Aliases for ANKS1B Gene
- Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1B 2 3
- AIDA-1 3 4
- EB-1 3 4
- EB1 3 6
- Amyloid-Beta Precursor Protein Intracellular Domain Associated Protein 1 3
- Ankyrin Repeat And Sterile Alpha Motif Domain-Containing Protein 1B 3
- Amyloid-Beta Protein Intracellular Domain-Associated Protein 1 4
External Ids for ANKS1B Gene
This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for ANKS1B Gene
ANKS1B (Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1B) is a Protein Coding gene. GO annotations related to this gene include ephrin receptor binding. An important paralog of this gene is ANKS1A.
UniProtKB/Swiss-Prot for ANKS1B Gene
Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells
Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.
Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing