Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANKRD66 Gene

Aliases for ANKRD66 Gene

  • Ankyrin Repeat Domain 66 2 3 5

External Ids for ANKRD66 Gene

Previous GeneCards Identifiers for ANKRD66 Gene

  • GC06P046716

Summaries for ANKRD66 Gene

GeneCards Summary for ANKRD66 Gene

ANKRD66 (Ankyrin Repeat Domain 66) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD66 Gene

Genomics for ANKRD66 Gene

Regulatory Elements for ANKRD66 Gene

Enhancers for ANKRD66 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F046749 0.5 ENCODE 0.8 +2.9 2879 0.9 TDRD6 MEP1A CYP39A1 ANKRD66 ENSG00000236164
GH06F046761 0.5 ENCODE 0.4 +14.2 14182 0.2 INSM2 FEZF1 ZNF366 ZNF239 PRDM10 RCOR1 KLF8 TCF7L2 ZNF639 STAT1 ENSG00000236164 ANKRD66
GH06F046756 0.4 Ensembl 0.4 +10.3 10284 0.8 PKNOX1 INSM2 KLF17 RAD21 RFX5 ZNF366 SCRT2 SMARCC1 ZNF362 CEBPB CYP39A1 ENSG00000236164 ANKRD66
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ANKRD66 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKRD66 Gene

Chromosome:
6
Start:
46,746,917 bp from pter
End:
46,759,506 bp from pter
Size:
12,590 bases
Orientation:
Plus strand

Genomic View for ANKRD66 Gene

Genes around ANKRD66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD66 Gene

Proteins for ANKRD66 Gene

  • Protein details for ANKRD66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B4E2M5-ANR66_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 66
    Protein Accession:
    B4E2M5

    Protein attributes for ANKRD66 Gene

    Size:
    251 amino acids
    Molecular mass:
    27916 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG65187.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ANKRD66 Gene

Post-translational modifications for ANKRD66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD66 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD66 Gene

Domains & Families for ANKRD66 Gene

Gene Families for ANKRD66 Gene

Protein Domains for ANKRD66 Gene

Graphical View of Domain Structure for InterPro Entry

B4E2M5

UniProtKB/Swiss-Prot:

ANR66_HUMAN :
  • Contains 3 ANK repeats.
Similarity:
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with ANKRD66: view

No data available for Suggested Antigen Peptide Sequences for ANKRD66 Gene

Function for ANKRD66 Gene

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD66 Gene

Localization for ANKRD66 Gene

Gene Ontology (GO) - Cellular Components for ANKRD66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
genes like me logo Genes that share ontologies with ANKRD66: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for ANKRD66 Gene

Pathways & Interactions for ANKRD66 Gene

SuperPathways for ANKRD66 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD66 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD66 Gene

Transcripts for ANKRD66 Gene

mRNA/cDNA for ANKRD66 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD66 Gene

Ankyrin repeat domain 66:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD66 Gene

No ASD Table

Relevant External Links for ANKRD66 Gene

GeneLoc Exon Structure for
ANKRD66
ECgene alternative splicing isoforms for
ANKRD66

Expression for ANKRD66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD66 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD66 Gene

This gene is overexpressed in Fallopian Tube (x8.1), Brain - Hypothalamus (x7.5), Cervix - Endocervix (x7.5), Brain - Caudate (basal ganglia) (x7.0), Brain - Hippocampus (x5.3), Brain - Amygdala (x4.9), and Lung (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of ANKRD66 Gene:

ANKRD66

SOURCE GeneReport for Unigene cluster for ANKRD66 Gene:

Hs.736491
genes like me logo Genes that share expression patterns with ANKRD66: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ANKRD66 Gene

Orthologs for ANKRD66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD66 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100614902 34
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia ANKRD66 34 35
  • 86.39 (n)
cow
(Bos Taurus)
Mammalia ANKRD66 34 35
  • 84.36 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd66 34
  • 82.3 (n)
mouse
(Mus musculus)
Mammalia Ankrd66 34 16 35
  • 80.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD66 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733445 34
  • 69.23 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101886816 34
  • 59.92 (n)
ANKRD66 35
  • 52 (a)
OneToOne
Species where no ortholog for ANKRD66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD66 Gene

ENSEMBL:
Gene Tree for ANKRD66 (if available)
TreeFam:
Gene Tree for ANKRD66 (if available)

Paralogs for ANKRD66 Gene

(2) SIMAP similar genes for ANKRD66 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD66: view

No data available for Paralogs for ANKRD66 Gene

Variants for ANKRD66 Gene

Sequence variations from dbSNP and Humsavar for ANKRD66 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs111455763 -- 46,749,557(+) CCCCC(C/G)CCCCC intron-variant
rs111473477 -- 46,758,408(+) TAAAC(A/G)AAAAC intron-variant, utr-variant-3-prime
rs111598152 -- 46,744,999(+) CTTTG(A/C)TAATT upstream-variant-2KB
rs111783074 -- 46,751,253(+) CAGTG(-/T)AAAAA intron-variant
rs112015884 -- 46,758,518(+) TCTCA(C/T)TCGGG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ANKRD66 Gene

Variant ID Type Subtype PubMed ID
esv2759425 CNV gain+loss 17122850
nsv428147 CNV gain 18775914
nsv830654 CNV gain 17160897

Variation tolerance for ANKRD66 Gene

Gene Damage Index Score: 5.82; 73.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD66 Gene

Disorders for ANKRD66 Gene

Relevant External Links for ANKRD66

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD66

No disorders were found for ANKRD66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD66 Gene

Publications for ANKRD66 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for ANKRD66 Gene

Sources for ANKRD66 Gene

Content
Loading form....