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Aliases for ANKRD7 Gene

Aliases for ANKRD7 Gene

  • Ankyrin Repeat Domain 7 2 3 5
  • Testis-Specific Ankyrin Motif Containing Protein 2 3
  • Testis-Specific Protein TSA806 3 4
  • Ankyrin Repeat Domain-Containing Protein 7 3
  • Testicular Tissue Protein Li 19 3
  • TSA806 3

External Ids for ANKRD7 Gene

Previous GeneCards Identifiers for ANKRD7 Gene

  • GC07P116342
  • GC07P117405
  • GC07P117419
  • GC07P117458
  • GC07P117652
  • GC07P117854
  • GC07P112230

Summaries for ANKRD7 Gene

GeneCards Summary for ANKRD7 Gene

ANKRD7 (Ankyrin Repeat Domain 7) is a Protein Coding gene. An important paralog of this gene is ANKRD20A2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD7 Gene

Genomics for ANKRD7 Gene

Regulatory Elements for ANKRD7 Gene

Enhancers for ANKRD7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G118182 1.1 ENCODE 7.4 -30.4 -30378 3.9 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 LSM8 ANKRD7
GH07G118311 1.4 FANTOM5 Ensembl ENCODE 4.9 +97.0 97006 1.2 TBP PKNOX1 FEZF1 TCF12 ELK1 SCRT2 ETV6 IKZF2 CREM CEBPB LSM8 ANKRD7 LOC102724495 LOC105375471
GH07G118223 0.4 FANTOM5 16.2 +9.2 9207 0.2 KDM1A ANKRD7 GC07M118229 PIR61803 PIR53116
GH07G118214 0.8 ENCODE 5.8 -0.1 -128 1.1 HIC1 ZNF316 ZNF157 POLR2A PATZ1 ZNF600 PRDM10 ZNF391 MAFK ZBTB20 LSM8 ANKRD7
GH07G118195 0.7 ENCODE 0.4 -18.6 -18628 0.2 CTCF ZNF654 TRIM22 RAD21 POLR2H POLR2A PBX2 SMC3 SIRT6 ZNF143 LSM8 ANKRD7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD7 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000217311 -68 1199 ZBTB21 HIC1 ZNF316 ZNF157 POLR2A PATZ1 ZNF600 PRDM10 ZNF391 MAFK

Genomic Location for ANKRD7 Gene

Chromosome:
7
Start:
118,214,669 bp from pter
End:
118,496,171 bp from pter
Size:
281,503 bases
Orientation:
Plus strand

Genomic View for ANKRD7 Gene

Genes around ANKRD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD7 Gene

Proteins for ANKRD7 Gene

  • Protein details for ANKRD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92527-ANKR7_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 7
    Protein Accession:
    Q92527
    Secondary Accessions:
    • B4DYF5
    • Q96QN1
    • Q9UDM3

    Protein attributes for ANKRD7 Gene

    Size:
    254 amino acids
    Molecular mass:
    29029 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH32799.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD7 Gene

Post-translational modifications for ANKRD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD7 Gene

No data available for DME Specific Peptides for ANKRD7 Gene

Domains & Families for ANKRD7 Gene

Gene Families for ANKRD7 Gene

Protein Domains for ANKRD7 Gene

Suggested Antigen Peptide Sequences for ANKRD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD7: view

No data available for UniProtKB/Swiss-Prot for ANKRD7 Gene

Function for ANKRD7 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD7 Gene

Localization for ANKRD7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD7 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD7 Gene

Pathways & Interactions for ANKRD7 Gene

SuperPathways for ANKRD7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008584 male gonad development TAS 8812458
genes like me logo Genes that share ontologies with ANKRD7: view

No data available for Pathways by source and SIGNOR curated interactions for ANKRD7 Gene

Transcripts for ANKRD7 Gene

Unigene Clusters for ANKRD7 Gene

Ankyrin repeat domain 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6: -
SP7: -

Relevant External Links for ANKRD7 Gene

GeneLoc Exon Structure for
ANKRD7
ECgene alternative splicing isoforms for
ANKRD7

Expression for ANKRD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD7 Gene

This gene is overexpressed in Testis (x51.6).

Protein differential expression in normal tissues from HIPED for ANKRD7 Gene

This gene is overexpressed in Liver, secretome (37.2), Testis (12.3), CD4 Tcells (10.2), and Adipocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD7 Gene



Protein tissue co-expression partners for ANKRD7 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD7 Gene:

ANKRD7

SOURCE GeneReport for Unigene cluster for ANKRD7 Gene:

Hs.729340

mRNA Expression by UniProt/SwissProt for ANKRD7 Gene:

Q92527-ANKR7_HUMAN
Tissue specificity: Testis specific.

Evidence on tissue expression from TISSUES for ANKRD7 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ANKRD7: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD7 Gene

Orthologs for ANKRD7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD7 34 35
  • 99.87 (n)
mouse
(Mus musculus)
Mammalia Ankrd7 34 16 35
  • 77.4 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd7 34
  • 73.96 (n)
dog
(Canis familiaris)
Mammalia ANKRD7 35
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
OneToMany
-- 35
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 3 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 7 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 35 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ANKRD7 35
  • 4 (a)
OneToMany
Species where no ortholog for ANKRD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD7 Gene

ENSEMBL:
Gene Tree for ANKRD7 (if available)
TreeFam:
Gene Tree for ANKRD7 (if available)

Paralogs for ANKRD7 Gene

Variants for ANKRD7 Gene

Sequence variations from dbSNP and Humsavar for ANKRD7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000486239 -- 118,239,639(+) ACCAA(C/G)TATAA intron-variant
rs1000509277 -- 118,233,216(+) GTTCG(C/T)TCCTT intron-variant
rs1000541889 -- 118,233,700(+) TTTAT(A/G)TGTGG intron-variant
rs1000555736 -- 118,240,311(+) TCCCC(A/C)CTCCC intron-variant
rs1000717410 -- 118,233,103(+) TGCTT(G/T)GTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD7 Gene

Variant ID Type Subtype PubMed ID
esv3614730 CNV loss 21293372
nsv5920 CNV insertion 18451855
nsv608259 CNV gain 21841781
nsv7405 OTHER inversion 18451855

Variation tolerance for ANKRD7 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD7 Gene

Disorders for ANKRD7 Gene

Relevant External Links for ANKRD7

Genetic Association Database (GAD)
ANKRD7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD7

No disorders were found for ANKRD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD7 Gene

Publications for ANKRD7 Gene

  1. Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. (PMID: 8812458) Ozaki K. … Nakamura Y. (Genomics 1996) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3 64
  5. ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior. (PMID: 22613542) Chen X.D. … Deng H.W. (Chin. Med. J. 2012) 3 64

Products for ANKRD7 Gene

Sources for ANKRD7 Gene

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