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Aliases for ANKRD65 Gene

Aliases for ANKRD65 Gene

  • Ankyrin Repeat Domain 65 2 3 5

External Ids for ANKRD65 Gene

Previous GeneCards Identifiers for ANKRD65 Gene

  • GC01M001355
  • GC01M001358

Summaries for ANKRD65 Gene

GeneCards Summary for ANKRD65 Gene

ANKRD65 (Ankyrin Repeat Domain 65) is a Protein Coding gene. An important paralog of this gene is ANKRD17.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD65 Gene

Genomics for ANKRD65 Gene

Regulatory Elements for ANKRD65 Gene

Enhancers for ANKRD65 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F001420 1.1 ENCODE 33 -0.4 -365 3.0 HDGF MLX ARID4B DMAP1 SLC30A9 KLF13 SP5 ZHX2 REST ZNF592 ANKRD65 ATAD3B SLC35E2 SLC35E2B LOC100129381 ENSG00000272455 MIR6727 TMEM88B
GH01F001356 1.5 FANTOM5 ENCODE 20.3 +62.5 62450 6.5 HDGF ARID4B SIN3A YBX1 DMAP1 ZNF2 ZNF143 FOS KLF13 SP5 ANKRD65 CCNL2 LOC100288379 MIR6727 ENSG00000240731 LINC00115 LOC100129381 SLC35E2 FAM87B ENSG00000230092
GH01F001417 0.9 Ensembl 33.4 +3.8 3820 0.8 ZNF76 ARID4B KLF17 RAD21 ZNF335 GLIS2 EGR2 SP3 JUNB ZEB2 ANKRD65 GC01M001386 LOC105378585
GH01F001405 1.1 ENCODE 25.4 +14.8 14771 3.6 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ANKRD65 MRPL20 ENSG00000230092 LINC01770 LOC100288379 GC01P001407 RN7SL657P
GH01F001397 1.2 ENCODE 22.9 +21.7 21707 5.5 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ANKRD65 ATAD3C LINC01770 PUSL1 MRPL20 ATAD3B SSU72 AURKAIP1 LOC148413 RN7SL657P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD65 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD65 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000529001 1620 1201 CTCF POLR2A SMARCA4 RNF2 ZBTB7A ZBTB26 KDM6A

Genomic Location for ANKRD65 Gene

Chromosome:
1
Start:
1,418,420 bp from pter
End:
1,421,820 bp from pter
Size:
3,401 bases
Orientation:
Minus strand

Genomic View for ANKRD65 Gene

Genes around ANKRD65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD65 Gene

Proteins for ANKRD65 Gene

  • Protein details for ANKRD65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E5RJM6-ANR65_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 65
    Protein Accession:
    E5RJM6
    Secondary Accessions:
    • J3KR93

    Protein attributes for ANKRD65 Gene

    Size:
    399 amino acids
    Molecular mass:
    41497 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD65 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD65 Gene

Post-translational modifications for ANKRD65 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD65 Gene

Domains & Families for ANKRD65 Gene

Gene Families for ANKRD65 Gene

Protein Domains for ANKRD65 Gene

Graphical View of Domain Structure for InterPro Entry

E5RJM6

UniProtKB/Swiss-Prot:

ANR65_HUMAN :
  • Contains 10 ANK repeats.
Similarity:
  • Contains 10 ANK repeats.
genes like me logo Genes that share domains with ANKRD65: view

No data available for Suggested Antigen Peptide Sequences for ANKRD65 Gene

Function for ANKRD65 Gene

Phenotypes for ANKRD65 Gene

genes like me logo Genes that share phenotypes with ANKRD65: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD65 Gene

Localization for ANKRD65 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ANKRD65 Gene

Pathways & Interactions for ANKRD65 Gene

SuperPathways for ANKRD65 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD65 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD65 Gene

Transcripts for ANKRD65 Gene

Unigene Clusters for ANKRD65 Gene

Ankyrin repeat domain 65:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD65 Gene

No ASD Table

Relevant External Links for ANKRD65 Gene

GeneLoc Exon Structure for
ANKRD65
ECgene alternative splicing isoforms for
ANKRD65

Expression for ANKRD65 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD65 Gene

Protein differential expression in normal tissues from HIPED for ANKRD65 Gene

This gene is overexpressed in Pancreatic juice (64.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD65 Gene



Protein tissue co-expression partners for ANKRD65 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD65 Gene:

ANKRD65

SOURCE GeneReport for Unigene cluster for ANKRD65 Gene:

Hs.381222
genes like me logo Genes that share expression patterns with ANKRD65: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKRD65 Gene

Orthologs for ANKRD65 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD65 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC457197 34
  • 97.49 (n)
dog
(Canis familiaris)
Mammalia ANKRD65 34 35
  • 79.67 (n)
cow
(Bos Taurus)
Mammalia ANKRD65 34 35
  • 79.22 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd65 34
  • 71.47 (n)
mouse
(Mus musculus)
Mammalia Ankrd65 34 16
  • 69.96 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD65 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd65 34
  • 49 (n)
zebrafish
(Danio rerio)
Actinopterygii ANKRD65 35
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea trp-4 35
  • 8 (a)
OneToOne
Species where no ortholog for ANKRD65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKRD65 Gene

ENSEMBL:
Gene Tree for ANKRD65 (if available)
TreeFam:
Gene Tree for ANKRD65 (if available)

Paralogs for ANKRD65 Gene

Variants for ANKRD65 Gene

Sequence variations from dbSNP and Humsavar for ANKRD65 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111246269 -- 1,420,157(+) GCCCC(A/G)CGCCC intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs111436371 -- 1,418,211(+) GGCGA(A/G/T)GTGTT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs111685822 -- 1,419,806(+) TCAGG(C/T)ACAGG intron-variant, upstream-variant-2KB
rs111858202 -- 1,422,379(+) CGTGC(A/G)ACTCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs112321355 -- 1,422,280(+) CCACC(A/G)CCCCC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ANKRD65 Gene

Variant ID Type Subtype PubMed ID
nsv950452 CNV deletion 24416366
nsv545000 CNV loss 21841781
nsv482937 CNV loss 15286789
nsv1143428 CNV deletion 24896259
nsv1074445 CNV deletion 25765185
nsv10161 CNV gain+loss 18304495
nsv1011818 CNV gain 25217958
nsv1009541 CNV gain 25217958
esv3577672 CNV loss 25503493
esv2758913 CNV gain+loss 17122850
dgv2n67 CNV gain 20364138

Variation tolerance for ANKRD65 Gene

Gene Damage Index Score: 9.12; 87.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD65 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD65

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD65 Gene

Disorders for ANKRD65 Gene

Relevant External Links for ANKRD65

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD65

No disorders were found for ANKRD65 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD65 Gene

Publications for ANKRD65 Gene

  1. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for ANKRD65 Gene

Sources for ANKRD65 Gene

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