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ANLN Gene

protein-coding   GIFtS: 56
GCID: GC07P036395

Anillin, Actin Binding Protein

(Previous names: anillin (Drosophila Scraps homolog), actin binding protein,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Anillin, Actin Binding Protein1 2
Anillin (Drosophila Scraps Homolog), Actin Binding Protein1
Anillin, Actin Binding Protein (Scraps Homolog, Drosophila)1
Scraps2
Actin-Binding Protein Anillin2
scra2

External Ids:    HGNC: 140821   Entrez Gene: 544432   Ensembl: ENSG000000114267   UniProtKB: Q9NQW63   

Export aliases for ANLN gene to outside databases

Previous GC identifers: GC07P036076 GC07P036170 GC07P036202 GC07P036309


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANLN Gene:
ANLN (anillin, actin binding protein) is a protein-coding gene. Diseases associated with ANLN include lower lip cancer, and lip cancer. GO annotations related to this gene include actin binding and phospholipid binding.

UniProtKB/Swiss-Prot: ANLN_HUMAN, Q9NQW6
Function: Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for
completion of cleavage furrow ingression

Gene Wiki entry for ANLN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANLN gene promoter:
         Max1   Sp1   AP-1   FOXD1   MIF-1   POU3F2   GATA-1   Max   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): ANLN promoter sequence
   Search Chromatin IP Primers for ANLN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15-p14   Ensembl cytogenetic band:  7p14.2   HGNC cytogenetic band: 7p15-p14

ANLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANLN gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P036395:  view genomic region     (about GC identifiers)

Start:
36,429,415 bp from pter      End:
36,493,400 bp from pter
Size:
63,986 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 36,467,432-36,531,402     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ANLN_HUMAN, Q9NQW6 (See protein sequence)
Recommended Name: Actin-binding protein anillin  
Size: 1124 amino acids; 124199 Da
Subunit: Interacts with F-actin. Interacts with CD2AP. May interact with RHOA. Interacts with FZR1/CDH1 during
mitotic exit
Developmental stage: Expressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and thymus. In
dividing cells expression increases during S and G2 phases, peaks at mitosis and subsequently drops as cells
enter G1 phase
Sequence caution: Sequence=AAH34692.1; Type=Erroneous initiation; Sequence=BAA91710.1; Type=Erroneous initiation;
Sequence=BAA91711.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ANLN:
2Y7B (3D)    
Secondary accessions: Q5CZ78 Q6NSK5 Q9H8Y4 Q9NVN9 Q9NVP0
Alternative splicing: 2 isoforms:  Q9NQW6-1   Q9NQW6-2   

Explore the universe of human proteins at neXtProt for ANLN: NX_Q9NQW6

Explore proteomics data for ANLN at MOPED

Post-translational modifications: 

  • Phosphorylated during mitosis1
  • Ubiquitinated, and this requires FZR1/CDH11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANLN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001271230.1  NP_001271231.1  NP_061155.2  

    ENSEMBL proteins: 
     ENSP00000265748   ENSP00000379380   ENSP00000404979   ENSP00000406584   ENSP00000398712  
     ENSP00000397465   ENSP00000413441   ENSP00000413522   ENSP00000400777   ENSP00000399553  

    ANLN Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ANLN
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    Novus Biologicals ANLN Protein
    Novus Biologicals ANLN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANLN

    ANLN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANLN
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    Abcam antibodies for ANLN
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    ThermoFisher Antibody for ANLN
    LSBio Antibodies in human, mouse, rat for ANLN

    ANLN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ANLN
    Cloud-Clone Corp. CLIAs for ANLN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    3 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR012966 DUF1709

    Graphical View of Domain Structure for InterPro Entry Q9NQW6

    ProtoNet protein and cluster: Q9NQW6

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: ANLN_HUMAN, Q9NQW6
    Similarity: Contains 1 PH domain


    ANLN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANLN_HUMAN, Q9NQW6
    Function: Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for
    completion of cleavage furrow ingression

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA10931866
         
    ANLN for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ANLN:
     Cell division defect  Decreased cell number, increas  Increased cell number in G2M,   Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANLN
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANLN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANLN

    miRNA
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    miRTarBase miRNAs that target ANLN:
    hsa-mir-503-5p (MIRT000651), hsa-mir-215-5p (MIRT024925), hsa-mir-424-5p (MIRT000660), hsa-mir-192-5p (MIRT026616)

    Block miRNA regulation of human, mouse, rat ANLN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANLN (see all 24):
    hsa-miR-217 hsa-miR-429 hsa-miR-15a hsa-miR-509-5p hsa-miR-503 hsa-miR-374a hsa-miR-424 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidANLN 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ANLN
    Predesigned siRNA for gene silencing in human, mouse, rat ANLN

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    GenScript: all cDNA clones in your preferred vector: ANLN (NM_018685)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANLN

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    Browse ESI BIO Cell Lines and PureStem Progenitors for ANLN 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANLN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANLN_HUMAN, Q9NQW6: Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Mainly found in the nucleus
    during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently
    concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase,
    when the protein becomes concentrated in the midbody
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005826actomyosin contractile ring IDA10931866
    GO:0015629actin cytoskeleton IDA10931866
    GO:0043231intracellular membrane-bounded organelle IDA--

    ANLN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANLN About    
    See pathways by source

    SuperPathContained pathways About
    1RB in Cancer
    RB in Cancer


    1 BioSystems Pathway for ANLN
        RB in Cancer


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANLN
    Interactions:

        GeneGlobe Interaction Network for ANLN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ANLN (Q9NQW62, 3 ENSP000002657484) via UniProtKB, MINT, STRING, and/or I2D (see all 780)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEPT7Q161812, 3, ENSP000003819924MINT-7945693 I2D: score=1 STRING: ENSP00000381992
    SUMO1P631652, 3, ENSP000003760764MINT-7947479 I2D: score=1 STRING: ENSP00000376076
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    TAF10Q129623, ENSP000002994244I2D: score=1 STRING: ENSP00000299424
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281mitotic cytokinesis IDA10931866
    GO:0000921septin ring assembly TAS10931866
    GO:0007067mitosis IEA--
    GO:0007096regulation of exit from mitosis TAS10931866

    ANLN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANLN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANLN gene (3 alternative transcripts): 
    NM_001284301.1  NM_001284302.1  NM_018685.3  

    Unigene Cluster for ANLN:

    Anillin, actin binding protein
    Hs.62180  [show with all ESTs]
    Unigene Representative Sequence: NM_018685
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265748(uc003tff.3 uc011kaz.2) ENST00000396068(uc003tfg.3 uc010kxe.3)
    ENST00000424865 ENST00000418118 ENST00000460598 ENST00000429082 ENST00000441696
    ENST00000452877 ENST00000495714 ENST00000428612 ENST00000446635 ENST00000457743
    ENST00000491782
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ANLN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANLN (see all 24):
    hsa-miR-217 hsa-miR-429 hsa-miR-15a hsa-miR-509-5p hsa-miR-503 hsa-miR-374a hsa-miR-424 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidANLN 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ANLN
    Predesigned siRNA for gene silencing in human, mouse, rat ANLN
    Clone
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    OriGene ORF clones in mouse, rat for ANLN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANLN (NM_018685)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANLN
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ANLN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANLN
      QuantiTect SYBR Green Assays in human, mouse, rat ANLN
      QuantiFast Probe-based Assays in human, mouse, rat ANLN

    Additional mRNA sequence: 

    AF273437.1 AK001468.1 AK001472.1 AK023208.1 AK094574.1 AK291254.1 AK299803.1 BC034692.1 
    BC070066.1 CR936650.1 

    14 DOTS entries:

    DT.40248861  DT.121063980  DT.95175438  DT.445053  DT.95136500  DT.100795481  DT.99966774  DT.100730948 
    DT.121063997  DT.121063998  DT.91767963  DT.100795480  DT.121064021  DT.92436232 

    Selected AceView cDNA sequences (see all 228):

    AA970372 CB143710 BE878572 CF264967 CB143955 BX955923 BM839210 AI818674 
    BP335998 BP335954 BM975256 AK094574 BU630457 CB112525 BQ006554 AI341261 
    BP355494 CB110596 AK001472 BP364072 AA307782 BU594877 AI660045 AK001468 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANLN (see all 20)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ·
    SP1:                                                                    -                                                                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                  -     -   
    SP5:                                                                                                                                                            

    ExUns: 12c · 12d ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
    SP1:                                                                                                      
    SP2:                                                                                                      
    SP3:                                            -                                                         
    SP4:  -     -                                                                                             
    SP5:                    -                                                                                 


    ECgene alternative splicing isoforms for ANLN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANLN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAACAGTG
    ANLN Expression
    About this image


    ANLN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
    ANLN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANLN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.62180

    UniProtKB/Swiss-Prot: ANLN_HUMAN, Q9NQW6
    Tissue specificity: Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta
    and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in
    heart, kidney, liver, lung, pancreas, prostate and spleen. Overexpressed in many tumor types including breast,
    colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors

        Custom PCR Arrays for ANLN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANLN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANLN gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anln1 , 5 anillin, actin binding protein1, 5 83.15(n)1
    80.77(a)1
      9 (8.93 cM)5
    687431  NM_028390.31  NP_082666.21 
     223312145 
    chicken
    (Gallus gallus)
    Aves ANLN1 anillin, actin binding protein 69.76(n)
    65.6(a)
      420738  XM_418836.4  XP_418836.3 
    lizard
    (Anolis carolinensis)
    Reptilia ANLN6
    anillin, actin binding protein
    60(a)
    1 ↔ 1
    6(46963049-47003873)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985692 contractile ring component anillin 76.55(n)    AY180201.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa12d062 wufa12d06 77.4(n)   335048  CK029209.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta scra3 cellularization actin binding 30(a)   43E3   --
    worm
    (Caenorhabditis elegans)
    Secernentea ani-36
    ani-26
    (see all 3)
    Protein ANI-2 (ani-2) mRNA, complete cds
    (see all 3)
    21(a)
    17(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    V(19697573-19705191) WBGene00012835
    II(6361162-6365304) WBGene00019608


    ENSEMBL Gene Tree for ANLN (if available)
    TreeFam Gene Tree for ANLN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANLN gene
    1 SIMAP similar gene for ANLN using alignment to 9 protein entries:     ANLN_HUMAN (see all proteins):
    FAM109A

    ANLN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANLN (see all 1374)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446786131,2
    C--36431811(+) GTCTGC/TAGGCT 1 -- int10--------
    rs1973571,2
    C,F,A,H--36431951(+) TTATAT/CTGAGT 1 -- int118Minor allele frequency- C:0.16MN NS EA NA CSA 2218
    rs1914138501,2
    --36432176(+) TCAAGA/GAATAT 1 -- int10--------
    rs1417499391,2
    --36432189(+) CTTGTA/GTTTAA 1 -- int10--------
    rs1456938201,2
    --36432242(+) ACTTAC/TATTTA 1 -- int10--------
    rs1973581,2
    C,F,H--36432338(+) AGGGAA/TCTTTT 1 -- int120Minor allele frequency- T:0.07NS EA NA WA CSA 1840
    rs1841868681,2
    --36432404(+) CAATAC/GAACAT 1 -- int10--------
    rs563263651,2
    C,F--36432417(+) ATATAC/TGTTTG 1 -- int11Minor allele frequency- T:0.11NA 120
    rs753054751,2
    C,F--36432455(+) GACCTA/TCTGCT 1 -- int11Minor allele frequency- T:0.04NA 120
    rs1885149761,2
    --36432518(+) AATGTA/GGGCAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for ANLN (36429415 - 36493400 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ANLN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734254CNV Deletion23290073
    esv2657144CNV Deletion23128226
    esv270354CNV Insertion20981092
    nsv511959CNV Loss21212237
    nsv521965CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANLN
    DNA2.0 Custom Variant and Variant Library Synthesis for ANLN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    9 diseases for ANLN:    
    About MalaCards
    lower lip cancer    lip cancer    choroiditis    renal cell carcinoma
    lung cancer    pancreatitis    hepatitis    endotheliitis
    prostatitis


    ANLN for disorders           About GeneDecksing

    Genetic Association Database (GAD): ANLN

    Export disorders for ANLN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANLN gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with ANLN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional analysis of a human homolog of the Drosophila actin binding protein anillin suggests a role in cytokinesis. (PubMed id 10931866)1, 2, 3, 9 Oegema K.... Field C.M. (J. Cell Biol. 2000)
    2. Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis. (PubMed id 16040610)1, 2, 9 Zhao W.-M. and Fang G. (J. Biol. Chem. 2005)
    3. The septin-binding protein anillin is overexpressed in diverse human tumors. (PubMed id 16203764)1, 2, 9 Hall P.A.... Russell S.E.H. (Clin. Cancer Res. 2005)
    4. Anillin binds nonmuscle myosin II and regulates the contractile ring. (PubMed id 15496454)1, 2, 9 Straight A.F.... Mitchison T.J. (Mol. Biol. Cell 2005)
    5. Self- and actin-templated assembly of mammalian septins. (PubMed id 12479805)1, 2, 9 Kinoshita M....Mitchison T.J. (Dev. Cell 2002)
    6. Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not. (PubMed id 15616196)1, 2, 9 Mollinari C.... Margolis R.L. (Mol. Biol. Cell 2005)
    7. MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. (PubMed id 16129829)1, 2, 9 Zhao W.-M. and Fang G. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    8. ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3- kinase/AKT pathway. (PubMed id 16357138)1, 2, 9 Suzuki C.... Nakamura Y. (Cancer Res. 2005)
    9. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    10. Clues to CD2-associated protein involvement in cytokinesis. (PubMed id 15800069)1, 2 Monzo P.... Cormont M. (Mol. Biol. Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54443 HGNC: 14082 AceView: ANLN Ensembl:ENSG00000011426 euGenes: HUgn54443
    ECgene: ANLN H-InvDB: ANLN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANLN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANLN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANLN gene:
    Search GeneIP for patents involving ANLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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