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ANKRD60 Gene

protein-coding   GIFtS: 34
GCID: GC20M056793

Ankyrin Repeat Domain 60

(Previous name: chromosome 20 open reading frame 86)
(Previous symbol: C20orf86)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 601 2
C20orf861 2 3
Chromosome 20 Open Reading Frame 861
Ankyrin Repeat Domain-Containing Protein 602
bA196N14.32

External Ids:    HGNC: 162171   Entrez Gene: 1407312   Ensembl: ENSG000001242277   UniProtKB: Q9BZ193   

Export aliases for ANKRD60 gene to outside databases

Previous GC identifers: GC20M056227 GC20M053576


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD60 Gene:
ANKRD60 (ankyrin repeat domain 60) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD60 gene promoter:
         Bach2   GCNF   Nkx2-5   FAC1   POU2F1   POU2F1a   GCNF-1   GCNF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ANKRD60

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD60


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.32   Ensembl cytogenetic band:  20q13.32   HGNC cytogenetic band: 20q13.32

ANKRD60 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD60 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M056793:  view genomic region     (about GC identifiers)

Start:
56,793,551 bp from pter      End:
56,803,709 bp from pter
Size:
10,159 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANR60_HUMAN, Q9BZ19 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 60  
Size: 345 amino acids; 37630 Da
Sequence caution: Sequence=CAI94996.3; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q4VXE6

Explore the universe of human proteins at neXtProt for ANKRD60: NX_Q9BZ19

Explore proteomics data for ANKRD60 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANKRD60 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000360209   ENSP00000396747  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    3 InterPro protein domains:
     IPR000626 Ubiquitin_dom
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9BZ19

    ProtoNet protein and cluster: Q9BZ19

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: ANR60_HUMAN, Q9BZ19
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 ubiquitin-like domain


    Find genes that share domains with ANKRD60           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ANKRD60           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ANKRD60

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion3
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD60
    Interactions:

        Search GeneGlobe Interaction Network for ANKRD60

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKRD60 (ANR60)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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    REFSEQ mRNAs for ANKRD60 gene: 
    NM_080674.1  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371167 ENST00000457363
    miRNA
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    1 AceView cDNA sequence:

    NM_080674 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKRD60 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ANKRD60 Expression
    About this image

    ANKRD60 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKRD60 Protein Expression
        Custom PCR Arrays for ANKRD60
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ANKRD60 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankrd601 , 5 ankyrin repeat domain 601, 5 73.16(n)1
    66.67(a)1
      2 (97.04 cM)5
    700651  NM_027303.11  NP_081579.11 
     1735686665 
    chicken
    (Gallus gallus)
    Aves ANKRD601 ankyrin repeat domain 60 56.65(n)
    47.85(a)
      419320  XM_004947216.1  XP_004947273.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANKRD606
    ankyrin repeat domain 60
    40(a)
    1 ↔ 1
    GL343217.1(215014-219317)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ankrd601 ankyrin repeat domain 60 51.44(n)
    44.44(a)
      100379950  XM_002932109.2  XP_002932155.1 


    ENSEMBL Gene Tree for ANKRD60 (if available)
    TreeFam Gene Tree for ANKRD60 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKRD60 gene
    2 SIMAP similar genes for ANKRD60 using alignment to 2 protein entries:     ANR60_HUMAN (see all proteins):
    ANKRD54    CDKN2A

    Find genes that share paralogs with ANKRD60           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKRD60 (see all 285)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11925141,2
    C,F,A--53586014(+) AGCTCC/TCGCAC 2 R syn1 ese39Minor allele frequency- T:0.31MN NA NS CSA WA EA 623
    rs717052861,2
    C--53587016(+) GAATG-/A/AA  
            
    AAAAA
    1 -- us2k10--------
    rs1823314341,2
    C--53588414(+) AAACGC/TATGAA 1 -- us2k10--------
    rs739171091,2
    C--53588486(+) GGTGCG/ATAGAA 1 -- us2k13Minor allele frequency- A:0.18WA EA 240
    rs1869333221,2
    --53588586(+) CAGTTA/GTCAAT 1 -- us2k10--------
    rs1911599961,2
    --56762299(+) ACACAC/TGACCT 1 -- ds50010--------
    rs1834204471,2
    --56762300(+) CACACA/GACCTC 1 -- ds50010--------
    rs61237791,2
    H--56762531(+) ACAGGC/TTTACC 1 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs1875478261,2
    --56762575(+) AAACAA/GGACAG 1 -- ds50010--------
    rs1432102101,2
    C--56762599(+) TGATTC/GAGGTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ANKRD60 (56793551 - 56803709 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ANKRD60: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANKRD60
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ANKRD60           About GenesLikeMe

    Genetic Association Database (GAD): ANKRD60
    Human Genome Epidemiology (HuGE) Navigator: ANKRD60 (5 documents)

    Export disorders for ANKRD60 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKRD60 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ANKRD60)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of 15 loci influencing height in a Korean population. (PubMed id 19893584)1, 4 Kim J.J....Lee J.K. (J. Hum. Genet. 2010)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140731 HGNC: 16217 AceView: C20orf86 Ensembl:ENSG00000124227 euGenes: HUgn140731
    ECgene: ANKRD60 H-InvDB: ANKRD60

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKRD60 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKRD60 gene:
    Search GeneIP for patents involving ANKRD60

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse compounds at ApexBio
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      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ANKRD60
     antibodies-online antibodies for ANKRD60 (8 products)
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     antibodies-online peptides for ANKRD60
     antibodies-online proteins for ANKRD60
           
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