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Aliases for ANKZF1 Gene

Aliases for ANKZF1 Gene

  • Ankyrin Repeat And Zinc Finger Domain Containing 1 2 3 5
  • Zinc Finger Protein 744 3 4
  • ZNF744 3 4
  • Ankyrin Repeat And Zinc Finger Domain-Containing Protein 1 3

External Ids for ANKZF1 Gene

Previous GeneCards Identifiers for ANKZF1 Gene

  • GC02P219802
  • GC02P220094
  • GC02P211947

Summaries for ANKZF1 Gene

GeneCards Summary for ANKZF1 Gene

ANKZF1 (Ankyrin Repeat And Zinc Finger Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ANKZF1 Gene

  • Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway.

Gene Wiki entry for ANKZF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKZF1 Gene

Genomics for ANKZF1 Gene

Regulatory Elements for ANKZF1 Gene

Enhancers for ANKZF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G219520 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +292.3 292268 3.5 HDGF PKNOX1 ATF1 ARNT ETS1 TCF12 GTF3C2 ZNF766 GLIS2 ELK1 ASIC4 CNOT9 NHEJ1 USP37 SLC23A3 BCS1L ANKZF1 ENSG00000272644 LOC105373885 TMEM198
GH02G218309 1.7 FANTOM5 Ensembl ENCODE 11.2 -918.0 -918013 3.7 HNRNPUL1 HDGF FOXA2 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 ENSG00000261338 AAMP PNKD CNOT9 NHEJ1 USP37 SLC23A3 SLC11A1 BCS1L ANKZF1
GH02G219244 1.4 ENCODE dbSUPER 12.6 +20.4 20361 11.3 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 GLB1L ZFAND2B ATG9A ANKZF1 DNAJB2 TUBA4A MIR153-1 PTPRN ENSG00000230432 CNPPD1
GH02G218301 1.5 Ensembl ENCODE dbSUPER 11.2 -928.2 -928169 0.9 PKNOX1 FOXA2 ATF1 ARNT ZFP64 ARID4B DMAP1 ZNF2 ZNF48 YY1 AAMP PNKD CNOT9 NHEJ1 SLC11A1 CTDSP1 MIR26B USP37 SLC23A3 BCS1L
GH02G219368 1.2 Ensembl ENCODE 12.8 +139.5 139549 2.4 FOXA2 FEZF1 ZNF2 GATA2 ZNF416 KLF7 YY2 REST TSHZ1 ZNF488 RNF25 CNOT9 STK36 ANKZF1 ENSG00000269068 RESP18 ASIC4 TMEM198 PTPRN SPEG
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKZF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKZF1 Gene

Chromosome:
2
Start:
219,229,757 bp from pter
End:
219,236,669 bp from pter
Size:
6,913 bases
Orientation:
Plus strand

Genomic View for ANKZF1 Gene

Genes around ANKZF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKZF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKZF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKZF1 Gene

Proteins for ANKZF1 Gene

  • Protein details for ANKZF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8Y5-ANKZ1_HUMAN
    Recommended name:
    Ankyrin repeat and zinc finger domain-containing protein 1
    Protein Accession:
    Q9H8Y5
    Secondary Accessions:
    • Q9NVZ4

    Protein attributes for ANKZF1 Gene

    Size:
    726 amino acids
    Molecular mass:
    80927 Da
    Quaternary structure:
    • Interacts (via VIM motif) with VCP.
    SequenceCaution:
    • Sequence=ABD65410.1; Type=Frameshift; Positions=318; Evidence={ECO:0000305}; Sequence=BAA91596.1; Type=Frameshift; Positions=318; Evidence={ECO:0000305};

neXtProt entry for ANKZF1 Gene

Post-translational modifications for ANKZF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKZF1 Gene

Domains & Families for ANKZF1 Gene

Protein Domains for ANKZF1 Gene

Suggested Antigen Peptide Sequences for ANKZF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H8Y5

UniProtKB/Swiss-Prot:

ANKZ1_HUMAN :
  • Belongs to the ANKZF1/VMS1 family.
Family:
  • Belongs to the ANKZF1/VMS1 family.
genes like me logo Genes that share domains with ANKZF1: view

Function for ANKZF1 Gene

Molecular function for ANKZF1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway.

Gene Ontology (GO) - Molecular Function for ANKZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004843 contributes_to thiol-dependent ubiquitin-specific protease activity IBA --
GO:0005515 protein binding IPI 22190034
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ANKZF1: view
genes like me logo Genes that share phenotypes with ANKZF1: view

Animal Model Products

CRISPR Products

miRNA for ANKZF1 Gene

miRTarBase miRNAs that target ANKZF1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKZF1 Gene

Localization for ANKZF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKZF1 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 3

Gene Ontology (GO) - Cellular Components for ANKZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0036266 Cdc48p-Npl4p-Vms1p AAA ATPase complex IBA --
genes like me logo Genes that share ontologies with ANKZF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANKZF1 Gene

Pathways & Interactions for ANKZF1 Gene

SuperPathways for ANKZF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IBA --
GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process IBA --
GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with ANKZF1: view

No data available for Pathways by source and SIGNOR curated interactions for ANKZF1 Gene

Drugs & Compounds for ANKZF1 Gene

No Compound Related Data Available

Transcripts for ANKZF1 Gene

Unigene Clusters for ANKZF1 Gene

Ankyrin repeat and zinc finger domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKZF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - -
SP13: - - - - -
SP14: - - - -
SP15:
SP16:
SP17:
SP18:
SP19: - - - - - - - - - - - - - - - - -
SP20: -
SP21: - - - - -
SP22:
SP23:
SP24:
SP25: - -
SP26: - - - - - - - - - - - -
SP27:
SP28:
SP29:

ExUns: 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b ^ 14a · 14b · 14c ·
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15: -
SP16: - -
SP17: - - -
SP18: - -
SP19:
SP20:
SP21: -
SP22: - - - -
SP23: - - - -
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:

ExUns: 14d ^ 15a · 15b ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24: -
SP25:
SP26:
SP27:
SP28:
SP29:

Relevant External Links for ANKZF1 Gene

GeneLoc Exon Structure for
ANKZF1
ECgene alternative splicing isoforms for
ANKZF1

Expression for ANKZF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKZF1 Gene

Protein differential expression in normal tissues from HIPED for ANKZF1 Gene

This gene is overexpressed in Lung (52.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANKZF1 Gene



Protein tissue co-expression partners for ANKZF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKZF1 Gene:

ANKZF1

SOURCE GeneReport for Unigene cluster for ANKZF1 Gene:

Hs.437647

Evidence on tissue expression from TISSUES for ANKZF1 Gene

  • Nervous system(4.6)
  • Intestine(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with ANKZF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKZF1 Gene

Orthologs for ANKZF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANKZF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKZF1 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia ANKZF1 34 35
  • 86.18 (n)
cow
(Bos Taurus)
Mammalia ANKZF1 34 35
  • 84.68 (n)
mouse
(Mus musculus)
Mammalia Ankzf1 34 16 35
  • 83.47 (n)
rat
(Rattus norvegicus)
Mammalia Ankzf1 34
  • 83.47 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKZF1 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKZF1 34 35
  • 55.8 (n)
lizard
(Anolis carolinensis)
Reptilia ANKZF1 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankzf1 34
  • 53.71 (n)
zebrafish
(Danio rerio)
Actinopterygii ankzf1 34 35
  • 53.4 (n)
worm
(Caenorhabditis elegans)
Secernentea vms-1 34 35
  • 44.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VMS1 35 37
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10916 35
  • 33 (a)
OneToOne
Species where no ortholog for ANKZF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKZF1 Gene

ENSEMBL:
Gene Tree for ANKZF1 (if available)
TreeFam:
Gene Tree for ANKZF1 (if available)

Paralogs for ANKZF1 Gene

No data available for Paralogs for ANKZF1 Gene

Variants for ANKZF1 Gene

Sequence variations from dbSNP and Humsavar for ANKZF1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000150580 -- 219,236,722(+) ACCAA(C/G)GGATC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000301786 -- 219,233,350(+) CAGCC(C/T)AGGGG nc-transcript-variant, reference, stop-gained
rs1000683660 -- 219,233,642(+) CTGTG(A/G)GCCAT intron-variant
rs1000763126 -- 219,231,106(+) ACTAA(A/T)TGGAA intron-variant, upstream-variant-2KB
rs1002446579 -- 219,230,273(+) CTCCA(C/G)ATGCA intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ANKZF1 Gene

Variant ID Type Subtype PubMed ID
esv3594357 CNV loss 21293372
esv3893555 CNV loss 25118596
nsv508885 CNV insertion 20534489
nsv820013 CNV loss 19587683
nsv834543 CNV loss 17160897

Variation tolerance for ANKZF1 Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKZF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKZF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKZF1 Gene

Disorders for ANKZF1 Gene

Relevant External Links for ANKZF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKZF1

No disorders were found for ANKZF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKZF1 Gene

Publications for ANKZF1 Gene

  1. The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors. (PMID: 21896481) Stapf C. … Buchberger A. (J. Biol. Chem. 2011) 2 3 4 64
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ANKZF1 Gene

Sources for ANKZF1 Gene

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