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Aliases for ANKS1A Gene

Aliases for ANKS1A Gene

  • Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1A 2 3 5
  • Ankyrin Repeat And SAM Domain Containing 1 2 3
  • ANKS1 3 4
  • Odin 3 4
  • Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1 2
  • KIAA0229 4

External Ids for ANKS1A Gene

Previous HGNC Symbols for ANKS1A Gene

  • ANKS1

Previous GeneCards Identifiers for ANKS1A Gene

  • GC06P034966
  • GC06P034857
  • GC06P034579
  • GC06P034953
  • GC06P035516

Summaries for ANKS1A Gene

GeneCards Summary for ANKS1A Gene

ANKS1A (Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1A) is a Protein Coding gene. Diseases associated with ANKS1A include adjustment disorder. An important paralog of this gene is CASKIN2.

UniProtKB/Swiss-Prot for ANKS1A Gene

  • Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity).

Gene Wiki entry for ANKS1A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKS1A Gene

Genomics for ANKS1A Gene

Regulatory Elements for ANKS1A Gene

Enhancers for ANKS1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANKS1A on UCSC Golden Path with GeneCards custom track

Promoters for ANKS1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANKS1A on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKS1A Gene

Chromosome:
6
Start:
34,889,261 bp from pter
End:
35,098,010 bp from pter
Size:
208,750 bases
Orientation:
Plus strand

Genomic View for ANKS1A Gene

Genes around ANKS1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKS1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKS1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKS1A Gene

Proteins for ANKS1A Gene

  • Protein details for ANKS1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92625-ANS1A_HUMAN
    Recommended name:
    Ankyrin repeat and SAM domain-containing protein 1A
    Protein Accession:
    Q92625
    Secondary Accessions:
    • A2RUC1
    • B4DQW8
    • Q5JYI9
    • Q5SYR2
    • Q86WQ7

    Protein attributes for ANKS1A Gene

    Size:
    1134 amino acids
    Molecular mass:
    123108 Da
    Quaternary structure:
    • Interacts with EPHA8; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination (By similarity). Interacts (via SAM domain) with EPHA2 (via SAM domain).
    SequenceCaution:
    • Sequence=BAA13218.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANKS1A Gene

    Alternative splice isoforms for ANKS1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKS1A Gene

Proteomics data for ANKS1A Gene at MOPED

Post-translational modifications for ANKS1A Gene

  • Phosphorylated on tyrosine residues in response to EGF and PDGF.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKS1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKS1A Gene

Domains & Families for ANKS1A Gene

Suggested Antigen Peptide Sequences for ANKS1A Gene

Graphical View of Domain Structure for InterPro Entry

Q92625

UniProtKB/Swiss-Prot:

ANS1A_HUMAN :
  • Contains 1 PID domain.
  • Contains 6 ANK repeats.
Domain:
  • Contains 1 PID domain.
  • Contains 2 SAM (sterile alpha motif) domains.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with ANKS1A: view

Function for ANKS1A Gene

Molecular function for ANKS1A Gene

UniProtKB/Swiss-Prot Function:
Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity).
genes like me logo Genes that share phenotypes with ANKS1A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ANKS1A

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKS1A Gene

Localization for ANKS1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKS1A Gene

Cytoplasm. Cell projection. Note=Cytoplasmic before and after growth factor treatment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKS1A Gene COMPARTMENTS Subcellular localization image for ANKS1A gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for ANKS1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ANKS1A: view

Pathways & Interactions for ANKS1A Gene

SuperPathways for ANKS1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKS1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006929 substrate-dependent cell migration ISS --
genes like me logo Genes that share ontologies with ANKS1A: view

No data available for Pathways by source and SIGNOR curated interactions for ANKS1A Gene

Drugs & Compounds for ANKS1A Gene

No Compound Related Data Available

Transcripts for ANKS1A Gene

Unigene Clusters for ANKS1A Gene

Ankyrin repeat and sterile alpha motif domain containing 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKS1A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^
SP1: - - -
SP2: - - - -
SP3:
SP4:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29
SP1:
SP2: - -
SP3: -
SP4:

Relevant External Links for ANKS1A Gene

GeneLoc Exon Structure for
ANKS1A
ECgene alternative splicing isoforms for
ANKS1A

Expression for ANKS1A Gene

mRNA expression in normal human tissues for ANKS1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKS1A Gene

This gene is overexpressed in Testis (23.4) and Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKS1A Gene



SOURCE GeneReport for Unigene cluster for ANKS1A Gene Hs.656492

mRNA Expression by UniProt/SwissProt for ANKS1A Gene

Q92625-ANS1A_HUMAN
Tissue specificity: Widely expressed (at protein level).
genes like me logo Genes that share expression patterns with ANKS1A: view

Protein tissue co-expression partners for ANKS1A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ANKS1A Gene

Orthologs for ANKS1A Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKS1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANKS1A 35
  • 87.37 (n)
  • 89.58 (a)
ANKS1A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKS1A 35
  • 89.76 (n)
  • 93.38 (a)
ANKS1A 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anks1 35
  • 84.72 (n)
  • 87.41 (a)
Anks1 16
Anks1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANKS1A 35
  • 99.41 (n)
  • 99.47 (a)
ANKS1A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anks1a 35
  • 84.92 (n)
  • 87.2 (a)
oppossum
(Monodelphis domestica)
Mammalia ANKS1A 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves ANKS1A 35
  • 76.93 (n)
  • 82.03 (a)
ANKS1A 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKS1A 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anks1a 35
  • 60.31 (n)
  • 63.81 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25324 35
zebrafish
(Danio rerio)
Actinopterygii anks1aa 36
  • 74 (a)
OneToMany
anks1ab 36
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11168 36
  • 31 (a)
ManyToMany
CG4393 36
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C11E4.6 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for ANKS1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKS1A Gene

ENSEMBL:
Gene Tree for ANKS1A (if available)
TreeFam:
Gene Tree for ANKS1A (if available)

Paralogs for ANKS1A Gene

Paralogs for ANKS1A Gene

(5) SIMAP similar genes for ANKS1A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ANKS1A: view

Variants for ANKS1A Gene

Sequence variations from dbSNP and Humsavar for ANKS1A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs820085 - 35,060,150(+) AGGTT(C/T)ACGGA reference, missense
rs6930932 - 34,985,133(+) AAATG(A/C)TGAAG reference, missense
rs1055759 -- 34,991,386(-) ATGAA(C/T)ATTTA intron-variant
rs1093985 -- 35,070,062(-) caaca(C/T)tgtga intron-variant
rs1093986 -- 35,069,829(-) ggctg(A/G)tcttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKS1A Gene

Variant ID Type Subtype PubMed ID
dgv6831n71 CNV Gain 21882294
nsv462905 CNV Gain 19166990
nsv885797 CNV Gain 21882294
nsv508402 CNV Loss 20534489
nsv5256 CNV Insertion 18451855
nsv5257 CNV Loss 18451855
esv2731909 CNV Deletion 23290073
esv2731910 CNV Deletion 23290073

Variation tolerance for ANKS1A Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.27; 70.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKS1A Gene

HapMap Linkage Disequilibrium report
ANKS1A
Human Gene Mutation Database (HGMD)
ANKS1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKS1A Gene

Disorders for ANKS1A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANKS1A Gene - From: DISEASES

Disorder Aliases PubMed IDs
adjustment disorder
  • adjustment disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ANKS1A

Genetic Association Database (GAD)
ANKS1A
Human Genome Epidemiology (HuGE) Navigator
ANKS1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKS1A
genes like me logo Genes that share disorders with ANKS1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKS1A Gene

Publications for ANKS1A Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 67
  2. In silico prediction of physical protein interactions and characterization of interactome orphans. (PMID: 25402006) Kotlyar M. … Jurisica I. (Nat. Methods 2015) 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam. (PMID: 26120079) Mercurio F.A. … Leone M. (Chembiochem 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ANKS1A Gene

Sources for ANKS1A Gene

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