
genes like me logo Genes that share domains with ANO10: view

Function for ANO10 Gene

Molecular function for ANO10 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.

Phenotypes for ANO10 Gene

genes like me logo Genes that share phenotypes with ANO10: view

Human Phenotype Ontology for ANO10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ANO10 Gene

MGI Knock Outs for ANO10:

Animal Model Products

miRNA for ANO10 Gene

miRTarBase miRNAs that target ANO10

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for ANO10 Gene

Localization for ANO10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANO10 Gene

Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANO10 Gene COMPARTMENTS Subcellular localization image for ANO10 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ANO10 Gene

Pathways & Interactions for ANO10 Gene

genes like me logo Genes that share pathways with ANO10: view

Pathways by source for ANO10 Gene

Interacting Proteins for ANO10 Gene

Gene Ontology (GO) - Biological Process for ANO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034220 ion transmembrane transport TAS --
GO:0098655 cation transmembrane transport IDA 22946059
GO:1902476 chloride transmembrane transport IDA,TAS --
genes like me logo Genes that share ontologies with ANO10: view

No data available for SIGNOR curated interactions for ANO10 Gene

Drugs & Compounds for ANO10 Gene

(1) Drugs for ANO10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for ANO10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
genes like me logo Genes that share compounds with ANO10: view

Transcripts for ANO10 Gene

Unigene Clusters for ANO10 Gene

Anoctamin 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANO10 Gene

No ASD Table

Relevant External Links for ANO10 Gene

GeneLoc Exon Structure for
ANO10
ECgene alternative splicing isoforms for
ANO10

Expression for ANO10 Gene

mRNA expression in normal human tissues for ANO10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANO10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.2) and Adrenal (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANO10 Gene



SOURCE GeneReport for Unigene cluster for ANO10 Gene Hs.656657

mRNA Expression by UniProt/SwissProt for ANO10 Gene

Q9NW15-ANO10_HUMAN
Tissue specificity: Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain.
genes like me logo Genes that share expression patterns with ANO10: view

Protein tissue co-expression partners for ANO10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ANO10 Gene

Orthologs for ANO10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANO10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANO10 35
  • 90.09 (n)
  • 92.11 (a)
ANO10 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANO10 35
  • 91.15 (n)
  • 92.26 (a)
ANO10 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ano10 35
  • 85.19 (n)
  • 91.78 (a)
Ano10 16
Ano10 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANO10 35
  • 99.34 (n)
  • 99.55 (a)
ANO10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ano10 35
  • 85.2 (n)
  • 91.36 (a)
oppossum
(Monodelphis domestica)
Mammalia ANO10 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANO10 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANO10 35
  • 74.28 (n)
  • 77.02 (a)
ANO10 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANO10 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ano10 35
  • 68.88 (n)
  • 70.11 (a)
zebrafish
(Danio rerio)
Actinopterygii ano10a 35
  • 65.79 (n)
  • 66.1 (a)
wufc37b04 35
ano10a 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009776 35
  • 49.59 (n)
  • 39.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta Axs 35
  • 48.54 (n)
  • 39.29 (a)
Axs 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IST2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73020 35
  • 44.85 (n)
  • 34.76 (a)
rice
(Oryza sativa)
Liliopsida Os01g0706700 35
  • 44.4 (n)
  • 35.62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for ANO10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANO10 Gene

ENSEMBL:
Gene Tree for ANO10 (if available)
TreeFam:
Gene Tree for ANO10 (if available)

Paralogs for ANO10 Gene

Paralogs for ANO10 Gene

Pseudogenes.org Pseudogenes for ANO10 Gene

genes like me logo Genes that share paralogs with ANO10: view

Variants for ANO10 Gene

Sequence variations from dbSNP and Humsavar for ANO10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs3772165 - 43,561,311(+) TCACC(C/T)GCACA reference, missense
rs17409162 - 43,549,835(+) TCATC(A/G/T)TTTCA reference, missense
rs17853862 - 43,549,769(+) GAAAG(A/G)CTGCA reference, missense
VAR_064888 Spinocerebellar ataxia, autosomal recessive, 10 (SCAR10)
rs716606 -- 43,644,901(+) agagg(C/T)cctct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANO10 Gene

Variant ID Type Subtype PubMed ID
esv5543 OTHER Inversion 19470904
esv1011105 CNV Insertion 20482838
esv1480257 CNV Insertion 17803354
dgv804n67 CNV Loss 20364138
nsv822070 CNV Loss 20364138
nsv820135 CNV Loss 19587683
esv2525562 CNV Insertion 19546169
esv270605 CNV Insertion 20981092
nsv834673 CNV Gain 17160897

Variation tolerance for ANO10 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANO10 Gene

HapMap Linkage Disequilibrium report
ANO10
Human Gene Mutation Database (HGMD)
ANO10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANO10 Gene

Disorders for ANO10 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ANO10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia, autosomal recessive 10
  • autosomal recessive spinocerebellar ataxia 10
adult-onset autosomal recessive cerebellar ataxia
  • spinocerebellar ataxia, autosomal recessive 10
autosomal recessive cerebellar ataxia
spinocerebellar ataxia 10
  • spinocerebellar ataxia type 10
- elite association - COSMIC cancer census association via MalaCards
Search ANO10 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ANO10_HUMAN
  • Spinocerebellar ataxia, autosomal recessive, 10 (SCAR10) [MIM:613728]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young adult years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging. {ECO:0000269 PubMed:21092923}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ANO10

Genetic Association Database (GAD)
ANO10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANO10
genes like me logo Genes that share disorders with ANO10: view

No data available for Genatlas for ANO10 Gene

Publications for ANO10 Gene

  1. Structure and function of TMEM16 proteins (anoctamins). (PMID: 24692353) Pedemonte N. … Galietta L.J. (Physiol. Rev. 2014) 2 3 67
  2. Genetics of dizziness: cerebellar and vestibular disorders. (PMID: 24275721) Requena T. … Lopez-Escamez J.A. (Curr. Opin. Neurol. 2014) 3
  3. Autosomal Recessive Cerebellar Ataxia Type 3 Due to ANO10 Mutations: Delineation and Genotype-Phenotype Correlation Study. (PMID: 25089919) Renaud M. … Koenig M. (JAMA Neurol 2014) 3
  4. ANO10 mutations cause ataxia and coenzyme Qa88a88 deficiency. (PMID: 25182700) Balreira A. … Horvath R. (J. Neurol. 2014) 3
  5. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PMID: 21984732) Scudieri P. … Galietta L.J. (Exp. Physiol. 2012) 3

Products for ANO10 Gene

Sources for ANO10 Gene

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