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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKRD6 Gene

protein-coding   GIFtS: 53
GCID: GC06P090142

Ankyrin Repeat Domain 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ankyrin Repeat Domain 61 2
KIAA09573 5
Ankyrin Repeat Domain-Containing Protein 62
diversin2
Diversin3

External Ids:    HGNC: 172801   Entrez Gene: 228812   Ensembl: ENSG000001352997   OMIM: 6105835   UniProtKB: Q9Y2G43   

Export aliases for ANKRD6 gene to outside databases

Previous GC identifers: GC06P090222 GC06P090093 GC06P090138 GC06P090199 GC06P087360


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ANKRD6 Gene: 
ANKRD6 (ankyrin repeat domain 6) is a protein-coding gene. Diseases associated with ANKRD6 include skin squamous cell carcinoma, and situs inversus, and among its related super-pathways are Wnt signaling pathway. An important paralog of this gene is ANKDD1A.

UniProtKB/Swiss-Prot: ANKR6_HUMAN, Q9Y2G4
Function: Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta
and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007299.13  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKRD6 gene promoter:
         COUP-TF1   c-Fos   AP-1   ATF-2   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANKRD6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.2-q16.1   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q14.2-q16.1

ANKRD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD6 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P090142:  view genomic region     (about GC identifiers)

Start:
90,142,889 bp from pter      End:
90,343,553 bp from pter
Size:
200,665 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANKR6_HUMAN, Q9Y2G4 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 6  
Size: 727 amino acids; 79971 Da
Subunit: Interacts with AXN1, AXN2 and CSNK1E/CKI-epsilon (By similarity)
Sequence caution: Sequence=BAA76801.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KUC3 Q5JUJ4 Q5JUJ5 Q8IUQ8 Q9NU24 Q9UFQ9
Alternative splicing: 4 isoforms:  Q9Y2G4-2   Q9Y2G4-1   Q9Y2G4-3   Q9Y2G4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD6: NX_Q9Y2G4

Explore proteomics data for ANKRD6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2G4

  • ANKRD6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANKRD6 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001229738.1  NP_001229740.1  NP_001229742.1  NP_001229743.1  NP_055757.3  

    ENSEMBL proteins: 
     ENSP00000358416   ENSP00000345767   ENSP00000396771   ENSP00000431061   ENSP00000429431  
     ENSP00000428377   ENSP00000430985   ENSP00000429337   ENSP00000430954   ENSP00000428309  
     ENSP00000429235   ENSP00000429782   ENSP00000429456   ENSP00000429531   ENSP00000430452  

    Human Recombinant Protein Products for ANKRD6: 
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    Novus Biologicals ANKRD6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANKRD6 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    ANKRD6 for ontologies           About GeneDecksing



    ANKRD6 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q9Y2G4

    ProtoNet protein and cluster: Q9Y2G4

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: ANKR6_HUMAN, Q9Y2G4
    Similarity: Contains 8 ANK repeats


    ANKRD6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANKR6_HUMAN, Q9Y2G4
    Function: Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta
    and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ANKRD6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ANKRD6:
     Decreased Tat-dependent transc  Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ANKRD6 
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    SwitchGear 3'UTR luciferase reporter plasmidANKRD6 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ANKRD6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt Signaling Pathway NetPath0.37


    1 BioSystems Pathway for ANKRD6
        Wnt Signaling Pathway NetPath


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANKRD6

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/7 Interacting proteins for ANKRD6 (Q9Y2G43 ENSP000003967714) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN2Q9Y2T13, ENSP000003026254I2D: score=2 STRING: ENSP00000302625
    CSNK1EP496743, ENSP000003529294I2D: score=2 STRING: ENSP00000352929
    C20orf24Q9BUV83, ENSP000003412134I2D: score=1 STRING: ENSP00000341213
    GSK3BP498413, ENSP000003248064I2D: score=1 STRING: ENSP00000324806
    AXIN1O151693I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0090090negative regulation of canonical Wnt receptor signaling pathway IEA--
    GO:2000096positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway IEA--

    ANKRD6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANKRD6 (ANKR6)

    Search CenterWatch for drugs/clinical trials and news about ANKRD6 / ANKR6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANKRD6 gene (5 alternative transcripts): 
    NM_001242809.1  NM_001242811.1  NM_001242813.1  NM_001242814.1  NM_014942.4  

    Unigene Cluster for ANKRD6:

    Ankyrin repeat domain 6
    Hs.702213  [show with all ESTs]
    Unigene Representative Sequence: NM_001242811
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000369408(uc003pne.4 uc003pni.4 uc003pnf.4 uc011dzy.2 uc010kcd.3)
    ENST00000520886 ENST00000339746 ENST00000447838 ENST00000520458 ENST00000465722
    ENST00000523798 ENST00000522441 ENST00000522779 ENST00000485637 ENST00000522705
    ENST00000518150 ENST00000520793 ENST00000518253 ENST00000524056 ENST00000520839
    ENST00000415924(uc003pnj.4) ENST00000479572
    miRNA
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    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate ANKRD6 (see all 31):
    hsa-miR-3164 hsa-miR-3934 hsa-miR-3128 hsa-miR-3200-5p hsa-miR-331-3p hsa-miR-373* hsa-miR-570 hsa-miR-27b*
    SwitchGear 3'UTR luciferase reporter plasmidANKRD6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKRD6
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANKRD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD6
    Sirion Biotech Customized lentivirus for stable overexpression of ANKRD6 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD6

    Additional mRNA sequence: 

    AB023174.1 AK021550.1 AK022699.1 AK074189.1 AK096867.1 AK295731.1 AK307792.1 AL117504.1 
    BC001078.2 BC042173.1 GU727626.1 

    17 DOTS entries:

    DT.97840648  DT.95367282  DT.40114639  DT.86849329  DT.100781528  DT.75146372  DT.97840649  DT.100022974 
    DT.109922  DT.91899112  DT.121383804  DT.121383821  DT.121383837  DT.121383880  DT.121383919  DT.121384025 
    DT.95317635 

    24/101 AceView cDNA sequences (see all 101):

    CB305804 AI222135 AI769641 BM907460 AI638241 BM998304 BM894090 AW270134 
    AA294856 AA443269 AW183582 BE677131 AI002436 CR608573 AA782996 AW103682 
    AA649159 BM986732 AL133992 CB047361 CB850929 BU948165 CA393945 AA994438 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD6 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
    SP1:        -     -     -     -     -     -     -                                                                                   -                 -     -   
    SP2:                                                                                                                                -                 -     -   
    SP3:                                                                                                        -     -                 -           -     -     -   
    SP4:                                                                                                                                -                 -     -   
    SP5:                                                                                                                                                            

    ExUns: 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b · 22c
    SP1:  -                                                     -           -     -                     
    SP2:  -     -                                               -                 -                     
    SP3:  -                                                     -           -     -                     
    SP4:  -                                                     -                 -                     
    SP5:                                                                    -     -                     


    ECgene alternative splicing isoforms for ANKRD6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKRD6 expression in normal human tissues (normalized intensities)      ANKRD6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTAAAAAAA
    ANKRD6 Expression
    About this image


    ANKRD6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Endothelial Cells Blood Brain Barrier
             Medulla Oblongata
             cerebellum   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Zeugopod Periosteum
             HyStem+BMP4-induced 4D20.8 cells
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose/nasal cavity   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon

    See ANKRD6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANKRD6

    SOURCE GeneReport for Unigene cluster: Hs.702213
        SABiosciences Custom PCR Arrays for ANKRD6
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ANKRD6 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankrd61 , 5 ankyrin repeat domain 61, 5 84.97(n)1
    84.97(a)1
      4 (14.42 cM)5
    1405771  NM_001012450.11  NP_001012453.11 
     328040355 
    chicken
    (Gallus gallus)
    Aves ANKRD61 ankyrin repeat domain 6 74.06(n)
    77.12(a)
      421813  XM_003641016.1  XP_003641064.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    ANKRD66
    ankyrin repeat domain 6

    67(a)
    possible ortholog
    1 ↔ 1
    AAWZ02036979(3256-5760)
    1(174822272-174954363)
    zebrafish
    (Danio rerio)
    Actinopterygii ankrd62 ankyrin repeat domain 6 72.42(n)   378477  AF395113.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dgo6
    diego
    14(a)
    1 ↔ 1
    2R(6703531-6707378)
    worm
    (Caenorhabditis elegans)
    Secernentea mib-16
    Protein MIB-1
    9(a)
    possible ortholog
    III(11286335-11290699)


    ENSEMBL Gene Tree for ANKRD6 (if available)
    TreeFam Gene Tree for ANKRD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANKRD6 gene
    ANKDD1A2  MIB12  MIB22  ANKDD1B2  
    18/35 SIMAP similar genes for ANKRD6 using alignment to 12 protein entries:     ANKR6_HUMAN (see all proteins) (see all similar genes):
    UACA    RAI14    IkBa    FEM1B    MIB2    GABPB1
    ANKRD54    PSMD10    ANK2    FANK1    CASKIN2    GPR75-ASB3
    ANKRD44    INVS    ANKS6    AGAP1    ANKDD1A    TANC2

    ANKRD6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3629 SNPs in ANKRD6 are shown (see all 3629)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400376301,2
    --90141068(+) AGAAAA/GGTCAT 3 -- us2k10--------
    rs1165692571,2
    F--90141105(+) ATCTAG/AGAACT 3 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1831088361,2
    --90141145(+) GAGCTA/GCAAGC 3 -- us2k10--------
    rs1855167181,2
    --90141251(+) CACCTC/GTAATC 3 -- us2k10--------
    rs1444202051,2
    C--90141275(+) AGGCTA/GAGGCC 3 -- us2k10--------
    rs1484064521,2
    --90141364(+) GGTGGC/TGCACA 3 -- us2k10--------
    rs772150661,2
    C--90141392(+) TCAGGA/CGGCAG 3 -- us2k10--------
    rs1450993381,2
    --90141632(+) AGTGTA/GGAAAC 3 -- us2k10--------
    rs1160780771,2
    F--90141703(+) AAGGAA/CAAGGA 3 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1475953021,2
    --90141810(+) GCACTC/TTGGGA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANKRD6 (90142889 - 90343553 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ANKRD6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2732410CNV Deletion23290073
    esv2732411CNV Deletion23290073
    esv2667529CNV Deletion23128226
    nsv886339CNV Loss21882294
    nsv886340CNV Loss21882294
    nsv886338CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610583    OMIM disorders: --

    4 diseases for ANKRD6:    About MalaCards
    skin squamous cell carcinoma    situs inversus    epididymitis    squamous cell carcinoma


    ANKRD6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ANKRD6
    Human Genome Epidemiology (HuGE) Navigator: ANKRD6 (1 document)

    Export disorders for ANKRD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKRD6 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with ANKRD6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Combined analysis of three genome-wide association st udies on vWF and FVIII plasma levels. (PubMed id 21810271)1, 4 Antoni G....Tregouet D.A. (2011)
    2. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
    6. The planar cell polarity (PCP) protein Diversin trans locates to the nucleus to interact with the transcription factor AF9. (PubMed id 19591803)1, 9 Haribaskar R....SchAofer T. (2009)
    7. Variants of the ankyrin repeat domain 6 gene (ANKRD6) and muscle and physical activity phenotypes among European-derived American adul ts. (PubMed id 22580979)1 Van Deveire K.N....Pescatello L.S. (2012)
    8. Genetic associations of variants in genes encoding HI V-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (2010)
    9. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1 Li J.... Liu Y. (2010)
    10. Regulation of planar cell polarity by Smurf ubiquitin ligases. (PubMed id 19379695)1 Narimatsu M....Wrana J.L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22881 HGNC: 17280 AceView: ANKRD6 Ensembl:ENSG00000135299 euGenes: HUgn22881
    ECgene: ANKRD6 H-InvDB: ANKRD6

    (According to HUGE)
    About This Section
    HUGE: KIAA0957

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKRD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANKRD6 gene:
    Search GeneIP for patents involving ANKRD6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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