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Aliases for ANKRD54 Gene

Aliases for ANKRD54 Gene

  • Ankyrin Repeat Domain 54 2 3
  • Lyn-Interacting Ankyrin Repeat Protein 2 3 4
  • LIAR 3 4 6
  • Ankyrin Repeat Domain-Containing Protein 54 3

External Ids for ANKRD54 Gene

Previous GeneCards Identifiers for ANKRD54 Gene

  • GC22M036556
  • GC22M038226
  • GC22M021193

Summaries for ANKRD54 Gene

GeneCards Summary for ANKRD54 Gene

ANKRD54 (Ankyrin Repeat Domain 54) is a Protein Coding gene. GO annotations related to this gene include protein complex binding and protein kinase regulator activity. An important paralog of this gene is ASB7.

UniProtKB/Swiss-Prot for ANKRD54 Gene

  • Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD54 Gene

Genomics for ANKRD54 Gene

Regulatory Elements for ANKRD54 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ANKRD54 Gene

Start:
37,830,854 bp from pter
End:
37,849,327 bp from pter
Size:
18,474 bases
Orientation:
Minus strand

Genomic View for ANKRD54 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD54 Gene

Proteins for ANKRD54 Gene

  • Protein details for ANKRD54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NXT1-ANR54_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 54
    Protein Accession:
    Q6NXT1
    Secondary Accessions:
    • Q6ZSB1
    • Q9UGV1

    Protein attributes for ANKRD54 Gene

    Size:
    300 amino acids
    Molecular mass:
    32505 Da
    Quaternary structure:
    • Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN. Forms a multiprotein complex with LYN and HCLS1. Interacts with TSN2, VAV1, DBNL AND LASP1.

    Alternative splice isoforms for ANKRD54 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD54 Gene

Proteomics data for ANKRD54 Gene at MOPED

Post-translational modifications for ANKRD54 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ANKRD54 Gene

Domains for ANKRD54 Gene

Gene Families for ANKRD54 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ANKRD54 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NXT1

UniProtKB/Swiss-Prot:

ANR54_HUMAN :
  • Q6NXT1
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with ANKRD54: view

Function for ANKRD54 Gene

Molecular function for ANKRD54 Gene

UniProtKB/Swiss-Prot Function: Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.

Gene Ontology (GO) - Molecular Function for ANKRD54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019887 protein kinase regulator activity IEA --
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with ANKRD54: view

Animal Model Products

CRISPR Products

miRNA for ANKRD54 Gene

miRTarBase miRNAs that target ANKRD54

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANKRD54 Gene

Localization for ANKRD54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD54 Gene

Nucleus. Cytoplasm. Midbody. Note=Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD54 Gene COMPARTMENTS Subcellular localization image for ANKRD54 gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for ANKRD54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0030496 midbody ISS --
genes like me logo Genes that share ontologies with ANKRD54: view

Pathways for ANKRD54 Gene

SuperPathways for ANKRD54 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006913 nucleocytoplasmic transport IEA --
GO:0045648 positive regulation of erythrocyte differentiation ISS --
GO:0045859 regulation of protein kinase activity IEA --
GO:1902531 regulation of intracellular signal transduction ISS --
genes like me logo Genes that share ontologies with ANKRD54: view

No data available for Pathways by source for ANKRD54 Gene

Transcripts for ANKRD54 Gene

Unigene Clusters for ANKRD54 Gene

Ankyrin repeat domain 54:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKRD54

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ANKRD54

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD54 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -
SP6: -
SP7: - - - -
SP8: - - - -
SP9:

Relevant External Links for ANKRD54 Gene

GeneLoc Exon Structure for
ANKRD54
ECgene alternative splicing isoforms for
ANKRD54

Expression for ANKRD54 Gene

mRNA expression in normal human tissues for ANKRD54 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKRD54 Gene

SOURCE GeneReport for Unigene cluster for ANKRD54 Gene Hs.135259

genes like me logo Genes that share expressions with ANKRD54: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKRD54 Gene

Orthologs for ANKRD54 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANKRD54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD54 35
  • 97.23 (n)
  • 96.89 (a)
ANKRD54 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD54 35
  • 88.73 (n)
  • 94.6 (a)
ANKRD54 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD54 35
  • 90.49 (n)
  • 93.96 (a)
ANKRD54 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd54 35
  • 86.51 (n)
  • 91.7 (a)
Ankrd54 16
Ankrd54 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD54 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd54 35
  • 86.39 (n)
  • 92.73 (a)
chicken
(Gallus gallus)
Aves ANKRD54 35
  • 77.5 (n)
  • 86.92 (a)
ANKRD54 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD54 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4216 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd54 35
  • 69.76 (n)
  • 77.43 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10527 35
zebrafish
(Danio rerio)
Actinopterygii ankrd54 35
  • 69.92 (n)
  • 72.03 (a)
ankrd54 36
  • 58 (a)
OneToOne
wufi33d09 35
fruit fly
(Drosophila melanogaster)
Insecta CG10809 36
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAS6 36
  • 18 (a)
OneToMany
Species with no ortholog for ANKRD54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD54 Gene

ENSEMBL:
Gene Tree for ANKRD54 (if available)
TreeFam:
Gene Tree for ANKRD54 (if available)

Paralogs for ANKRD54 Gene

Paralogs for ANKRD54 Gene

Pseudogenes.org Pseudogenes for ANKRD54 Gene

genes like me logo Genes that share paralogs with ANKRD54: view

Variants for ANKRD54 Gene

Sequence variations from dbSNP and Humsavar for ANKRD54 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs2413486 -- 37,841,555(+) ACACA(A/C)ACAAA intron-variant
rs2413487 -- 37,841,557(+) ACACA(A/C)AAAAA intron-variant
rs3091367 -- 37,831,814(+) GGCAT(C/G)TGCGG utr-variant-3-prime, nc-transcript-variant
rs3884917 -- 37,831,924(+) CAGGA(C/G)GGCAG utr-variant-3-prime, nc-transcript-variant
rs5756830 -- 37,834,818(+) cactt(C/T)gggag intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ANKRD54 Gene

Variant ID Type Subtype PubMed ID
dgv4965n71 CNV Loss 21882294
nsv915035 CNV Loss 21882294
dgv1406e1 CNV Complex 17122850
dgv4966n71 CNV Loss 21882294
esv2666189 CNV Deletion 23128226

Relevant External Links for ANKRD54 Gene

HapMap Linkage Disequilibrium report
ANKRD54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD54 Gene

Disorders for ANKRD54 Gene

Relevant External Links for ANKRD54

Genetic Association Database (GAD)
ANKRD54
genes like me logo Genes that share disorders with ANKRD54: view

No data available for UniProtKB/Swiss-Prot for ANKRD54 Gene

Publications for ANKRD54 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54). (PMID: 22527282) Gustafsson M.O. … Nore B.F. (Mol. Cell. Biol. 2012) 2 3
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ANKRD54 Gene

Sources for ANKRD54 Gene

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