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Aliases for ANKS3 Gene

Aliases for ANKS3 Gene

  • Ankyrin Repeat And Sterile Alpha Motif Domain Containing 3 2 3 5
  • KIAA1977 4

External Ids for ANKS3 Gene

Previous GeneCards Identifiers for ANKS3 Gene

  • GC16M004687
  • GC16M004747
  • GC16M004748
  • GC16M004749

Summaries for ANKS3 Gene

GeneCards Summary for ANKS3 Gene

ANKS3 (Ankyrin Repeat And Sterile Alpha Motif Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is RNASEL.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKS3 Gene

Genomics for ANKS3 Gene

Regulatory Elements for ANKS3 Gene

Promoters for ANKS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANKS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKS3 Gene

Chromosome:
16
Start:
4,696,510 bp from pter
End:
4,734,378 bp from pter
Size:
37,869 bases
Orientation:
Minus strand

Genomic View for ANKS3 Gene

Genes around ANKS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKS3 Gene

Proteins for ANKS3 Gene

  • Protein details for ANKS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZW76-ANKS3_HUMAN
    Recommended name:
    Ankyrin repeat and SAM domain-containing protein 3
    Protein Accession:
    Q6ZW76
    Secondary Accessions:
    • B4DWU4
    • D3DUE2
    • Q8TF25

    Protein attributes for ANKS3 Gene

    Size:
    656 amino acids
    Molecular mass:
    72038 Da
    Quaternary structure:
    • Interacts with ANKS6, BICC1, NPHP1 AND NEK8 (By similarity). Interacts with HIF1AN (By similarity).

    Three dimensional structures from OCA and Proteopedia for ANKS3 Gene

    Alternative splice isoforms for ANKS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKS3 Gene

Proteomics data for ANKS3 Gene at MOPED

Post-translational modifications for ANKS3 Gene

No data available for DME Specific Peptides for ANKS3 Gene

Domains & Families for ANKS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZW76

UniProtKB/Swiss-Prot:

ANKS3_HUMAN :
  • Contains 1 SAM (sterile alpha motif) domain.
  • Contains 6 ANK repeats.
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with ANKS3: view

Function for ANKS3 Gene

Phenotypes for ANKS3 Gene

GenomeRNAi human phenotypes for ANKS3:
genes like me logo Genes that share phenotypes with ANKS3: view

Animal Model Products

miRNA for ANKS3 Gene

miRTarBase miRNAs that target ANKS3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKS3 Gene

Localization for ANKS3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKS3 Gene COMPARTMENTS Subcellular localization image for ANKS3 gene
Compartment Confidence
cytosol 4
nucleus 4

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKS3 Gene

Pathways & Interactions for ANKS3 Gene

SuperPathways for ANKS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKS3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKS3 Gene

Drugs & Compounds for ANKS3 Gene

No Compound Related Data Available

Transcripts for ANKS3 Gene

Unigene Clusters for ANKS3 Gene

Ankyrin repeat and sterile alpha motif domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKS3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^
SP1: - - -
SP2:
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - -
SP10: - - - - -
SP11: - - - - - - - -
SP12: - - - - -
SP13:
SP14: - - - - - - - - - -
SP15: - - - - - - -
SP16: -
SP17: - - -
SP18:

ExUns: 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for ANKS3 Gene

GeneLoc Exon Structure for
ANKS3
ECgene alternative splicing isoforms for
ANKS3

Expression for ANKS3 Gene

mRNA expression in normal human tissues for ANKS3 Gene

Protein differential expression in normal tissues from HIPED for ANKS3 Gene

This gene is overexpressed in Lung (33.0), Plasma (14.4), Monocytes (12.2), and Tlymphocyte (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKS3 Gene



SOURCE GeneReport for Unigene cluster for ANKS3 Gene Hs.654859

genes like me logo Genes that share expression patterns with ANKS3: view

Protein tissue co-expression partners for ANKS3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKS3 Gene

Orthologs for ANKS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKS3 36
  • 98 (a)
OneToOne
ANKS3 35
  • 97.35 (n)
  • 96.32 (a)
cow
(Bos Taurus)
Mammalia ANKS3 35
  • 86.7 (n)
  • 86.13 (a)
ANKS3 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKS3 36
  • 84 (a)
OneToOne
ANKS3 35
  • 86.02 (n)
  • 85.1 (a)
mouse
(Mus musculus)
Mammalia Anks3 16
Anks3 36
  • 82 (a)
OneToOne
Anks3 35
  • 82.87 (n)
  • 82.92 (a)
oppossum
(Monodelphis domestica)
Mammalia ANKS3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Anks3 35
  • 83.81 (n)
  • 84.76 (a)
chicken
(Gallus gallus)
Aves ANKS3 35
  • 72.13 (n)
  • 70.08 (a)
ANKS3 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKS3 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anks3 35
  • 64.18 (n)
  • 62.66 (a)
zebrafish
(Danio rerio)
Actinopterygii ANKS3 36
  • 53 (a)
OneToOne
zgc:172142 35
  • 62.05 (n)
  • 58.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta m-cup 36
  • 12 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y39C12A.1 35
  • 44.52 (n)
  • 35.38 (a)
Y39C12A.1 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for ANKS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKS3 Gene

ENSEMBL:
Gene Tree for ANKS3 (if available)
TreeFam:
Gene Tree for ANKS3 (if available)

Paralogs for ANKS3 Gene

Paralogs for ANKS3 Gene

genes like me logo Genes that share paralogs with ANKS3: view

Variants for ANKS3 Gene

Sequence variations from dbSNP and Humsavar for ANKS3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs863980 - 4,701,044(-) CCCGC(A/G)CTGCA nc-transcript-variant, reference, missense
rs9936675 - 4,698,010(+) GGCTG(C/G/T)ACCAG nc-transcript-variant, reference, missense
rs703812 -- 4,714,348(+) TGCAC(C/T)GCAGC intron-variant
rs703814 -- 4,730,868(+) caaaa(A/C)aaaaa intron-variant
rs841212 -- 4,699,914(-) TGTTT(C/G)TCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKS3 Gene

Variant ID Type Subtype PubMed ID
dgv2587n71 CNV Loss 21882294
dgv2588n71 CNV Loss 21882294
dgv2589n71 CNV Loss 21882294
nsv905243 CNV Loss 21882294
dgv2590n71 CNV Loss 21882294
nsv905248 CNV Loss 21882294
nsv905249 CNV Loss 21882294
esv2668934 CNV Deletion 23128226
nsv905250 CNV Loss 21882294
nsv512421 CNV Loss 21212237
esv8161 CNV Loss 19470904
esv2664089 CNV Deletion 23128226
esv33706 CNV Gain 17666407
nsv435669 CNV Deletion 17901297

Variation tolerance for ANKS3 Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKS3 Gene

HapMap Linkage Disequilibrium report
ANKS3
Human Gene Mutation Database (HGMD)
ANKS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKS3 Gene

Disorders for ANKS3 Gene

Relevant External Links for ANKS3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKS3

No disorders were found for ANKS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKS3 Gene

Publications for ANKS3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3. (PMID: 24998259) Leettola C.N. … Bowie J.U. (BMC Struct. Biol. 2014) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3

Products for ANKS3 Gene

Sources for ANKS3 Gene

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