ANKRD52 Gene
protein-coding GIFtS: 44
GCID: GC12M056631
|
|
ankyrin repeat domain 52
| |
Aliases
for ANKRD52 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat Domain 521 2 | | ANKRD332 | | PP6-ARS-C1 2 3 | | CVWG58372 | | Ankyrin Repeat Domain-Containing Protein 522 3 | | Ankyrin Repeat Domain 332 | | Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit ARS-C2 3 | | Protein Phosphatase 6 Ankyrin Repeat Subunit C2 | | FLJ342361 | | Serine/Threonine-Protein Phosphatase 6 Regulatory Ankyrin Repeat Subunit C2 |
Export aliases for ANKRD52 gene to outside databasesPrevious GC identifers: GC12M054920 GC12U900660 GC12M053670 |
Summaries
for ANKRD52 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ANR52_HUMAN, Q8NB46Function: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition ofphosphoprotein substrates
|
Genomic Views
for ANKRD52 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKRD52 gene promoter:
TBP ER-alpha GR GR-beta Sox9 GR-alpha NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKRD52
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD52 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.3ANKRD52 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M056631: view genomic region
(about GC identifiers)
Start:
|
56,631,591 bp from pter |
End:
|
56,652,175 bp from pter |
Size:
|
20,585 bases |
Orientation:
|
minus strand |
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Proteins
for ANKRD52 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANR52_HUMAN, Q8NB46 (See
protein sequence)Recommended Name: Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C Size: 1076 amino acids; 115077 Da
Subunit: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalyticsubunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS).Interacts with PPP6R1
Secondary accessions: A6NE79 B1Q2K2Explore the universe of human proteins at neXtProt for ANKRD52: NX_Q8NB46
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NB46
ANKRD52 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775866.2
ENSEMBL proteins: ENSP00000267116 ENSP00000416967
Human Recombinant Protein Products:
ANKRD52 Antibody Products:
Assay Products for ANKRD52: |
Protein
Domains /
Families
for ANKRD52 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKRD52 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NB46ProtoNet protein and cluster: Q8NB46 UniProtKB/Swiss-Prot: ANR52_HUMAN, Q8NB46Similarity: Contains 28 ANK repeats |
Function
for ANKRD52 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ANR52_HUMAN, Q8NB46Function: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition ofphosphoprotein substrates
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD52 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD52
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD52 |
|
Pathways & Interactions
for ANKRD52 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD52
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/29 Interacting proteins for ANKRD52 (Q8NB462, 3 ENSP000002671164) via UniProtKB, MINT, STRING, and/or I2D (see all 29)About this table
|
Drugs & Compounds
for ANKRD52 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKRD52
Search CenterWatch for drugs/clinical trials and news about ANKRD52 / ANR52
|
Transcripts
for ANKRD52 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKRD52 gene: NM_173595.3 Unigene Cluster for ANKRD52: Ankyrin repeat domain 52 Hs.524506 [show with all ESTs]Unigene Representative Sequence: AB1909905 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000548241 ENST00000267116(uc001skm.4) ENST00000548081 ENST00000551023
ENST00000417002(uc001skn.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD52 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD52
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANKRD52 (NM_173595) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD52 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANKRD52 |
Additional cDNA sequence: AB190990.1 AK125379.1 AK126893.1 AY358160.1 BC024309.1 BC042070.1 12 DOTS entries: DT.442157 DT.91710825 DT.121142147 DT.91882537 DT.204222 DT.121142140 DT.40188918 DT.121142123 DT.70103773 DT.95167243 DT.95315272 DT.97801055 24/99 AceView cDNA sequences (see all 99): AA380710 BU102143 BM551138 AK125379 BM847805 AA781665 BM710593 BU101999 AK056831 AI749863 BU634302 AA459069 AI880337 BM762938 BM823868 BM929503 BM683572 BC042070 AI084067 AA406623 AA430699 BG829264 CO245439 AW130055
GeneLoc Exon Structure
|
Expression
for ANKRD52 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKRD52 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTTGGGAT
About this image
See ANKRD52 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD52
SOURCE GeneReport for Unigene cluster: Hs.524506
SABiosciences Custom PCR Arrays for ANKRD52
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD52
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANKRD52 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD52 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD52 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD52 |
Orthologs
for ANKRD52 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ANKRD52 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ANKRD521 |
ankyrin repeat domain 52 |
79.93(n)
89.66(a) |
|
426469 NM_001012939.1 NP_001012957.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ANKRD526 |
-- |
90(a) |
1 ↔ 1 |
2(93532943-93583075) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.188312 |
Transcribed sequence with weak similarity to protein more |
70.97(n) |
|
BM141633.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
nompC6 |
no mechanoreceptor potential C |
11(a) |
possible ortholog |
2L(5342321-5365760) |
rice
(Oryza sativa) |
Liliopsida |
-- |
ankyrin repeat domain-containing protein 50, putat... |
20(a) |
possible ortholog |
3(25568429-25570099) |
ENSEMBL Gene Tree for ANKRD52 (if available)
TreeFam Gene Tree for ANKRD52 (if available) |
Paralogs
for ANKRD52 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKRD52 gene
- TANC22 TNKS22 ANKRD172 ANK32 ANKHD12 ANK12 ANKHD1-EIF4EBP32 TNKS2
- ANKRD502 TANC12 INVS2 ANKRD282 ANK22 ANKRD442
12 SIMAP similar genes for ANKRD52 using alignment to 2 protein entries: ANR52_HUMAN (see all proteins):LOC91526 ANKRD44 ANKRD28 CDKN2C DKFZp761E1322 IkBa
MTPN PPP1R12A CDKN2D ANKDD1A PSMD10 ANKRD10
ANKRD52 for paralogs About GeneDecksing
|
Genomic Variants
for ANKRD52 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKRD52 (56631591 - 56652175 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ANKRD52
1 CNV: 0164 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD52 |
|
Disorders
/ Diseases
for ANKRD52 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ANKRD52 for disorders About GeneDecksing
1  disease for ANKRD52: About MalaCardsneuronitis
Human Genome Epidemiology (HuGE) Navigator: ANKRD52 (3 documents)
Export disorders for ANKRD52 gene to outside databases
|
Publications
for ANKRD52 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKRD52 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with ANKRD52) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PubMed id 18186651)1, 2 Stefansson B.... Brautigan D.L. (2008)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Protein phosphatase 6 regulates mitotic spindle forma tion by controlling the T-loop phosphorylation state of Aurora A bound to its a ctivator TPX2. (PubMed id 21187329)1 Zeng K....Gruneberg U. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
|
External Searches for ANKRD52 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANKRD52 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKRD52 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANKRD52 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKRD52 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANKRD52 gene:
Search GeneIP for patents involving ANKRD52
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKRD52 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 | | | ANKRD52 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD52 |
|  |  |  | | | | ThermoFisher Antibodies for ANKRD52 |
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