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ANKS4B Gene

protein-coding   GIFtS: 46
GCID: GC16P021244

Ankyrin Repeat And Sterile Alpha Motif Domain Containing...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat And Sterile Alpha Motif Domain Containing 4B1 2     Harmonin-Interacting Ankyrin-Repeat Containing Protein2
HARP2 3 5     Harp3
Harmonin-Interacting Ankyrin Repeat-Containing Protein2 3     FLJ388195
Ankyrin Repeat And SAM Domain-Containing Protein 4B2     

External Ids:    HGNC: 267951   Entrez Gene: 2576292   Ensembl: ENSG000001753117   OMIM: 6099015   UniProtKB: Q8N8V43   

Export aliases for ANKS4B gene to outside databases

Previous GC identifers: GC16P021153 GC16P019780


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKS4B Gene:
ANKS4B (ankyrin repeat and sterile alpha motif domain containing 4B) is a protein-coding gene. Diseases associated with ANKS4B include usher syndrome type i, and usher syndrome. An important paralog of this gene is USH1G.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANKS4B gene promoter:
         CREB   RFX1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKS4B promoter sequence
   Search Chromatin IP Primers for ANKS4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKS4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12.2

ANKS4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKS4B gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P021244:  view genomic region     (about GC identifiers)

Start:
21,244,986 bp from pter      End:
21,263,750 bp from pter
Size:
18,765 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANS4B_HUMAN, Q8N8V4 (See protein sequence)
Recommended Name: Ankyrin repeat and SAM domain-containing protein 4B  
Size: 417 amino acids; 46597 Da
Subunit: Interacts through its C-terminus with USH1C PDZ 1 domain (By similarity)
Sequence caution: Sequence=BAC04707.1; Type=Erroneous termination; Positions=418; Note=Translated as stop;

Explore the universe of human proteins at neXtProt for ANKS4B: NX_Q8N8V4

Explore proteomics data for ANKS4B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANKS4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_665872.2  
    ENSEMBL proteins: 
     ENSP00000308772  

    ANKS4B Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for ANKS4B

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    Cloud-Clone Corp. ELISAs for ANKS4B
    Cloud-Clone Corp. CLIAs for ANKS4B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing
    SAMD: Sterile alpha motif (SAM) domain containing

    5 InterPro protein domains:
     IPR021129 SAM_type1
     IPR002110 Ankyrin_rpt
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q8N8V4

    ProtoNet protein and cluster: Q8N8V4

    2 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: ANS4B_HUMAN, Q8N8V4
    Similarity: Contains 3 ANK repeats
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    ANKS4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ANKS4B for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Anks4b (no phenotypes)

    ANKS4B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANKS4B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANKS4B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANKS4B

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANKS4B:
    hsa-mir-335-5p (MIRT019069)

    Block miRNA regulation of human, mouse, rat ANKS4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANKS4B (see all 10):
    hsa-miR-30c hsa-miR-4272 hsa-miR-30d hsa-miR-455-3p hsa-miR-30a hsa-miR-629* hsa-miR-30b hsa-miR-1256
    SwitchGear 3'UTR luciferase reporter plasmidANKS4B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ANKS4B
    Predesigned siRNA for gene silencing in human, mouse, rat ANKS4B

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ANKS4B

    Clone
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    OriGene clones in human, mouse for ANKS4B (see all 5)
    OriGene ORF clones in mouse, rat for ANKS4B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANKS4B (NM_145865)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANKS4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKS4B

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKS4B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane2
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--

    ANKS4B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKS4B
    Interactions:

        Search GeneGlobe Interaction Network for ANKS4B

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for ANKS4B (Q8N8V43 ENSP000003087724) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN1O151693I2D: score=1 
    AXIN2Q9Y2T13I2D: score=1 
    NKD2Q969F23I2D: score=1 
    TRAF1Q130773I2D: score=1 
    USH1CENSP000000052264STRING: ENSP00000005226
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKS4B (ANS4B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANKS4B gene: 
    NM_145865.2  

    Unigene Cluster for ANKS4B:

    Ankyrin repeat and sterile alpha motif domain containing 4B
    Hs.115959  [show with all ESTs]
    Unigene Representative Sequence: NM_145865
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000311620(uc010bwp.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat ANKS4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANKS4B (see all 10):
    hsa-miR-30c hsa-miR-4272 hsa-miR-30d hsa-miR-455-3p hsa-miR-30a hsa-miR-629* hsa-miR-30b hsa-miR-1256
    SwitchGear 3'UTR luciferase reporter plasmidANKS4B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ANKS4B
    Predesigned siRNA for gene silencing in human, mouse, rat ANKS4B
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANKS4B (NM_145865)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANKS4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKS4B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ANKS4B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANKS4B
      QuantiTect SYBR Green Assays in human, mouse, rat ANKS4B
      QuantiFast Probe-based Assays in human, mouse, rat ANKS4B

    Additional mRNA sequence: 

    BC111784.1 BC112368.1 

    1 DOTS entry:

    DT.75133009 

    11 AceView cDNA sequences:

    AI791939 BX279747 NM_145865 AW291272 BF807638 AA568220 AK096138 AI913751 
    AI732645 BE871236 BF509562 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKS4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTACAAGTA
    ANKS4B Expression
    About this image

    ANKS4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKS4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.115959

    UniProtKB/Swiss-Prot: ANS4B_HUMAN, Q8N8V4
    Tissue specificity: Expressed in kidney and small intestine

        Custom PCR Arrays for ANKS4B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKS4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANKS4B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anks4b1 , 5 ankyrin repeat and sterile alpha motif domain containing more1, 5 83.33(n)1
    83.17(a)1
      7 (64.45 cM)5
    720741  NM_028085.21  NP_082361.21 
     1201738585 
    chicken
    (Gallus gallus)
    Aves ANKS4B1 ankyrin repeat and sterile alpha motif domain containing more 62.71(n)
    58.59(a)
      427007  XM_424609.4  XP_424609.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    51(a)
    49(a)
    many → 1
    many → 1
    AAWZ02036656(546-6601)
    GL344422.1(38168-43435)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia anks4b1 ankyrin repeat and sterile alpha motif domain containing more 58.75(n)
    53.75(a)
      100158613  NM_001128029.1  NP_001121501.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anks4b1 ankyrin repeat and sterile alpha motif domain containing more 57.43(n)
    51.89(a)
      431735  NM_001002188.1  NP_001002188.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sans6
    Sans ortholog
    27(a)
    1 → many
    2R(8824400-8827917)


    ENSEMBL Gene Tree for ANKS4B (if available)
    TreeFam Gene Tree for ANKS4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKS4B gene
    USH1G2  
    1 SIMAP similar gene for ANKS4B using alignment to 1 protein entry:     ANS4B_HUMAN:
    USH1G

    ANKS4B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKS4B (see all 362)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2004400891,2
    C--21243082(+) TTTTG-/TTTTTT 1 -- us2k10--------
    rs798139511,2
    C,F--21243131(+) GTGTTA/GTTTAA 1 -- us2k12Minor allele frequency- G:0.21NA EA 240
    rs1826097671,2
    --21243235(+) CTTAAA/GCTATA 1 -- us2k10--------
    rs769436921,2
    C--21243295(+) ACCATA/CAGTTG 1 -- us2k10--------
    rs783908941,2
    C--21243298(+) ATAAGA/TTGATA 1 -- us2k10--------
    rs10127271,2
    C,F,A,H--21243437(+) AGTATT/GTGCTT 1 -- us2k1 tfbs324Minor allele frequency- G:0.23NS EA NA WA 2436
    rs1876081671,2
    --21243473(+) TCAATC/TTTTCT 1 -- us2k10--------
    rs72021101,2
    C,F,H--21243649(+) AGTTAT/CTGATA 1 -- us2k130Minor allele frequency- C:0.12NS EA NA WA 3010
    rs1479151461,2
    --21243769(+) GTGGTA/GTTTTC 1 -- us2k10--------
    rs1400708321,2
    --21243859(+) GACAAC/TCACTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANKS4B (21244986 - 21263750 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ANKS4B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436835CNV Insertion17901297
    nsv905576CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANKS4B
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKS4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609901    OMIM disorders: --

    3 diseases for ANKS4B:    
    About MalaCards
    usher syndrome type i    usher syndrome    maturity-onset diabetes of the young

    1 disease from the University of Copenhagen DISEASES database for ANKS4B:
    maturity-onset diabetes of the young

    ANKS4B for disorders           About GeneDecksing


    Export disorders for ANKS4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKS4B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ANKS4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin. (PubMed id 12588794)1, 2 Weil D.... Petit C. (Hum. Mol. Genet. 2003)
    3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    4. Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues. (PubMed id 15461667)1 Johnston A.M....GA^A+ez L.J. (amp 2004)
    5. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 257629 HGNC: 26795 AceView: FLJ38819 Ensembl:ENSG00000175311 euGenes: HUgn257629
    ECgene: ANKS4B H-InvDB: ANKS4B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKS4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKS4B gene:
    Search GeneIP for patents involving ANKS4B

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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