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ANKS6 Gene

protein-coding   GIFtS: 51
GCID: GC09M101493

Ankyrin Repeat And Sterile Alpha Motif Domain Containing...

(Previous names: sterile alpha motif domain containing 6, ankyrin repeat...)
(Previous symbols: SAMD6, ANKRD14)
  See ANKS6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat And Sterile Alpha Motif Domain Containing 61 2     Sterile Alpha Motif Domain-Containing Protein 62 3
ANKRD141 2 3     SAM Domain-Containing Protein 62 3
SAMD61 2 3     NPHP162 5
PKDR12 3 5     Ankyrin Repeat And SAM Domain-Containing Protein 62
Ankyrin Repeat Domain 141 2     samCystin2
Sterile Alpha Motif Domain Containing 61 2     SamCystin3
Ankyrin Repeat Domain-Containing Protein 142 3     

External Ids:    HGNC: 267241   Entrez Gene: 2032862   Ensembl: ENSG000001651387   OMIM: 6153705   UniProtKB: Q68DC23   

Export aliases for ANKS6 gene to outside databases

Previous GC identifers: GC09M100533 GC09M071093


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKS6 Gene:
ANKS6 (ankyrin repeat and sterile alpha motif domain containing 6) is a protein-coding gene. Diseases associated with ANKS6 include nephronophthisis 16, and infantile autosomal recessive medullary cystic kidney disease. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is TANC2.

UniProtKB/Swiss-Prot: ANKS6_HUMAN, Q68DC2
Function: Required for renal function




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANKS6 gene promoter:
         ATF-2   MyoD   Lmo2   AP-2gamma   CRE-BP1   AP-2beta   ZIC2/Zic2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKS6 promoter sequence
   Search Chromatin IP Primers for ANKS6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.33   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q31.1

ANKS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKS6 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M101493:  view genomic region     (about GC identifiers)

Start:
101,493,611 bp from pter      End:
101,559,247 bp from pter
Size:
65,637 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANKS6_HUMAN, Q68DC2 (See protein sequence)
Recommended Name: Ankyrin repeat and SAM domain-containing protein 6  
Size: 871 amino acids; 92219 Da
Subunit: Self-associates. Interacts (via SAM domain) with BICC1 (via KH domains) in an RNA-dependent manner (By
similarity). Central component of a complex containing at least ANKS6, INVS, NEK8 and NPHP3. ANKS6 may organize
complex assembly by linking INVS and NPHP3 to NEK8 and INVS may target the complex to the proximal ciliary
axoneme
Sequence caution: Sequence=AAH64367.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC04317.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAH18298.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAH69985.2; Type=Erroneous gene model
prediction; Sequence=CAH69986.2; Type=Erroneous gene model prediction; Sequence=CAH71295.2; Type=Erroneous gene
model prediction; Sequence=CAH71296.2; Type=Erroneous gene model prediction;
Secondary accessions: A0SE62 Q5VSL0 Q5VSL2 Q5VSL3 Q5VSL4 Q68DB8 Q6P2R2 Q8N9L6 Q96D62
Alternative splicing: 3 isoforms:  Q68DC2-1   Q68DC2-3   Q68DC2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKS6: NX_Q68DC2

Explore proteomics data for ANKS6 at MOPED

Post-translational modifications: 

  • Hydroxylated at Asn-138, most probably by HIF1AN. This hydroxylation results in decreased NEK8-binding1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANKS6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775822.3  
    ENSEMBL proteins: 
     ENSP00000398648   ENSP00000364159   ENSP00000297837   ENSP00000364158   ENSP00000442189  

    ANKS6 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANKS6

     
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    antibodies-online proteins for ANKS6 

     
    antibodies-online peptides for ANKS6

    ANKS6 Antibody Products:

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    antibodies-online antibodies for ANKS6 (19 products) 

    ANKS6 Assay Products:

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    Cloud-Clone Corp. CLIAs for ANKS6
    Search eBioscience for ELISAs for ANKS6 
    antibodies-online kits for ANKS6 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing
    SAMD: Sterile alpha motif (SAM) domain containing

    5 InterPro protein domains:
     IPR021129 SAM_type1
     IPR002110 Ankyrin_rpt
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q68DC2

    ProtoNet protein and cluster: Q68DC2

    2 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: ANKS6_HUMAN, Q68DC2
    Domain: The ankyrin repeats and the SAM domain are essential for self-association (By similarity). Ankyrin repeats
    are necessary and sufficient for NEK8-binding
    Similarity: Contains 11 ANK repeats
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with ANKS6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANKS6_HUMAN, Q68DC2
    Function: Required for renal function

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IEA--
         
    Find genes that share ontologies with ANKS6           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ANKS6

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANKS6:
    hsa-mir-124-3p (MIRT022581)

    Block miRNA regulation of human, mouse, rat ANKS6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANKS6 (see all 15):
    hsa-miR-3164 hsa-miR-3173-3p hsa-miR-3194-5p hsa-miR-330-5p hsa-miR-4299 hsa-miR-1285 hsa-miR-3922-3p hsa-miR-612
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKS6

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANKS6_HUMAN, Q68DC2: Cell projection, cilium (By similarity). Cytoplasm (By similarity). Note=Localizes to the
    proximal region of the primary cilium in the presence of INVS (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005929cilium IEA--

    Find genes that share ontologies with ANKS6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKS6
    Interactions:

        Search GeneGlobe Interaction Network for ANKS6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for ANKS6 (Q68DC22, 3 ENSP000002978374) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8201818 I2D: score=1 STRING: ENSP00000250416
    CPEB1ENSP000004141874STRING: ENSP00000414187
    CPEB2ENSP000002599974STRING: ENSP00000259997
    CPEB3ENSP000002659974STRING: ENSP00000265997
    CPEB4ENSP000002650854STRING: ENSP00000265085
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKS6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANKS6 gene: 
    NM_173551.3  

    Unigene Cluster for ANKS6:

    Ankyrin repeat and sterile alpha motif domain containing 6
    Hs.406890  [show with all ESTs]
    Unigene Representative Sequence: NM_173551
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444472(uc004ayv.2) ENST00000375019(uc004ayx.2) ENST00000353234
    ENST00000486778 ENST00000466120 ENST00000471846 ENST00000375018(uc004ayt.3 uc004ayy.2 uc004ayu.3)
    ENST00000540940
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ANKS6 (see all 15):
    hsa-miR-3164 hsa-miR-3173-3p hsa-miR-3194-5p hsa-miR-330-5p hsa-miR-4299 hsa-miR-1285 hsa-miR-3922-3p hsa-miR-612
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      QuantiTect SYBR Green Assays in human, mouse, rat ANKS6
      QuantiFast Probe-based Assays in human, mouse, rat ANKS6

    Additional mRNA sequence: 

    AK074328.1 AK094247.1 AK126614.1 AK127702.1 BC012981.2 BC064367.1 CR749467.1 CR749472.1 

    14 DOTS entries:

    DT.91754089  DT.211334  DT.87046743  DT.100715723  DT.91857333  DT.92422396  DT.436633  DT.92422397 
    DT.99956132  DT.91662882  DT.95222014  DT.95321026  DT.100688531  DT.121143276 

    Selected AceView cDNA sequences (see all 132):

    AA707110 AK127702 BM712195 BU684750 BF939405 BU618570 AA627945 BU689528 
    BC064367 AI142639 AK074328 AI052071 AI435508 AI368621 BM797790 BM743278 
    BM695107 CR625196 BQ000746 BE792853 N75541 BE314115 AK126614 BM712067 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ANKS6    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
    SP1:                                -                                               -     -     -               
    SP2:                                -                             -                                             
    SP3:                                -                             -                       -     -               
    SP4:                                                                                                            
    SP5:                                                                                            -               


    ECgene alternative splicing isoforms for ANKS6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKS6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ANKS6 Expression
    About this image

    ANKS6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKS6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406890
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANKS6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anks61 , 5 ankyrin repeat and sterile alpha motif domain containing more1, 5 84.43(n)1
    86.96(a)1
      4 (25.88 cM)5
    756911  NM_001024136.11  NP_001019307.11 
     470156695 
    chicken
    (Gallus gallus)
    Aves ANKS61 ankyrin repeat and sterile alpha motif domain containing more 69.12(n)
    70.36(a)
      420977  XM_004935173.1  XP_004935230.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANKS66
    ankyrin repeat and sterile alpha motif domain cont...
    65(a)
    1 ↔ 1
    4(66844756-66877622)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.134222 Xenopus laevis transcribed sequence with weak similarity more 76.05(n)    BJ069222.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-145p14.56
    si:dkey-145p14.5
    20(a)
    many ↔ many
    9(33893653-33908876) ENSDARG00000007077
    fruit fly
    (Drosophila melanogaster)
    Insecta CG425346
    --
    11(a)
    1 → many
    3R(23166344-23198296)
    worm
    (Caenorhabditis elegans)
    Secernentea nphp-26
    Protein NPHP-2 (nphp-2) mRNA, complete cds
    15(a)
    1 → many
    V(1895797-1906560) WBGene00021304


    ENSEMBL Gene Tree for ANKS6 (if available)
    TreeFam Gene Tree for ANKS6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKS6 gene
    TANC22  ANKRD172  ANKS32  ANKRD292  FEM1A2  ANKHD12  FANK12  KIDINS2202  
    ANKHD1-EIF4EBP32  FEM1B2  TANC12  FEM1C2  
    5 SIMAP similar genes for ANKS6 using alignment to 4 protein entries:     ANKS6_HUMAN (see all proteins):
    IkBa    DKFZp761E1322    MTPN    ANKDD1A    ANKRD6

    Find genes that share paralogs with ANKS6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKS6 (see all 1408)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0701064
    Nephronophthisis 16 (NPHP16)4--see VAR_0701062 A P mis40--------
    rs746203081,2
    C,F--101493823(+) TAGAGG/ATGGAG 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1166837381,2
    C--101493824(+) AGAGGG/TGGAGA 1 -- ds50010--------
    rs1439453021,2
    C--101493908(+) TGGGA-/GGGTCC 1 -- ds50010--------
    rs455435351,2
    F--101493958(+) CCCCAA/GGTTGG 1 -- ds50011Minor allele frequency- G:0.03EA 120
    rs132993201,2
    C--101493968(+) GCGGGG/TGTCCT 1 -- ds5001 ese30--------
    rs132994751,2
    H--101494015(+) TCTCAG/CCCTTA 1 -- ds50014Minor allele frequency- C:0.00NS EA 412
    rs1446798621,2
    C--101494069(+) CTGGGC/TTTTGT 1 -- ds50010--------
    rs3375911,2
    C,F,A,H--101494079(-) GAGCTT/CGAGCA 1 -- ds5001 ese324Minor allele frequency- C:0.24NS EA NA WA CSA 2352
    rs1485010011,2
    --101494190(+) TTAAGG/TCAGGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ANKS6 (101493611 - 101559247 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ANKS6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv989098CNV Loss20482838
    dgv8264n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): ANKS6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANKS6
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKS6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615370   
    OMIM disorders: 615382  
    UniProtKB/Swiss-Prot: ANKS6_HUMAN, Q68DC2
  • Nephronophthisis 16 (NPHP16) [MIM:615382]: A form of nephronophthisis, a chronic tubulo-interstitial
    nephritis that progresses to end-stage renal failure. Some patients have cystic kidneys of normal size and no
    extrarenal manifestations, whereas others have enlarged renal size and severe extrarenal defects, including
    hypertrophic obstructive cardiomyopathy, aortic stenosis, pulmonary stenosis, patent ductus arteriosus, situs
    inversus, and periportal liver fibrosis. Note=The disease is caused by mutations affecting the gene represented
    in this entry

  • 3 diseases for ANKS6:    
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    nephronophthisis 16    infantile autosomal recessive medullary cystic kidney disease    juvenile autosomal recessive medullary cystic kidney disease

    1 disease from the University of Copenhagen DISEASES database for ANKS6:
    Tooth agenesis

    Find genes that share disorders with ANKS6           About GenesLikeMe

    Genetic Association Database (GAD): ANKS6
    Human Genome Epidemiology (HuGE) Navigator: ANKS6 (1 document)

    Export disorders for ANKS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKS6 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ANKS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3. (PubMed id 23793029)1, 2, 3 Hoff S....Lienkamp S.S. (Nat. Genet. 2013)
    2. Genomic organization and mutation screening of the human ortholog of Pkdr1 associated with polycystic kidney disease in the rat. (PubMed id 18434273)1, 2 Kaisaki P.J....Bihoreau M.T. (Eur J Med Genet 2008)
    3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 203286 HGNC: 26724 AceView: SAMD6 Ensembl:ENSG00000165138 euGenes: HUgn203286
    ECgene: ANKS6 H-InvDB: ANKS6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKS6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKS6 gene:
    Search GeneIP for patents involving ANKS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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