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Aliases for ANLN Gene

Aliases for ANLN Gene

  • Anillin, Actin Binding Protein 2 3
  • Anillin, Actin Binding Protein (Scraps Homolog, Drosophila) 2
  • Anillin (Drosophila Scraps Homolog), Actin Binding Protein 2
  • Actin-Binding Protein Anillin 3
  • Scraps 3
  • FSGS8 3
  • Scra 3

External Ids for ANLN Gene

Summaries for ANLN Gene

Entrez Gene Summary for ANLN Gene

  • This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

GeneCards Summary for ANLN Gene

ANLN (Anillin, Actin Binding Protein) is a Protein Coding gene. Diseases associated with ANLN include focal segmental glomerulosclerosis 8 and familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis. Among its related pathways are RB in Cancer. GO annotations related to this gene include phospholipid binding and actin binding.

UniProtKB/Swiss-Prot for ANLN Gene

  • Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. May play a significant role in podocyte cell migration (PubMed:24676636).

Gene Wiki entry for ANLN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANLN Gene

Genomics for ANLN Gene

Genomic Location for ANLN Gene

Start:
36,389,806 bp from pter
End:
36,453,791 bp from pter
Size:
63,986 bases
Orientation:
Plus strand

Genomic View for ANLN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANLN Gene

Regulatory Elements for ANLN Gene

Proteins for ANLN Gene

  • Protein details for ANLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQW6-ANLN_HUMAN
    Recommended name:
    Actin-binding protein anillin
    Protein Accession:
    Q9NQW6
    Secondary Accessions:
    • Q5CZ78
    • Q6NSK5
    • Q9H8Y4
    • Q9NVN9
    • Q9NVP0

    Protein attributes for ANLN Gene

    Size:
    1124 amino acids
    Molecular mass:
    124199 Da
    Quaternary structure:
    • Interacts with F-actin. Interacts with CD2AP. May interact with RHOA. Interacts with FZR1/CDH1 during mitotic exit.
    SequenceCaution:
    • Sequence=AAH34692.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91710.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91711.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANLN Gene

    Alternative splice isoforms for ANLN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANLN Gene

Proteomics data for ANLN Gene at MOPED

Post-translational modifications for ANLN Gene

No data available for DME Specific Peptides for ANLN Gene

Domains for ANLN Gene

Gene Families for ANLN Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for ANLN Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

ANLN_HUMAN
Domain:
  • Contains 1 PH domain.:
    • Q9NQW6
genes like me logo Genes that share domains with ANLN: view

Function for ANLN Gene

Molecular function for ANLN Gene

UniProtKB/Swiss-Prot Function: Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. May play a significant role in podocyte cell migration (PubMed:24676636).

Gene Ontology (GO) - Molecular Function for ANLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 10931866
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ANLN: view

Phenotypes for ANLN Gene

genes like me logo Genes that share phenotypes with ANLN: view

miRNA for ANLN Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANLN Gene

Localization for ANLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANLN Gene

Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANLN Gene COMPARTMENTS Subcellular localization image for ANLN gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ANLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005826 actomyosin contractile ring IDA 10931866
GO:0015629 actin cytoskeleton IDA 10931866
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ANLN: view

Pathways for ANLN Gene

SuperPathways for ANLN Gene

Superpath Contained pathways
1 RB in Cancer
genes like me logo Genes that share pathways with ANLN: view

Pathways by source for ANLN Gene

1 BioSystems pathway for ANLN Gene

Gene Ontology (GO) - Biological Process for ANLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IDA 10931866
GO:0000921 septin ring assembly TAS 10931866
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007096 regulation of exit from mitosis TAS 10931866
genes like me logo Genes that share ontologies with ANLN: view

Transcripts for ANLN Gene

Unigene Clusters for ANLN Gene

Anillin, actin binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANLN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ·
SP1: -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10: - - -
SP11: - -
SP12: - -
SP13:
SP14: - -
SP15: -
SP16: - -
SP17: - -
SP18: -
SP19:
SP20:

ExUns: 12c · 12d ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1:
SP2:
SP3: -
SP4: - -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for ANLN Gene

GeneLoc Exon Structure for
ANLN
ECgene alternative splicing isoforms for
ANLN

Expression for ANLN Gene

mRNA expression in normal human tissues for ANLN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANLN Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (14.7), Brain - Substantia nigra (8.0), and Brain - Hippocampus (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANLN Gene

SOURCE GeneReport for Unigene cluster for ANLN Gene Hs.62180

mRNA Expression by UniProt/SwissProt for ANLN Gene

Q9NQW6-ANLN_HUMAN
Tissue specificity: Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
genes like me logo Genes that share expressions with ANLN: view

Orthologs for ANLN Gene

This gene was present in the common ancestor of animals.

Orthologs for ANLN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANLN 36
  • 99.32 (n)
  • 99.47 (a)
ANLN 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANLN 36
  • 89.39 (n)
  • 86.65 (a)
ANLN 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANLN 36
  • 89.93 (n)
  • 88.52 (a)
ANLN 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anln 36
  • 83.15 (n)
  • 80.77 (a)
Anln 16
Anln 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANLN 37
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANLN 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anln 36
  • 81.26 (n)
  • 77.52 (a)
chicken
(Gallus gallus)
Aves ANLN 36
  • 69.76 (n)
  • 65.6 (a)
ANLN 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANLN 37
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398569 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491625 36
  • 64.36 (n)
  • 60.33 (a)
Str.7526 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1959 36
zebrafish
(Danio rerio)
Actinopterygii anln 36
  • 57.9 (n)
  • 54.95 (a)
anln 37
  • 46 (a)
OneToOne
wufa12d06 36
fruit fly
(Drosophila melanogaster)
Insecta scra 37
  • 21 (a)
OneToOne
scra 38
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea ani-1 37
  • 17 (a)
OneToMany
ani-2 37
  • 17 (a)
OneToMany
ani-3 37
  • 21 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4355 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10671 37
  • 39 (a)
OneToOne
Species with no ortholog for ANLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANLN Gene

ENSEMBL:
Gene Tree for ANLN (if available)
TreeFam:
Gene Tree for ANLN (if available)

Paralogs for ANLN Gene

Selected SIMAP similar genes for ANLN Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ANLN: view

No data available for Paralogs for ANLN Gene

Variants for ANLN Gene

Sequence variations from dbSNP and Humsavar for ANLN Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs197357 -- 36,392,342(+) TTATA(C/T)TGAGT intron-variant
rs197358 -- 36,392,729(+) AGGGA(A/T)CTTTT intron-variant
rs197359 -- 36,393,559(+) gttac(A/G)tgcat intron-variant
rs197360 -- 36,395,347(+) tgtcc(C/T)gttcc intron-variant
rs197361 -- 36,398,062(+) AGGCA(A/G)TTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANLN Gene

Variant ID Type Subtype PubMed ID
esv270354 CNV Insertion 20981092
nsv511959 CNV Loss 21212237
esv2734254 CNV Deletion 23290073
esv2657144 CNV Deletion 23128226
nsv521965 CNV Loss 19592680

Relevant External Links for ANLN Gene

HapMap Linkage Disequilibrium report
ANLN
Human Gene Mutation Database (HGMD)
ANLN

Disorders for ANLN Gene

UniProtKB/Swiss-Prot

ANLN_HUMAN
  • Focal segmental glomerulosclerosis 8 (FSGS8) [MIM:616032]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. {ECO:0000269 PubMed:24676636}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ANLN

Genetic Association Database (GAD)
ANLN
genes like me logo Genes that share disorders with ANLN: view

Publications for ANLN Gene

  1. Functional analysis of a human homolog of the Drosophila actin binding protein anillin suggests a role in cytokinesis. (PMID: 10931866) Oegema K. … Field C.M. (J. Cell Biol. 2000) 2 3 4 23
  2. Self- and actin-templated assembly of mammalian septins. (PMID: 12479805) Kinoshita M. … Mitchison T.J. (Dev. Cell 2002) 3 4 23
  3. Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not. (PMID: 15616196) Mollinari C. … Margolis R.L. (Mol. Biol. Cell 2005) 3 4 23
  4. Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis. (PMID: 16040610) Zhao W.-M. … Fang G. (J. Biol. Chem. 2005) 3 4 23
  5. MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. (PMID: 16129829) Zhao W.-M. … Fang G. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23

Products for ANLN Gene

  • Addgene plasmids for ANLN

Sources for ANLN Gene

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