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Aliases for ANKRD6 Gene

Aliases for ANKRD6 Gene

  • Ankyrin Repeat Domain 6 2 3
  • Diversin 2 3 4
  • KIAA0957 4

External Ids for ANKRD6 Gene

Previous GeneCards Identifiers for ANKRD6 Gene

  • GC06P090222
  • GC06P090093
  • GC06P090138
  • GC06P090199
  • GC06P090142
  • GC06P087360

Summaries for ANKRD6 Gene

GeneCards Summary for ANKRD6 Gene

ANKRD6 (Ankyrin Repeat Domain 6) is a Protein Coding gene. Among its related pathways are Wnt signaling pathway (KEGG). An important paralog of this gene is ANKRD1.

UniProtKB/Swiss-Prot for ANKRD6 Gene

  • Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD6 Gene

Genomics for ANKRD6 Gene

Regulatory Elements for ANKRD6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ANKRD6 Gene

Chromosome:
6
Start:
89,433,170 bp from pter
End:
89,633,834 bp from pter
Size:
200,665 bases
Orientation:
Plus strand

Genomic View for ANKRD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD6 Gene

Proteins for ANKRD6 Gene

  • Protein details for ANKRD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2G4-ANKR6_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 6
    Protein Accession:
    Q9Y2G4
    Secondary Accessions:
    • B3KUC3
    • Q5JUJ4
    • Q5JUJ5
    • Q8IUQ8
    • Q9NU24
    • Q9UFQ9

    Protein attributes for ANKRD6 Gene

    Size:
    727 amino acids
    Molecular mass:
    79971 Da
    Quaternary structure:
    • Interacts with AXN1, AXN2 and CSNK1E/CKI-epsilon.
    SequenceCaution:
    • Sequence=BAA76801.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD6 Gene

Proteomics data for ANKRD6 Gene at MOPED

Post-translational modifications for ANKRD6 Gene

  • Ubiquitination at Lys 40
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANKRD6 Gene

Domains & Families for ANKRD6 Gene

Gene Families for ANKRD6 Gene

Protein Domains for ANKRD6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2G4

UniProtKB/Swiss-Prot:

ANKR6_HUMAN :
  • Contains 8 ANK repeats.
Similarity:
  • Contains 8 ANK repeats.
genes like me logo Genes that share domains with ANKRD6: view

Function for ANKRD6 Gene

Molecular function for ANKRD6 Gene

UniProtKB/Swiss-Prot Function:
Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.

Gene Ontology (GO) - Molecular Function for ANKRD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ANKRD6: view

Phenotypes for ANKRD6 Gene

genes like me logo Genes that share phenotypes with ANKRD6: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKRD6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD6 Gene

Localization for ANKRD6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD6 Gene COMPARTMENTS Subcellular localization image for ANKRD6 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ANKRD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ANKRD6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANKRD6 Gene

Pathways & Interactions for ANKRD6 Gene

SuperPathways for ANKRD6 Gene

Superpath Contained pathways
1 Wnt signaling pathway (KEGG)
genes like me logo Genes that share pathways with ANKRD6: view

Pathways by source for ANKRD6 Gene

1 BioSystems pathway for ANKRD6 Gene

SIGNOR curated interactions for ANKRD6 Gene

Activates:

Gene Ontology (GO) - Biological Process for ANKRD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046330 positive regulation of JNK cascade IBA --
GO:0090090 negative regulation of canonical Wnt signaling pathway IBA --
GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway IEA --
genes like me logo Genes that share ontologies with ANKRD6: view

Drugs & Compounds for ANKRD6 Gene

No Compound Related Data Available

Transcripts for ANKRD6 Gene

Unigene Clusters for ANKRD6 Gene

Ankyrin repeat domain 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKRD6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - - - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - -
SP5:
SP6:
SP7: -
SP8: - - - -
SP9:
SP10: - - - - - - - - - - - - - - -
SP11: - -
SP12:
SP13: - - -
SP14: -
SP15: - - - - - -

ExUns: 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b · 22c
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10: - -
SP11: -
SP12: -
SP13:
SP14:
SP15:

Relevant External Links for ANKRD6 Gene

GeneLoc Exon Structure for
ANKRD6
ECgene alternative splicing isoforms for
ANKRD6

Expression for ANKRD6 Gene

mRNA expression in normal human tissues for ANKRD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD6 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.5) and Brain - Cerebellum (x4.5).

Protein differential expression in normal tissues from HIPED for ANKRD6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD6 Gene



SOURCE GeneReport for Unigene cluster for ANKRD6 Gene Hs.702213

genes like me logo Genes that share expression patterns with ANKRD6: view

Protein tissue co-expression partners for ANKRD6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ANKRD6 Gene

Orthologs for ANKRD6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANKRD6 35
  • 89.43 (n)
  • 91.69 (a)
ANKRD6 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD6 35
  • 90.92 (n)
  • 92.71 (a)
ANKRD6 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd6 35
  • 84.93 (n)
  • 84.97 (a)
Ankrd6 16
Ankrd6 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANKRD6 35
  • 99.54 (n)
  • 99.59 (a)
ANKRD6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd6 35
  • 84.43 (n)
  • 84.43 (a)
oppossum
(Monodelphis domestica)
Mammalia ANKRD6 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD6 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD6 35
  • 73.34 (n)
  • 77.5 (a)
ANKRD6 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD6 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd6 35
  • 66.53 (n)
  • 67.59 (a)
zebrafish
(Danio rerio)
Actinopterygii ankrd6 35
ankrd6b 35
  • 60.23 (n)
  • 57.18 (a)
ankrd6a 36
  • 40 (a)
OneToMany
ankrd6b 36
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dgo 36
  • 17 (a)
OneToOne
Species with no ortholog for ANKRD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD6 Gene

ENSEMBL:
Gene Tree for ANKRD6 (if available)
TreeFam:
Gene Tree for ANKRD6 (if available)

Paralogs for ANKRD6 Gene

Paralogs for ANKRD6 Gene

genes like me logo Genes that share paralogs with ANKRD6: view

Variants for ANKRD6 Gene

Sequence variations from dbSNP and Humsavar for ANKRD6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs41487148 -- 89,616,938(+) ACTGA(C/T)GAGTG intron-variant
rs41439454 -- 89,461,364(-) ACTAA(C/T)GTACT intron-variant
rs41273321 -- 89,596,096(+) TGTGA(A/G)ATGGG intron-variant
rs36197559 -- 89,578,186(+) TATGC(-/T)TTTCA intron-variant
rs36125165 -- 89,495,384(+) CAGCA(-/G)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD6 Gene

Variant ID Type Subtype PubMed ID
nsv886338 CNV Loss 21882294
esv2732410 CNV Deletion 23290073
esv2667529 CNV Deletion 23128226
esv2732411 CNV Deletion 23290073
nsv886339 CNV Loss 21882294
nsv886340 CNV Loss 21882294

Variation tolerance for ANKRD6 Gene

Residual Variation Intolerance Score: 77.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.41; 81.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD6 Gene

HapMap Linkage Disequilibrium report
ANKRD6
Human Gene Mutation Database (HGMD)
ANKRD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD6 Gene

Disorders for ANKRD6 Gene

Relevant External Links for ANKRD6

Genetic Association Database (GAD)
ANKRD6
Human Genome Epidemiology (HuGE) Navigator
ANKRD6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD6
genes like me logo Genes that share disorders with ANKRD6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD6 Gene

Publications for ANKRD6 Gene

  1. Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear. (PMID: 25218921) Jones C. … Chen P. (Dev. Biol. 2014) 2 67
  2. Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways. (PMID: 19802005) van Amerongen R. … Berns A. (Oncogene 2010) 23 67
  3. Centrosomal localization of Diversin and its relevance to Wnt signaling. (PMID: 19789178) Itoh K. … Sokol S.Y. (J. Cell. Sci. 2009) 23 67
  4. The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9. (PMID: 19591803) Haribaskar R. … SchAofer T. (Biochem. Biophys. Res. Commun. 2009) 23 67
  5. Diversolides A-G, guaianolides from the roots of Ferula diversivittata. (PMID: 18804823) Iranshahi M. … Ahmad V.U. (Phytochemistry 2008) 23 67

Products for ANKRD6 Gene

Sources for ANKRD6 Gene

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