Aliases for ANO1 Gene
External Ids for ANO1 Gene
Previous Symbols for ANO1 Gene
GeneCards Summary for ANO1 Gene
ANO1 (Anoctamin 1, Calcium Activated Chloride Channel) is a Protein Coding gene. Diseases associated with ANO1 include small intestinal sarcoma and oral cancer. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include intracellular calcium activated chloride channel activity. An important paralog of this gene is ANO5.
UniProtKB/Swiss-Prot for ANO1 Gene
Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
ANO1 functions as a calcium-activated chloride channel (CaCC). It is ubiquitously expressed in epithelia and is thought to be important in epithelial fluid transport.