Aliases for ANO1 Gene
External Ids for ANO1 Gene
Previous HGNC Symbols for ANO1 Gene
Previous GeneCards Identifiers for ANO1 Gene
GeneCards Summary for ANO1 Gene
ANO1 (Anoctamin 1) is a Protein Coding gene. Diseases associated with ANO1 include Frontal Sinus Squamous Cell Carcinoma and Liver Leiomyoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Neuroscience. GO annotations related to this gene include protein homodimerization activity and intracellular calcium activated chloride channel activity. An important paralog of this gene is ANO2.
UniProtKB/Swiss-Prot for ANO1 Gene
Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Chloride channels are a family of anion-selective channels involved in the regulation of the excitability of neurons, skeletal, cardiac and smooth muscle, cell volume regulation, transepithelial salt transport and the acidification of intra- and extracellular compartments.