ANKS3 Gene
protein-coding GIFtS: 47
GCID: GC16M004747
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|
ankyrin repeat and sterile alpha motif domain containing...
| |
Aliases
for ANKS3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Ankyrin Repeat And Sterile Alpha Motif Domain Containing 31 2 | | KIAA19771 3 | | FLJ323451 | | FLJ327671 | | Ankyrin Repeat And SAM Domain-Containing Protein 32 |
| External Ids: | HGNC: 294221 | Entrez Gene: 1244012 | Ensembl: ENSG000001680967 | UniProtKB: Q6ZW763 | | ORGUL members: | |
|---|
| NONCODE:n411666 | |
Export aliases for ANKS3 gene to outside databasesPrevious GC identifer: GC16M004687
|---|
Summaries
for ANKS3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ANKS3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKS3 gene promoter:
SREBP-1c HTF STAT5A SREBP-1b HEN1 MEF-2A POU2F1 SREBP-1a POU2F1a ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKS3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKS3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3ANKS3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M004747: view genomic region
(about GC identifiers)
Start:
|
4,746,513 bp from pter |
End:
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4,784,379 bp from pter |
Size:
|
37,867 bases |
Orientation:
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minus strand |
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Proteins
for ANKS3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANKS3_HUMAN, Q6ZW76 (See
protein sequence)Recommended Name: Ankyrin repeat and SAM domain-containing protein 3 Size: 656 amino acids; 72038 Da
Secondary accessions: B4DWU4 D3DUE2 Q8TF25Alternative splicing: 2 isoforms: Q6ZW76-1 Q6ZW76-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ANKS3: NX_Q6ZW76
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZW76
ANKS3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001229858.1 NP_597707.1
ENSEMBL proteins: ENSP00000304586 ENSP00000467591 ENSP00000465203 ENSP00000465294 ENSP00000467439 ENSP00000466162 ENSP00000468234 ENSP00000466228 ENSP00000465306 ENSP00000465373 ENSP00000467783 ENSP00000465454 ENSP00000466362 ENSP00000468464 ENSP00000467474 ENSP00000465361 ENSP00000468380 ENSP00000465566 ENSP00000406796 ENSP00000388270
Human Recombinant Protein Products:
ANKS3 Antibody Products:
Assay Products for ANKS3: |
Protein
Domains /
Families
for ANKS3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKS3 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZW76ProtoNet protein and cluster: Q6ZW76 2 Blocks protein families: IPB001660 Sterile alpha motif SAM IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ANKS3_HUMAN, Q6ZW76Similarity: Contains 6 ANK repeatsSimilarity: Contains 1 SAM (sterile alpha motif) domain |
Function
for ANKS3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKS3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKS3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ANKS3 (NM_133450) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKS3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKS3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKS3 |
1 GenomeRNAi human phenotype for ANKS3:
|
Pathways & Interactions
for ANKS3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKS3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for ANKS3 (Q6ZW762, 3 ENSP000003045864) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ANKS3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKS3
Search CenterWatch for drugs/clinical trials and news about ANKS3
|
Transcripts
for ANKS3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKS3 gene (2 alternative transcripts): NM_001242929.1 NM_133450.3 Unigene Cluster for ANKS3: Ankyrin repeat and sterile alpha motif domain containing 3 Hs.654859 [show with all ESTs]Unigene Representative Sequence: AB07585718/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29): ENST00000591185 ENST00000589035 ENST00000590803 ENST00000591653 ENST00000304283(uc002cxi.2 uc002cxj.2 uc021tcj.1 uc021tck.1 uc002cxk.3 uc010uxs.2)
ENST00000590193 ENST00000592077 ENST00000585773 ENST00000588513 ENST00000588398
ENST00000592840 ENST00000590730 ENST00000586605 ENST00000592421 ENST00000592068
ENST00000586166 ENST00000592698 ENST00000586159
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKS3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKS3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANKS3 (NM_133450) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKS3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKS3 |
Additional cDNA sequence: AB075857.1 AK056907.1 AK123371.1 AK123496.1 AK301683.1 BC032314.1 BC050387.1 NR_040252.1 14 DOTS entries: DT.97841053 DT.425369 DT.97841054 DT.100803894 DT.95160682 DT.97825352 DT.411625 DT.100705167 DT.120660424 DT.100704491 DT.120660443 DT.411624 DT.75147314 DT.91849868 24/109 AceView cDNA sequences (see all 109): CR624377 AB075857 AI560632 AI686618 AI982591 AI342763 BF373197 NM_133450 AI084348 AI623930 AK057329 BM687279 AK123371 BQ708528 AW079720 AK123496 CA432332 BF001153 BX371980 BU072139 AI372992 BG177947 AA477155 BE550443
GeneLoc Exon Structure
5/18 Alternative Splicing Database (ASD) splice patterns (SP) for ANKS3 (see all 18) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 |
|---|
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| SP1: | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ANKS3
|
Expression
for ANKS3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ANKS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKS3
SOURCE GeneReport for Unigene cluster: Hs.654859
SABiosciences Custom PCR Arrays for ANKS3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKS3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANKS3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKS3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKS3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKS3 |
Orthologs
for ANKS3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ANKS3 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for ANKS3 (if available)
TreeFam Gene Tree for ANKS3 (if available) |
Paralogs
for ANKS3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKS3 gene
- FANK12
7 SIMAP similar genes for ANKS3 using alignment to 18 protein entries: ANKS3_HUMAN (see all proteins):CDKN2C DKFZp761E1322 MTPN ANKRD6 OSBPL1A TANC2
ANKRD46
ANKS3 for paralogs About GeneDecksing
|
Genomic Variants
for ANKS3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKS3 (4746513 - 4784379 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ANKS3
3 CNVs: 7110 23004 61491 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKS3 |
|
Disorders
/ Diseases
for ANKS3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ANKS3 for disorders About GeneDecksing
1  disease for ANKS3: About MalaCardsataxia
Export disorders for ANKS3 gene to outside databases
|
Publications
for ANKS3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKS3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANKS3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1 Beausoleil S.A.... Gygi S.P. (2006)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ANKS3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANKS3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKS3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ANKS3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKS3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANKS3 gene:
Search GeneIP for patents involving ANKS3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKS3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ANKS3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKS3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKS3 | | | OriGene Protein Over-expression Lysate for ANKS3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ANKS3 | | OriGene 3'-UTR Clone for ANKS3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKS3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKS3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ANKS3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANKS3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKS3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKS3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKS3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKS3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKS3 |
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 |  |  |  | |
| | | | Search Tocris compounds for ANKS3 |
| |  |  |  |  | | | | |
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 | | | ANKS3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKS3 |
|  |  |  | | | | Search ThermoFisher Antibodies for ANKS3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKS3 |
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