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Aliases for ANKRD60 Gene

Aliases for ANKRD60 Gene

  • Ankyrin Repeat Domain 60 2 3 5
  • C20orf86 3 4
  • Ankyrin Repeat Domain-Containing Protein 60 3
  • Chromosome 20 Open Reading Frame 86 2
  • BA196N14.3 3

External Ids for ANKRD60 Gene

Previous HGNC Symbols for ANKRD60 Gene

  • C20orf86

Previous GeneCards Identifiers for ANKRD60 Gene

  • GC20M056227
  • GC20M056793
  • GC20M053576

Summaries for ANKRD60 Gene

GeneCards Summary for ANKRD60 Gene

ANKRD60 (Ankyrin Repeat Domain 60) is a Protein Coding gene.

Additional gene information for ANKRD60 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD60 Gene

Genomics for ANKRD60 Gene

Regulatory Elements for ANKRD60 Gene

Enhancers for ANKRD60 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H058622 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -395.2 -395154 2 HDGF PKNOX1 SIN3A YBX1 ZBTB7B ZNF207 FOS REST SMARCB1 ZNF592 NELFCD LOC101927932 PPP4R1L STX16 ENSG00000270279 PIEZO1P2 ANKRD60 ENSG00000227282 ENSG00000254419 PIR40957
GH20H058649 1.5 ENCODE dbSUPER 14.6 -423.4 -423417 5 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC LOC101927932 PPP4R1L NELFCD ENSG00000254419 STX16 NPEPL1 ENSG00000270279 PIEZO1P2 ANKRD60 ENSG00000227282
GH20H058887 1.3 ENCODE dbSUPER 14.6 -663.9 -663903 9 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 PIEZO1P2 ENSG00000270279 ENSG00000227282 ANKRD60 LOC101927932 NELFCD PPP4R1L ENSG00000270951 GC20M058910
GH20H057627 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +599.8 599753 3 SIX4 L3MBTL2 CEBPB MAX USF2 GABPA MTA3 POLR2A ETV6 SPI1 ZBP1 ANKRD60 RBM38 GC20P057650
GH20H058372 1.2 Ensembl ENCODE 10.3 -145.8 -145834 4 HDGF ATF1 TCF12 ZNF207 REST MIER2 ZNF592 KAT8 MEF2D NFIL3 PPP4R1L RAB22A ANKRD60 APCDD1L APCDD1L-AS1 ENSG00000254419 VAPB PIR40663
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD60 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKRD60 Gene

Chromosome:
20
Start:
58,216,126 bp from pter
End:
58,228,653 bp from pter
Size:
12,528 bases
Orientation:
Minus strand

Genomic View for ANKRD60 Gene

Genes around ANKRD60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD60 Gene

Proteins for ANKRD60 Gene

  • Protein details for ANKRD60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZ19-ANR60_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 60
    Protein Accession:
    Q9BZ19
    Secondary Accessions:
    • Q4VXE6

    Protein attributes for ANKRD60 Gene

    Size:
    345 amino acids
    Molecular mass:
    37630 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI94996.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ANKRD60 Gene

Post-translational modifications for ANKRD60 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD60 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD60 Gene

Domains & Families for ANKRD60 Gene

Gene Families for ANKRD60 Gene

Protein Domains for ANKRD60 Gene

Suggested Antigen Peptide Sequences for ANKRD60 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD60: view

No data available for UniProtKB/Swiss-Prot for ANKRD60 Gene

Function for ANKRD60 Gene

Phenotypes From GWAS Catalog for ANKRD60 Gene

Phenotypes for ANKRD60 Gene

GenomeRNAi human phenotypes for ANKRD60:
genes like me logo Genes that share phenotypes with ANKRD60: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ANKRD60
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD60 Gene

Localization for ANKRD60 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD60 gene
Compartment Confidence
mitochondrion 3
cytosol 3
peroxisome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ANKRD60 Gene

Pathways & Interactions for ANKRD60 Gene

SuperPathways for ANKRD60 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD60 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD60 Gene

Drugs & Compounds for ANKRD60 Gene

No Compound Related Data Available

Transcripts for ANKRD60 Gene

mRNA/cDNA for ANKRD60 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ANKRD60
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD60 Gene

No ASD Table

Relevant External Links for ANKRD60 Gene

GeneLoc Exon Structure for
ANKRD60
ECgene alternative splicing isoforms for
ANKRD60

Expression for ANKRD60 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD60 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD60 Gene

This gene is overexpressed in Testis (x52.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD60 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANKRD60 Gene:

ANKRD60
genes like me logo Genes that share expression patterns with ANKRD60: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD60 Gene

Orthologs for ANKRD60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD60 33 34
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia ANKRD60 33 34
  • 79.19 (n)
dog
(Canis familiaris)
Mammalia ANKRD60 33 34
  • 78.07 (n)
mouse
(Mus musculus)
Mammalia Ankrd60 33 16 34
  • 73.16 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd60 33
  • 72.65 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD60 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD60 33 34
  • 56.65 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD60 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd60 33
  • 51.44 (n)
Species where no ortholog for ANKRD60 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANKRD60 Gene

ENSEMBL:
Gene Tree for ANKRD60 (if available)
TreeFam:
Gene Tree for ANKRD60 (if available)

Paralogs for ANKRD60 Gene

(2) SIMAP similar genes for ANKRD60 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD60: view

No data available for Paralogs for ANKRD60 Gene

Variants for ANKRD60 Gene

Sequence variations from dbSNP and Humsavar for ANKRD60 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000549632 -- 58,228,722(+) CCATG(C/G)GCCCC upstream-variant-2KB
rs1000813832 -- 58,215,745(+) CCCAA(G/T)GCCAC downstream-variant-500B
rs1000951879 -- 58,217,173(+) TGCCT(A/G)TAAAT utr-variant-3-prime
rs1001097610 -- 58,222,667(+) CAGCA(A/C)CTGGC intron-variant
rs1001263498 -- 58,222,462(+) TCCGA(A/G)TTTCT intron-variant

Variation tolerance for ANKRD60 Gene

Gene Damage Index Score: 7.62; 82.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD60 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANKRD60 Gene

Disorders for ANKRD60 Gene

Relevant External Links for ANKRD60

Genetic Association Database (GAD)
ANKRD60
Human Genome Epidemiology (HuGE) Navigator
ANKRD60
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD60

No disorders were found for ANKRD60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD60 Gene

Publications for ANKRD60 Gene

  1. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim JJ … Lee JK (Journal of human genetics 2010) 3 45 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 60

Products for ANKRD60 Gene

Sources for ANKRD60 Gene

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