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Aliases for ANKRD63 Gene

Aliases for ANKRD63 Gene

  • Ankyrin Repeat Domain 63 2 3 5

External Ids for ANKRD63 Gene

Previous GeneCards Identifiers for ANKRD63 Gene

  • GC15M040574

Summaries for ANKRD63 Gene

GeneCards Summary for ANKRD63 Gene

ANKRD63 (Ankyrin Repeat Domain 63) is a Protein Coding gene. An important paralog of this gene is ANKRD46.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD63 Gene

Genomics for ANKRD63 Gene

Regulatory Elements for ANKRD63 Gene

Enhancers for ANKRD63 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G040090 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.1 +182.6 182629 18.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 DNAJC17 ENSG00000259211 BMF CHST14 SRP14-AS1 SRP14 RAD51-AS1 PLCB2 BUB1B EIF2AK4
GH15G040044 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +232.6 232571 12.1 HDGF FOXA2 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 BMF PLCB2 EIF2AK4 SRP14 PAK6 ANKRD63 C15orf56 RPLP0P10 SRP14-AS1 GC15M040064
GH15G040080 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +200.9 200871 3.5 PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 ZNF766 SP5 MXD4 NFYC SRP14 SRP14-AS1 BMF EIF2AK4 ANKRD63 PAK6 C15orf56 PLCB2 RPLP0P10 SPINT1
GH15G040326 1.6 Ensembl ENCODE dbSUPER 11.7 -58.1 -58077 28.7 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 ZNF766 CBX5 KNSTRN DISP2 IVD ENSG00000259211 DNAJC17 BAHD1 ANKRD63 RPLP0P10 PLCB2 C15orf56
GH15G040420 1.4 Ensembl ENCODE dbSUPER 12 -138.3 -138324 2.3 AGO1 ARID4B ZNF48 ZNF121 GLIS2 ZNF143 KLF13 REST KAT8 SMARCA4 KNSTRN IVD DISP2 PHGR1 C15orf52 RNA5SP392 ANKRD63 RPLP0P10 PLCB2 CHST14
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD63 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD63 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075488 587 801 HDAC1 ATF1 RB1 CREB3L1 AGO1 ZNF2 ZNF48 ZNF766 EGR1 EGR2

Genomic Location for ANKRD63 Gene

Chromosome:
15
Start:
40,278,369 bp from pter
End:
40,282,987 bp from pter
Size:
4,619 bases
Orientation:
Minus strand

Genomic View for ANKRD63 Gene

Genes around ANKRD63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD63 Gene

Proteins for ANKRD63 Gene

  • Protein details for ANKRD63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JTQ0-ANR63_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 63
    Protein Accession:
    C9JTQ0

    Protein attributes for ANKRD63 Gene

    Size:
    380 amino acids
    Molecular mass:
    39620 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD63 Gene

Post-translational modifications for ANKRD63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD63 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD63 Gene

Domains & Families for ANKRD63 Gene

Gene Families for ANKRD63 Gene

Protein Domains for ANKRD63 Gene

Suggested Antigen Peptide Sequences for ANKRD63 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD63: view

No data available for UniProtKB/Swiss-Prot for ANKRD63 Gene

Function for ANKRD63 Gene

Animal Model Products

miRNA for ANKRD63 Gene

miRTarBase miRNAs that target ANKRD63

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD63 Gene

Localization for ANKRD63 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD63 gene
Compartment Confidence
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD63 Gene

Pathways & Interactions for ANKRD63 Gene

SuperPathways for ANKRD63 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD63 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD63 Gene

Drugs & Compounds for ANKRD63 Gene

No Compound Related Data Available

Transcripts for ANKRD63 Gene

mRNA/cDNA for ANKRD63 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD63 Gene

Ankyrin repeat domain 63:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD63 Gene

No ASD Table

Relevant External Links for ANKRD63 Gene

GeneLoc Exon Structure for
ANKRD63
ECgene alternative splicing isoforms for
ANKRD63

Expression for ANKRD63 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD63 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD63 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x18.8), Brain - Putamen (basal ganglia) (x9.7), and Brain - Caudate (basal ganglia) (x8.6).

Protein differential expression in normal tissues from HIPED for ANKRD63 Gene

This gene is overexpressed in Saliva (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD63 Gene



Protein tissue co-expression partners for ANKRD63 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD63 Gene:

ANKRD63

SOURCE GeneReport for Unigene cluster for ANKRD63 Gene:

Hs.711376
genes like me logo Genes that share expression patterns with ANKRD63: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD63 Gene

Orthologs for ANKRD63 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ANKRD63 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD63 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia ANKRD63 34 35
  • 90 (n)
cow
(Bos Taurus)
Mammalia ANKRD63 34 35
  • 87.11 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd63 34
  • 86.93 (n)
mouse
(Mus musculus)
Mammalia Ankrd63 34 16 35
  • 86.58 (n)
Species where no ortholog for ANKRD63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANKRD63 Gene

ENSEMBL:
Gene Tree for ANKRD63 (if available)
TreeFam:
Gene Tree for ANKRD63 (if available)

Paralogs for ANKRD63 Gene

Paralogs for ANKRD63 Gene

(1) SIMAP similar genes for ANKRD63 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANKRD63: view

Variants for ANKRD63 Gene

Sequence variations from dbSNP and Humsavar for ANKRD63 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000268494 -- 40,280,331(+) ACACT(G/T)TAGTC utr-variant-3-prime
rs1000298837 -- 40,281,749(+) TGGTA(A/G)GGCCA reference, synonymous-codon
rs1000322635 -- 40,280,616(+) CTCCA(C/G)GGGTG utr-variant-3-prime
rs1001063169 -- 40,283,415(+) AATCC(C/G/T)AAAGT upstream-variant-2KB
rs1001120302 -- 40,277,971(+) AGAGC(C/T)TGGAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ANKRD63 Gene

Variant ID Type Subtype PubMed ID
esv34145 CNV loss 18971310
nsv457118 CNV loss 19166990
nsv471240 CNV loss 18288195
nsv510660 CNV deletion 20534489
nsv517541 CNV loss 19592680
nsv569227 CNV loss 21841781
nsv952611 CNV deletion 24416366

Variation tolerance for ANKRD63 Gene

Gene Damage Index Score: 2.21; 39.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD63 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD63

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD63 Gene

Disorders for ANKRD63 Gene

Relevant External Links for ANKRD63

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD63

No disorders were found for ANKRD63 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD63 Gene

Publications for ANKRD63 Gene

  1. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 64
  2. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4 64

Products for ANKRD63 Gene

Sources for ANKRD63 Gene

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