ANKRD65 Gene
protein-coding GIFtS: 32
GCID: GC01M001355
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ankyrin repeat domain 65
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Aliases
for ANKRD65 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Ankyrin Repeat Domain 651 2 | | Ankyrin Repeat Domain-Containing Protein 652 |
| External Ids: | HGNC: 429501 | Entrez Gene: 4418692 | Ensembl: ENSG000002350987 | UniProtKB: E5RJM63 | | ORGUL members: | |
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| NONCODE:n407416 | |
Export aliases for ANKRD65 gene to outside databases
|---|
Summaries
for ANKRD65 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ANKRD65 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004350.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ANKRD65
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKRD65
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD65 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33ANKRD65 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M001355: view genomic region
(about GC identifiers)
Start:
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1,353,800 bp from pter |
End:
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1,357,149 bp from pter |
Size:
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3,350 bases |
Orientation:
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minus strand |
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Proteins
for ANKRD65 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANR65_HUMAN, E5RJM6 (See
protein sequence)Recommended Name: Ankyrin repeat domain-containing protein 65 Size: 399 amino acids; 41497 Da
Secondary accessions: J3KR93Alternative splicing: 3 isoforms: E5RJM6-1 E5RJM6-2 E5RJM6-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ANKRD65: NX_E5RJM6
ANKRD65 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (3 alternative transcripts):
NP_001138682.1 NP_001230464.1 NP_001230465.1
ENSEMBL proteins: ENSP00000429035 ENSP00000428419 ENSP00000428201 ENSP00000427903 ENSP00000445688
Human Recombinant Protein Products:
ANKRD65 Antibody Products:
Assay Products for ANKRD65: |
Protein
Domains /
Families
for ANKRD65 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKRD65 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry E5RJM6ProtoNet protein and cluster: E5RJM6 UniProtKB/Swiss-Prot: ANR65_HUMAN, E5RJM6Similarity: Contains 10 ANK repeats |
Function
for ANKRD65 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD65 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD65
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for ANKRD65 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD65 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANKRD65 |
1 GenomeRNAi human phenotype for ANKRD65:
|
Pathways & Interactions
for ANKRD65 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD65
|
Drugs & Compounds
for ANKRD65 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKRD65
Search CenterWatch for drugs/clinical trials and news about ANKRD65 / ANR65
|
Transcripts
for ANKRD65 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKRD65 gene (3 alternative transcripts): NM_001145210.2 NM_001243535.1 NM_001243536.1 Unigene Cluster for ANKRD65: Ankyrin repeat domain 65 Hs.381222 [show with all ESTs]Unigene Representative Sequence: NM_0011452106 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000520296(uc001afp.3) ENST00000427211(uc001afq.3) ENST00000454272
ENST00000442470 ENST00000436362 ENST00000537107(uc010nyo.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD65 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD65
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for ANKRD65 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD65 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANKRD65 |
Additional cDNA sequence: BC018095.1 BC063445.1 BC073150.1 BC094869.1 M32220.1 6 DOTS entries: DT.100761671 DT.91690961 DT.95371719 DT.70103963 DT.100761676 DT.95242476 24/74 AceView cDNA sequences (see all 74): BE503132 BF515859 BI755193 BC073150 AI522076 AI190276 BU170270 CK819891 BM353987 BU731480 AI094806 BM563298 CB321756 BF724652 AI184936 BM142089 AI922941 BC063445 BE218962 BM465285 BE795877 BE798505 BC018095 BE263901
GeneLoc Exon Structure
|
Expression
for ANKRD65 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKRD65 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAATCTTC
About this image
Genevestigator expression for ANKRD65
SOURCE GeneReport for Unigene cluster: Hs.381222
SABiosciences Custom PCR Arrays for ANKRD65
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD65
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ANKRD65 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD65 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD65 |
Orthologs
for ANKRD65 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ANKRD65 gene from 3/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ANKRD656 |
-- |
30(a) |
1 ↔ 1 |
GL343701.1(77002-83449) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-203b8.61 |
si:ch211-203b8.6 |
50.31(n)
41.56(a) |
|
566073 NM_001128730.1 NP_001122202.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y32G9A.66 |
-- |
8(a) |
1 ↔ 1 |
V(1895796-1906518) |
ENSEMBL Gene Tree for ANKRD65 (if available)
TreeFam Gene Tree for ANKRD65 (if available) |
Paralogs
for ANKRD65 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKRD65 gene
- ANKRD162
18/24 SIMAP similar genes for ANKRD65 using alignment to 2 protein entries: ANR65_HUMAN (see all proteins)
(see all similar genes):ANKRD54 RAI14 ANKRD12 ASB8 GABPB1 PPP1R12A
DKFZp761E1322 MTPN ANK2 PSMD10 ANKRD6 ANKDD1A
ANKRD44 TNKS CASKIN2 IkBa ANKRD42 ASB3
ANKRD65 for paralogs About GeneDecksing
|
Genomic Variants
for ANKRD65 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKRD65 (1353800 - 1357149 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANKRD65: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ANKRD65 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ANKRD65 for disorders About GeneDecksing
1  disease for ANKRD65: About MalaCardslung cancer
Export disorders for ANKRD65 gene to outside databases
|
Publications
for ANKRD65 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKRD65 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANKRD65) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
- Transcription of human endogenous retroviral long terminal repeat (LTR) sequence in a lung cancer cell line. (PubMed id 2302192)1 Tomita N....Matsubara K. (1990)
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External Searches for ANKRD65 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ANKRD65 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKRD65 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANKRD65 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ANKRD65 gene:
Search GeneIP for patents involving ANKRD65
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKRD65 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ANKRD65 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKRD65 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD65 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ANKRD65 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD65 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD65 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANKRD65 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD65 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD65 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKRD65 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD65 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD65 |
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 |  |  |  | |
| | | | Search Tocris compounds for ANKRD65 |
| |  |  |  |  | | | | |
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 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for ANKRD65 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANKRD65 |
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