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Aliases for ANKZF1 Gene

Aliases for ANKZF1 Gene

  • Ankyrin Repeat And Zinc Finger Domain Containing 1 2 3
  • Zinc Finger Protein 744 3 4
  • ZNF744 3 4

External Ids for ANKZF1 Gene

Previous GeneCards Identifiers for ANKZF1 Gene

  • GC02P219802
  • GC02P220094
  • GC02P211947

Summaries for ANKZF1 Gene

GeneCards Summary for ANKZF1 Gene

ANKZF1 (Ankyrin Repeat And Zinc Finger Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ANKZF1 Gene

  • Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway.

Gene Wiki entry for ANKZF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKZF1 Gene

Genomics for ANKZF1 Gene

Regulatory Elements for ANKZF1 Gene

Genomic Location for ANKZF1 Gene

Chromosome:
2
Start:
219,229,757 bp from pter
End:
219,236,669 bp from pter
Size:
6,913 bases
Orientation:
Plus strand

Genomic View for ANKZF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKZF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKZF1 Gene

Proteins for ANKZF1 Gene

  • Protein details for ANKZF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8Y5-ANKZ1_HUMAN
    Recommended name:
    Ankyrin repeat and zinc finger domain-containing protein 1
    Protein Accession:
    Q9H8Y5
    Secondary Accessions:
    • Q9NVZ4

    Protein attributes for ANKZF1 Gene

    Size:
    726 amino acids
    Molecular mass:
    80927 Da
    Quaternary structure:
    • Interacts (via VIM motif) with VCP.
    SequenceCaution:
    • Sequence=ABD65410.1; Type=Frameshift; Positions=318; Evidence={ECO:0000305}; Sequence=BAA91596.1; Type=Frameshift; Positions=318; Evidence={ECO:0000305};

neXtProt entry for ANKZF1 Gene

Proteomics data for ANKZF1 Gene at MOPED

Post-translational modifications for ANKZF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ANKZF1 Gene

Domains & Families for ANKZF1 Gene

Protein Domains for ANKZF1 Gene

Suggested Antigen Peptide Sequences for ANKZF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H8Y5

UniProtKB/Swiss-Prot:

ANKZ1_HUMAN :
  • Belongs to the ANKZF1/VMS1 family.
  • Contains 2 ANK repeats.
Family:
  • Belongs to the ANKZF1/VMS1 family.
Similarity:
  • Contains 2 ANK repeats.
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with ANKZF1: view

Function for ANKZF1 Gene

Molecular function for ANKZF1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway.

Gene Ontology (GO) - Molecular Function for ANKZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 contributes_to ubiquitin-specific protease activity IBA --
GO:0005515 protein binding IPI 22190034
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ANKZF1: view
genes like me logo Genes that share phenotypes with ANKZF1: view

Animal Model Products

miRNA for ANKZF1 Gene

miRTarBase miRNAs that target ANKZF1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKZF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKZF1 Gene

Localization for ANKZF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKZF1 Gene COMPARTMENTS Subcellular localization image for ANKZF1 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ANKZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0036266 Cdc48p-Npl4p-Vms1p AAA ATPase complex IBA --
genes like me logo Genes that share ontologies with ANKZF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANKZF1 Gene

Pathways & Interactions for ANKZF1 Gene

SuperPathways for ANKZF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IBA --
GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process IBA --
GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with ANKZF1: view

No data available for Pathways by source and SIGNOR curated interactions for ANKZF1 Gene

Drugs & Compounds for ANKZF1 Gene

No Compound Related Data Available

Transcripts for ANKZF1 Gene

Unigene Clusters for ANKZF1 Gene

Ankyrin repeat and zinc finger domain containing 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKZF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKZF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - -
SP13: - - - - -
SP14: - - - -
SP15:
SP16:
SP17:
SP18:
SP19: - - - - - - - - - - - - - - - - -
SP20: -
SP21: - - - - -
SP22:
SP23:
SP24:
SP25: - -
SP26: - - - - - - - - - - - -
SP27:
SP28:
SP29:

ExUns: 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b ^ 14a · 14b · 14c ·
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15: -
SP16: - -
SP17: - - -
SP18: - -
SP19:
SP20:
SP21: -
SP22: - - - -
SP23: - - - -
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:

ExUns: 14d ^ 15a · 15b ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24: -
SP25:
SP26:
SP27:
SP28:
SP29:

Relevant External Links for ANKZF1 Gene

GeneLoc Exon Structure for
ANKZF1
ECgene alternative splicing isoforms for
ANKZF1

Expression for ANKZF1 Gene

mRNA expression in normal human tissues for ANKZF1 Gene

Protein differential expression in normal tissues from HIPED for ANKZF1 Gene

This gene is overexpressed in Lung (52.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKZF1 Gene



SOURCE GeneReport for Unigene cluster for ANKZF1 Gene Hs.437647

genes like me logo Genes that share expression patterns with ANKZF1: view

Protein tissue co-expression partners for ANKZF1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKZF1 Gene

Orthologs for ANKZF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANKZF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANKZF1 35
  • 84.68 (n)
  • 80.36 (a)
ANKZF1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKZF1 35
  • 86.18 (n)
  • 83.36 (a)
ANKZF1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankzf1 35
  • 83.47 (n)
  • 78.73 (a)
Ankzf1 16
Ankzf1 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANKZF1 35
  • 99.54 (n)
  • 99.31 (a)
ANKZF1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankzf1 35
  • 83.47 (n)
  • 79.3 (a)
oppossum
(Monodelphis domestica)
Mammalia ANKZF1 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKZF1 35
  • 55.8 (n)
  • 50.15 (a)
ANKZF1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKZF1 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankzf1 35
  • 53.71 (n)
  • 47.68 (a)
zebrafish
(Danio rerio)
Actinopterygii ankzf1 35
  • 53.4 (n)
  • 47.24 (a)
ankzf1 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea vms-1 35
  • 44.93 (n)
  • 34.57 (a)
vms-1 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VMS1 36
  • 24 (a)
OneToOne
VMS1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10916 36
  • 33 (a)
OneToOne
Species with no ortholog for ANKZF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKZF1 Gene

ENSEMBL:
Gene Tree for ANKZF1 (if available)
TreeFam:
Gene Tree for ANKZF1 (if available)

Paralogs for ANKZF1 Gene

No data available for Paralogs for ANKZF1 Gene

Variants for ANKZF1 Gene

Sequence variations from dbSNP and Humsavar for ANKZF1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2293074 -- 219,233,664(+) GGAGA(C/T)TTATA intron-variant
rs2293075 -- 219,235,479(+) GGACT(C/G)TCGGG reference, missense, nc-transcript-variant, intron-variant
rs2293076 - 219,235,487(+) GGGCC(C/T)GGCCA reference, missense, nc-transcript-variant, intron-variant
rs2293077 -- 219,235,507(+) GTTGC(A/G)GCTGA synonymous-codon, reference, nc-transcript-variant, intron-variant
rs2293078 -- 219,235,961(+) GGGTG(C/G)CCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKZF1 Gene

Variant ID Type Subtype PubMed ID
nsv875869 CNV Loss 21882294
nsv875870 CNV Gain+Loss 21882294
nsv834543 CNV Loss 17160897
nsv508885 CNV Insertion 20534489
nsv820013 CNV Loss 19587683

Variation tolerance for ANKZF1 Gene

Residual Variation Intolerance Score: 86.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKZF1 Gene

HapMap Linkage Disequilibrium report
ANKZF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKZF1 Gene

Disorders for ANKZF1 Gene

Relevant External Links for ANKZF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKZF1
genes like me logo Genes that share disorders with ANKZF1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKZF1 Gene

Publications for ANKZF1 Gene

  1. The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors. (PMID: 21896481) Stapf C. … Buchberger A. (J. Biol. Chem. 2011) 2 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 67
  4. The structural and functional basis of the p97/valosin-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97. (PMID: 21914798) HAonzelmann P. … Schindelin H. (J. Biol. Chem. 2011) 67
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67

Products for ANKZF1 Gene

Sources for ANKZF1 Gene

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