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Aliases for ANKRD52 Gene

Aliases for ANKRD52 Gene

  • Ankyrin Repeat Domain 52 2 3 5
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit ARS-C 3 4
  • Protein Phosphatase 6 Ankyrin Repeat Subunit C 2 3
  • Ankyrin Repeat Domain-Containing Protein 52 3 4
  • PP6-ARS-C 3 4
  • Ankyrin Repeat Domain 33 3
  • CVWG5837 3
  • ANKRD33 3

External Ids for ANKRD52 Gene

Previous GeneCards Identifiers for ANKRD52 Gene

  • GC12M054920
  • GC12U900660
  • GC12M056631
  • GC12M053670

Summaries for ANKRD52 Gene

GeneCards Summary for ANKRD52 Gene

ANKRD52 (Ankyrin Repeat Domain 52) is a Protein Coding gene. An important paralog of this gene is TANC1.

UniProtKB/Swiss-Prot for ANKRD52 Gene

  • Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD52 Gene

Genomics for ANKRD52 Gene

Regulatory Elements for ANKRD52 Gene

Enhancers for ANKRD52 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANKRD52 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD52 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANKRD52 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKRD52 Gene

56,237,807 bp from pter
56,258,391 bp from pter
20,585 bases
Minus strand

Genomic View for ANKRD52 Gene

Genes around ANKRD52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD52 Gene

Proteins for ANKRD52 Gene

  • Protein details for ANKRD52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
    Protein Accession:
    Secondary Accessions:
    • A6NE79
    • B1Q2K2

    Protein attributes for ANKRD52 Gene

    1076 amino acids
    Molecular mass:
    115077 Da
    Quaternary structure:
    • Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1.

neXtProt entry for ANKRD52 Gene

Proteomics data for ANKRD52 Gene at MOPED

Post-translational modifications for ANKRD52 Gene

  • Ubiquitination at Lys 337
  • Modification sites at PhosphoSitePlus

Other Protein References for ANKRD52 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD52 Gene

Domains & Families for ANKRD52 Gene

Protein Domains for ANKRD52 Gene

Suggested Antigen Peptide Sequences for ANKRD52 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 28 ANK repeats.
  • Contains 28 ANK repeats.
genes like me logo Genes that share domains with ANKRD52: view

Function for ANKRD52 Gene

Molecular function for ANKRD52 Gene

UniProtKB/Swiss-Prot Function:
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

Animal Model Products

CRISPR Products

miRNA for ANKRD52 Gene

miRTarBase miRNAs that target ANKRD52

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD52 Gene

Localization for ANKRD52 Gene

Subcellular locations from

Jensen Localization Image for ANKRD52 Gene COMPARTMENTS Subcellular localization image for ANKRD52 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD52 Gene

Pathways & Interactions for ANKRD52 Gene

SuperPathways for ANKRD52 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD52 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKRD52 Gene

Drugs & Compounds for ANKRD52 Gene

No Compound Related Data Available

Transcripts for ANKRD52 Gene

Unigene Clusters for ANKRD52 Gene

Ankyrin repeat domain 52:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD52 Gene

No ASD Table

Relevant External Links for ANKRD52 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRD52 Gene

mRNA expression in normal human tissues for ANKRD52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD52 Gene

This gene is overexpressed in Lung (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD52 Gene

SOURCE GeneReport for Unigene cluster for ANKRD52 Gene Hs.524506

genes like me logo Genes that share expression patterns with ANKRD52: view

Protein tissue co-expression partners for ANKRD52 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKRD52 Gene

Orthologs for ANKRD52 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD52 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANKRD52 35
  • 94.64 (n)
  • 99.44 (a)
ANKRD52 36
  • 99 (a)
(Canis familiaris)
Mammalia ANKRD52 35
  • 94.73 (n)
  • 98.51 (a)
ANKRD52 36
  • 99 (a)
(Mus musculus)
Mammalia Ankrd52 35
  • 93.18 (n)
  • 99.07 (a)
Ankrd52 16
Ankrd52 36
  • 99 (a)
(Pan troglodytes)
Mammalia ANKRD52 35
  • 99.75 (n)
  • 99.91 (a)
ANKRD52 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ankrd52 35
  • 93.06 (n)
  • 99.16 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 18 (a)
(Gallus gallus)
Aves ANKRD52 35
  • 79.93 (n)
  • 89.66 (a)
ANKRD52 36
  • 90 (a)
(Anolis carolinensis)
Reptilia ANKRD52 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd52 35
  • 75.17 (n)
  • 82.65 (a)
(Danio rerio)
Actinopterygii ankrd52a 35
  • 67.76 (n)
  • 68.2 (a)
Dr.18831 35
ANKRD52 (2 of 2) 36
  • 61 (a)
ankrd52a 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta nompC 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for ANKRD52:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD52 Gene

Gene Tree for ANKRD52 (if available)
Gene Tree for ANKRD52 (if available)

Paralogs for ANKRD52 Gene

(12) SIMAP similar genes for ANKRD52 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD52: view

Variants for ANKRD52 Gene

Sequence variations from dbSNP and Humsavar for ANKRD52 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7296038 -- 56,249,558(+) AGTGT(C/T)Ctttt intron-variant
rs12815735 -- 56,239,219(+) GGAGG(A/G)AGCCC utr-variant-3-prime
rs747890 -- 56,243,147(+) CTACT(C/G)AGAGT reference, missense
rs773650 -- 56,245,808(-) GAACC(A/G)GGGAG intron-variant
rs808919 -- 56,254,127(+) TTGGT(C/G/T)GAGAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ANKRD52 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Variation tolerance for ANKRD52 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.89% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ANKRD52 Gene

Disorders for ANKRD52 Gene

Relevant External Links for ANKRD52

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANKRD52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD52 Gene

Publications for ANKRD52 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for ANKRD52 Gene

Sources for ANKRD52 Gene