Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANLN Gene

protein-coding GIFtS: 52
GCID: GC07P036395

anillin, actin binding protein

(Previous names: anillin (Drosophila Scraps homolog), actin binding protein,...)

Explore 8 diseases affiliated with
ANLN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Anillin, Actin Binding Protein¹ ²		Anillin (Drosophila Scraps Homolog), Actin Binding Protein¹
Scraps¹ ²		Anillin, Actin Binding Protein (Scraps Homolog, Drosophila)¹
Scra¹		Actin-Binding Protein Anillin²
ANILLIN¹

External Ids:	HGNC: 14082¹	Entrez Gene: 54443²	Ensembl: ENSG00000011426⁷	UniProtKB: Q9NQW6³

Export aliases for ANLN gene to outside databases

Previous GC identifers: GC07P036076 GC07P036170 GC07P036202 GC07P036309

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ANLN_HUMAN, Q9NQW6

Function: Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of

cleavage furrow ingression

Gene Wiki entry for ANLN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANLN gene promoter:
Max1 Sp1 AP-1 FOXD1 MIF-1 POU3F2 GATA-1 Max c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): ANLN promoter sequence

Search SABiosciences Chromatin IP Primers for ANLN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANLN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15-p14 Ensembl cytogenetic band: 7p14.2 HGNC cytogenetic band: 7p15-p14

ANLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANLN gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P036395: view genomic region (about GC identifiers)

Start:	36,429,415 bp from pter	End:	36,493,400 bp from pter
Size:	63,986 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 36,467,432-36,531,402

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANLN_HUMAN, Q9NQW6 (See protein sequence)

Recommended Name: Actin-binding protein anillin

Size: 1124 amino acids; 124199 Da

Subunit: Interacts with F-actin. Interacts with CD2AP. May interact with RHOA. Interacts with FZR1/CDH1 during mitotic

exit

Subcellular location: Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Mainly found in the nucleus during

interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates

in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein

becomes concentrated in the midbody

Developmental stage: Expressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and thymus. In

dividing cells expression increases during S and G2 phases, peaks at mitosis and subsequently drops as cells enter G1

phase

Sequence caution: Sequence=AAH34692.1; Type=Erroneous initiation; Sequence=BAA91710.1; Type=Erroneous initiation;

Sequence=BAA91711.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for ANLN:

2Y7B (3D)

Secondary accessions: Q5CZ78 Q6NSK5 Q9H8Y4 Q9NVN9 Q9NVP0

Alternative splicing: 2 isoforms: Q9NQW6-1 Q9NQW6-2

Explore the universe of human proteins at neXtProt for ANLN: NX_Q9NQW6

Post-translational modifications:

Phosphorylated during mitosis¹

Ubiquitinated, and this requires FZR1/CDH1¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NQW6

ANLN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_061155.2

ENSEMBL proteins:

ENSP00000265748 ENSP00000379380 ENSP00000404979 ENSP00000406584 ENSP00000398712

ENSP00000397465 ENSP00000413441 ENSP00000413522 ENSP00000400777 ENSP00000399553

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ANLN OriGene Custom Protein Services for ANLN
	GenScript Custom Purified and Recombinant Proteins Services for ANLN
	Novus Biologicals ANLN Protein Novus Biologicals ANLN Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ANLN

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005826	actomyosin contractile ring	IDA	10931866
GO:0015629	actin cytoskeleton	IDA	10931866

ANLN for ontologies About GeneDecksing

ANLN Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ANLN
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): ANLN OriGene Custom Antibody Services for ANLN
	GenScript Custom Superior Antibodies Services for ANLN
	Novus Biologicals ANLN Antibodies
	Search for Antibodies for ANLN at Abcam
	Uscn Antibodies for ANLN
	ThermoFisher Antibodies for ANLN

Assay Products for ANLN:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ANLN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ANLN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANLN for domains About GeneDecksing

3 InterPro domains/families:

IPR001849 Pleckstrin_homology

IPR011993 PH_like_dom

IPR012966 DUF1709

Graphical View of Domain Structure for InterPro Entry Q9NQW6

ProtoNet protein and cluster: Q9NQW6

1 Blocks protein family: IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: ANLN_HUMAN, Q9NQW6

Similarity: Contains 1 PH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ANLN_HUMAN, Q9NQW6

Function: Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of

cleavage furrow ingression

miRNA Products:		miRTarBase miRNAs that target ANLN: hsa-mir-503 (MIRT000651), hsa-mir-424 (MIRT000660)

		OriGene 3'-UTR Clone: ANLN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANLN
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate ANLN (see all 24):
		hsa-miR-217 hsa-miR-429 hsa-miR-15a hsa-miR-509-5p hsa-miR-503 hsa-miR-374a hsa-miR-424 hsa-miR-195

		SwitchGear 3'UTR luciferase reporter plasmid: ANLN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANLN (see all 4) OriGene shRNA RFP: ANLN OriGene siRNA: ANLN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANLN

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ANLN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANLN (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANLN OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ANLN (NM_018685)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANLN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANLN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ANLN
		Search LifeMap BioReagents cell lines for ANLN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANLN

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IDA	10931866
GO:0005543	phospholipid binding	IEA	--

ANLN for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for ANLN:

Cell division defect

Decreased cell number, increas

Increased cell number in G2M,

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ANLN

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/744 Interacting proteins for ANLN (Q9NQW6^{2, 3} ENSP00000265748⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 744)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SEPT7	Q16181²^,³, ENSP00000381992⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000381992
SUMO1	P63165²^,³, ENSP00000376076⁴	MINT-7947479 I2D: score=1 STRING: ENSP00000376076
CDC5L	Q99459², ENSP00000360532⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000360532
SNW1	Q13573², ENSP00000261531⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000261531
TAF10	Q12962³, ENSP00000299424⁴	I2D: score=1 STRING: ENSP00000299424

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000910	cytokinesis	IDA	10931866
GO:0000921	septin ring assembly	TAS	10931866
GO:0007067	mitosis	IEA	--
GO:0007096	regulation of exit from mitosis	TAS	10931866

ANLN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ANLN
Search CenterWatch for drugs/clinical trials and news about ANLN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ANLN gene:

NM_018685.2

Unigene Cluster for ANLN:

Anillin, actin binding protein

Hs.62180 [show with all ESTs]

Unigene Representative Sequence: NM_018685

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265748(uc003tff.3 uc011kaz.2) ENST00000396068(uc003tfg.3 uc010kxe.3)

ENST00000424865 ENST00000418118 ENST00000460598 ENST00000429082 ENST00000441696

ENST00000452877 ENST00000495714 ENST00000428612 ENST00000446635 ENST00000457743

ENST00000491782

miRNA Products:		OriGene 3'-UTR Clone: ANLN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANLN
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate ANLN (see all 24):
		hsa-miR-217 hsa-miR-429 hsa-miR-15a hsa-miR-509-5p hsa-miR-503 hsa-miR-374a hsa-miR-424 hsa-miR-195

		SwitchGear 3'UTR luciferase reporter plasmid: ANLN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANLN (see all 4) OriGene shRNA RFP: ANLN OriGene siRNA: ANLN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANLN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANLN (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANLN OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ANLN (NM_018685)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANLN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANLN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANLN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ANLN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANLN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANLN

Additional cDNA sequence:

AF273437.1 AK001468.1 AK001472.1 AK023208.1 AK094574.1 AK291254.1 AK299803.1 BC034692.1

BC070066.1 CR936650.1

14 DOTS entries:

DT.40248861 DT.121063980 DT.95175438 DT.445053 DT.95136500 DT.100795481 DT.99966774 DT.100730948

DT.121063997 DT.121063998 DT.91767963 DT.100795480 DT.121064021 DT.92436232

24/228 AceView cDNA sequences (see all 228):

BP336464 AA251247 BP335623 BM828811 AA361805 CA423488 CB133722 BF060685

BQ434804 AA307782 BQ946271 CB143710 CB112525 AK094574 AK001472 AI341261

BP364072 BE878572 AI818674 BP355494 AA970372 BU630457 CB143955 BM975256

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for ANLN (see all 20) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c	·	9d	·	9e	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	·
SP1:																							-
SP2:
SP3:
SP4:																																																	-		-
SP5:

ExUns:	12c	·	12d	^	13a	·	13b	^	14a	·	14b	·	14c	^	15a	·	15b	·	15c	^	16	^	17	^	18	^	19a	·	19b	^	20a	·	20b
SP1:
SP2:
SP3:															-
SP4:	-		-
SP5:							-

ECgene alternative splicing isoforms for ANLN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANLN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACAACAGTG

About this image

ANLN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Epicardium

Kidney Endothelial Cells

Endothelium

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Adult human kidney epithelial cells (Primary Cell)

Kidney

See ANLN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANLN

SOURCE GeneReport for Unigene cluster: Hs.62180

UniProtKB/Swiss-Prot: ANLN_HUMAN, Q9NQW6

Tissue specificity: Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and

testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart,

kidney, liver, lung, pancreas, prostate and spleen. Overexpressed in many tumor types including breast, colorectal,

endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors

SABiosciences Custom PCR Arrays for ANLN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANLN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ANLN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANLN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANLN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANLN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ANLN gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Anln^{1 , 5}	anillin, actin binding protein^{1, 5}	83.18(n)¹ 80.77(a)¹		9 (8.93 cM)⁵ 68743¹ NM_028390.3¹ NP_082666.2¹ 22331214⁵
chicken (Gallus gallus)	Aves	ANLN¹	anillin, actin binding protein	69.76(n) 65.6(a)		420738 XM_418836.3 XP_418836.3
lizard (Anolis carolinensis)	Reptilia	ANLN⁶	--	62(a)	1 ↔ 1	6(46968926-47001035)
African clawed frog (Xenopus laevis)	Amphibia	LOC398569²	contractile ring component anillin	76.55(n)		AY180201.1
zebrafish (Danio rerio)	Actinopterygii	wufa12d06²	wufa12d06	77.4(n)		335048 CK029209.1
fruit fly (Drosophila melanogaster)	Insecta	scra³	cellularization actin binding	30(a)		43E3 --
worm (Caenorhabditis elegans)	Secernentea	ani-3⁶ ani-1⁶ (see all 3)	Anillin-like protein 1 (see all 3)	17(a) 14(a) (see all 3)	many → 1 many → 1 (see all 3)	V(19697543-19705161) III(12446255-12453103)

ENSEMBL Gene Tree for ANLN (if available)
TreeFam Gene Tree for ANLN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144678613^1,2		--	36431811(+)	`GTCTGC/TAGGCT`	1	--	int¹		0	--	--	--	--
rs197357^1,2	C,F,A,H,	--	36431951(+)	`TTATAT/CTGAGT`	1	--	int¹		18		MN NS EA NA CSA	2218
rs66528740^1,2	C	--	36432123(+)	`TTTTT-/TTAATGC`	1	--	int¹		0	--	--	--	--
rs191413850^1,2		--	36432176(+)	`TCAAGA/GAATAT`	1	--	int¹		0	--	--	--	--
rs141749939^1,2		--	36432189(+)	`CTTGTA/GTTTAA`	1	--	int¹		0	--	--	--	--
rs145693820^1,2		--	36432242(+)	`ACTTAC/TATTTA`	1	--	int¹		0	--	--	--	--
rs197358^1,2	C,F,H,	--	36432338(+)	`AGGGAA/TCTTTT`	1	--	int¹		20		NS EA NA WA CSA	1840
rs184186868^1,2		--	36432404(+)	`CAATAC/GAACAT`	1	--	int¹		0	--	--	--	--
rs56326365^1,2	C,F,	--	36432417(+)	`ATATAC/TGTTTG`	1	--	int¹		1		NA	120
rs75305475^1,2	F,	--	36432455(+)	`GACCTA/TCTGCT`	1	--	int¹		1		NA	120

HapMap Linkage Disequilibrium report for ANLN (36429415 - 36493400 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANLN: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANLN

DNA2.0 Custom Variant and Variant Library Synthesis for ANLN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ANLN for disorders About GeneDecksing

8 diseases for ANLN: About MalaCards

lower lip cancer lip cancer renal cell carcinoma lung cancer

carcinoma pancreatitis hepatitis prostatitis

Export disorders for ANLN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ANLN gene, integrated from 9 sources (see all 61):
(articles sorted by number of sources associating them with ANLN)

Utopia: connect your pdf to the dynamic
world of online information

Functional analysis of a human homolog of the Drosophila actin binding protein anillin suggests a role in cytokinesis. (PubMed id 10931866)^{1, 2, 3, 9} Oegema K.... Field C.M. (2000)
Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis. (PubMed id 16040610)^{1, 2, 9} Zhao W.-M. and Fang G. (2005)
The septin-binding protein anillin is overexpressed in diverse human tumors. (PubMed id 16203764)^{1, 2, 9} Hall P.A.... Russell S.E.H. (2005)
Anillin binds nonmuscle myosin II and regulates the contractile ring. (PubMed id 15496454)^{1, 2, 9} Straight A.F.... Mitchison T.J. (2005)
Self- and actin-templated assembly of mammalian septins. (PubMed id 12479805)^{1, 2, 9} Kinoshita M....Mitchison T.J. (2002)
Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not. (PubMed id 15616196)^{1, 2, 9} Mollinari C.... Margolis R.L. (2005)
MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. (PubMed id 16129829)^{1, 2, 9} Zhao W.-M. and Fang G. (2005)
ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3- kinase/AKT pathway. (PubMed id 16357138)^{1, 2, 9} Suzuki C.... Nakamura Y. (2005)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Clues to CD2-associated protein involvement in cytokinesis. (PubMed id 15800069)^{1, 2} Monzo P.... Cormont M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54443	HGNC: 14082	AceView: ANLN	Ensembl:ENSG00000011426	euGenes: HUgn54443
ECgene: ANLN	H-InvDB: ANLN

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANLN	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ANLN	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ANLN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ANLN gene:
Search GeneIP for patents involving ANLN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of ANLN

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for ANLN		OriGene shRNA RFP for ANLN
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANLN		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANLN
	OriGene Protein Over-expression Lysate for ANLN		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ANLN		OriGene 3'-UTR Clone for ANLN
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANLN		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANLN
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ANLN		OriGene Custom Protein Services for ANLN
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANLN
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANLN
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANLN
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANLN
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANLN
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANLN

	GenScript Custom Purified and Recombinant Proteins Services for ANLN		GenScript cDNA clones with any tag delivered in your preferred vector for ANLN
	GenScript Custom Assay Services for ANLN		GenScript Custom Superior Antibodies Services for ANLN
	GenScript Custom overexpressing Cell Line Services for ANLN		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ANLN promoter
	Search Chromatin IP Primers for ANLN
	RT² qPCR Primer Assay in human, mouse, rat ANLN
	GNC Network for ANLN
	SABiosciences Custom PCR Arrays for ANLN

Search Tocris compounds for ANLN

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ANLN antibodies
	ANLN proteins
	ANLN lysates

	Search for Antibodies for ANLN at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for ANLN
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ANLN Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ANLN

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANLN

	SwitchGear 3'UTR luciferase reporter plasmids for ANLN
	SwitchGear Promoter luciferase reporter plasmids for ANLN

ThermoFisher Antibodies for ANLN

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANLN

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ANLN gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

ANLN Gene

anillin, actin binding protein

Aliases
for ANLN gene

Summaries
for ANLN gene

Genomic Views
for ANLN gene

Proteins
for ANLN gene

Protein Domains /
Families
for ANLN gene

Function
for ANLN gene

Pathways & Interactions
for ANLN gene

Drugs & Compounds
for ANLN gene

Transcripts
for ANLN gene

Expression
for ANLN gene

Orthologs
for ANLN gene

Paralogs
for ANLN gene

Genomic Variants
for ANLN gene

Disorders / Diseases
for ANLN gene

Publications
for ANLN gene

External Searches for ANLN gene

Genome Databases showing ANLN gene

Other Databases showing ANLN gene

Specialized Databases showing ANLN gene

Intellectual Property
for ANLN gene

Products
for ANLN gene

View Random Gene

Advanced Search

Export list of displayed genes

ANLN Gene

anillin, actin binding protein

Aliasesfor ANLN gene

Summariesfor ANLN gene

Genomic Viewsfor ANLN gene

Proteinsfor ANLN gene

Protein Domains /Familiesfor ANLN gene

Functionfor ANLN gene

Pathways & Interactionsfor ANLN gene

Drugs & Compoundsfor ANLN gene

Transcriptsfor ANLN gene

Expression for ANLN gene

Orthologsfor ANLN gene

Paralogsfor ANLN gene

Genomic Variantsfor ANLN gene

Disorders / Diseasesfor ANLN gene

Publicationsfor ANLN gene

External Searches for ANLN gene

Genome Databases showing ANLN gene

Other Databases showing ANLN gene

Specialized Databases showing ANLN gene

Intellectual Propertyfor ANLN gene

Productsfor ANLN gene

View Random Gene

Aliases
for ANLN gene

Summaries
for ANLN gene

Genomic Views
for ANLN gene

Proteins
for ANLN gene

Protein Domains /
Families
for ANLN gene

Function
for ANLN gene

Pathways & Interactions
for ANLN gene

Drugs & Compounds
for ANLN gene

Transcripts
for ANLN gene

Expression
for ANLN gene

Orthologs
for ANLN gene

Paralogs
for ANLN gene

Genomic Variants
for ANLN gene

Disorders / Diseases
for ANLN gene

Publications
for ANLN gene

Intellectual Property
for ANLN gene

Products
for ANLN gene