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Aliases for ANKRD53 Gene

Aliases for ANKRD53 Gene

  • Ankyrin Repeat Domain 53 2 3 5

External Ids for ANKRD53 Gene

Previous GeneCards Identifiers for ANKRD53 Gene

  • GC02P071059
  • GC02P071205
  • GC02P070942

Summaries for ANKRD53 Gene

GeneCards Summary for ANKRD53 Gene

ANKRD53 (Ankyrin Repeat Domain 53) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ANKRD53 Gene

  • Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD53 Gene

Genomics for ANKRD53 Gene

Regulatory Elements for ANKRD53 Gene

Enhancers for ANKRD53 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G070107 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -866.4 -866361 7.3 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PCBP1-AS1 C2orf42 FAM136A GMCL1 ANKRD53 LOC105374796 NAGK SNRNP27 MXD1 PCYOX1
GH02G071128 1.4 ENCODE dbSUPER 10.7 +153.5 153495 4.4 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF610 MPHOSPH10 TEX261 NAGK ANKRD53 MCEE LOC101060051
GH02G071000 1.6 FANTOM5 Ensembl ENCODE 8.9 +24.6 24600 2.0 HDGF MLX WRNIP1 ARID4B DMAP1 ZNF2 ZNF48 GLIS2 CBX5 ELK1 TEX261 MPHOSPH10 ANKRD53 NAGK ENSG00000258881 OR7E91P
GH02G071478 1.3 FANTOM5 ENCODE dbSUPER 10.7 +500.4 500404 0.3 PKNOX1 CEBPB CEBPG EP300 RAD21 FOXA1 JUND ZNF585B CEBPA FOS ANKRD53 DYSF NAGK GC02P071578
GH02G071226 1.1 ENCODE 10.7 +249.8 249772 1.8 HDGF PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 ZBTB7B YY1 ZNF143 FOS MPHOSPH10 TEX261 ANKRD53 PAIP2B ENSG00000233870
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD53 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD53 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000291453 90 1001 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 FOS SP3 SP5
ENSR00000118743 1690 1001 YY1 ZNF7 FOXA1 JUND POLR2A SMARCA4 EGR1 HNF4A ZBTB33

Genomic Location for ANKRD53 Gene

Chromosome:
2
Start:
70,977,210 bp from pter
End:
70,986,674 bp from pter
Size:
9,465 bases
Orientation:
Plus strand

Genomic View for ANKRD53 Gene

Genes around ANKRD53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD53 Gene

Proteins for ANKRD53 Gene

  • Protein details for ANKRD53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9V6-ANR53_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 53
    Protein Accession:
    Q8N9V6
    Secondary Accessions:
    • Q8IYP8

    Protein attributes for ANKRD53 Gene

    Size:
    530 amino acids
    Molecular mass:
    59571 Da
    Quaternary structure:
    • Interacts with PSRC1; recruited by PSRC1 to the spindle during mitosis (PubMed:26820536).

    Alternative splice isoforms for ANKRD53 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD53 Gene

Post-translational modifications for ANKRD53 Gene

Other Protein References for ANKRD53 Gene

No data available for DME Specific Peptides for ANKRD53 Gene

Domains & Families for ANKRD53 Gene

Gene Families for ANKRD53 Gene

Protein Domains for ANKRD53 Gene

Suggested Antigen Peptide Sequences for ANKRD53 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD53: view

No data available for UniProtKB/Swiss-Prot for ANKRD53 Gene

Function for ANKRD53 Gene

Molecular function for ANKRD53 Gene

UniProtKB/Swiss-Prot Function:
Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization.

Gene Ontology (GO) - Molecular Function for ANKRD53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26820536
genes like me logo Genes that share ontologies with ANKRD53: view
genes like me logo Genes that share phenotypes with ANKRD53: view

Animal Models for ANKRD53 Gene

MGI Knock Outs for ANKRD53:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKRD53 Gene

Localization for ANKRD53 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD53 Gene

Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at the spindle around the centrosome at prophase and prometaphase and at the spindle poles at metaphase and anaphase (PubMed:26820536). {ECO:0000269 PubMed:26820536}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD53 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for ANKRD53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 26820536
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA,IDA 26820536
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ANKRD53: view

Pathways & Interactions for ANKRD53 Gene

SuperPathways for ANKRD53 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007080 mitotic metaphase plate congression IMP 26820536
GO:0031116 positive regulation of microtubule polymerization IMP 26820536
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ANKRD53: view

No data available for Pathways by source and SIGNOR curated interactions for ANKRD53 Gene

Transcripts for ANKRD53 Gene

Unigene Clusters for ANKRD53 Gene

Ankyrin repeat domain 53:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD53 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - - - -
SP6:

Relevant External Links for ANKRD53 Gene

GeneLoc Exon Structure for
ANKRD53
ECgene alternative splicing isoforms for
ANKRD53

Expression for ANKRD53 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD53 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD53 Gene

This gene is overexpressed in Testis (x12.2).

Protein differential expression in normal tissues from HIPED for ANKRD53 Gene

This gene is overexpressed in Plasma (59.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD53 Gene



Protein tissue co-expression partners for ANKRD53 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD53 Gene:

ANKRD53

SOURCE GeneReport for Unigene cluster for ANKRD53 Gene:

Hs.512744

Evidence on tissue expression from TISSUES for ANKRD53 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ANKRD53: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD53 Gene

Orthologs for ANKRD53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD53 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD53 34 35
  • 99.12 (n)
cow
(Bos Taurus)
Mammalia ANKRD53 34 35
  • 80.13 (n)
dog
(Canis familiaris)
Mammalia ANKRD53 34 35
  • 77.73 (n)
mouse
(Mus musculus)
Mammalia Ankrd53 34 16 35
  • 70.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD53 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD53 35
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732970 34
  • 48.64 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC567792 34
  • 48.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToOne
Species where no ortholog for ANKRD53 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD53 Gene

ENSEMBL:
Gene Tree for ANKRD53 (if available)
TreeFam:
Gene Tree for ANKRD53 (if available)

Paralogs for ANKRD53 Gene

(2) SIMAP similar genes for ANKRD53 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ANKRD53: view

No data available for Paralogs for ANKRD53 Gene

Variants for ANKRD53 Gene

Sequence variations from dbSNP and Humsavar for ANKRD53 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000188860 -- 70,985,812(+) TCAGG(A/G)AGGCA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000461676 -- 70,980,354(+) TAACA(C/G)ACCTA intron-variant
rs1001736976 -- 70,979,145(+) ACTGC(C/T)CTCGC intron-variant, reference, synonymous-codon
rs1002104412 -- 70,979,342(+) CGACA(A/T)GGTAA intron-variant, reference, missense
rs1002120408 -- 70,983,933(+) AATGG(C/T)GGTGG intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD53 Gene

Variant ID Type Subtype PubMed ID
nsv1013232 CNV gain 25217958
nsv1146915 OTHER inversion 26484159
nsv517881 CNV loss 19592680

Variation tolerance for ANKRD53 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.12; 80.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD53 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD53

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD53 Gene

Disorders for ANKRD53 Gene

Relevant External Links for ANKRD53

Genetic Association Database (GAD)
ANKRD53
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD53

No disorders were found for ANKRD53 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD53 Gene

Publications for ANKRD53 Gene

  1. ANKRD53 interacts with DDA3 and regulates chromosome integrity during mitosis. (PMID: 26820536) Kim S. … Jang C.Y. (Biochem. Biophys. Res. Commun. 2016) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for ANKRD53 Gene

Sources for ANKRD53 Gene

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