ANKRD7 Gene
protein-coding GIFtS: 46
GCID: GC07P117854
|
|
ankyrin repeat domain 7
| |
Aliases
for ANKRD7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat Domain 71 2 | | TSA8061 2 | | Testis-Specific Protein TSA8062 3 | | Ankyrin Repeat Domain-Containing Protein 72 | | Testis-Specific Ankyrin Motif Containing Protein2 |
Export aliases for ANKRD7 gene to outside databasesPrevious GC identifers: GC07P116342 GC07P117405 GC07P117419 GC07P117458 GC07P117652 GC07P112230 |
Summaries
for ANKRD7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ANKRD7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKRD7 gene promoter:
Nkx2-5 CUTL1 C/EBPalpha GATA-2 MEF-2A POU2F1a FOXO1a Sox9 aMEF-2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKRD7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31 Ensembl cytogenetic band: 7q31.31 HGNC cytogenetic band: 7q31ANKRD7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P117854: view genomic region
(about GC identifiers)
Start:
|
117,854,727 bp from pter |
End:
|
117,882,785 bp from pter |
Size:
|
28,059 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 117,260,122-117,278,198 |
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Proteins
for ANKRD7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANKR7_HUMAN, Q92527 (See
protein sequence)Recommended Name: Ankyrin repeat domain-containing protein 7 Size: 254 amino acids; 29029 Da
Sequence caution: Sequence=AAH32799.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DYF5 Q96QN1 Q9UDM3Alternative splicing: 2 isoforms: Q92527-1 Q92527-2 (Gene prediction based on EST data)Explore the universe of human proteins at neXtProt for ANKRD7: NX_Q92527
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92527
ANKRD7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_062618.2
ENSEMBL proteins: ENSP00000265224 ENSP00000417353 ENSP00000395595 ENSP00000388473 ENSP00000349612
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ANKRD7 for ontologies About GeneDecksing
ANKRD7 Antibody Products:
Assay Products for ANKRD7: |
Protein
Domains /
Families
for ANKRD7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKRD7 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92527ProtoNet protein and cluster: Q92527 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ANKR7_HUMAN, Q92527Similarity: Contains 5 ANK repeats |
Function
for ANKRD7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD7 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD7 |
|
Pathways & Interactions
for ANKRD7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD7
3 Interacting proteins for ANKRD7 (Q925272, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
ANKRD7 for ontologies About GeneDecksing
|
Drugs & Compounds
for ANKRD7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKRD7
Search CenterWatch for drugs/clinical trials and news about ANKRD7 / ANKR7
|
Transcripts
for ANKRD7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKRD7 gene (2 alternative transcripts): NM_001077708.1 NM_019644.3 Unigene Cluster for ANKRD7: Ankyrin repeat domain 7 Hs.729340 [show with all ESTs]Unigene Representative Sequence: NM_0196447 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000477532 ENST00000265224 ENST00000486422 ENST00000417525 ENST00000433239
ENST00000490445 ENST00000357099(uc003vji.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD7 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANKRD7 (NM_019644) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD7 |
Additional cDNA sequence: AK302407.1 BC007020.2 BC032799.1 D78334.1 7 DOTS entries: DT.215097 DT.91721179 DT.40287450 DT.100008648 DT.100754708 DT.91721177 DT.99962990 24/174 AceView cDNA sequences (see all 174): BI831866 BM554194 BP369843 BP369355 AA412638 AI015086 AA382262 AW235280 BI831682 BF478140 BC032799 AA412515 AL046631 AA383217 AA435914 BI464265 AI917718 AI150274 AW274930 BI827177 BG719053 AA609762 BU569049 AA432261
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD7 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ANKRD7
|
Expression
for ANKRD7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKRD7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTAAAACA
About this image
See ANKRD7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD7
SOURCE GeneReport for Unigene cluster: Hs.729340
UniProtKB/Swiss-Prot: ANKR7_HUMAN, Q92527Tissue specificity: Testis specific
SABiosciences Custom PCR Arrays for ANKRD7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD7
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD7 |
Orthologs
for ANKRD7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ANKRD7 gene from 3/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ANKRD626 |
Uncharacterized protein |
11(a) |
1 → many |
1(26091172-26138404) |
lizard
(Anolis carolinensis) |
Reptilia |
ANKRD626 |
-- |
44(a) |
1 → many |
GL344195.1(39104-48393) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-272n13.36 |
si:ch211-272n13.3 |
5(a) |
1 → many |
25(3581527-3655709) |
ENSEMBL Gene Tree for ANKRD7 (if available)
TreeFam Gene Tree for ANKRD7 (if available) |
Paralogs
for ANKRD7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKRD7 gene
- POTEF2 POTEI2 ANKRD30A2 ANKRD362 POTEB2 ANKRD30BL2 ANKRD20A32 POTEH2
- ENSG000001552822 ANKRD30B2 ENSG000002663022 ANKRD36C2 POTEJ2 POTEC2 ANKRD20A22 POTEG2
- ANKRD262 ANKRD622 ANKRD18A2 ENSG000001882192 POTEM2 ANKRD20A12 LOC1009963312 CCDC144A2
- POTED2 ANKRD20A42 ANKRD18B2 LOC1002889662
18/24 SIMAP similar genes for ANKRD7 using alignment to 3 protein entries: ANKR7_HUMAN (see all proteins)
(see all similar genes):ANKRD26 ANKRD30BL ANKRD20A5P ANKRD26P1 POTEB ANKRD19P
ANKRD36B ANKRD62 ANKRD36 ANKRD30B ANKRD36C POTEE
POTEM POTEH POTEC POTEF ANKRD44 MGC26718
ANKRD7 for paralogs About GeneDecksing
|
Genomic Variants
for ANKRD7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKRD7 (117854727 - 117882785 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANKRD7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD7 |
|
Disorders
/ Diseases
for ANKRD7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ANKRD7 for disorders About MalaCards
ANKRD7 for disorders About GeneDecksing
OMIM gene information: 610731
OMIM disorders: --
1 disease from the University of Copenhagen DISEASES database for ANKRD7:Alcohol dependence Export disorders for ANKRD7 gene to outside databases
|
Publications
for ANKRD7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKRD7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANKRD7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. (PubMed id 8812458)1, 2, 3 Ozaki K.... Nakamura Y. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- ANKRD7 and CYTL1 are novel risk genes for alcohol drin king behavior. (PubMed id 22613542)1 Chen X.D....Deng H.W. (2012)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
|
External Searches for ANKRD7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANKRD7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKRD7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANKRD7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKRD7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANKRD7 gene:
Search GeneIP for patents involving ANKRD7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKRD7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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