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ANKRD7 Gene

protein-coding   GIFtS: 47
GCID: GC07P117854

Ankyrin Repeat Domain 7

  Search for ANKRD7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ankyrin Repeat Domain 71 2
Testis-Specific Ankyrin Motif Containing Protein1 2
Testis-Specific Protein TSA8062 3
TSA8062
Ankyrin Repeat Domain-Containing Protein 72

External Ids:    HGNC: 185881   Entrez Gene: 563112   Ensembl: ENSG000001060137   OMIM: 6107315   UniProtKB: Q925273   
ORGUL members:         

Export aliases for ANKRD7 gene to outside databases

Previous GC identifers: GC07P116342 GC07P117405 GC07P117419 GC07P117458 GC07P117652 GC07P112230


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD7 Gene:
ANKRD7 (ankyrin repeat domain 7) is a protein-coding gene. An important paralog of this gene is POTEF.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD7 gene promoter:
         Nkx2-5   CUTL1   C/EBPalpha   GATA-2   MEF-2A   POU2F1a   FOXO1a   Sox9   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD7 promoter sequence
   Search Chromatin IP Primers for ANKRD7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31   Ensembl cytogenetic band:  7q31.31   HGNC cytogenetic band: 7q31

ANKRD7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD7 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P117854:  view genomic region     (about GC identifiers)

Start:
117,854,727 bp from pter      End:
117,882,785 bp from pter
Size:
28,059 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 117,260,122-117,278,198     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANKR7_HUMAN, Q92527 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 7  
Size: 254 amino acids; 29029 Da
Sequence caution: Sequence=AAH32799.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DYF5 Q96QN1 Q9UDM3
Alternative splicing: 2 isoforms:  Q92527-1   Q92527-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ANKRD7: NX_Q92527

Explore proteomics data for ANKRD7 at MOPED


See ANKRD7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_062618.2  
ENSEMBL proteins: 
 ENSP00000265224   ENSP00000417353   ENSP00000395595   ENSP00000388473   ENSP00000349612  

ANKRD7 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ANKRD: Ankyrin repeat domain containing

2 InterPro protein domains:
 IPR002110 Ankyrin_rpt
 IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry Q92527

ProtoNet protein and cluster: Q92527

1 Blocks protein domain: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: ANKR7_HUMAN, Q92527
Similarity: Contains 5 ANK repeats


Find genes that share domains with ANKRD7           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with ANKRD7           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANKRD7
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4 qRT-PCR Assays for microRNAs that regulate ANKRD7:
hsa-miR-203 hsa-miR-495 hsa-miR-513a-3p hsa-miR-3674
SwitchGear 3'UTR luciferase reporter plasmidANKRD7 3' UTR sequence
Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD7
Interactions:

    Search GeneGlobe Interaction Network for ANKRD7

3 Interacting proteins for ANKRD7 (Q925272, 3) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MARK3P274482, 3MINT-63624 I2D: score=3 
EWSR1Q018443I2D: score=1 
RELAQ042063I2D: score=1 
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008584male gonad development TAS8812458

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ANKRD7 (ANKR7)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ANKRD7 gene (2 alternative transcripts): 
NM_001077708.1  NM_019644.3  

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000477532 ENST00000265224 ENST00000486422 ENST00000417525 ENST00000433239
ENST00000490445 ENST00000357099(uc003vji.3)
miRNA
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4 qRT-PCR Assays for microRNAs that regulate ANKRD7:
hsa-miR-203 hsa-miR-495 hsa-miR-513a-3p hsa-miR-3674
SwitchGear 3'UTR luciferase reporter plasmidANKRD7 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat ANKRD7
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GenScript: all cDNA clones in your preferred vector: ANKRD7 (NM_019644)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD7
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  QuantiTect SYBR Green Assays in human, mouse, rat ANKRD7
  QuantiFast Probe-based Assays in human, mouse, rat ANKRD7

Selected AceView cDNA sequences (see all 174):

AI015086 BP369355 BM554194 AA412515 BC032799 AL046631 AW235280 AA435914 
BI831682 BP369843 BI831866 AA383217 AA412638 AA382262 BF478140 BP369869 
AW589873 AA789201 AI126287 BE550342 AA609762 BG722960 BU569049 AL046632 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD7 (see all 7)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8
SP1:                          -                                               -               
SP2:                    -     -                                               -               
SP3:                                                                    -     -               
SP4:                                                                                          
SP5:                                                                                          


ECgene alternative splicing isoforms for ANKRD7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ANKRD7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TATTAAAACA
ANKRD7 Expression
About this image


ANKRD7 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Testis (Reproductive System)    fully expand to see all 4 entries
         XY Germ Cells Testis Cord
         Testis Interstitium
 
 Gonad
         XY Germ Cells Testis Cord
ANKRD7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ANKRD7 Protein Expression

UniProtKB/Swiss-Prot: ANKR7_HUMAN, Q92527
Tissue specificity: Testis specific

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ANKRD7 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ankrd71 , 5 ankyrin repeat domain 71, 5 77.4(n)1
65.37(a)1
  6 (8.16 cM)5
751961  NM_001167757.11  NP_001161229.11 
 188663185 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
7(a)
1 → many
1(24064036-24111623)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
35(a)
many ↔ many
GL344195.1(38786-58936)
zebrafish
(Danio rerio)
Actinopterygii ANKRD76
ankyrin repeat domain 7
4(a)
1 → many
25(3581527-3655709) ENSDARG00000013015


ENSEMBL Gene Tree for ANKRD7 (if available)
TreeFam Gene Tree for ANKRD7 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ANKRD7 gene
POTEF2  POTEI2  ANKRD30A2  POTEB22  ANKRD362  POTEB2  ANKRD30BL2  ANKRD20A32  
POTEH2  ANKRD30B2  LOC6442492  ENSG000002663022  ANKRD36C2  POTEJ2  POTEC2  ANKRD20A22  
ANKRD262  POTEG2  ANKRD622  ANKRD18A2  POTEM2  ANKRD20A12  CCDC144A2  POTED2  
POTEE2  ANKRD20A42  ANKRD18B2  LOC1002889662  
Selected SIMAP similar genes for ANKRD7 using alignment to 3 protein entries:     ANKR7_HUMAN (see all proteins) (see all similar genes):
ANKRD26    ANKRD30BL    ANKRD20A5P    ANKRD26P1    POTEB    ANKRD19P
ANKRD36B    ANKRD62    POTEB2    ANKRD36    ANKRD30B    ANKRD36C
POTEE    POTEM    POTEH    POTEC    POTEF    ANKRD44

Find genes that share paralogs with ANKRD7           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ANKRD7 (see all 424)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1884453421,2
--117862729(+) CTGATC/TAGATG 1 -- us2k10--------
rs732055871,2
C--117862781(+) TTTTGC/TCTTGA 1 -- us2k10--------
rs1150970101,2
F--117862899(+) TATAAT/CATAAA 1 -- us2k11Minor allele frequency- C:0.02WA 118
rs1808739521,2
--117862973(+) CAGACG/TAGAAC 1 -- us2k10--------
rs624665591,2
C,F--117862974(+) AGACTA/GGAACT 1 -- us2k15Minor allele frequency- G:0.08NA CSA WA EA 362
rs1385782201,2
C--117863038(+) ATAACA/CCAGCA 1 -- us2k10--------
rs1858980941,2
--117863057(+) AGATAC/TGATAA 1 -- us2k10--------
rs1904266071,2
--117863094(+) ACAATC/TGACAG 1 -- us2k10--------
rs1493073321,2
--117863135(+) AAGATA/GAAATT 1 -- us2k10--------
rs1455557831,2
C--117863178(+) AAAAAG/TCTGTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ANKRD7 (117854727 - 117882785 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for ANKRD7:    About this table    
Variant IDTypeSubtypePubMed ID
nsv5920CNV Insertion18451855
nsv889089CNV Loss21882294
nsv889090CNV Loss21882294
nsv889088CNV Gain21882294
nsv7405OTHER Inversion18451855

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610731    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for ANKRD7:
Alcohol dependence

Find genes that share disorders with ANKRD7           About GenesLikeMe

Genetic Association Database (GAD): ANKRD7

Export disorders for ANKRD7 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ANKRD7 gene, integrated from 10 sources (see all 18):
(articles sorted by number of sources associating them with ANKRD7)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. (PubMed id 8812458)1, 2, 3 Ozaki K.... Nakamura Y. (Genomics 1996)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
  4. ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior. (PubMed id 22613542)1 Chen X.D....Deng H.W. (Chin. Med. J. 2012)
  5. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)
  6. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
  7. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
  8. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
  9. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
  10. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)4 Lunetta K.L....Murabito J.M. (BMC Med. Genet. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 56311 HGNC: 18588 AceView: ANKRD7 Ensembl:ENSG00000106013 euGenes: HUgn56311
ECgene: ANKRD7 H-InvDB: ANKRD7

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ANKRD7 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ANKRD7 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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