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Aliases for ANKRD63 Gene

Aliases for ANKRD63 Gene

  • Ankyrin Repeat Domain 63 2 3 5

External Ids for ANKRD63 Gene

Previous GeneCards Identifiers for ANKRD63 Gene

  • GC15M040574

Summaries for ANKRD63 Gene

GeneCards Summary for ANKRD63 Gene

ANKRD63 (Ankyrin Repeat Domain 63) is a Protein Coding gene. An important paralog of this gene is ANKRD46.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD63 Gene

Genomics for ANKRD63 Gene

Regulatory Elements for ANKRD63 Gene

Promoters for ANKRD63 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANKRD63 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKRD63 Gene

40,278,369 bp from pter
40,282,987 bp from pter
4,619 bases
Minus strand

Genomic View for ANKRD63 Gene

Genes around ANKRD63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD63 Gene

Proteins for ANKRD63 Gene

  • Protein details for ANKRD63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat domain-containing protein 63
    Protein Accession:

    Protein attributes for ANKRD63 Gene

    380 amino acids
    Molecular mass:
    39620 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD63 Gene

Proteomics data for ANKRD63 Gene at MOPED

Post-translational modifications for ANKRD63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD63 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD63 Gene

Domains & Families for ANKRD63 Gene

Gene Families for ANKRD63 Gene

Protein Domains for ANKRD63 Gene

Suggested Antigen Peptide Sequences for ANKRD63 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 ANK repeats.
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with ANKRD63: view

Function for ANKRD63 Gene

miRNA for ANKRD63 Gene

miRTarBase miRNAs that target ANKRD63

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD63 Gene

Localization for ANKRD63 Gene

Subcellular locations from

Jensen Localization Image for ANKRD63 Gene COMPARTMENTS Subcellular localization image for ANKRD63 gene
Compartment Confidence
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD63 Gene

Pathways & Interactions for ANKRD63 Gene

SuperPathways for ANKRD63 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD63 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKRD63 Gene

Drugs & Compounds for ANKRD63 Gene

No Compound Related Data Available

Transcripts for ANKRD63 Gene

mRNA/cDNA for ANKRD63 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD63 Gene

Ankyrin repeat domain 63:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD63 Gene

No ASD Table

Relevant External Links for ANKRD63 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRD63 Gene

mRNA expression in normal human tissues for ANKRD63 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD63 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x18.8), Brain - Putamen (basal ganglia) (x9.7), and Brain - Caudate (basal ganglia) (x8.6).

Protein differential expression in normal tissues from HIPED for ANKRD63 Gene

This gene is overexpressed in Saliva (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD63 Gene

SOURCE GeneReport for Unigene cluster for ANKRD63 Gene Hs.711376

genes like me logo Genes that share expression patterns with ANKRD63: view

Protein tissue co-expression partners for ANKRD63 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ANKRD63 Gene

Orthologs for ANKRD63 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ANKRD63 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANKRD63 35
  • 87.11 (n)
  • 92.89 (a)
ANKRD63 36
  • 94 (a)
(Canis familiaris)
Mammalia ANKRD63 35
  • 90 (n)
  • 95 (a)
ANKRD63 36
  • 96 (a)
(Mus musculus)
Mammalia Ankrd63 35
  • 86.58 (n)
  • 92.11 (a)
Ankrd63 16
Ankrd63 36
  • 86 (a)
(Pan troglodytes)
Mammalia ANKRD63 35
  • 99.47 (n)
  • 99.47 (a)
ANKRD63 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ankrd63 35
  • 86.93 (n)
  • 91.84 (a)
Species with no ortholog for ANKRD63:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANKRD63 Gene

Gene Tree for ANKRD63 (if available)
Gene Tree for ANKRD63 (if available)

Paralogs for ANKRD63 Gene

Paralogs for ANKRD63 Gene

(1) SIMAP similar genes for ANKRD63 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANKRD63: view

Variants for ANKRD63 Gene

Sequence variations from dbSNP and Humsavar for ANKRD63 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1869904 -- 40,278,251(-) CGTCC(C/T)ACTGT downstream-variant-500B
rs1869905 -- 40,278,189(-) CAGGC(C/G)GGGCC downstream-variant-500B
rs3214840 -- 40,279,150(-) CCCCG(-/CT)GTCTG utr-variant-3-prime
rs4924445 -- 40,281,212(+) AACCA(A/G)TCAAT intron-variant, downstream-variant-500B
rs4924446 -- 40,281,515(+) GACAG(A/G)CAGAG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ANKRD63 Gene

Variant ID Type Subtype PubMed ID
nsv904095 CNV Loss 21882294
nsv471240 CNV Loss 18288195
esv34145 CNV Loss 18971310
dgv2359n71 CNV Loss 21882294
nsv510660 CNV Loss 20534489
nsv517541 CNV Loss 19592680
nsv904098 CNV Loss 21882294
nsv457118 CNV Loss 19166990

Variation tolerance for ANKRD63 Gene

Gene Damage Index Score: 2.21; 39.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD63 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD63 Gene

Disorders for ANKRD63 Gene

Relevant External Links for ANKRD63

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANKRD63 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD63 Gene

Publications for ANKRD63 Gene

  1. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 67

Products for ANKRD63 Gene

Sources for ANKRD63 Gene

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