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Aliases for ANKRD55 Gene

Aliases for ANKRD55 Gene

  • Ankyrin Repeat Domain 55 2 3 5

External Ids for ANKRD55 Gene

Previous GeneCards Identifiers for ANKRD55 Gene

  • GC05M055432
  • GC05M052368
  • GC05M055395

Summaries for ANKRD55 Gene

GeneCards Summary for ANKRD55 Gene

ANKRD55 (Ankyrin Repeat Domain 55) is a Protein Coding gene. Diseases associated with ANKRD55 include Oligoarticular Juvenile Arthritis and Polyarticular Onset Juvenile Idiopathic Arthritis.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD55 Gene

Genomics for ANKRD55 Gene

Regulatory Elements for ANKRD55 Gene

Enhancers for ANKRD55 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ANKRD55 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKRD55 Gene

Chromosome:
5
Start:
56,099,678 bp from pter
End:
56,233,359 bp from pter
Size:
133,682 bases
Orientation:
Minus strand

Genomic View for ANKRD55 Gene

Genes around ANKRD55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD55 Gene

Proteins for ANKRD55 Gene

  • Protein details for ANKRD55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KP44-ANR55_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 55
    Protein Accession:
    Q3KP44
    Secondary Accessions:
    • B3KVT8
    • Q3KP45
    • Q9HAD3

    Protein attributes for ANKRD55 Gene

    Size:
    614 amino acids
    Molecular mass:
    68414 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD55 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD55 Gene

Post-translational modifications for ANKRD55 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD55 Gene

No data available for DME Specific Peptides for ANKRD55 Gene

Domains & Families for ANKRD55 Gene

Gene Families for ANKRD55 Gene

Protein Domains for ANKRD55 Gene

Suggested Antigen Peptide Sequences for ANKRD55 Gene

Graphical View of Domain Structure for InterPro Entry

Q3KP44

UniProtKB/Swiss-Prot:

ANR55_HUMAN :
  • Contains 9 ANK repeats.
Similarity:
  • Contains 9 ANK repeats.
genes like me logo Genes that share domains with ANKRD55: view

Function for ANKRD55 Gene

Phenotypes for ANKRD55 Gene

genes like me logo Genes that share phenotypes with ANKRD55: view

Human Phenotype Ontology for ANKRD55 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD55 Gene

Localization for ANKRD55 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD55 Gene COMPARTMENTS Subcellular localization image for ANKRD55 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD55 Gene

Pathways & Interactions for ANKRD55 Gene

SuperPathways for ANKRD55 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD55 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD55 Gene

Drugs & Compounds for ANKRD55 Gene

No Compound Related Data Available

Transcripts for ANKRD55 Gene

Unigene Clusters for ANKRD55 Gene

Ankyrin repeat domain 55:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD55 Gene

No ASD Table

Relevant External Links for ANKRD55 Gene

GeneLoc Exon Structure for
ANKRD55
ECgene alternative splicing isoforms for
ANKRD55

Expression for ANKRD55 Gene

mRNA expression in normal human tissues for ANKRD55 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD55 Gene

This gene is overexpressed in Whole Blood (x16.4), Brain - Hypothalamus (x5.3), and Testis (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of ANKRD55 Gene:

ANKRD55

SOURCE GeneReport for Unigene cluster for ANKRD55 Gene:

Hs.436214
genes like me logo Genes that share expression patterns with ANKRD55: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ANKRD55 Gene

Orthologs for ANKRD55 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANKRD55 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANKRD55 34
  • 88.64 (n)
  • 89.46 (a)
ANKRD55 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD55 34
  • 88.91 (n)
  • 89.4 (a)
ANKRD55 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd55 34
  • 84.56 (n)
  • 85.81 (a)
Ankrd55 16
Ankrd55 35
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANKRD55 34
  • 99.4 (n)
  • 99.02 (a)
ANKRD55 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd55 34
  • 84.5 (n)
  • 86.32 (a)
oppossum
(Monodelphis domestica)
Mammalia ANKRD55 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD55 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD55 34
  • 70.08 (n)
  • 68.76 (a)
ANKRD55 35
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD55 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd55 34
  • 67.69 (n)
  • 68.2 (a)
zebrafish
(Danio rerio)
Actinopterygii ankrd55 34
  • 63.9 (n)
  • 61.49 (a)
ankrd55 35
  • 54 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVO2 35
  • 22 (a)
OneToOne
Species where no ortholog for ANKRD55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD55 Gene

ENSEMBL:
Gene Tree for ANKRD55 (if available)
TreeFam:
Gene Tree for ANKRD55 (if available)

Paralogs for ANKRD55 Gene

(6) SIMAP similar genes for ANKRD55 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ANKRD55: view

No data available for Paralogs for ANKRD55 Gene

Variants for ANKRD55 Gene

Sequence variations from dbSNP and Humsavar for ANKRD55 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs321776 - 56,111,715(+) GAGCA(C/T)GTTGA reference, missense
VAR_055516 -
rs159066 -- 56,228,094(+) aaaga(C/T)atgtt intron-variant
rs159067 -- 56,228,156(+) gacta(C/T)gacct intron-variant
rs159545 -- 56,161,300(+) CTGAA(A/T)GAATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ANKRD55 Gene

Variant ID Type Subtype PubMed ID
dgv1607e212 CNV loss 25503493
dgv164n73 CNV deletion 24416366
dgv9787n54 CNV loss 21841781
esv1152739 CNV deletion 17803354
esv1539040 CNV insertion 17803354
esv23752 CNV loss 19812545
esv2667446 CNV deletion 23128226
esv2677484 CNV deletion 23128226
esv2730194 CNV deletion 23290073
esv274955 CNV loss 21479260
esv29252 CNV loss 19812545
esv3293385 CNV deletion 24192839
esv3331343 CNV insertion 20981092
esv3337539 CNV insertion 20981092
esv3357462 CNV insertion 20981092
esv3416017 CNV duplication 20981092
esv3565940 CNV deletion 23714750
esv3605111 CNV loss 21293372
esv3605112 CNV loss 21293372
esv3605115 CNV loss 21293372
esv993277 CNV deletion 20482838
nsv1024291 CNV gain 25217958
nsv1074831 CNV deletion 25765185
nsv1112420 CNV deletion 24896259
nsv1136997 CNV deletion 24896259
nsv1143135 CNV tandem duplication 24896259
nsv329245 CNV deletion 16902084
nsv513238 CNV loss 21212237
nsv519960 CNV loss 19592680
nsv598186 CNV loss 21841781
nsv980644 CNV duplication 23825009

Variation tolerance for ANKRD55 Gene

Residual Variation Intolerance Score: 27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD55 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD55

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD55 Gene

Disorders for ANKRD55 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ANKRD55 Gene - From: Orphanet

Disorder Aliases PubMed IDs
oligoarticular juvenile arthritis
  • pauciarticular chronic arthritis
polyarticular onset juvenile idiopathic arthritis
  • juvenile chronic polyarthritis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ANKRD55

Genetic Association Database (GAD)
ANKRD55
Human Genome Epidemiology (HuGE) Navigator
ANKRD55
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD55
genes like me logo Genes that share disorders with ANKRD55: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKRD55 Gene

Publications for ANKRD55 Gene

  1. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J. … Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 46 65
  2. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PMID: 20453842) Stahl E.A. … Plenge R.M. (Nat. Genet. 2010) 3 46 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for ANKRD55 Gene

Sources for ANKRD55 Gene

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