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Aliases for ANKZF1 Gene

Aliases for ANKZF1 Gene

  • Ankyrin Repeat And Zinc Finger Domain Containing 1 2 3 5
  • Zinc Finger Protein 744 3 4
  • ZNF744 3 4
  • Ankyrin Repeat And Zinc Finger Domain-Containing Protein 1 3

External Ids for ANKZF1 Gene

Previous GeneCards Identifiers for ANKZF1 Gene

  • GC02P219802
  • GC02P220094
  • GC02P211947

Summaries for ANKZF1 Gene

GeneCards Summary for ANKZF1 Gene

ANKZF1 (Ankyrin Repeat And Zinc Finger Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ANKZF1 Gene

  • Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway.

Gene Wiki entry for ANKZF1 Gene

Additional gene information for ANKZF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKZF1 Gene

Genomics for ANKZF1 Gene

Regulatory Elements for ANKZF1 Gene

Enhancers for ANKZF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H218393 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.2 -828.8 -828751 14 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 CNOT9 AAMP USP37 STK36 ANKZF1 TNS1 BCS1L ENSG00000273466 NHEJ1 TMBIM1
GH02H218730 2 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -497.1 -497068 4 FOXA2 MLX ARNT ARID4B SIN3A YY1 SLC30A9 FOS SP5 MXD4 SLC11A1 BCS1L CYP27A1 PLCD4 NHEJ1 ANKZF1 SLC23A3 AAMP GMPPA RNF25
GH02H218710 1.4 ENCODE dbSUPER 14.6 -518.5 -518546 2 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B AAMP CNOT9 STK36 DES ANKZF1 LINC00608 ENSG00000234638 RNF25 STK11IP TNS1
GH02H219520 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +292.3 292268 3 HDGF PKNOX1 ATF1 ARNT ETS1 TCF12 GTF3C2 ZNF766 GLIS2 GATA2 ASIC4 CNOT9 NHEJ1 USP37 SLC23A3 BCS1L ANKZF1 TMEM198 ENSG00000269068 ENSG00000272644
GH02H219244 1.4 ENCODE dbSUPER 12.6 +20.4 20361 11 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GLB1L ZFAND2B DES LINC00608 LINC01803 ENSG00000234638 ANKZF1 ATG9A DNAJB2 TUBA4A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKZF1 on UCSC Golden Path with GeneCards custom track

Promoters for ANKZF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000130517 -57 2201 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for ANKZF1 Gene

Chromosome:
2
Start:
219,229,757 bp from pter
End:
219,236,669 bp from pter
Size:
6,913 bases
Orientation:
Plus strand

Genomic View for ANKZF1 Gene

Genes around ANKZF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKZF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKZF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKZF1 Gene

Proteins for ANKZF1 Gene

  • Protein details for ANKZF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8Y5-ANKZ1_HUMAN
    Recommended name:
    Ankyrin repeat and zinc finger domain-containing protein 1
    Protein Accession:
    Q9H8Y5
    Secondary Accessions:
    • Q9NVZ4

    Protein attributes for ANKZF1 Gene

    Size:
    726 amino acids
    Molecular mass:
    80927 Da
    Quaternary structure:
    • Interacts (via VIM motif) with VCP.
    SequenceCaution:
    • Sequence=ABD65410.1; Type=Frameshift; Positions=318; Evidence={ECO:0000305}; Sequence=BAA91596.1; Type=Frameshift; Positions=318; Evidence={ECO:0000305};

neXtProt entry for ANKZF1 Gene

Post-translational modifications for ANKZF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKZF1 Gene

Domains & Families for ANKZF1 Gene

Gene Families for ANKZF1 Gene

Protein Domains for ANKZF1 Gene

Suggested Antigen Peptide Sequences for ANKZF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H8Y5

UniProtKB/Swiss-Prot:

ANKZ1_HUMAN :
  • Belongs to the ANKZF1/VMS1 family.
Family:
  • Belongs to the ANKZF1/VMS1 family.
genes like me logo Genes that share domains with ANKZF1: view

Function for ANKZF1 Gene

Molecular function for ANKZF1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway.

Phenotypes From GWAS Catalog for ANKZF1 Gene

Gene Ontology (GO) - Molecular Function for ANKZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004843 contributes_to thiol-dependent ubiquitin-specific protease activity IBA --
GO:0005515 protein binding IPI 22190034
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ANKZF1: view
genes like me logo Genes that share phenotypes with ANKZF1: view

Animal Model Products

CRISPR Products

miRNA for ANKZF1 Gene

miRTarBase miRNAs that target ANKZF1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ANKZF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKZF1 Gene

Localization for ANKZF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKZF1 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANKZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0036266 Cdc48p-Npl4p-Vms1p AAA ATPase complex IBA --
genes like me logo Genes that share ontologies with ANKZF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANKZF1 Gene

Pathways & Interactions for ANKZF1 Gene

SuperPathways for ANKZF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IBA --
GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process IBA --
GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with ANKZF1: view

No data available for Pathways by source and SIGNOR curated interactions for ANKZF1 Gene

Drugs & Compounds for ANKZF1 Gene

No Compound Related Data Available

Transcripts for ANKZF1 Gene

Unigene Clusters for ANKZF1 Gene

Ankyrin repeat and zinc finger domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ANKZF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ANKZF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - -
SP13: - - - - -
SP14: - - - -
SP15:
SP16:
SP17:
SP18:
SP19: - - - - - - - - - - - - - - - - -
SP20: -
SP21: - - - - -
SP22:
SP23:
SP24:
SP25: - -
SP26: - - - - - - - - - - - -
SP27:
SP28:
SP29:

ExUns: 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b ^ 14a · 14b · 14c ·
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15: -
SP16: - -
SP17: - - -
SP18: - -
SP19:
SP20:
SP21: -
SP22: - - - -
SP23: - - - -
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:

ExUns: 14d ^ 15a · 15b ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24: -
SP25:
SP26:
SP27:
SP28:
SP29:

Relevant External Links for ANKZF1 Gene

GeneLoc Exon Structure for
ANKZF1
ECgene alternative splicing isoforms for
ANKZF1

Expression for ANKZF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKZF1 Gene

Protein differential expression in normal tissues from HIPED for ANKZF1 Gene

This gene is overexpressed in Lung (52.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANKZF1 Gene



Protein tissue co-expression partners for ANKZF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKZF1 Gene:

ANKZF1

SOURCE GeneReport for Unigene cluster for ANKZF1 Gene:

Hs.437647

Evidence on tissue expression from TISSUES for ANKZF1 Gene

  • Nervous system(4.6)
  • Intestine(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with ANKZF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKZF1 Gene

Orthologs for ANKZF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANKZF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKZF1 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia ANKZF1 33 34
  • 86.18 (n)
cow
(Bos Taurus)
Mammalia ANKZF1 33 34
  • 84.68 (n)
mouse
(Mus musculus)
Mammalia Ankzf1 33 16 34
  • 83.47 (n)
rat
(Rattus norvegicus)
Mammalia Ankzf1 33
  • 83.47 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKZF1 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKZF1 33 34
  • 55.8 (n)
lizard
(Anolis carolinensis)
Reptilia ANKZF1 34
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankzf1 33
  • 53.71 (n)
zebrafish
(Danio rerio)
Actinopterygii ankzf1 33 34
  • 53.4 (n)
worm
(Caenorhabditis elegans)
Secernentea vms-1 34 33
  • 44.93 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VMS1 36 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10916 34
  • 33 (a)
OneToOne
Species where no ortholog for ANKZF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKZF1 Gene

ENSEMBL:
Gene Tree for ANKZF1 (if available)
TreeFam:
Gene Tree for ANKZF1 (if available)

Paralogs for ANKZF1 Gene

No data available for Paralogs for ANKZF1 Gene

Variants for ANKZF1 Gene

Sequence variations from dbSNP and Humsavar for ANKZF1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000150580 -- 219,236,722(+) ACCAA(C/G)GGATC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000301786 -- 219,233,350(+) CAGCC(C/T)AGGGG nc-transcript-variant, reference, stop-gained
rs1000683660 -- 219,233,642(+) CTGTG(A/G)GCCAT intron-variant
rs1000763126 -- 219,231,106(+) ACTAA(A/T)TGGAA intron-variant, upstream-variant-2KB
rs1002446579 -- 219,230,273(+) CTCCA(C/G)ATGCA intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ANKZF1 Gene

Variant ID Type Subtype PubMed ID
esv3594357 CNV loss 21293372
esv3893555 CNV loss 25118596
nsv508885 CNV insertion 20534489
nsv820013 CNV loss 19587683
nsv834543 CNV loss 17160897

Variation tolerance for ANKZF1 Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKZF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKZF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKZF1 Gene

Disorders for ANKZF1 Gene

Relevant External Links for ANKZF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKZF1

No disorders were found for ANKZF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKZF1 Gene

Publications for ANKZF1 Gene

  1. The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors. (PMID: 21896481) Stapf C … Buchberger A (The Journal of biological chemistry 2011) 2 3 4 60
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 60
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for ANKZF1 Gene

Sources for ANKZF1 Gene

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