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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKZF1 Gene

protein-coding   GIFtS: 49
GCID: GC02P220094

Ankyrin Repeat And Zinc Finger Domain Containing 1

  Search for ANKZF1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ankyrin Repeat And Zinc Finger Domain Containing 11 2
Zinc Finger Protein 7442 3
ZNF7442 3
Ankyrin Repeat And Zinc Finger Domain-Containing Protein 12

External Ids:    HGNC: 255271   Entrez Gene: 551392   Ensembl: ENSG000001635167   UniProtKB: Q9H8Y53   

Export aliases for ANKZF1 gene to outside databases

Previous GC identifers: GC02P219802 GC02P211947


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ANKZF1 Gene: 
ANKZF1 (ankyrin repeat and zinc finger domain containing 1) is a protein-coding gene. GO annotations related to this gene include protein binding and zinc ion binding.

UniProtKB/Swiss-Prot: ANKZ1_HUMAN, Q9H8Y5
Function: Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity)

Gene Wiki entry for ANKZF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKZF1 gene promoter:
         AP-1   ATF-2   MyoD   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKZF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANKZF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKZF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

ANKZF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKZF1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P220094:  view genomic region     (about GC identifiers)

Start:
220,094,479 bp from pter      End:
220,101,391 bp from pter
Size:
6,913 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANKZ1_HUMAN, Q9H8Y5 (See protein sequence)
Recommended Name: Ankyrin repeat and zinc finger domain-containing protein 1  
Size: 726 amino acids; 80927 Da
Sequence caution: Sequence=ABD65410.1; Type=Frameshift; Positions=318; Sequence=BAA91596.1; Type=Frameshift;
Positions=318;
Secondary accessions: Q9NVZ4

Explore the universe of human proteins at neXtProt for ANKZF1: NX_Q9H8Y5

Explore proteomics data for ANKZF1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H8Y5

  • ANKZF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANKZF1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001035869.1  NP_001269721.1  NP_060559.2  

    ENSEMBL proteins: 
     ENSP00000321617   ENSP00000394359   ENSP00000386815   ENSP00000404113   ENSP00000406514  
     ENSP00000386337   ENSP00000399667   ENSP00000394652  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR020683 Ankyrin_rpt-contain_dom
     IPR007087 Znf_C2H2
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q9H8Y5

    ProtoNet protein and cluster: Q9H8Y5

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: ANKZ1_HUMAN, Q9H8Y5
    Similarity: Belongs to the ANKZF1/VMS1 family
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 C2H2-type zinc finger


    ANKZF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANKZ1_HUMAN, Q9H8Y5
    Function: Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ANKZF1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ANKZF1:
     Increased cell number in G1, a  Increased gamma-H2AX phosphory 

    Animal Models:
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKZF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKZF1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/12 Interacting proteins for ANKZF1 (Q9H8Y51, 2, 3 ENSP000003216174) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNAJB11Q9UBS42, 3, ENSP000002650284MINT-8254144 I2D: score=2 STRING: ENSP00000265028
    AURKBQ96GD42, 3MINT-65645 I2D: score=4 
    NRSN2Q9GZP12, 3MINT-65647 I2D: score=4 
    CA2P009182, 3MINT-65644 I2D: score=3 
    VCPP550723, ENSP000003517774I2D: score=3 STRING: ENSP00000351777
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANKZF1 (ANKZ1)

    Search CenterWatch for drugs/clinical trials and news about ANKZF1 / ANKZ1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANKZF1 gene (3 alternative transcripts): 
    NM_001042410.1  NM_001282792.1  NM_018089.2  

    Unigene Cluster for ANKZF1:

    Ankyrin repeat and zinc finger domain containing 1
    Hs.437647  [show with all ESTs]
    Unigene Representative Sequence: NM_018089
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000323348(uc002vkg.3 uc002vkh.3) ENST00000464763 ENST00000453432
    ENST00000409849 ENST00000475202 ENST00000474225 ENST00000467884 ENST00000461731
    ENST00000477479 ENST00000496346 ENST00000435521 ENST00000463792 ENST00000486203
    ENST00000416565 ENST00000410034(uc002vki.3) ENST00000447157 ENST00000436226
    ENST00000491181
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    SwitchGear 3'UTR luciferase reporter plasmidANKZF1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKZF1
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    Additional mRNA sequence: 

    AK001277.1 AK023206.1 AK225275.1 AK225309.1 AK303077.1 AK303537.1 BC000238.1 BC008948.2 
    BC028334.1 DQ412564.1 

    24/32 DOTS entries (see all 32):

    DT.114586  DT.91673782  DT.100036772  DT.100811499  DT.121017572  DT.102825567  DT.95230033  DT.97767551 
    DT.100008603  DT.121017596  DT.100811488  DT.100811496  DT.101981430  DT.95230023  DT.121017676  DT.91719667 
    DT.91749958  DT.97846165  DT.121017439  DT.121017597  DT.100811491  DT.121017455  DT.100768668  DT.100811487 

    24/222 AceView cDNA sequences (see all 222):

    BQ437720 AA587358 AL539884 BM999674 BM844519 AA232368 BQ268301 BM840476 
    AU131200 BE252947 BX644266 AU125434 AI963574 CR601291 AA232369 CA429629 
    Z40281 BM542507 BU619023 BE504596 W86135 BC000238 BC028334 BQ720401 

    GeneLoc Exon Structure

    5/29 Alternative Splicing Database (ASD) splice patterns (SP) for ANKZF1 (see all 29)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ·
    SP1:                                -     -                 -     -     -                       -                       -     -     -     -     -               
    SP2:                                -     -                       -     -                       -                       -     -     -     -     -               
    SP3:                                                                                            -                       -     -     -     -     -               
    SP4:                                -     -                 -     -     -     -     -     -     -                       -     -     -     -     -               
    SP5:                                      -                       -     -                       -                       -     -     -     -     -               

    ExUns: 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b ^ 14a · 14b · 14c ·
    SP1:                                      -                                                                                                                     
    SP2:                                                                                                                                                            
    SP3:                                      -                                                                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 14d ^ 15a · 15b ^ 16a · 16b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for ANKZF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKZF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGAATC
    ANKZF1 Expression
    About this image


    See ANKZF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANKZF1

    SOURCE GeneReport for Unigene cluster: Hs.437647
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANKZF1 gene from 8/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankzf11 , 5 ankyrin repeat and zinc finger domain containing 11, 5 83.63(n)1
    79.06(a)1
      1 (38.62 cM)5
    522311  NM_026187.51  NP_080463.31 
     751921515 
    chicken
    (Gallus gallus)
    Aves ANKZF11 ankyrin repeat and zinc finger domain containing 1 55.38(n)
    49.71(a)
      429038  XM_001232759.2  XP_001232760.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANKZF16
    ankyrin repeat and zinc finger domain containing 1...
    44(a)
    1 ↔ 1
    1(95771503-95789436)
    zebrafish
    (Danio rerio)
    Actinopterygii ankzf11 ankyrin repeat and zinc finger domain containing 1 52.33(n)
    45.77(a)
      553307  XM_691721.5  XP_696813.2 
    worm
    (Caenorhabditis elegans)
    Secernentea vms-11 Protein VMS-1 42.14(n)
    30.85(a)
      176141  NM_066364.4  NP_498765.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VMS1(YDR049W)4 Component of a Cdc48p-complex involved in protein quality more   --   4(553254-555152) 851618  NP_010334.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G019301 zinc finger protein-like protein 47.89(n)
    40.24(a)
      839310  NM_100073.2  NP_563641.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g05746001 hypothetical protein 45.68(n)
    40.26(a)
      4336732  NM_001060154.1  NP_001053619.1 


    ENSEMBL Gene Tree for ANKZF1 (if available)
    TreeFam Gene Tree for ANKZF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/190 SNPs in ANKZF1 are shown (see all 190)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs770866771,2
    C,F--220096615(+) GGGCTC/GCCTTT 2 -- int11Minor allele frequency- G:0.11WA 118
    rs130076501,2
    C,F,H--220096678(+) GAAAGA/CAAGCT 4 R S mis1 trp39Minor allele frequency- C:0.01NS EA NA EU 2403
    rs1886880321,2
    C--220096681(+) AGAAAA/GCTACT 4 K syn10--------
    rs2004705471,2
    C--220096757(+) ACCAAA/GAACAG 4 K E mis10--------
    rs38174241,2
    C,F,H--220096903(+) AGAATA/TCTATA 2 -- int19Minor allele frequency- T:0.14EA NS WA NA 2256
    rs1386874481,2
    C--220096934(+) GGCCAC/GGCTGG 2 -- int10--------
    rs1912535431,2
    C--220097100(+) GTAGGA/GGGACC 2 -- int10--------
    rs1995083201,2
    --220097212(+) TTCAGC/GAGATC 4 A G mis10--------
    rs617476821,2
    C,F--220097257(+) AGCCAG/CTGAGG 4 /T /S mis16Minor allele frequency- C:0.02NS WA NA EA EU 1721
    rs1997331841,2
    C--220097283(+) TGGATC/TGGGAG 4 R W mis11Minor allele frequency- T:0.00EU 1323

    HapMap Linkage Disequilibrium report for ANKZF1 (220094479 - 220101391 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ANKZF1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508885CNV Insertion20534489
    nsv834543CNV Loss17160897
    nsv820013CNV Loss19587683
    nsv875869CNV Loss21882294
    nsv875870CNV Gain+Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKZF1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with ANKZF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors. (PubMed id 21896481)1 Stapf C....Buchberger A. (2011)
    7. The structural and functional basis of the p97/valosi n-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97. (PubMed id 21914798)1 HAonzelmann P. and Schindelin H. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55139 HGNC: 25527 AceView: FLJ10415 Ensembl:ENSG00000163516 euGenes: HUgn55139
    ECgene: ANKZF1 H-InvDB: ANKZF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKZF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANKZF1 gene:
    Search GeneIP for patents involving ANKZF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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