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Aliases for ANKRD6 Gene

Aliases for ANKRD6 Gene

  • Ankyrin Repeat Domain 6 2 3 5
  • Diversin 2 3 4
  • Ankyrin Repeat Domain-Containing Protein 6 3
  • Diego Homolog (Drosophila) 2
  • Diego Homolog 3
  • KIAA0957 4

External Ids for ANKRD6 Gene

Previous GeneCards Identifiers for ANKRD6 Gene

  • GC06P090222
  • GC06P090093
  • GC06P090138
  • GC06P090199
  • GC06P090142
  • GC06P087360

Summaries for ANKRD6 Gene

GeneCards Summary for ANKRD6 Gene

ANKRD6 (Ankyrin Repeat Domain 6) is a Protein Coding gene. An important paralog of this gene is KIDINS220.

UniProtKB/Swiss-Prot for ANKRD6 Gene

  • Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD6 Gene

Genomics for ANKRD6 Gene

Regulatory Elements for ANKRD6 Gene

Enhancers for ANKRD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G089409 1 ENCODE 10.7 -21.6 -21553 3.9 PKNOX1 SIN3A FEZF1 ZNF121 GLIS2 ZNF207 ZNF263 SP3 REST SREBF1 LYRM2 ANKRD6 SRSF12 ENSG00000237027 RRAGD GC06M089406
GH06G089482 1 Ensembl ENCODE 10.5 +50.2 50184 1.7 FOXA2 FEZF1 THRB ZFHX2 SCRT2 ZNF350 ZNF600 PRDM10 ZNF548 ZBTB20 CASP8AP2 ANKRD6 ENSG00000237027 MDN1 RN7SL11P LOC105377889
GH06G089610 0.7 ENCODE 12.7 +177.1 177077 0.1 CTCF ZNF146 ZNF792 JUN CEBPG ZNF2 RAD21 PATZ1 ZNF143 SMC3 ANKRD6 LYRM2 ENSG00000237027 LOC105377887 GC06P089570
GH06G089499 0.7 ENCODE 10.6 +67.6 67586 2.1 ZNF362 ZSCAN4 TEAD4 ZNF394 ZNF501 REST CHD7 OSR2 PRDM6 SMARCA4 ENSG00000237027 ANKRD6 LOC105377889 RN7SL11P
GH06G089525 0.5 ENCODE 11.5 +92.8 92767 0.2 MEF2D PKNOX1 ZNF843 ZXDB ENSG00000237027 ANKRD6 LOC105377889
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD6 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000199902 230 1201 ZNF48 GLIS2 ZNF143 KLF7 ZNF548 SP3 REST ZNF518A GLIS1 ZNF785

Genomic Location for ANKRD6 Gene

Chromosome:
6
Start:
89,433,170 bp from pter
End:
89,633,834 bp from pter
Size:
200,665 bases
Orientation:
Plus strand

Genomic View for ANKRD6 Gene

Genes around ANKRD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD6 Gene

Proteins for ANKRD6 Gene

  • Protein details for ANKRD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2G4-ANKR6_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 6
    Protein Accession:
    Q9Y2G4
    Secondary Accessions:
    • B3KUC3
    • Q5JUJ4
    • Q5JUJ5
    • Q8IUQ8
    • Q9NU24
    • Q9UFQ9

    Protein attributes for ANKRD6 Gene

    Size:
    727 amino acids
    Molecular mass:
    79971 Da
    Quaternary structure:
    • Interacts with AXN1, AXN2 and CSNK1E/CKI-epsilon.
    SequenceCaution:
    • Sequence=BAA76801.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD6 Gene

Post-translational modifications for ANKRD6 Gene

  • Ubiquitination at posLast=4040
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANKRD6 Gene

Domains & Families for ANKRD6 Gene

Gene Families for ANKRD6 Gene

Protein Domains for ANKRD6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD6: view

No data available for UniProtKB/Swiss-Prot for ANKRD6 Gene

Function for ANKRD6 Gene

Molecular function for ANKRD6 Gene

UniProtKB/Swiss-Prot Function:
Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.
genes like me logo Genes that share phenotypes with ANKRD6: view

Animal Models for ANKRD6 Gene

MGI Knock Outs for ANKRD6:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKRD6 Gene

Localization for ANKRD6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD6 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ANKRD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ANKRD6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANKRD6 Gene

Pathways & Interactions for ANKRD6 Gene

SuperPathways for ANKRD6 Gene

No Data Available

SIGNOR curated interactions for ANKRD6 Gene

Activates:

Gene Ontology (GO) - Biological Process for ANKRD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046330 positive regulation of JNK cascade IBA --
GO:0090090 negative regulation of canonical Wnt signaling pathway IBA --
GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway IEA --
genes like me logo Genes that share ontologies with ANKRD6: view

No data available for Pathways by source for ANKRD6 Gene

Transcripts for ANKRD6 Gene

Unigene Clusters for ANKRD6 Gene

Ankyrin repeat domain 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - - - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - -
SP5:
SP6:
SP7: -
SP8: - - - -
SP9:
SP10: - - - - - - - - - - - - - - -
SP11: - -
SP12:
SP13: - - -
SP14: -
SP15: - - - - - -

ExUns: 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b · 22c
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10: - -
SP11: -
SP12: -
SP13:
SP14:
SP15:

Relevant External Links for ANKRD6 Gene

GeneLoc Exon Structure for
ANKRD6
ECgene alternative splicing isoforms for
ANKRD6

Expression for ANKRD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD6 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.5) and Brain - Cerebellum (x4.5).

Protein differential expression in normal tissues from HIPED for ANKRD6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD6 Gene



Protein tissue co-expression partners for ANKRD6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD6 Gene:

ANKRD6

SOURCE GeneReport for Unigene cluster for ANKRD6 Gene:

Hs.702213

Evidence on tissue expression from TISSUES for ANKRD6 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ANKRD6: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD6 Gene

Orthologs for ANKRD6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD6 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia ANKRD6 34 35
  • 90.92 (n)
cow
(Bos Taurus)
Mammalia ANKRD6 34 35
  • 89.43 (n)
mouse
(Mus musculus)
Mammalia Ankrd6 34 16 35
  • 84.93 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd6 34
  • 84.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD6 35
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKRD6 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD6 34 35
  • 73.34 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD6 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd6 34
  • 66.53 (n)
zebrafish
(Danio rerio)
Actinopterygii ankrd6b 34 35
  • 60.23 (n)
ankrd6a 35
  • 40 (a)
OneToMany
ankrd6 34
fruit fly
(Drosophila melanogaster)
Insecta dgo 35
  • 17 (a)
OneToOne
Species where no ortholog for ANKRD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD6 Gene

ENSEMBL:
Gene Tree for ANKRD6 (if available)
TreeFam:
Gene Tree for ANKRD6 (if available)

Paralogs for ANKRD6 Gene

Variants for ANKRD6 Gene

Sequence variations from dbSNP and Humsavar for ANKRD6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000005008 -- 89,606,412(+) CAATG(C/G)AGTTG intron-variant
rs1000013792 -- 89,564,067(+) GAGGC(A/G)ATTAC intron-variant
rs1000025754 -- 89,498,620(+) ATGAT(A/G)TGAAG intron-variant
rs1000042547 -- 89,503,732(+) TAGTC(A/G)GAGAA intron-variant
rs1000045113 -- 89,597,282(+) TCCTG(C/T)ACTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD6 Gene

Variant ID Type Subtype PubMed ID
dgv6089n100 CNV gain 25217958
esv2667529 CNV deletion 23128226
esv2732410 CNV deletion 23290073
esv2732411 CNV deletion 23290073
esv3609900 CNV loss 21293372
esv3609901 CNV gain 21293372
esv3609902 CNV gain 21293372
esv3609903 CNV gain 21293372
esv3609904 CNV gain 21293372
esv3609906 CNV loss 21293372
esv3890901 CNV gain 25118596
esv3890902 CNV loss 25118596
esv3890903 CNV gain 25118596
nsv1027007 CNV gain 25217958
nsv1073997 CNV deletion 25765185
nsv604124 CNV loss 21841781
nsv965747 CNV duplication 23825009

Variation tolerance for ANKRD6 Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.41; 81.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD6 Gene

Human Gene Mutation Database (HGMD)
ANKRD6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD6 Gene

Disorders for ANKRD6 Gene

Relevant External Links for ANKRD6

Genetic Association Database (GAD)
ANKRD6
Human Genome Epidemiology (HuGE) Navigator
ANKRD6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD6

No disorders were found for ANKRD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD6 Gene

Publications for ANKRD6 Gene

  1. Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear. (PMID: 25218921) Jones C. … Chen P. (Dev. Biol. 2014) 2 3 64
  2. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. (PMID: 21810271) Antoni G. … Tregouet D.A. (BMC Med. Genet. 2011) 3 46 64
  3. The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9. (PMID: 19591803) Haribaskar R. … SchAofer T. (Biochem. Biophys. Res. Commun. 2009) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for ANKRD6 Gene

Sources for ANKRD6 Gene

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