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Aliases for ANKRD53 Gene

Aliases for ANKRD53 Gene

  • Ankyrin Repeat Domain 53 2 3

External Ids for ANKRD53 Gene

Summaries for ANKRD53 Gene

GeneCards Summary for ANKRD53 Gene

ANKRD53 (Ankyrin Repeat Domain 53) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD53 Gene

Genomics for ANKRD53 Gene

Genomic Location for ANKRD53 Gene

Start:
70,978,028 bp from pter
End:
70,985,499 bp from pter
Size:
7,472 bases
Orientation:
Plus strand

Genomic View for ANKRD53 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD53 Gene

Regulatory Elements for ANKRD53 Gene

Proteins for ANKRD53 Gene

  • Protein details for ANKRD53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9V6-ANR53_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 53
    Protein Accession:
    Q8N9V6
    Secondary Accessions:
    • Q8IYP8

    Protein attributes for ANKRD53 Gene

    Size:
    530 amino acids
    Molecular mass:
    59571 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD53 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD53 Gene

Proteomics data for ANKRD53 Gene at MOPED

Post-translational modifications for ANKRD53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD53 Gene

No data available for DME Specific Peptides for ANKRD53 Gene

Domains for ANKRD53 Gene

Gene Families for ANKRD53 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ANKRD53 Gene

UniProtKB/Swiss-Prot:

ANR53_HUMAN
Similarity:
  • Contains 3 ANK repeats.:
    • Q8N9V6
genes like me logo Genes that share domains with ANKRD53: view

Function for ANKRD53 Gene

Gene Ontology (GO) - Molecular Function for ANKRD53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ANKRD53: view

Phenotypes for ANKRD53 Gene

genes like me logo Genes that share phenotypes with ANKRD53: view

miRNA for ANKRD53 Gene

miRTarBase miRNAs that target ANKRD53

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANKRD53 Gene

Localization for ANKRD53 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD53 Gene COMPARTMENTS Subcellular localization image for ANKRD53 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for ANKRD53 Gene

Pathways for ANKRD53 Gene

SuperPathways for ANKRD53 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD53 Gene

None

No data available for Pathways by source for ANKRD53 Gene

Transcripts for ANKRD53 Gene

Unigene Clusters for ANKRD53 Gene

Ankyrin repeat domain 53:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD53 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - - - -
SP6:

Relevant External Links for ANKRD53 Gene

GeneLoc Exon Structure for
ANKRD53
ECgene alternative splicing isoforms for
ANKRD53

Expression for ANKRD53 Gene

mRNA expression in normal human tissues for ANKRD53 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD53 Gene

This gene is overexpressed in Testis (12.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANKRD53 Gene

SOURCE GeneReport for Unigene cluster for ANKRD53 Gene Hs.512744

genes like me logo Genes that share expressions with ANKRD53: view

Orthologs for ANKRD53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD53 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD53 36
  • 99.12 (n)
  • 98.3 (a)
ANKRD53 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD53 36
  • 80.13 (n)
  • 70.89 (a)
ANKRD53 37
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD53 36
  • 77.73 (n)
  • 66.39 (a)
ANKRD53 37
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd53 36
  • 70.06 (n)
  • 58.29 (a)
Ankrd53 16
Ankrd53 37
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD53 37
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD53 37
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732970 36
  • 48.64 (n)
  • 39.37 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC567792 36
  • 48.43 (n)
  • 37.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToOne
Species with no ortholog for ANKRD53:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD53 Gene

ENSEMBL:
Gene Tree for ANKRD53 (if available)
TreeFam:
Gene Tree for ANKRD53 (if available)

Paralogs for ANKRD53 Gene

Selected SIMAP similar genes for ANKRD53 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ANKRD53: view

No data available for Paralogs for ANKRD53 Gene

Variants for ANKRD53 Gene

Sequence variations from dbSNP and Humsavar for ANKRD53 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1115049 -- 70,978,846(+) GCTGC(A/G)GGGAG intron-variant
rs1115050 -- 70,978,928(+) AAGCC(A/C)GCAGA intron-variant
rs2041689 -- 70,976,212(+) GGTAC(A/G)GAGGA upstream-variant-2KB
rs2160070 -- 70,984,331(+) ACATC(A/T)CTCCC intron-variant
rs2418653 -- 70,977,116(+) gggac(A/G)ggggg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ANKRD53 Gene

Variant ID Type Subtype PubMed ID
nsv874253 CNV Gain 21882294
nsv517881 CNV Loss 19592680

Relevant External Links for ANKRD53 Gene

HapMap Linkage Disequilibrium report
ANKRD53

Disorders for ANKRD53 Gene

Relevant External Links for ANKRD53

Genetic Association Database (GAD)
ANKRD53
genes like me logo Genes that share disorders with ANKRD53: view

No data available for UniProtKB/Swiss-Prot for ANKRD53 Gene

Publications for ANKRD53 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for ANKRD53 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ANKRD53
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ANKRD53
    • Block miRNA regulation of ANKRD53 using miScript Target Protectors

    Sources for ANKRD53 Gene

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