Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANKRD60 Gene

Aliases for ANKRD60 Gene

  • Ankyrin Repeat Domain 60 2 3 5
  • C20orf86 3 4
  • Ankyrin Repeat Domain-Containing Protein 60 3
  • Chromosome 20 Open Reading Frame 86 2
  • BA196N14.3 3

External Ids for ANKRD60 Gene

Previous HGNC Symbols for ANKRD60 Gene

  • C20orf86

Previous GeneCards Identifiers for ANKRD60 Gene

  • GC20M056227
  • GC20M056793
  • GC20M053576

Summaries for ANKRD60 Gene

GeneCards Summary for ANKRD60 Gene

ANKRD60 (Ankyrin Repeat Domain 60) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD60 Gene

Genomics for ANKRD60 Gene

Regulatory Elements for ANKRD60 Gene

Enhancers for ANKRD60 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G057627 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +599.8 599753 3.5 SIX4 CTCF MAX RAD21 GATA3 POLR2A NFYB SMC3 ETV6 L3MBTL2 ZBP1 ANKRD60 RBM38 GC20P057650
GH20G058372 1.3 Ensembl ENCODE 10.3 -145.8 -145834 4.2 HDGF ATF1 YBX1 ZNF48 TCF12 ZNF207 NFYC REST MIER2 ZNF592 RAB22A PPP4R1L ANKRD60 APCDD1L APCDD1L-AS1 VAPB PIR40663
GH20G058456 1.3 FANTOM5 ENCODE 10.3 -229.4 -229403 2.8 HDGF PKNOX1 WRNIP1 YBX1 ZBTB7B GLIS2 GATA2 CBX5 ZNF143 ZNF207 VAPB ANKRD60 APCDD1L-AS1
GH20G058407 1.2 Ensembl ENCODE 10 -179.7 -179746 2.5 ELF3 PKNOX1 ARNT ARID4B ZBTB40 SCRT2 FOS IKZF2 CREM ZNF362 VAPB ANKRD60 APCDD1L-AS1
GH20G058179 1.1 Ensembl ENCODE 10.3 +49.0 48980 1.1 RB1 NFIB SIN3A ZNF2 ZNF48 ZBTB7B RAD21 GLIS2 EGR1 ZNF143 PCK1 ANKRD60 CTCFL LOC105372694 C20orf85
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD60 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKRD60 Gene

Chromosome:
20
Start:
58,216,126 bp from pter
End:
58,228,653 bp from pter
Size:
12,528 bases
Orientation:
Minus strand

Genomic View for ANKRD60 Gene

Genes around ANKRD60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD60 Gene

Proteins for ANKRD60 Gene

  • Protein details for ANKRD60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZ19-ANR60_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 60
    Protein Accession:
    Q9BZ19
    Secondary Accessions:
    • Q4VXE6

    Protein attributes for ANKRD60 Gene

    Size:
    345 amino acids
    Molecular mass:
    37630 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI94996.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ANKRD60 Gene

Post-translational modifications for ANKRD60 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD60 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD60 Gene

Domains & Families for ANKRD60 Gene

Gene Families for ANKRD60 Gene

Protein Domains for ANKRD60 Gene

Suggested Antigen Peptide Sequences for ANKRD60 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD60: view

No data available for UniProtKB/Swiss-Prot for ANKRD60 Gene

Function for ANKRD60 Gene

Phenotypes for ANKRD60 Gene

GenomeRNAi human phenotypes for ANKRD60:
genes like me logo Genes that share phenotypes with ANKRD60: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD60 Gene

Localization for ANKRD60 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD60 gene
Compartment Confidence
mitochondrion 3
cytosol 3
peroxisome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD60 Gene

Pathways & Interactions for ANKRD60 Gene

SuperPathways for ANKRD60 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD60 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD60 Gene

Drugs & Compounds for ANKRD60 Gene

No Compound Related Data Available

Transcripts for ANKRD60 Gene

mRNA/cDNA for ANKRD60 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD60 Gene

No ASD Table

Relevant External Links for ANKRD60 Gene

GeneLoc Exon Structure for
ANKRD60
ECgene alternative splicing isoforms for
ANKRD60

Expression for ANKRD60 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD60 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD60 Gene

This gene is overexpressed in Testis (x52.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD60 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANKRD60 Gene:

ANKRD60
genes like me logo Genes that share expression patterns with ANKRD60: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD60 Gene

Orthologs for ANKRD60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD60 34 35
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia ANKRD60 34 35
  • 79.19 (n)
dog
(Canis familiaris)
Mammalia ANKRD60 34 35
  • 78.07 (n)
mouse
(Mus musculus)
Mammalia Ankrd60 34 16 35
  • 73.16 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd60 34
  • 72.65 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD60 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD60 34 35
  • 56.65 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD60 35
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd60 34
  • 51.44 (n)
Species where no ortholog for ANKRD60 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANKRD60 Gene

ENSEMBL:
Gene Tree for ANKRD60 (if available)
TreeFam:
Gene Tree for ANKRD60 (if available)

Paralogs for ANKRD60 Gene

(2) SIMAP similar genes for ANKRD60 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD60: view

No data available for Paralogs for ANKRD60 Gene

Variants for ANKRD60 Gene

Sequence variations from dbSNP and Humsavar for ANKRD60 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000549632 -- 58,228,722(+) CCATG(C/G)GCCCC upstream-variant-2KB
rs1000813832 -- 58,215,745(+) CCCAA(G/T)GCCAC downstream-variant-500B
rs1000951879 -- 58,217,173(+) TGCCT(A/G)TAAAT utr-variant-3-prime
rs1001097610 -- 58,222,667(+) CAGCA(A/C)CTGGC intron-variant
rs1001263498 -- 58,222,462(+) TCCGA(A/G)TTTCT intron-variant

Variation tolerance for ANKRD60 Gene

Gene Damage Index Score: 7.62; 82.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD60 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANKRD60 Gene

Disorders for ANKRD60 Gene

Relevant External Links for ANKRD60

Genetic Association Database (GAD)
ANKRD60
Human Genome Epidemiology (HuGE) Navigator
ANKRD60
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD60

No disorders were found for ANKRD60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD60 Gene

Publications for ANKRD60 Gene

  1. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim J.J. … Lee J.K. (J. Hum. Genet. 2010) 3 46 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3 64

Products for ANKRD60 Gene

Sources for ANKRD60 Gene

Content
Loading form....