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Aliases for ANKRD65 Gene

Aliases for ANKRD65 Gene

  • Ankyrin Repeat Domain 65 2 3 5

External Ids for ANKRD65 Gene

Previous GeneCards Identifiers for ANKRD65 Gene

  • GC01M001355
  • GC01M001358

Summaries for ANKRD65 Gene

GeneCards Summary for ANKRD65 Gene

ANKRD65 (Ankyrin Repeat Domain 65) is a Protein Coding gene. An important paralog of this gene is TRPA1.

Additional gene information for ANKRD65 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD65 Gene

Genomics for ANKRD65 Gene

Regulatory Elements for ANKRD65 Gene

Enhancers for ANKRD65 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H001356 1.7 FANTOM5 ENCODE dbSUPER 20.3 +62.5 62450 6.5 HDGF ATF1 ARNT ARID4B YBX1 DMAP1 ZNF48 ZNF2 GLIS2 FOS SLC35E2 LOC100129381 ANKRD65 CCNL2 LOC100288379 SDF4 ENSG00000272455 INTS11 ENSG00000240731 LINC00115
GH01H001420 1 ENCODE 33 -0.4 -365 3 FOXA2 MLX ARID4B DMAP1 SLC30A9 ZNF766 GLIS2 CAVIN1 SP5 REST ANKRD65 ENSG00000240731 ATAD3B INTS11 FAM87B CCNL2 LOC100288379 ENSG00000234396 LINC00115 MXRA8
GH01H001303 1.4 ENCODE dbSUPER 20.1 +114.6 114616 6.9 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ATAD3B INTS11 ENSG00000240731 LINC00115 SLC35E2 CCNL2 LOC105378580 ANKRD65 SCNN1D ENSG00000229905
GH01H001405 1.1 ENCODE 25.4 +14.8 14771 3.6 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 INTS11 ATAD3B CCNL2 ENSG00000240731 LOC100288379 LINC00115 SLC35E2 ENSG00000230092 CDK11A LOC100129381
GH01H001397 1.2 ENCODE 22.9 +21.7 21707 5.5 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SSRP1 ZNF610 INTS11 ATAD3B ENSG00000240731 CCNL2 ENSG00000230092 SLC35E2 NOC2L LOC100129381 LOC100288379 CDK11B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD65 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD65 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000190 1520 601 CTCF ZFX

Genomic Locations for ANKRD65 Gene

Genomic Locations for ANKRD65 Gene
chr1:1,418,420-1,421,820
(GRCh38/hg38)
Size:
3,401 bases
Orientation:
Minus strand
chr1:1,353,800-1,357,149
(GRCh37/hg19)

Genomic View for ANKRD65 Gene

Genes around ANKRD65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD65 Gene

Proteins for ANKRD65 Gene

  • Protein details for ANKRD65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E5RJM6-ANR65_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 65
    Protein Accession:
    E5RJM6
    Secondary Accessions:
    • J3KR93

    Protein attributes for ANKRD65 Gene

    Size:
    399 amino acids
    Molecular mass:
    41497 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD65 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD65 Gene

Post-translational modifications for ANKRD65 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD65 Gene

Domains & Families for ANKRD65 Gene

Gene Families for ANKRD65 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD65 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD65: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ANKRD65 Gene

Function for ANKRD65 Gene

Phenotypes From GWAS Catalog for ANKRD65 Gene

Phenotypes for ANKRD65 Gene

genes like me logo Genes that share phenotypes with ANKRD65: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD65 Gene

Localization for ANKRD65 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ANKRD65 Gene

Pathways & Interactions for ANKRD65 Gene

SuperPathways for ANKRD65 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD65 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD65 Gene

Drugs & Compounds for ANKRD65 Gene

No Compound Related Data Available

Transcripts for ANKRD65 Gene

Unigene Clusters for ANKRD65 Gene

Ankyrin repeat domain 65:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD65 Gene

No ASD Table

Relevant External Links for ANKRD65 Gene

GeneLoc Exon Structure for
ANKRD65
ECgene alternative splicing isoforms for
ANKRD65

Expression for ANKRD65 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD65 Gene

Protein differential expression in normal tissues from HIPED for ANKRD65 Gene

This gene is overexpressed in Pancreatic juice (64.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD65 Gene



Protein tissue co-expression partners for ANKRD65 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD65 Gene:

ANKRD65

SOURCE GeneReport for Unigene cluster for ANKRD65 Gene:

Hs.381222
genes like me logo Genes that share expression patterns with ANKRD65: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD65 Gene

Orthologs for ANKRD65 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD65 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC457197 33
  • 97.49 (n)
dog
(Canis familiaris)
Mammalia ANKRD65 33 34
  • 79.67 (n)
cow
(Bos Taurus)
Mammalia ANKRD65 33 34
  • 79.22 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd65 33
  • 71.47 (n)
mouse
(Mus musculus)
Mammalia Ankrd65 33 16
  • 69.96 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD65 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd65 33
  • 49 (n)
zebrafish
(Danio rerio)
Actinopterygii ANKRD65 34
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea trp-4 34
  • 8 (a)
OneToOne
Species where no ortholog for ANKRD65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKRD65 Gene

ENSEMBL:
Gene Tree for ANKRD65 (if available)
TreeFam:
Gene Tree for ANKRD65 (if available)

Paralogs for ANKRD65 Gene

Paralogs for ANKRD65 Gene

genes like me logo Genes that share paralogs with ANKRD65: view

Variants for ANKRD65 Gene

Sequence variations from dbSNP and Humsavar for ANKRD65 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000010885 -- 1,422,375(+) GCAAC(C/G)TGCGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000146004 -- 1,422,527(+) GGTGG(A/G)AAGTC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000538355 -- 1,422,481(+) GCTCC(C/G)TAAGG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000624828 -- 1,423,506(+) GGAGT(C/G/T)TCACT downstream-variant-500B, upstream-variant-2KB
rs1000843734 -- 1,418,001(+) CACAT(C/G)ATCTC intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ANKRD65 Gene

Variant ID Type Subtype PubMed ID
nsv950452 CNV deletion 24416366
nsv545000 CNV loss 21841781
nsv482937 CNV loss 15286789
nsv1143428 CNV deletion 24896259
nsv1074445 CNV deletion 25765185
nsv10161 CNV gain+loss 18304495
nsv1011818 CNV gain 25217958
nsv1009541 CNV gain 25217958
esv3577672 CNV loss 25503493
esv2758913 CNV gain+loss 17122850
dgv2n67 CNV gain 20364138

Variation tolerance for ANKRD65 Gene

Gene Damage Index Score: 9.12; 87.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD65 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD65

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD65 Gene

Disorders for ANKRD65 Gene

Relevant External Links for ANKRD65

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD65

No disorders were found for ANKRD65 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD65 Gene

Publications for ANKRD65 Gene

  1. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L … Zhang L (The Journal of biological chemistry 2013) 3 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60
  5. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 60

Products for ANKRD65 Gene

Sources for ANKRD65 Gene

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