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Aliases for ANO10 Gene

Aliases for ANO10 Gene

  • Anoctamin 10 2 3
  • Transmembrane Protein 16K 2 3 4
  • TMEM16K 3 4 6
  • SCAR10 3 6
  • Anoctamin-10 3

External Ids for ANO10 Gene

Previous HGNC Symbols for ANO10 Gene

  • TMEM16K

Previous GeneCards Identifiers for ANO10 Gene

  • GC03M043385

Summaries for ANO10 Gene

Entrez Gene Summary for ANO10 Gene

  • The transmembrane protein encoded by this gene is a member of a family of calcium-activated chloride channels. Defects in this gene may be a cause of autosomal recessive spinocerebellar ataxia-10. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

GeneCards Summary for ANO10 Gene

ANO10 (Anoctamin 10) is a Protein Coding gene. Diseases associated with ANO10 include spinocerebellar ataxia, autosomal recessive 10 and adult-onset autosomal recessive cerebellar ataxia. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include intracellular calcium activated chloride channel activity. An important paralog of this gene is ANO5.

UniProtKB/Swiss-Prot for ANO10 Gene

  • Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANO10 Gene

Genomics for ANO10 Gene

Regulatory Elements for ANO10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ANO10 Gene

43,354,859 bp from pter
43,691,594 bp from pter
336,736 bases
Minus strand

Genomic View for ANO10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANO10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANO10 Gene

Proteins for ANO10 Gene

  • Protein details for ANO10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K8K3
    • A8MV74
    • B3KTZ1
    • B3KY93
    • B4DJ83
    • B4DNK2
    • B7WP12
    • C9JHS1
    • Q8IXX9

    Protein attributes for ANO10 Gene

    660 amino acids
    Molecular mass:
    76329 Da
    Quaternary structure:
    No Data Available
    • The term anoctamin was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology
    • Sequence=BAA91573.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BC038855; Type=Frameshift; Positions=42; Evidence={ECO:0000305};

    Alternative splice isoforms for ANO10 Gene


neXtProt entry for ANO10 Gene

Proteomics data for ANO10 Gene at MOPED

Post-translational modifications for ANO10 Gene

  • Ubiquitination at Lys193
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ANO10 Gene

Domains for ANO10 Gene

Gene Families for ANO10 Gene

  • ANO :Ion channels / Chloride channels : Calcium activated : Anoctamins

Protein Domains for ANO10 Gene


Suggested Antigen Peptide Sequences for ANO10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NW15
  • Belongs to the anoctamin family.
genes like me logo Genes that share domains with ANO10: view

Function for ANO10 Gene

Molecular function for ANO10 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.

Gene Ontology (GO) - Molecular Function for ANO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005227 calcium activated cation channel activity IDA 22946059
GO:0005229 NOT intracellular calcium activated chloride channel activity IDA 21984732
genes like me logo Genes that share ontologies with ANO10: view

Phenotypes for ANO10 Gene

GenomeRNAi human phenotypes for ANO10:
genes like me logo Genes that share phenotypes with ANO10: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANO10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ANO10 Gene

Localization for ANO10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANO10 Gene

Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.

Subcellular locations from

Jensen Localization Image for ANO10 Gene COMPARTMENTS Subcellular localization image for ANO10 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ANO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 22075693
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANO10: view

Pathways for ANO10 Gene

genes like me logo Genes that share pathways with ANO10: view

Pathways by source for ANO10 Gene

Interacting Proteins for ANO10 Gene

Gene Ontology (GO) - Biological Process for ANO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport IDA 22946059
GO:0006821 chloride transport IDA 22946059
GO:0008219 cell death --
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with ANO10: view

Compounds for ANO10 Gene

(2) HMDB Compounds for ANO10 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • Cl2
genes like me logo Genes that share compounds with ANO10: view

Transcripts for ANO10 Gene

Unigene Clusters for ANO10 Gene

Anoctamin 10:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANO10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANO10 Gene

No ASD Table

Relevant External Links for ANO10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANO10 Gene

mRNA expression in normal human tissues for ANO10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ANO10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.2) and Adrenal (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANO10 Gene

SOURCE GeneReport for Unigene cluster for ANO10 Gene Hs.656657

mRNA Expression by UniProt/SwissProt for ANO10 Gene

Tissue specificity: Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain.
genes like me logo Genes that share expressions with ANO10: view

Expression partners for ANO10 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ANO10 Gene

Orthologs for ANO10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANO10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANO10 35
  • 90.09 (n)
  • 92.11 (a)
ANO10 36
  • 92 (a)
(Canis familiaris)
Mammalia ANO10 35
  • 91.15 (n)
  • 92.26 (a)
ANO10 36
  • 92 (a)
(Mus musculus)
Mammalia Ano10 35
  • 85.19 (n)
  • 91.78 (a)
Ano10 16
Ano10 36
  • 92 (a)
(Pan troglodytes)
Mammalia ANO10 35
  • 99.34 (n)
  • 99.55 (a)
ANO10 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ano10 35
  • 85.2 (n)
  • 91.36 (a)
(Monodelphis domestica)
Mammalia ANO10 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia ANO10 36
  • 78 (a)
(Gallus gallus)
Aves ANO10 35
  • 74.28 (n)
  • 77.02 (a)
ANO10 36
  • 75 (a)
(Anolis carolinensis)
Reptilia ANO10 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ano10 35
  • 68.88 (n)
  • 70.11 (a)
(Danio rerio)
Actinopterygii ano10a 35
  • 65.79 (n)
  • 66.1 (a)
wufc37b04 35
ano10a 36
  • 66 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009776 35
  • 49.59 (n)
  • 39.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta Axs 35
  • 48.54 (n)
  • 39.29 (a)
Axs 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IST2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73020 35
  • 44.85 (n)
  • 34.76 (a)
(Oryza sativa)
Liliopsida Os01g0706700 35
  • 44.4 (n)
  • 35.62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for ANO10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANO10 Gene

Gene Tree for ANO10 (if available)
Gene Tree for ANO10 (if available)

Paralogs for ANO10 Gene

Paralogs for ANO10 Gene Pseudogenes for ANO10 Gene

genes like me logo Genes that share paralogs with ANO10: view

Variants for ANO10 Gene

Sequence variations from dbSNP and Humsavar for ANO10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs737516 -- 43,516,593(-) CTAAT(A/G)TGTGT intron-variant
rs906154 -- 43,412,105(+) TAAGG(C/G)TATCT intron-variant
rs906155 -- 43,404,851(-) CACCC(A/G)GGATG intron-variant
rs906156 -- 43,402,848(-) ATTTG(G/T)TGTAG intron-variant
rs906157 -- 43,402,228(-) CCAAC(C/T)TCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANO10 Gene

Variant ID Type Subtype PubMed ID
esv5543 OTHER Inversion 19470904
esv1011105 CNV Insertion 20482838
esv1480257 CNV Insertion 17803354
dgv804n67 CNV Loss 20364138
nsv822070 CNV Loss 20364138
nsv820135 CNV Loss 19587683
esv2525562 CNV Insertion 19546169
esv270605 CNV Insertion 20981092
nsv834673 CNV Gain 17160897

Relevant External Links for ANO10 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANO10 Gene

Disorders for ANO10 Gene

(1) OMIM Diseases for ANO10 Gene (613726)


  • Spinocerebellar ataxia, autosomal recessive, 10 (SCAR10) [MIM:613728]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young adult years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging. {ECO:0000269 PubMed:21092923}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ANO10 Gene

Relevant External Links for ANO10

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ANO10: view

No data available for Novoseek inferred disease relationships and Genatlas for ANO10 Gene

Publications for ANO10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PMID: 21984732) Scudieri P. … Galietta L.J. (Exp. Physiol. 2012) 3 4
  3. ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. (PMID: 22075693) Duran C. … Hartzell H.C. (Am. J. Physiol. 2012) 3 4
  4. Structure and function of TMEM16 proteins (anoctamins). (PMID: 24692353) Pedemonte N. … Galietta L.J. (Physiol. Rev. 2014) 2 3
  5. Anoctamins are a family of Ca2+ activated Cl- channels. (PMID: 22946059) Tian Y. … Kunzelmann K. (J. Cell Sci. 2012) 3 4

Products for ANO10 Gene

Sources for ANO10 Gene

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