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Aliases for ANKS1A Gene

Aliases for ANKS1A Gene

  • Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1A 2 3
  • ANKS1 3 4 6
  • Odin 3 4 6
  • Ankyrin Repeat And SAM Domain Containing 1 2 3
  • KIAA0229 4 6
  • Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1 2
  • Ankyrin Repeat And SAM Domain-Containing Protein 1A 3

External Ids for ANKS1A Gene

Previous Symbols for ANKS1A Gene

  • ANKS1

Summaries for ANKS1A Gene

GeneCards Summary for ANKS1A Gene

ANKS1A (Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1A) is a Protein Coding gene. Diseases associated with ANKS1A include adjustment disorder. GO annotations related to this gene include ephrin receptor binding. An important paralog of this gene is CASKIN2.

UniProtKB/Swiss-Prot for ANKS1A Gene

  • Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity).

Gene Wiki entry for ANKS1A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKS1A Gene

Genomics for ANKS1A Gene

Genomic Location for ANKS1A Gene

34,889,261 bp from pter
35,091,413 bp from pter
202,153 bases
Plus strand

Genomic View for ANKS1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKS1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKS1A Gene

Regulatory Elements for ANKS1A Gene

Proteins for ANKS1A Gene

  • Protein details for ANKS1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat and SAM domain-containing protein 1A
    Protein Accession:
    Secondary Accessions:
    • A2RUC1
    • B4DQW8
    • Q5JYI9
    • Q5SYR2
    • Q86WQ7

    Protein attributes for ANKS1A Gene

    1134 amino acids
    Molecular mass:
    123108 Da
    Quaternary structure:
    • Interacts with EPHA8; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination (By similarity). Interacts (via SAM domain) with EPHA2 (via SAM domain).
    • Sequence=BAA13218.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANKS1A Gene

    Alternative splice isoforms for ANKS1A Gene


neXtProt entry for ANKS1A Gene

Proteomics data for ANKS1A Gene at MOPED

Post-translational modifications for ANKS1A Gene

  • Phosphorylated on tyrosine residues in response to EGF and PDGF.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKS1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKS1A Gene

Domains for ANKS1A Gene

Gene Families for ANKS1A Gene

  • ANKRD :Ankyrin repeat domain containing
  • SAMD :Sterile alpha motif (SAM) domain containing


  • Contains 1 PID domain.:
    • Q92625
  • Contains 2 SAM (sterile alpha motif) domains.:
    • Q92625
  • Contains 6 ANK repeats.:
    • Q92625
genes like me logo Genes that share domains with ANKS1A: view

Function for ANKS1A Gene

Molecular function for ANKS1A Gene

UniProtKB/Swiss-Prot Function: Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity).

Gene Ontology (GO) - Molecular Function for ANKS1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16273093
genes like me logo Genes that share ontologies with ANKS1A: view

Phenotypes for ANKS1A Gene

genes like me logo Genes that share phenotypes with ANKS1A: view

miRNA for ANKS1A Gene

miRTarBase miRNAs that target ANKS1A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANKS1A Gene

Localization for ANKS1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKS1A Gene

Cytoplasm. Cell projection. Note=Cytoplasmic before and after growth factor treatment.

Subcellular locations from

Jensen Localization Image for ANKS1A Gene COMPARTMENTS Subcellular localization image for ANKS1A gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for ANKS1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0043005 neuron projection ISS --
genes like me logo Genes that share ontologies with ANKS1A: view

Pathways for ANKS1A Gene

SuperPathways for ANKS1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKS1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006929 substrate-dependent cell migration ISS --
GO:0016322 neuron remodeling ISS --
GO:0048013 ephrin receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with ANKS1A: view

No data available for Pathways by source for ANKS1A Gene

Transcripts for ANKS1A Gene

Unigene Clusters for ANKS1A Gene

Ankyrin repeat and sterile alpha motif domain containing 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKS1A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^
SP1: - - -
SP2: - - - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29
SP2: - -
SP3: -

Relevant External Links for ANKS1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKS1A Gene

mRNA expression in normal human tissues for ANKS1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKS1A Gene

SOURCE GeneReport for Unigene cluster for ANKS1A Gene Hs.656492

mRNA Expression by UniProt/SwissProt for ANKS1A Gene

Tissue specificity: Widely expressed (at protein level)
genes like me logo Genes that share expressions with ANKS1A: view

Orthologs for ANKS1A Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKS1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANKS1A 36
  • 99.41 (n)
  • 99.47 (a)
  • 99 (a)
(Bos Taurus)
Mammalia ANKS1A 36
  • 87.37 (n)
  • 89.58 (a)
  • 90 (a)
(Canis familiaris)
Mammalia ANKS1A 36
  • 89.76 (n)
  • 93.38 (a)
  • 94 (a)
(Mus musculus)
Mammalia Anks1 36
  • 84.72 (n)
  • 87.41 (a)
Anks1 16
Anks1 37
  • 87 (a)
(Monodelphis domestica)
Mammalia ANKS1A 37
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 65 (a)
-- 37
  • 86 (a)
(Rattus norvegicus)
Mammalia Anks1a 36
  • 84.92 (n)
  • 87.2 (a)
(Gallus gallus)
Aves ANKS1A 36
  • 76.93 (n)
  • 82.03 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia ANKS1A 37
  • 73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25324 36
tropical clawed frog
(Silurana tropicalis)
Amphibia anks1a 36
  • 60.31 (n)
  • 63.81 (a)
(Danio rerio)
Actinopterygii anks1aa 37
  • 74 (a)
anks1ab 37
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11168 37
  • 31 (a)
CG4393 37
  • 25 (a)
(Caenorhabditis elegans)
Secernentea C11E4.6 37
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 51 (a)
Species with no ortholog for ANKS1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKS1A Gene

Gene Tree for ANKS1A (if available)
Gene Tree for ANKS1A (if available)

Paralogs for ANKS1A Gene

Paralogs for ANKS1A Gene

Selected SIMAP similar genes for ANKS1A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ANKS1A: view

Variants for ANKS1A Gene

Sequence variations from dbSNP and Humsavar for ANKS1A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2004 -- 35,088,770(-) AGGAC(A/G)TGGTG utr-variant-3-prime, downstream-variant-500B
rs2005 -- 35,088,666(+) CTCCC(A/G)CTGCC utr-variant-3-prime, downstream-variant-500B
rs13084 -- 35,088,760(+) GGCCT(G/T)CCACC utr-variant-3-prime, downstream-variant-500B
rs707967 -- 35,080,657(+) TCTGT(C/T)GGGGA intron-variant
rs707968 -- 35,090,340(+) TGCGC(A/G)CATGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ANKS1A Gene

Variant ID Type Subtype PubMed ID
dgv6831n71 CNV Gain 21882294
nsv462905 CNV Gain 19166990
nsv885797 CNV Gain 21882294
nsv508402 CNV Loss 20534489
nsv5256 CNV Insertion 18451855
nsv5257 CNV Loss 18451855
esv2731909 CNV Deletion 23290073
esv2731910 CNV Deletion 23290073

Relevant External Links for ANKS1A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for ANKS1A Gene

(1) MalaCards Diseases for ANKS1A Gene

Search for ANKS1A Gene in MalaCards »

(1) University of Copenhagen DISEASES for ANKS1A Gene

Relevant External Links for ANKS1A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ANKS1A: view

No data available for UniProtKB/Swiss-Prot for ANKS1A Gene

Publications for ANKS1A Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases. (PMID: 12439753) Pandey A. … Mann M. (Oncogene 2002) 3 4
  5. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 49

Products for ANKS1A Gene

Sources for ANKS1A Gene

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