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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKS6 Gene

protein-coding   GIFtS: 46
GCID: GC09M101493

ankyrin repeat and sterile alpha motif domain containing...

(Previous names: sterile alpha motif domain containing 6, ankyrin repeat...)
(Previous symbols: SAMD6, ANKRD14)
 Explore 7 diseases affiliated with
ANKS6 via our new
 Human Malady Compendium 
Biological research products
for ANKS6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ankyrin Repeat And Sterile Alpha Motif Domain Containing 61 2     SAM Domain-Containing Protein 62 3
ANKRD141 2 3     FLJ369281
SAMD61 2 3     OTTHUMG000000203461
Ankyrin Repeat Domain 141 2     Ankyrin Repeat And SAM Domain-Containing Protein 62
Sterile Alpha Motif Domain Containing 61 2     SamCystin3
Ankyrin Repeat Domain-Containing Protein 142 3     SamCystin3
Sterile Alpha Motif Domain-Containing Protein 62 3     

External Ids:    HGNC: 267241   Entrez Gene: 2032862   Ensembl: ENSG000001651387   UniProtKB: Q68DC23   

Export aliases for ANKS6 gene to outside databases

Previous GC identifers: GC09M100533 GC09M071093


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ANKS6_HUMAN, Q68DC2
Function: Required for renal function (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKS6 gene promoter:
         ATF-2   MyoD   Lmo2   AP-2gamma   CRE-BP1   AP-2beta   ZIC2/Zic2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKS6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANKS6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.33   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q31.1

ANKS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKS6 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M101493:  view genomic region     (about GC identifiers)

Start:
101,493,611 bp from pter      End:
101,559,247 bp from pter
Size:
65,637 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANKS6_HUMAN, Q68DC2 (See protein sequence)
Recommended Name: Ankyrin repeat and SAM domain-containing protein 6  
Size: 871 amino acids; 92219 Da
Sequence caution: Sequence=AAH64367.1; Type=Erroneous initiation; Sequence=BAC04317.1; Type=Erroneous initiation;
Sequence=CAH18298.1; Type=Erroneous initiation; Sequence=CAH69985.2; Type=Erroneous gene model prediction;
Sequence=CAH69986.2; Type=Erroneous gene model prediction; Sequence=CAH71295.2; Type=Erroneous gene model prediction;
Sequence=CAH71296.2; Type=Erroneous gene model prediction;
Secondary accessions: A0SE62 Q5VSL0 Q5VSL2 Q5VSL3 Q5VSL4 Q68DB8 Q6P2R2 Q8N9L6 Q96D62
Alternative splicing: 3 isoforms:  Q68DC2-1   Q68DC2-3   Q68DC2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKS6: NX_Q68DC2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q68DC2

  • ANKS6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_775822.3  
    ENSEMBL proteins: 
     ENSP00000398648   ENSP00000364159   ENSP00000297837   ENSP00000364158   ENSP00000442189  

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    Uscn Proteins for ANKS6

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--


    ANKS6 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ANKS6 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR021129 SAM_type1
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q68DC2

    ProtoNet protein and cluster: Q68DC2

    2 Blocks protein families:
    IPB001660 Sterile alpha motif SAM
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: ANKS6_HUMAN, Q68DC2
    Similarity: Contains 11 ANK repeats
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ANKS6_HUMAN, Q68DC2
    Function: Required for renal function (By similarity)

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKS6

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IEA--


    ANKS6 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKS6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ANKS6 (Q68DC22, 3 ENSP000002978374) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8201818 I2D: score=1 STRING: ENSP00000250416
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANKS6
    Search CenterWatch for drugs/clinical trials and news about ANKS6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANKS6 gene: 
    NM_173551.3  

    Unigene Cluster for ANKS6:

    Ankyrin repeat and sterile alpha motif domain containing 6
    Hs.406890  [show with all ESTs]
    Unigene Representative Sequence: NM_173551
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444472(uc004ayv.2) ENST00000375019(uc004ayx.2) ENST00000353234
    ENST00000493393 ENST00000486778 ENST00000466120 ENST00000471846 ENST00000375018(uc004ayt.3 uc004ayy.2 uc004ayu.3)
    ENST00000540940

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    hsa-miR-3164 hsa-miR-3173-3p hsa-miR-3194-5p hsa-miR-330-5p hsa-miR-4299 hsa-miR-1285 hsa-miR-3922-3p hsa-miR-612
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    Additional cDNA sequence: 

    AK074328.1 AK094247.1 AK126614.1 AK127702.1 BC012981.2 BC064367.1 CR749467.1 CR749472.1 

    16 DOTS entries:

    DT.91754089  DT.211334  DT.100715723  DT.92422396  DT.87046743  DT.91857333  DT.436633  DT.92422397 
    DT.99956132  DT.91662882  DT.95193590  DT.95222014  DT.95294974  DT.95321026  DT.100688531  DT.121143276 

    24/132 AceView cDNA sequences (see all 132):

    AA233205 AI744582 BX507639 BU618775 BM470948 AK126614 BM712067 BE314115 
    BE792853 N75541 CR625196 BQ000746 BM695107 BM743278 BM797790 AK074328 
    AI435508 AI368621 AI052071 AI142639 BU689528 AA627945 BC064367 BU618570 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ANKS6    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
    SP1:                                -                                               -     -     -               
    SP2:                                -                             -                                             
    SP3:                                -                             -                       -     -               
    SP4:                                                                                                            
    SP5:                                                                                            -               


    ECgene alternative splicing isoforms for ANKS6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKS6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ANKS6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANKS6

    SOURCE GeneReport for Unigene cluster: Hs.406890
        SABiosciences Custom PCR Arrays for ANKS6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKS6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ANKS6 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anks61 , 5 ankyrin repeat and sterile alpha motif domain containing more1, 5 78.72(n)1
    81.1(a)1
      4 (25.88 cM)5
    756911  NM_001024136.11  NP_001019307.11 
     470156695 
    chicken
    (Gallus gallus)
    Aves ANKS61 ankyrin repeat and sterile alpha motif domain containing more 70.21(n)
    71.88(a)
      420977  XM_419064.3  XP_419064.3 
    lizard
    (Anolis carolinensis)
    Reptilia ANKS66
    --
    64(a)
    1 ↔ 1
    4(66849704-66877580)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.134222 Xenopus laevis transcribed sequence with weak similarity more 76.05(n)    BJ069222.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C01H6.26
    Protein C01H6.2
    22(a)
    1 ↔ 1
    I(7204543-7207715)


    ENSEMBL Gene Tree for ANKS6 (if available)
    TreeFam Gene Tree for ANKS6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANKS6 gene
    BICC12  
    5 SIMAP similar genes for ANKS6 using alignment to 4 protein entries:     ANKS6_HUMAN (see all proteins):
    IkBa    DKFZp761E1322    MTPN    ANKDD1A    ANKRD6

    ANKS6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1086 NCBI SNPs in ANKS6 are shown (see all 1086    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs746203081,2
    C,F,--101493823(+) TAGAGG/ATGGAG 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1166837381,2
    C,--101493824(+) AGAGGG/TGGAGA 1 -- ds50010--------
    rs1439453021,2
    C,--101493905(+) TGGGA-/GGGTCC 1 -- ds50010--------
    rs455435351,2
    F,--101493958(+) CCCCAA/GGTTGG 1 -- ds50011Minor allele frequency- G:0.03EA 120
    rs132993201,2
    C--101493968(+) GCGGGG/TGTCCT 1 -- ds5001 ese30--------
    rs132994751,2
    H--101494015(+) TCTCAG/CCCTTA 1 -- ds50014Minor allele frequency- C:0.00NS EA 412
    rs1446798621,2
    --101494069(+) CTGGGC/TTTTGT 1 -- ds50010--------
    rs3375911,2
    C,F,A,H,--101494079(-) GAGCTT/CGAGCA 1 -- ds5001 ese324Minor allele frequency- C:0.24NS EA NA WA CSA 2352
    rs1485010011,2
    --101494190(+) TTAAGG/TCAGGG 1 -- ds50010--------
    rs1814492401,2
    --101494196(+) CAGGGC/TCTAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ANKS6 (101493611 - 101559247 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ANKS6: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKS6
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ANKS6 for disorders           About GeneDecksing

    7 diseases for ANKS6:    About MalaCards
    cleft lip/palate    cleft lip    tooth agenesis    nephronopthisis
    polycystic kidney disease    kidney disease    cystic kidney

    1 disease from the University of Copenhagen DISEASES database for ANKS6:
    Tooth agenesis
    Human Genome Epidemiology (HuGE) Navigator: ANKS6 (1 document)

    Export disorders for ANKS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKS6 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ANKS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    6. Genomic organization and mutation screening of the human ortholog of Pkdr1 associated with polycystic kidney disease in the rat. (PubMed id 18434273)1 Kaisaki P.J....Bihoreau M.T. (2008)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    8. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1 Vieira A.R....Marazita M.L. (2008)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 203286 HGNC: 26724 AceView: SAMD6 Ensembl:ENSG00000165138 euGenes: HUgn203286
    ECgene: ANKS6 H-InvDB: ANKS6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKS6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANKS6 gene:
    Search GeneIP for patents involving ANKS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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