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ANKRD55 Gene

protein-coding   GIFtS: 48
GCID: GC05M055395

Ankyrin Repeat Domain 55

  See ANKRD55-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 551 2
Ankyrin Repeat Domain-Containing Protein 552

External Ids:    HGNC: 256811   Entrez Gene: 797222   Ensembl: ENSG000001645127   OMIM: 6151895   UniProtKB: Q3KP443   

Export aliases for ANKRD55 gene to outside databases

Previous GC identifers: GC05M055432 GC05M052368


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD55 Gene:
ANKRD55 (ankyrin repeat domain 55) is a protein-coding gene. Diseases associated with ANKRD55 include oligoarticular juvenile arthritis, and polyarticular onset juvenile idiopathic arthritis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD55 gene promoter:
         Pbx1a   CBF-C   NF-YB   Pax-3   CBF-A   CBF-B   CP1C   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD55 promoter sequence
   Search Chromatin IP Primers for ANKRD55

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD55


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

ANKRD55 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD55 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M055395:  view genomic region     (about GC identifiers)

Start:
55,395,507 bp from pter      End:
55,529,186 bp from pter
Size:
133,680 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANR55_HUMAN, Q3KP44 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 55  
Size: 614 amino acids; 68414 Da
Secondary accessions: B3KVT8 Q3KP45 Q9HAD3
Alternative splicing: 3 isoforms:  Q3KP44-1   Q3KP44-2   Q3KP44-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD55: NX_Q3KP44

Explore proteomics data for ANKRD55 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANKRD55 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078945.2  
    ENSEMBL proteins: 
     ENSP00000342295   ENSP00000424230   ENSP00000429421   ENSP00000423507  

    ANKRD55 Human Recombinant Protein Products:

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    Abcam antibodies for ANKRD55
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    LSBio Antibodies in human, mouse, rat for ANKRD55

    ANKRD55 Assay Products:

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    Cloud-Clone Corp. ELISAs for ANKRD55
    Cloud-Clone Corp. CLIAs for ANKRD55
    Search eBioscience for ELISAs for ANKRD55 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q3KP44

    ProtoNet protein and cluster: Q3KP44

    UniProtKB/Swiss-Prot: ANR55_HUMAN, Q3KP44
    Similarity: Contains 9 ANK repeats


    Find genes that share domains with ANKRD55           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ANKRD55           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANKRD55
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    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate ANKRD55:
    hsa-miR-135b hsa-miR-3118 hsa-miR-134 hsa-miR-545 hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidANKRD55 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANKRD55

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    GenScript: all cDNA clones in your preferred vector: ANKRD55 (NM_024669)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANKRD55
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD55

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD55


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD55
    Interactions:

        Search GeneGlobe Interaction Network for ANKRD55

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ANKRD55 (Q3KP443 ENSP000003422954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZSCAN1Q8NBB43, ENSP000002823264I2D: score=1 STRING: ENSP00000282326
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKRD55 (ANR55)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANKRD55 gene (2 alternative transcripts): 
    NM_001039935.1  NM_024669.2  

    Unigene Cluster for ANKRD55:

    Ankyrin repeat domain 55
    Hs.436214  [show with all ESTs]
    Unigene Representative Sequence: NM_024669
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341048(uc003jqu.3) ENST00000504958 ENST00000434982 ENST00000505970
    ENST00000513241 ENST00000519114
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate ANKRD55:
    hsa-miR-135b hsa-miR-3118 hsa-miR-134 hsa-miR-545 hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidANKRD55 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ANKRD55
    Predesigned siRNA for gene silencing in human, mouse, rat ANKRD55
    Clone
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    OriGene clones in human, mouse for ANKRD55 (see all 8)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANKRD55 (NM_024669)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANKRD55
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD55
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ANKRD55
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANKRD55
      QuantiTect SYBR Green Assays in human, mouse, rat ANKRD55
      QuantiFast Probe-based Assays in human, mouse, rat ANKRD55

    Additional mRNA sequence: 

    AK021857.1 AK123389.1 BC106914.2 BC106915.2 

    6 DOTS entries:

    DT.120797181  DT.40117486  DT.40119762  DT.111092  DT.75171767  DT.92419846 

    Selected AceView cDNA sequences (see all 59):

    BI825655 AA383108 BF509000 BX952892 AK123389 AK021857 AA351312 NM_024669 
    AU119582 AA459693 BG209061 BG200214 AA351313 BG198636 BG221500 BG220538 
    BF594106 BG221499 AA812525 BG185219 BG183103 BX952891 AW072386 BG215966 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKRD55 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACTGTTT
    ANKRD55 Expression
    About this image


    ANKRD55 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Testis (Reproductive System)
    ANKRD55 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKRD55 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436214
        Custom PCR Arrays for ANKRD55
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ANKRD55
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    QuantiFast Probe-based Assays in human, mouse, rat ANKRD55
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD55

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ANKRD55 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankrd551 , 5 ankyrin repeat domain 551, 5 84.56(n)1
    85.81(a)1
      13 (63.73 cM)5
    773181  NM_029898.31  NP_084174.21 
     1122884515 
    chicken
    (Gallus gallus)
    Aves ANKRD551 ankyrin repeat domain 55 70.08(n)
    68.76(a)
      100858831  XM_003642944.2  XP_003642992.2 
    lizard
    (Anolis carolinensis)
    Reptilia ANKRD556
    ankyrin repeat domain 55
    60(a)
    1 ↔ 1
    2(2199811-2230618)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ankrd551 ankyrin repeat domain 55 67.69(n)
    68.2(a)
      780326  NM_001079397.1  NP_001072865.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ankrd551 ankyrin repeat domain 55 63.9(n)
    61.49(a)
      100006755  XM_005155506.1  XP_005155563.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AVO26
    Component of a complex containing the Tor2p kinase...
    22(a)
    1 ↔ 1
    XIII(406304-407584) YMR068W


    ENSEMBL Gene Tree for ANKRD55 (if available)
    TreeFam Gene Tree for ANKRD55 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKRD55 gene
    6 SIMAP similar genes for ANKRD55 using alignment to 3 protein entries:     ANR55_HUMAN (see all proteins):
    DKFZp761E1322    MTPN    ANKRD44    INVS    ANKRD54    ANK2

    Find genes that share paralogs with ANKRD55           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKRD55 (see all 3209)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1864511,2
    C,F,O,A,H--55395112(+) AGACCC/TCTAGC 1 -- int126Minor allele frequency- T:0.42NS EA NA WA CSA 2903
    rs1469053091,2
    C--55395150(+) ATCTTA/GGTAAG 1 -- int10--------
    rs772440401,2
    F--55395168(+) GTTAGT/CTGTAG 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1479461651,2
    --55395237(+) TTATTC/TTGAAA 1 -- int10--------
    rs1418534611,2
    --55395261(+) AAATAG/TGTAGA 1 -- int10--------
    rs19786751,2
    C,F,A,H--55395342(+) ATGACT/CTCTCC 1 -- int15Minor allele frequency- C:0.05NS EA WA 538
    rs1132765911,2
    C,F--55395364(+) ATCAAT/ACATAT 1 -- int12Minor allele frequency- A:0.02NA 122
    rs775317931,2
    C,F--55395455(+) GAACTG/AACAAT 1 -- int11Minor allele frequency- A:0.04NA 120
    rs1504101131,2
    C--55395587(+) TGTTTC/GTCTGG 1 -- ut310--------
    rs39300441,2
    C,A--55395610(+) TTTTTG/TTTTTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ANKRD55 (55395507 - 55529186 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ANKRD55 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1152739CNV Deletion17803354
    esv2730194CNV Deletion23290073
    esv2667446CNV Deletion23128226
    esv993277CNV Deletion20482838
    esv2677484CNV Deletion23128226
    esv273609CNV Insertion20981092
    esv268402CNV Insertion20981092
    esv1539040CNV Insertion17803354
    esv274436CNV Insertion20981092
    esv269957CNV Insertion20981092

    Human Gene Mutation Database (HGMD): ANKRD55
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANKRD55
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKRD55

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615189    OMIM disorders: --

    2 diseases for ANKRD55:    
    About MalaCards
    oligoarticular juvenile arthritis    polyarticular onset juvenile idiopathic arthritis


    Find genes that share disorders with ANKRD55           About GenesLikeMe

    Genetic Association Database (GAD): ANKRD55
    Human Genome Epidemiology (HuGE) Navigator: ANKRD55 (3 documents)

    Export disorders for ANKRD55 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKRD55 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ANKRD55)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    2. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (Nat. Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (Nature 2004)
    6. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)1 Sherva R....Green R.C. (amp 2014)
    7. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    8. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PubMed id 23263486)1 KAPttgen A....Gieger C. (Nat. Genet. 2013)
    9. Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased I^-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort. (PubMed id 23457408)1 Harder M.N....Pedersen O. (J. Clin. Endocrinol. Metab. 2013)
    10. Genome-wide significant association of ANKRD55 rs6859219 and multiple sclerosis risk. (PubMed id 23315543)1 Lill C.M....Bertram L. (J. Med. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79722 HGNC: 25681 AceView: FLJ11795 Ensembl:ENSG00000164512 euGenes: HUgn79722
    ECgene: ANKRD55 H-InvDB: ANKRD55

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKRD55 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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