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Aliases for ANKRD52 Gene

Aliases for ANKRD52 Gene

  • Ankyrin Repeat Domain 52 2 3
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit ARS-C 3 4
  • Protein Phosphatase 6 Ankyrin Repeat Subunit C 2 3
  • Ankyrin Repeat Domain-Containing Protein 52 3 4
  • PP6-ARS-C 3 4
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Ankyrin Repeat Subunit C 3
  • Ankyrin Repeat Domain 33 3
  • CVWG5837 3
  • ANKRD33 3

External Ids for ANKRD52 Gene

Summaries for ANKRD52 Gene

GeneCards Summary for ANKRD52 Gene

ANKRD52 (Ankyrin Repeat Domain 52) is a Protein Coding gene. An important paralog of this gene is ANKRD65.

UniProtKB/Swiss-Prot for ANKRD52 Gene

  • Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD52 Gene

Genomics for ANKRD52 Gene

Genomic Location for ANKRD52 Gene

Start:
56,237,807 bp from pter
End:
56,258,391 bp from pter
Size:
20,585 bases
Orientation:
Minus strand

Genomic View for ANKRD52 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD52 Gene

Regulatory Elements for ANKRD52 Gene

Proteins for ANKRD52 Gene

  • Protein details for ANKRD52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NB46-ANR52_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
    Protein Accession:
    Q8NB46
    Secondary Accessions:
    • A6NE79
    • B1Q2K2

    Protein attributes for ANKRD52 Gene

    Size:
    1076 amino acids
    Molecular mass:
    115077 Da
    Quaternary structure:
    • Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1.

neXtProt entry for ANKRD52 Gene

Proteomics data for ANKRD52 Gene at MOPED

Post-translational modifications for ANKRD52 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys337

Other Protein References for ANKRD52 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD52 Gene

Domains for ANKRD52 Gene

Gene Families for ANKRD52 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • PPP6R :Serine/threonine phosphatases / Protein phosphatase 6, regulatory subunits

Protein Domains for ANKRD52 Gene

Suggested Antigen Peptide Sequences for ANKRD52 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NB46

UniProtKB/Swiss-Prot:

ANR52_HUMAN
Similarity:
  • Contains 28 ANK repeats.:
    • Q8NB46
genes like me logo Genes that share domains with ANKRD52: view

Function for ANKRD52 Gene

Molecular function for ANKRD52 Gene

UniProtKB/Swiss-Prot Function: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates

Gene Ontology (GO) - Molecular Function for ANKRD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18186651
genes like me logo Genes that share ontologies with ANKRD52: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANKRD52 Gene

Localization for ANKRD52 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD52 Gene COMPARTMENTS Subcellular localization image for ANKRD52 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD52 Gene

Pathways for ANKRD52 Gene

SuperPathways for ANKRD52 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD52 Gene

None

No data available for Pathways by source for ANKRD52 Gene

Transcripts for ANKRD52 Gene

Unigene Clusters for ANKRD52 Gene

Ankyrin repeat domain 52:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD52 Gene

No ASD Table

Relevant External Links for ANKRD52 Gene

GeneLoc Exon Structure for
ANKRD52
ECgene alternative splicing isoforms for
ANKRD52

Expression for ANKRD52 Gene

mRNA expression in normal human tissues for ANKRD52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANKRD52 Gene

SOURCE GeneReport for Unigene cluster for ANKRD52 Gene Hs.524506

genes like me logo Genes that share expressions with ANKRD52: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKRD52 Gene

Orthologs for ANKRD52 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD52 35
  • 99.75 (n)
  • 99.91 (a)
ANKRD52 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD52 35
  • 94.64 (n)
  • 99.44 (a)
ANKRD52 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD52 35
  • 94.73 (n)
  • 98.51 (a)
ANKRD52 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd52 35
  • 93.18 (n)
  • 99.07 (a)
Ankrd52 16
Ankrd52 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 18 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ankrd52 35
  • 93.06 (n)
  • 99.16 (a)
chicken
(Gallus gallus)
Aves ANKRD52 35
  • 79.93 (n)
  • 89.66 (a)
ANKRD52 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD52 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd52 35
  • 75.17 (n)
  • 82.65 (a)
zebrafish
(Danio rerio)
Actinopterygii ANKRD52 (2 of 2) 36
  • 61 (a)
OneToMany
ankrd52a 35
  • 67.76 (n)
  • 68.2 (a)
ankrd52a 36
  • 68 (a)
OneToMany
Dr.18831 35
fruit fly
(Drosophila melanogaster)
Insecta nompC 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for ANKRD52:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD52 Gene

ENSEMBL:
Gene Tree for ANKRD52 (if available)
TreeFam:
Gene Tree for ANKRD52 (if available)

Paralogs for ANKRD52 Gene

Paralogs for ANKRD52 Gene

Selected SIMAP similar genes for ANKRD52 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD52: view

Variants for ANKRD52 Gene

Sequence variations from dbSNP and Humsavar for ANKRD52 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs747890 -- 56,243,147(+) CTACT(C/G)AGAGT missense, reference
rs773650 -- 56,245,808(-) GAACC(A/G)GGGAG intron-variant
rs808919 -- 56,254,127(+) TTGGT(C/G)GAGAC reference, synonymous-codon
rs871130 -- 56,254,993(+) AGATT(C/T)GTGCC intron-variant
rs1274490 -- 56,255,817(-) AGTGC(C/T)CTGCA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ANKRD52 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Relevant External Links for ANKRD52 Gene

HapMap Linkage Disequilibrium report
ANKRD52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD52 Gene

Disorders for ANKRD52 Gene

Relevant External Links for ANKRD52

Genetic Association Database (GAD)
ANKRD52
Human Genome Epidemiology (HuGE) Navigator
ANKRD52
genes like me logo Genes that share disorders with ANKRD52: view

No data available for UniProtKB/Swiss-Prot for ANKRD52 Gene

Publications for ANKRD52 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  5. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PMID: 18186651) Stefansson B. … Brautigan D.L. (Biochemistry 2008) 3 4

Products for ANKRD52 Gene

Sources for ANKRD52 Gene

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