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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANKRD55 Gene

protein-coding GIFtS: 43
GCID: GC05M055432

ankyrin repeat domain 55

Explore 4 diseases affiliated with
ANKRD55 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ankyrin Repeat Domain 55¹ ²
FLJ11795¹
Ankyrin Repeat Domain-Containing Protein 55²

External Ids:	HGNC: 25681¹	Entrez Gene: 79722²	Ensembl: ENSG00000164512⁷	UniProtKB: Q3KP44³

Export aliases for ANKRD55 gene to outside databases

Previous GC identifer: GC05M052368

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANKRD55 gene promoter:
Pbx1a CBF-C NF-YB Pax-3 CBF-A CBF-B CP1C CP1A NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANKRD55 promoter sequence

Search SABiosciences Chromatin IP Primers for ANKRD55

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD55

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2

ANKRD55 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD55 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M055432: view genomic region (about GC identifiers)

Start:	55,395,507 bp from pter	End:	55,529,186 bp from pter
Size:	133,680 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANR55_HUMAN, Q3KP44 (See protein sequence)

Recommended Name: Ankyrin repeat domain-containing protein 55

Size: 614 amino acids; 68414 Da

Secondary accessions: B3KVT8 Q3KP45 Q9HAD3

Alternative splicing: 3 isoforms: Q3KP44-1 Q3KP44-2 Q3KP44-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD55: NX_Q3KP44

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q3KP44

ANKRD55 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_078945.2

ENSEMBL proteins:

ENSP00000423180 ENSP00000424230 ENSP00000429421 ENSP00000422370 ENSP00000423507

ENSP00000427747 ENSP00000342295

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANKRD55 for domains About GeneDecksing

2 InterPro domains/families:

IPR020683 Ankyrin_rpt-contain_dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q3KP44

ProtoNet protein and cluster: Q3KP44

UniProtKB/Swiss-Prot: ANR55_HUMAN, Q3KP44

Similarity: Contains 9 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ANKRD55

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ANKRD55 (Q3KP44³ ENSP00000342295⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZSCAN1	Q8NBB4³, ENSP00000282326⁴	I2D: score=1 STRING: ENSP00000282326

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ANKRD55
Search CenterWatch for drugs/clinical trials and news about ANKRD55 / ANR55

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ANKRD55 gene (2 alternative transcripts):

NM_001039935.1 NM_024669.2

Unigene Cluster for ANKRD55:

Ankyrin repeat domain 55

Hs.436214 [show with all ESTs]

Unigene Representative Sequence: NM_024669

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000507283(uc003jqt.3) ENST00000504958 ENST00000434982 ENST00000505970

ENST00000513241 ENST00000519586 ENST00000519114 ENST00000341048(uc003jqu.3)

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Additional cDNA sequence:

AK021857.1 AK123389.1 BC106914.2 BC106915.2

5 DOTS entries:

DT.120797181 DT.40117486 DT.111092 DT.40119762 DT.75171767

24/59 AceView cDNA sequences (see all 59):

BX952892 AA459693 AU119582 BI825655 AK021857 NM_024669 AA351312 AK123389

BF509000 AA383108 BX952891 BG215966 BG209061 BG200214 AW269928 BG221500

BG198636 BU853526 BG221499 BG183103 AW072386 AI420680 AA812525 BG208529

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANKRD55 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCACTGTTT

About this image

ANKRD55 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ANKRD55 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD55

SOURCE GeneReport for Unigene cluster: Hs.436214

SABiosciences Custom PCR Arrays for ANKRD55

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANKRD55 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100858831¹	ankyrin repeat domain-containing protein 55-like	70.06(n) 68.64(a)		100858831 XM_003642944.1 XP_003642992.1
lizard (Anolis carolinensis)	Reptilia	ANKRD55⁶	--	65(a)	1 ↔ 1	2(2200184-2230247)
zebrafish (Danio rerio)	Actinopterygii	ankrd55¹	ankyrin repeat domain 55	63.85(n) 61.14(a)		100006755 XM_001345383.3 XP_001345419.3
fruit fly (Drosophila melanogaster)	Insecta	nompC⁶	no mechanoreceptor potential C	4(a)	possible ortholog	2L(5342321-5365760)
worm (Caenorhabditis elegans)	Secernentea	T28D6.4⁶	Protein T28D6.4	6(a)	1 ↔ 1	III(11360356-11366114)
rice (Oryza sativa)	Liliopsida	--	ankyrin repeat domain-containing protein 50, putat...	12(a)	possible ortholog	3(25568429-25570099)

ENSEMBL Gene Tree for ANKRD55 (if available)
TreeFam Gene Tree for ANKRD55 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6861696^1,2	C,	--	52401204(+)	`ggtcgG/Agagtt`	1	--	int¹		1		WA	2
rs186451^1,2	C,F,O,A,H,	--	55395112(+)	`AGACCC/TCTAGC`	1	--	int¹		26		NS EA NA WA CSA	2903
rs146905309^1,2		--	55395150(+)	`ATCTTA/GGTAAG`	1	--	int¹		0	--	--	--	--
rs77244040^1,2	F,	--	55395168(+)	`GTTAGT/CTGTAG`	1	--	int¹		1		WA	118
rs147946165^1,2		--	55395237(+)	`TTATTC/TTGAAA`	1	--	int¹		0	--	--	--	--
rs141853461^1,2		--	55395261(+)	`AAATAG/TGTAGA`	1	--	int¹		0	--	--	--	--
rs1978675^1,2	C,F,A,H,	--	55395342(+)	`ATGACT/CTCTCC`	1	--	int¹		5		NS EA WA	538
rs113276591^1,2	C,	--	55395364(+)	`ATCAAT/ACATAT`	1	--	int¹		2		NA	122
rs77531793^1,2	C,F,	--	55395455(+)	`GAACTG/AACAAT`	1	--	int¹		1		NA	120
rs150410113^1,2		--	55395587(+)	`TGTTTC/GTCTGG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ANKRD55 (55395507 - 55529186 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for ANKRD55
4 CNVs: 23771 64207 6405 64208
5 Indels: 93059 93058 80925 93060 80924

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ANKRD55 for disorders About GeneDecksing

4 diseases for ANKRD55: About MalaCards

rheumatoid arthritis arthritis prostate cancer prostatitis

Human Genome Epidemiology (HuGE) Navigator: ANKRD55 (3 documents)

Export disorders for ANKRD55 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ANKRD55 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ANKRD55)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)^{1, 2} Schmutz J.... Rubin E.M. (2004)
ANKRD55 and DHCR7 are novel multiple sclerosis risk lo ci. (PubMed id 22130326)¹ Alloza I....Vandenbroeck K. (2012)
Meta-analysis of genome-wide association studies in c eliac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. (PubMed id 21383967)¹ Zhernakova A....Plenge R.M. (2011)
Genome-wide association study meta-analysis identifie s seven new rheumatoid arthritis risk loci. (PubMed id 20453842)¹ Stahl E.A....Plenge R.M. (2010)
Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)¹ Teslovich T.M....Kathiresan S. (2010)
Inherited genetic variant predisposes to aggressive b ut not indolent prostate cancer. (PubMed id 20080650)¹ Xu J....Isaacs W.B. (2010)
An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)
Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in Africa n-Americans. (PubMed id 20973039)¹ Hughes L.B....Bridges S.L. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79722	HGNC: 25681	AceView: FLJ11795	Ensembl:ENSG00000164512	euGenes: HUgn79722
ECgene: ANKRD55	H-InvDB: ANKRD55

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANKRD55	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANKRD55 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ANKRD55 gene:
Search GeneIP for patents involving ANKRD55

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ANKRD55 gene at Home site.

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ANKRD55 Gene

ankyrin repeat domain 55

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ANKRD55 Gene

ankyrin repeat domain 55

Aliasesfor ANKRD55 gene

Summariesfor ANKRD55 gene

Genomic Viewsfor ANKRD55 gene

Proteinsfor ANKRD55 gene

Protein Domains /Familiesfor ANKRD55 gene

Functionfor ANKRD55 gene

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for ANKRD55 gene

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for ANKRD55 gene

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for ANKRD55 gene

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for ANKRD55 gene

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for ANKRD55 gene

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for ANKRD55 gene

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for ANKRD55 gene

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for ANKRD55 gene

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