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ANKRD6 Gene

protein-coding   GIFtS: 52
GCID: GC06P090142

Ankyrin Repeat Domain 6

  Search for ANKRD6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 61 2
KIAA09573 5
Ankyrin Repeat Domain-Containing Protein 62
diversin2
Diversin3

External Ids:    HGNC: 172801   Entrez Gene: 228812   Ensembl: ENSG000001352997   OMIM: 6105835   UniProtKB: Q9Y2G43   

Export aliases for ANKRD6 gene to outside databases

Previous GC identifers: GC06P090222 GC06P090093 GC06P090138 GC06P090199 GC06P087360


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD6 Gene:
ANKRD6 (ankyrin repeat domain 6) is a protein-coding gene. An important paralog of this gene is ANKRD2.

UniProtKB/Swiss-Prot: ANKR6_HUMAN, Q9Y2G4
Function: Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta
and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD6 gene promoter:
         COUP-TF1   c-Fos   AP-1   ATF-2   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD6 promoter sequence
   Search Chromatin IP Primers for ANKRD6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.2-q16.1   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q14.2-q16.1

ANKRD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD6 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P090142:  view genomic region     (about GC identifiers)

Start:
90,142,889 bp from pter      End:
90,343,553 bp from pter
Size:
200,665 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANKR6_HUMAN, Q9Y2G4 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 6  
Size: 727 amino acids; 79971 Da
Subunit: Interacts with AXN1, AXN2 and CSNK1E/CKI-epsilon (By similarity)
Sequence caution: Sequence=BAA76801.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KUC3 Q5JUJ4 Q5JUJ5 Q8IUQ8 Q9NU24 Q9UFQ9
Alternative splicing: 4 isoforms:  Q9Y2G4-2   Q9Y2G4-1   Q9Y2G4-3   Q9Y2G4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD6: NX_Q9Y2G4

Explore proteomics data for ANKRD6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys40
  • Modification sites at PhosphoSitePlus

  • See ANKRD6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001229738.1  NP_001229740.1  NP_001229742.1  NP_001229743.1  NP_055757.3  

    ENSEMBL proteins: 
     ENSP00000358416   ENSP00000345767   ENSP00000396771   ENSP00000431061   ENSP00000429431  
     ENSP00000428377   ENSP00000430985   ENSP00000429337   ENSP00000430954   ENSP00000428309  
     ENSP00000429235   ENSP00000429782   ENSP00000429456   ENSP00000429531   ENSP00000430452  

    ANKRD6 Human Recombinant Protein Products:

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    Novus Biologicals ANKRD6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANKRD6

     
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    ANKRD6 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for ANKRD6

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    Search eBioscience for ELISAs for ANKRD6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y2G4

    ProtoNet protein and cluster: Q9Y2G4

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: ANKR6_HUMAN, Q9Y2G4
    Similarity: Contains 8 ANK repeats


    Find genes that share domains with ANKRD6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANKR6_HUMAN, Q9Y2G4
    Function: Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta
    and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ANKRD6           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ANKRD6:
     Decreased Tat-dependent transc  Decreased p24 protein expressi 

         1 MGI phenotypic allele for Ankrd6 (no phenotypes)

    Find genes that share phenotypes with ANKRD6           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANKRD6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANKRD6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANKRD6

    miRNA
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    hsa-mir-192-5p (MIRT026861), hsa-mir-215-5p (MIRT024472)

    Block miRNA regulation of human, mouse, rat ANKRD6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANKRD6 (see all 31):
    hsa-miR-3164 hsa-miR-3934 hsa-miR-3128 hsa-miR-3200-5p hsa-miR-331-3p hsa-miR-373* hsa-miR-570 hsa-miR-27b*
    SwitchGear 3'UTR luciferase reporter plasmidANKRD6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ANKRD6
    Predesigned siRNA for gene silencing in human, mouse, rat ANKRD6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ANKRD6 (NM_014942)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANKRD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD6

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IBA--

    Find genes that share ontologies with ANKRD6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANKRD6 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt Signaling Pathway NetPath0.37


    1 BioSystems Pathway for ANKRD6
        Wnt Signaling Pathway NetPath


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD6
    Interactions:

        GeneGlobe Interaction Network for ANKRD6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for ANKRD6 (Q9Y2G43 ENSP000003967714) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN2Q9Y2T13, ENSP000003026254I2D: score=2 STRING: ENSP00000302625
    CSNK1EP496743, ENSP000003529294I2D: score=2 STRING: ENSP00000352929
    C20orf24Q9BUV83, ENSP000003412134I2D: score=1 STRING: ENSP00000341213
    GSK3BP498413, ENSP000003248064I2D: score=1 STRING: ENSP00000324806
    DVL2O146413, ENSP000000053404I2D: score=1 STRING: ENSP00000005340
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046330positive regulation of JNK cascade IBA--
    GO:0090090negative regulation of canonical Wnt signaling pathway IBA--
    GO:2000096positive regulation of Wnt signaling pathway, planar cell polarity pathway IEA--

    Find genes that share ontologies with ANKRD6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKRD6 (ANKR6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANKRD6 gene (5 alternative transcripts): 
    NM_001242809.1  NM_001242811.1  NM_001242813.1  NM_001242814.1  NM_014942.4  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000369408(uc003pne.4 uc003pni.4 uc003pnf.4 uc011dzy.2 uc010kcd.3)
    ENST00000520886 ENST00000339746 ENST00000447838 ENST00000520458 ENST00000465722
    ENST00000523798 ENST00000522441 ENST00000522779 ENST00000485637 ENST00000522705
    ENST00000518150 ENST00000520793 ENST00000518253 ENST00000524056 ENST00000520839
    ENST00000415924(uc003pnj.4) ENST00000479572
    miRNA
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    Block miRNA regulation of human, mouse, rat ANKRD6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANKRD6 (see all 31):
    hsa-miR-3164 hsa-miR-3934 hsa-miR-3128 hsa-miR-3200-5p hsa-miR-331-3p hsa-miR-373* hsa-miR-570 hsa-miR-27b*
    SwitchGear 3'UTR luciferase reporter plasmidANKRD6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ANKRD6
    Predesigned siRNA for gene silencing in human, mouse, rat ANKRD6
    Clone
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    OriGene clones in human, mouse for ANKRD6 (see all 6)
    OriGene ORF clones in mouse, rat for ANKRD6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANKRD6 (NM_014942)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANKRD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD6
    Primer
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    OriGene qPCR primer pairs and template standards for ANKRD6
    OriGene qSTAR qPCR primer pairs in human, mouse for ANKRD6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANKRD6
      QuantiTect SYBR Green Assays in human, mouse, rat ANKRD6
      QuantiFast Probe-based Assays in human, mouse, rat ANKRD6

    Selected AceView cDNA sequences (see all 101):

    AA649159 AI002436 BU948165 AI638241 AW270134 BM907460 AA443269 CR608573 
    BM894090 AW103682 CB047361 CB305804 AI769641 AI222135 CB850929 AA782996 
    BE677131 AA294856 CA393945 AW183582 BM998304 AL133992 BM986732 AA994438 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD6 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
    SP1:        -     -     -     -     -     -     -                                                                                   -                 -     -   
    SP2:                                                                                                                                -                 -     -   
    SP3:                                                                                                        -     -                 -           -     -     -   
    SP4:                                                                                                                                -                 -     -   
    SP5:                                                                                                                                                            

    ExUns: 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b · 22c
    SP1:  -                                                     -           -     -                     
    SP2:  -     -                                               -                 -                     
    SP3:  -                                                     -           -     -                     
    SP4:  -                                                     -                 -                     
    SP5:                                                                    -     -                     


    ECgene alternative splicing isoforms for ANKRD6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKRD6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTAAAAAAA
    ANKRD6 Expression
    About this image


    ANKRD6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Zeugopod Periosteum
             HyStem+BMP4-induced 4D20.8 cells
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
             Medulla Oblongata
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
    ANKRD6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKRD6 Protein Expression
        Custom PCR Arrays for ANKRD6
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    QuantiFast Probe-based Assays in human, mouse, rat ANKRD6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANKRD6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankrd61 , 5 ankyrin repeat domain 61, 5 84.93(n)1
    84.97(a)1
      4 (14.42 cM)5
    1405771  NM_001012450.11  NP_001012453.11 
     328040355 
    chicken
    (Gallus gallus)
    Aves ANKRD61 ankyrin repeat domain 6 73.34(n)
    77.5(a)
      421813  XM_004940383.1  XP_004940440.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANKRD66
    ankyrin repeat domain 6
    68(a)
    1 ↔ 1
    1(174822272-174954363)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ankrd61 ankyrin repeat domain 6 66.53(n)
    67.59(a)
      100101692  NM_001112901.1  NP_001106372.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ankrd62 ankyrin repeat domain 6 72.42(n)   378477  AF395113.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dgo6
    diego
    17(a)
    1 ↔ 1
    2R(6703531-6707378)


    ENSEMBL Gene Tree for ANKRD6 (if available)
    TreeFam Gene Tree for ANKRD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKRD6 gene
    ANKRD22  GABPB12  ANKRD232  GABPB22  ANKRD12  
    Selected SIMAP similar genes for ANKRD6 using alignment to 12 protein entries:     ANKR6_HUMAN (see all proteins) (see all similar genes):
    UACA    RAI14    IkBa    FEM1B    MIB2    GABPB1
    ANKRD54    PSMD10    ANK2    FANK1    CASKIN2    FPGT-TNNI3K
    GPR75-ASB3    ANKRD44    INVS    ANKS6    AGAP1    ANKDD1A

    Find genes that share paralogs with ANKRD6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKRD6 (see all 3629)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400376301,2
    --90141068(+) AGAAAA/GGTCAT 3 -- us2k10--------
    rs1165692571,2
    F--90141105(+) ATCTAG/AGAACT 3 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1831088361,2
    --90141145(+) GAGCTA/GCAAGC 3 -- us2k10--------
    rs1855167181,2
    --90141251(+) CACCTC/GTAATC 3 -- us2k10--------
    rs1444202051,2
    C--90141275(+) AGGCTA/GAGGCC 3 -- us2k10--------
    rs1484064521,2
    --90141364(+) GGTGGC/TGCACA 3 -- us2k10--------
    rs772150661,2
    C--90141392(+) TCAGGA/CGGCAG 3 -- us2k10--------
    rs1450993381,2
    --90141632(+) AGTGTA/GGAAAC 3 -- us2k10--------
    rs1160780771,2
    F--90141703(+) AAGGAA/CAAGGA 3 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1475953021,2
    --90141810(+) GCACTC/TTGGGA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANKRD6 (90142889 - 90343553 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ANKRD6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732410CNV Deletion23290073
    esv2732411CNV Deletion23290073
    esv2667529CNV Deletion23128226
    nsv886339CNV Loss21882294
    nsv886340CNV Loss21882294
    nsv886338CNV Loss21882294

    Human Gene Mutation Database (HGMD): ANKRD6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANKRD6
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKRD6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610583    OMIM disorders: --


    Find genes that share disorders with ANKRD6           About GenesLikeMe

    Genetic Association Database (GAD): ANKRD6
    Human Genome Epidemiology (HuGE) Navigator: ANKRD6 (1 document)

    Export disorders for ANKRD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKRD6 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with ANKRD6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. (PubMed id 21810271)1, 4 Antoni G....Tregouet D.A. (BMC Med. Genet. 2011)
    2. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    6. The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9. (PubMed id 19591803)1, 9 Haribaskar R....SchAofer T. (Biochem. Biophys. Res. Commun. 2009)
    7. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 23934736)1 Yu B....Boerwinkle E. (Genet. Epidemiol. 2013)
    8. Variants of the ankyrin repeat domain 6 gene (ANKRD6) and muscle and physical activity phenotypes among European-derived American adults. (PubMed id 22580979)1 Van Deveire K.N....Pescatello L.S. (amp 2012)
    9. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    10. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1 Li J.... Liu Y. (Mol. Cell. Proteomics 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22881 HGNC: 17280 AceView: ANKRD6 Ensembl:ENSG00000135299 euGenes: HUgn22881
    ECgene: ANKRD6 H-InvDB: ANKRD6

    (According to HUGE)
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    HUGE: KIAA0957

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKRD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKRD6 gene:
    Search GeneIP for patents involving ANKRD6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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