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Aliases for ANKRD53 Gene

Aliases for ANKRD53 Gene

  • Ankyrin Repeat Domain 53 2 3 5

External Ids for ANKRD53 Gene

Previous GeneCards Identifiers for ANKRD53 Gene

  • GC02P071059
  • GC02P071205
  • GC02P070942

Summaries for ANKRD53 Gene

GeneCards Summary for ANKRD53 Gene

ANKRD53 (Ankyrin Repeat Domain 53) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD53 Gene

Genomics for ANKRD53 Gene

Regulatory Elements for ANKRD53 Gene

Promoters for ANKRD53 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANKRD53 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKRD53 Gene

Chromosome:
2
Start:
70,977,210 bp from pter
End:
70,986,674 bp from pter
Size:
9,465 bases
Orientation:
Plus strand

Genomic View for ANKRD53 Gene

Genes around ANKRD53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD53 Gene

Proteins for ANKRD53 Gene

  • Protein details for ANKRD53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9V6-ANR53_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 53
    Protein Accession:
    Q8N9V6
    Secondary Accessions:
    • Q8IYP8

    Protein attributes for ANKRD53 Gene

    Size:
    530 amino acids
    Molecular mass:
    59571 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD53 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD53 Gene

Proteomics data for ANKRD53 Gene at MOPED

Post-translational modifications for ANKRD53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD53 Gene

No data available for DME Specific Peptides for ANKRD53 Gene

Domains & Families for ANKRD53 Gene

Gene Families for ANKRD53 Gene

Protein Domains for ANKRD53 Gene

Suggested Antigen Peptide Sequences for ANKRD53 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9V6

UniProtKB/Swiss-Prot:

ANR53_HUMAN :
  • Contains 3 ANK repeats.
Similarity:
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with ANKRD53: view

Function for ANKRD53 Gene

genes like me logo Genes that share phenotypes with ANKRD53: view

Animal Models for ANKRD53 Gene

MGI Knock Outs for ANKRD53:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKRD53 Gene

Localization for ANKRD53 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD53 Gene COMPARTMENTS Subcellular localization image for ANKRD53 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD53 Gene

Pathways & Interactions for ANKRD53 Gene

SuperPathways for ANKRD53 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD53 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD53 Gene

Drugs & Compounds for ANKRD53 Gene

No Compound Related Data Available

Transcripts for ANKRD53 Gene

Unigene Clusters for ANKRD53 Gene

Ankyrin repeat domain 53:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD53 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - - - -
SP6:

Relevant External Links for ANKRD53 Gene

GeneLoc Exon Structure for
ANKRD53
ECgene alternative splicing isoforms for
ANKRD53

Expression for ANKRD53 Gene

mRNA expression in normal human tissues for ANKRD53 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD53 Gene

This gene is overexpressed in Testis (x12.2).

Protein differential expression in normal tissues from HIPED for ANKRD53 Gene

This gene is overexpressed in Plasma (59.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD53 Gene



SOURCE GeneReport for Unigene cluster for ANKRD53 Gene Hs.512744

genes like me logo Genes that share expression patterns with ANKRD53: view

Protein tissue co-expression partners for ANKRD53 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ANKRD53 Gene

Orthologs for ANKRD53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD53 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANKRD53 35
  • 80.13 (n)
  • 70.89 (a)
ANKRD53 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD53 35
  • 77.73 (n)
  • 66.39 (a)
ANKRD53 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd53 35
  • 70.06 (n)
  • 58.29 (a)
Ankrd53 16
Ankrd53 36
  • 50 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANKRD53 35
  • 99.12 (n)
  • 98.3 (a)
ANKRD53 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD53 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD53 36
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732970 35
  • 48.64 (n)
  • 39.37 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC567792 35
  • 48.43 (n)
  • 37.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for ANKRD53:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD53 Gene

ENSEMBL:
Gene Tree for ANKRD53 (if available)
TreeFam:
Gene Tree for ANKRD53 (if available)

Paralogs for ANKRD53 Gene

(2) SIMAP similar genes for ANKRD53 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ANKRD53: view

No data available for Paralogs for ANKRD53 Gene

Variants for ANKRD53 Gene

Sequence variations from dbSNP and Humsavar for ANKRD53 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_030300 -
VAR_054427 -
VAR_061018 -
VAR_067464 -
VAR_067465 -

Structural Variations from Database of Genomic Variants (DGV) for ANKRD53 Gene

Variant ID Type Subtype PubMed ID
nsv874253 CNV Gain 21882294
nsv517881 CNV Loss 19592680

Variation tolerance for ANKRD53 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.12; 80.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD53 Gene

HapMap Linkage Disequilibrium report
ANKRD53

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD53 Gene

Disorders for ANKRD53 Gene

Relevant External Links for ANKRD53

Genetic Association Database (GAD)
ANKRD53
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD53

No disorders were found for ANKRD53 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD53 Gene

Publications for ANKRD53 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ANKRD53 Gene

Sources for ANKRD53 Gene

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