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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKRD60 Gene

protein-coding   GIFtS: 34
GCID: GC20M056793

Ankyrin Repeat Domain 60

(Previous name: chromosome 20 open reading frame 86)
(Previous symbol: C20orf86)
  Search for ANKRD60
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ankyrin Repeat Domain 601 2
C20orf861 2 3
Chromosome 20 Open Reading Frame 861
Ankyrin Repeat Domain-Containing Protein 602
bA196N14.32

External Ids:    HGNC: 162171   Entrez Gene: 1407312   Ensembl: ENSG000001242277   UniProtKB: Q9BZ193   

Export aliases for ANKRD60 gene to outside databases

Previous GC identifers: GC20M056227 GC20M053576


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ANKRD60 Gene: 
ANKRD60 (ankyrin repeat domain 60) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKRD60 gene promoter:
         Bach2   GCNF   Nkx2-5   FAC1   POU2F1   POU2F1a   GCNF-1   GCNF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ANKRD60

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD60


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.32   Ensembl cytogenetic band:  20q13.32   HGNC cytogenetic band: 20q13.32

ANKRD60 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD60 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M056793:  view genomic region     (about GC identifiers)

Start:
56,793,551 bp from pter      End:
56,803,709 bp from pter
Size:
10,159 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANR60_HUMAN, Q9BZ19 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 60  
Size: 345 amino acids; 37630 Da
Sequence caution: Sequence=CAI94996.3; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q4VXE6

Explore the universe of human proteins at neXtProt for ANKRD60: NX_Q9BZ19

Explore proteomics data for ANKRD60 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BZ19

  • ANKRD60 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANKRD60 Protein Expression

    ENSEMBL proteins: 
     ENSP00000360209   ENSP00000396747  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    3 InterPro protein domains:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR019955 Ubiquitin_supergroup
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q9BZ19

    ProtoNet protein and cluster: Q9BZ19

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: ANR60_HUMAN, Q9BZ19
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 ubiquitin-like domain


    ANKRD60 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ANKRD60 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD60

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANKRD60 (ANR60)

    Search CenterWatch for drugs/clinical trials and news about ANKRD60 / ANR60

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for ANKRD60 gene: 
    NM_080674.1  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371167 ENST00000457363
    miRNA
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    1 AceView cDNA sequence:

    NM_080674 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKRD60 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ANKRD60 Expression
    About this image


    See ANKRD60 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANKRD60
        SABiosciences Custom PCR Arrays for ANKRD60
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ANKRD60 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankrd601 , 5 ankyrin repeat domain 601, 5 72.61(n)1
    64.03(a)1
      2 (97.04 cM)5
    700651  NM_027303.11  NP_081579.11 
     1735686665 
    chicken
    (Gallus gallus)
    Aves ANKRD601 ankyrin repeat domain 60 54.57(n)
    45.97(a)
      419320  XM_417492.2  XP_417492.2 
    lizard
    (Anolis carolinensis)
    Reptilia ANKRD606
    Uncharacterized protein
    40(a)
    1 ↔ 1
    GL343217.1(215014-219317)


    ENSEMBL Gene Tree for ANKRD60 (if available)
    TreeFam Gene Tree for ANKRD60 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANKRD60 gene
    2 SIMAP similar genes for ANKRD60 using alignment to 2 protein entries:     ANR60_HUMAN (see all proteins):
    ANKRD54    CDKN2A

    ANKRD60 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/285 SNPs in ANKRD60 are shown (see all 285)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11925141,2
    C,F,A--53586014(+) AGCTCC/TCGCAC 2 R syn1 ese39Minor allele frequency- T:0.31MN NA NS CSA WA EA 623
    rs717052861,2
    C--53587016(+) GAATG-/A/AA  
            
    AAAAA
    1 -- us2k10--------
    rs1823314341,2
    C--53588414(+) AAACGC/TATGAA 1 -- us2k10--------
    rs739171091,2
    C--53588486(+) GGTGCG/ATAGAA 1 -- us2k13Minor allele frequency- A:0.18WA EA 240
    rs1869333221,2
    --53588586(+) CAGTTA/GTCAAT 1 -- us2k10--------
    rs1911599961,2
    --56762299(+) ACACAC/TGACCT 1 -- ds50010--------
    rs1834204471,2
    --56762300(+) CACACA/GACCTC 1 -- ds50010--------
    rs61237791,2
    H--56762531(+) ACAGGC/TTTACC 1 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs1875478261,2
    --56762575(+) AAACAA/GGACAG 1 -- ds50010--------
    rs1432102101,2
    C--56762599(+) TGATTC/GAGGTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ANKRD60 (56793551 - 56803709 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ANKRD60: --
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ANKRD60

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ANKRD60 for disorders           About MalaCards

    ANKRD60 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ANKRD60
    Human Genome Epidemiology (HuGE) Navigator: ANKRD60 (5 documents)

    Export disorders for ANKRD60 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKRD60 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ANKRD60)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of 15 loci influencing height in a Kor ean population. (PubMed id 19893584)1, 4 Kim J.J....Lee J.K. (2010)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    4. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140731 HGNC: 16217 AceView: C20orf86 Ensembl:ENSG00000124227 euGenes: HUgn140731
    ECgene: ANKRD60 H-InvDB: ANKRD60

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKRD60 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANKRD60 gene:
    Search GeneIP for patents involving ANKRD60

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD60
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ANKRD60
     Browse SwitchGear Promoter luciferase reporter plasmids for ANKRD60
     Search ThermoFisher Antibodies for ANKRD60
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANKRD60
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ANKRD60
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ANKRD60
    Customized:
     lentivirus for stable overexpression of ANKRD60
     lentivirus expression plasmids for stable overexpression of ANKRD60
     adenovirus for overexpression of ANKRD60
     LSBio Antibodies in human, mouse, rat for ANKRD60
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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