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Aliases for ANO1 Gene

Aliases for ANO1 Gene

  • Anoctamin 1, Calcium Activated Chloride Channel 2 3
  • TMEM16A 3 4 6
  • Discovered On Gastrointestinal Stromal Tumors Protein 1 3 4
  • Tumor-Amplified And Overexpressed Sequence 2 3 4
  • Oral Cancer Overexpressed 2 2 3
  • Transmembrane Protein 16A 2 4
  • ORAOV2 3 4
  • TAOS2 3 4
  • DOG1 3 4
  • Transmembrane Protein 16A (Eight Membrane-Spanning Domains) 3
  • Oral Cancer Overexpressed Protein 2 4
  • Ca2+-Activated Cl- Channel 3
  • Anoctamin-1 3
  • FLJ10261 6

External Ids for ANO1 Gene

Previous HGNC Symbols for ANO1 Gene

  • ORAOV2
  • TMEM16A

Previous GeneCards Identifiers for ANO1 Gene

  • GC11P069604
  • GC11P069925
  • GC11P066184
  • GC11P069927

Summaries for ANO1 Gene

GeneCards Summary for ANO1 Gene

ANO1 (Anoctamin 1, Calcium Activated Chloride Channel) is a Protein Coding gene. Diseases associated with ANO1 include small intestinal sarcoma and oral cancer. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include intracellular calcium activated chloride channel activity. An important paralog of this gene is ANO5.

UniProtKB/Swiss-Prot for ANO1 Gene

  • Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.

Tocris Summary for ANO1 Gene

  • ANO1 functions as a calcium-activated chloride channel (CaCC). It is ubiquitously expressed in epithelia and is thought to be important in epithelial fluid transport.

Gene Wiki entry for ANO1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANO1 Gene

Genomics for ANO1 Gene

Regulatory Elements for ANO1 Gene

Genomic Location for ANO1 Gene

Start:
69,985,875 bp from pter
End:
70,189,545 bp from pter
Size:
203,671 bases
Orientation:
Plus strand

Genomic View for ANO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANO1 Gene

Proteins for ANO1 Gene

  • Protein details for ANO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XXA6-ANO1_HUMAN
    Recommended name:
    Anoctamin-1
    Protein Accession:
    Q5XXA6
    Secondary Accessions:
    • A8KAM3
    • Q8IYY8
    • Q8N7V3

    Protein attributes for ANO1 Gene

    Size:
    986 amino acids
    Molecular mass:
    114078 Da
    Quaternary structure:
    • Homodimer. Interacts with CFTR.
    Miscellaneous:
    • The term anoctamin was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology

    Alternative splice isoforms for ANO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANO1 Gene

Proteomics data for ANO1 Gene at MOPED

Post-translational modifications for ANO1 Gene

  • Glycosylation at Asn832
  • Modification sites at PhosphoSitePlus

Other Protein References for ANO1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANO1 (ANO1)

No data available for DME Specific Peptides for ANO1 Gene

Domains for ANO1 Gene

Gene Families for ANO1 Gene

HGNC:
  • ANO :Ion channels / Chloride channels : Calcium activated : Anoctamins
IUPHAR :

Protein Domains for ANO1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANO1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5XXA6

UniProtKB/Swiss-Prot:

ANO1_HUMAN :
  • Q5XXA6
Domain:
  • The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.
Family:
  • Belongs to the anoctamin family.
genes like me logo Genes that share domains with ANO1: view

Function for ANO1 Gene

Molecular function for ANO1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
ATP and calmodulin are essential for its activation. Channel activity is inhibited by CFTR protein and by chloride inhibitors such as niflumic acid (NFA) and 4,4-diisothiocyanatostilbene-2,2-disulfonic acid (DIDS).
UniProtKB/Swiss-Prot Function:
Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.

Gene Ontology (GO) - Molecular Function for ANO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005227 calcium activated cation channel activity IDA 22946059
GO:0005229 intracellular calcium activated chloride channel activity ISS --
GO:0005515 protein binding IPI 22178883
GO:0042803 protein homodimerization activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with ANO1: view
genes like me logo Genes that share phenotypes with ANO1: view

Animal Models for ANO1 Gene

MGI Knock Outs for ANO1:

miRNA for ANO1 Gene

miRTarBase miRNAs that target ANO1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANO1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ANO1 Gene

Localization for ANO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANO1 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANO1 Gene COMPARTMENTS Subcellular localization image for ANO1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ANO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with ANO1: view

Pathways for ANO1 Gene

genes like me logo Genes that share pathways with ANO1: view

Pathways by source for ANO1 Gene

Interacting Proteins for ANO1 Gene

Gene Ontology (GO) - Biological Process for ANO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport IDA 22946059
GO:0006821 chloride transport ISS --
GO:0007275 multicellular organismal development IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0042391 regulation of membrane potential IEA --
genes like me logo Genes that share ontologies with ANO1: view

Compounds for ANO1 Gene

(5) Tocris Compounds for ANO1 Gene

Compound Action Cas Number
CaCCinh-A01 Calcium-activated chloride channel (CaCC) inhibitor [407587-33-1]
CFTRinh 172 Voltage-independent, selective CFTR chloride channel blocker [307510-92-5]
Chromanol 293B IKs blocker. Also blocks ICFTR [163163-23-3]
DCPIB Selective blocker of VSAC/ICl, swell. Inhibits glucose-stimulated insulin release [82749-70-0]
Eact Activator of Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) [461000-66-8]

(2) HMDB Compounds for ANO1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Chlorine
  • Cl2
16887-00-6

(12) IUPHAR Ligand for ANO1 Gene

Ligand Type Action Affinity Pubmed IDs
fluoxetine Inhibitor Inhibition 8.5
mibefradil Pore Blocker Antagonist 6.8
NPPB Activator Activation 6.49
DCDPC Channel blocker None
tannic acid Channel blocker None
SITS Channel blocker None
9-A-C Channel blocker None
niflumic acid Channel blocker None
flufenamic acid Channel blocker None
Ins(3,4,5,6)P4 Channel blocker None
Ca2+ Antagonist Antagonist
DIDS Channel blocker None
genes like me logo Genes that share compounds with ANO1: view

Transcripts for ANO1 Gene

Unigene Clusters for ANO1 Gene

Anoctamin 1, calcium activated chloride channel:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANO1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANO1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6:

ExUns: 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for ANO1 Gene

GeneLoc Exon Structure for
ANO1
ECgene alternative splicing isoforms for
ANO1

Expression for ANO1 Gene

mRNA expression in normal human tissues for ANO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANO1 Gene

This gene is overexpressed in Artery - Aorta (7.1).

Protein differential expression in normal tissues for ANO1 Gene

This gene is overexpressed in Lung (59.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANO1 Gene

SOURCE GeneReport for Unigene cluster for ANO1 Gene Hs.503074

mRNA Expression by UniProt/SwissProt for ANO1 Gene

Q5XXA6-ANO1_HUMAN
Tissue specificity: Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles.
genes like me logo Genes that share expressions with ANO1: view

In Situ Assay Products

No data available for Expression partners for ANO1 Gene

Orthologs for ANO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANO1 35
  • 90.24 (n)
  • 93.87 (a)
ANO1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANO1 35
  • 89.18 (n)
  • 93.51 (a)
ANO1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ano1 35
  • 85.44 (n)
  • 92.28 (a)
Ano1 16
Ano1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANO1 35
  • 98.3 (n)
  • 98.07 (a)
rat
(Rattus norvegicus)
Mammalia Ano1 35
  • 85.68 (n)
  • 91.97 (a)
oppossum
(Monodelphis domestica)
Mammalia ANO1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANO1 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANO1 35
  • 77.08 (n)
  • 87.07 (a)
ANO1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANO1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ano1 35
  • 73.5 (n)
  • 80.88 (a)
zebrafish
(Danio rerio)
Actinopterygii ano1 35
  • 68.33 (n)
  • 65.44 (a)
CABZ01015106.1 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16718 35
  • 53.57 (n)
  • 46.04 (a)
CG10353 36
  • 30 (a)
ManyToMany
CG16718 36
  • 33 (a)
ManyToMany
Species with no ortholog for ANO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANO1 Gene

ENSEMBL:
Gene Tree for ANO1 (if available)
TreeFam:
Gene Tree for ANO1 (if available)

Paralogs for ANO1 Gene

Paralogs for ANO1 Gene

Selected SIMAP similar genes for ANO1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ANO1: view

Variants for ANO1 Gene

Sequence variations from dbSNP and Humsavar for ANO1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs481845 -- 70,187,477(+) TCCTG(A/G)TCAAA intron-variant
rs510663 -- 70,182,493(-) TGCAG(G/T)GGACA intron-variant
rs510718 -- 70,188,348(+) GGCCC(C/G)TAGAA utr-variant-3-prime, intron-variant
rs535483 -- 70,180,469(-) atgtc(A/C)aaacc intron-variant
rs545174 -- 70,181,046(-) AAACC(C/T)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANO1 Gene

Variant ID Type Subtype PubMed ID
esv23827 CNV Gain 19812545
esv2744704 CNV Deletion 23290073
esv1360750 CNV Deletion 17803354
esv2744705 CNV Deletion 23290073
esv2744706 CNV Deletion 23290073
esv2744707 CNV Deletion 23290073
esv1620418 CNV Deletion 17803354
esv1322895 CNV Insertion 17803354
nsv897887 CNV Loss 21882294
esv1765426 CNV Insertion 17803354
nsv825977 CNV Gain 20364138
nsv820744 CNV Deletion 20802225
dgv227n67 CNV Loss 20364138
esv2744709 CNV Deletion 23290073
dgv222e199 CNV Deletion 23128226
esv9664 CNV Loss 19470904
nsv39653 CNV Loss 16902084
dgv228n67 CNV Loss 20364138
esv23581 CNV Gain+Loss 19812545
nsv39588 CNV Loss 16902084
nsv897888 CNV Loss 21882294
nsv469969 CNV Loss 18288195
esv2744710 CNV Deletion 23290073

Relevant External Links for ANO1 Gene

HapMap Linkage Disequilibrium report
ANO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANO1 Gene

Disorders for ANO1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ANO1 Gene in MalaCards »

(2) Diseases for ANO1 Gene including...

(2) University of Copenhagen DISEASES for ANO1 Gene

(1) Novoseek inferred disease relationships for ANO1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for ANO1

Genetic Association Database (GAD)
ANO1
Human Genome Epidemiology (HuGE) Navigator
ANO1
genes like me logo Genes that share disorders with ANO1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for ANO1 Gene

Publications for ANO1 Gene

  1. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. (PMID: 12739008) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 3 4 23
  2. Identification and characterization of TMEM16E and TMEM16F genes in silico. (PMID: 15067359) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 23
  3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 48
  4. TMEM16A confers receptor-activated calcium-dependent chloride conductance. (PMID: 18724360) Yang Y.D. … Oh U. (Nature 2008) 2 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for ANO1 Gene

Sources for ANO1 Gene

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