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Aliases for ANKRD52 Gene

Aliases for ANKRD52 Gene

  • Ankyrin Repeat Domain 52 2 3 5
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit ARS-C 3 4
  • Protein Phosphatase 6 Ankyrin Repeat Subunit C 2 3
  • Ankyrin Repeat Domain-Containing Protein 52 3 4
  • PP6-ARS-C 3 4
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Ankyrin Repeat Subunit C 3
  • Ankyrin Repeat Domain 33 3
  • CVWG5837 3
  • ANKRD33 3

External Ids for ANKRD52 Gene

Previous GeneCards Identifiers for ANKRD52 Gene

  • GC12M054920
  • GC12U900660
  • GC12M056631
  • GC12M053670

Summaries for ANKRD52 Gene

GeneCards Summary for ANKRD52 Gene

ANKRD52 (Ankyrin Repeat Domain 52) is a Protein Coding gene. An important paralog of this gene is ANKRD28.

UniProtKB/Swiss-Prot for ANKRD52 Gene

  • Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD52 Gene

Genomics for ANKRD52 Gene

Regulatory Elements for ANKRD52 Gene

Enhancers for ANKRD52 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F057109 1.2 ENCODE 73.4 -852.9 -852863 3.8 CREB3L1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 MCM3 SP3 NEMP1 BAZ2A ANKRD52 CTDSP2 RN7SL809P ENSG00000224713 ENSG00000258317 ZC3H10 TSPAN31 RNU6-343P
GH12F056718 1.2 ENCODE 72.6 -464.2 -464168 8.9 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF263 MCM3 NEMP1 BAZ2A ANKRD52 RN7SL809P ENSG00000224713 TMEM198B ZC3H10 RNU6-343P CDK2 SMARCC2
GH12F056220 1.2 ENCODE 63 +35.5 35510 5.7 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 NEMP1 ANKRD52 BAZ2A PHC1P1 ZBTB39 TMEM198B SMARCC2 RN7SL809P ENSG00000258317 STAT2
GH12F056266 1.1 ENCODE 63.2 -8.8 -8803 2.0 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302 NEMP1 ANKRD52 BAZ2A PHC1P1 ZBTB39 SMARCC2 RN7SL809P ENSG00000258317 CDK2 TMEM198B
GH12F055826 1 FANTOM5 62.8 +432.2 432213 0.2 ZNF493 ZFP64 INSM2 ZEB1 ZNF366 ZNF354C KLF7 ZNF202 ZNF680 ZNF654 ANKRD52 BAZ2A PHC1P1 TMEM198B SMARCC2 RN7SL809P ENSG00000258317 STAT2 ZC3H10 ENSG00000257740
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD52 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD52 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000088825 91 1801 ATF1 ZNF133 ARID4B SIN3A GLI4 DMAP1 ZNF48 ZNF121 GLIS2 ZNF143

Genomic Location for ANKRD52 Gene

Chromosome:
12
Start:
56,237,807 bp from pter
End:
56,258,391 bp from pter
Size:
20,585 bases
Orientation:
Minus strand

Genomic View for ANKRD52 Gene

Genes around ANKRD52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD52 Gene

Proteins for ANKRD52 Gene

  • Protein details for ANKRD52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NB46-ANR52_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
    Protein Accession:
    Q8NB46
    Secondary Accessions:
    • A6NE79
    • B1Q2K2

    Protein attributes for ANKRD52 Gene

    Size:
    1076 amino acids
    Molecular mass:
    115077 Da
    Quaternary structure:
    • Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1.

neXtProt entry for ANKRD52 Gene

Post-translational modifications for ANKRD52 Gene

  • Ubiquitination at Lys 337
  • Modification sites at PhosphoSitePlus

Other Protein References for ANKRD52 Gene

No data available for DME Specific Peptides for ANKRD52 Gene

Domains & Families for ANKRD52 Gene

Protein Domains for ANKRD52 Gene

Suggested Antigen Peptide Sequences for ANKRD52 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NB46

UniProtKB/Swiss-Prot:

ANR52_HUMAN :
  • Contains 28 ANK repeats.
Similarity:
  • Contains 28 ANK repeats.
genes like me logo Genes that share domains with ANKRD52: view

Function for ANKRD52 Gene

Molecular function for ANKRD52 Gene

UniProtKB/Swiss-Prot Function:
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

Gene Ontology (GO) - Molecular Function for ANKRD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18186651
genes like me logo Genes that share ontologies with ANKRD52: view

Animal Model Products

miRNA for ANKRD52 Gene

miRTarBase miRNAs that target ANKRD52

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD52 Gene

Localization for ANKRD52 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD52 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD52 Gene

Pathways & Interactions for ANKRD52 Gene

SuperPathways for ANKRD52 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD52 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD52 Gene

Transcripts for ANKRD52 Gene

Unigene Clusters for ANKRD52 Gene

Ankyrin repeat domain 52:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD52 Gene

No ASD Table

Relevant External Links for ANKRD52 Gene

GeneLoc Exon Structure for
ANKRD52
ECgene alternative splicing isoforms for
ANKRD52

Expression for ANKRD52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD52 Gene

This gene is overexpressed in Lung (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD52 Gene



Protein tissue co-expression partners for ANKRD52 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD52 Gene:

ANKRD52

SOURCE GeneReport for Unigene cluster for ANKRD52 Gene:

Hs.524506
genes like me logo Genes that share expression patterns with ANKRD52: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKRD52 Gene

Orthologs for ANKRD52 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD52 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia ANKRD52 34 35
  • 94.73 (n)
cow
(Bos Taurus)
Mammalia ANKRD52 34 35
  • 94.64 (n)
mouse
(Mus musculus)
Mammalia Ankrd52 34 16 35
  • 93.18 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd52 34
  • 93.06 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 62 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 18 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ANKRD52 34 35
  • 79.93 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD52 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd52 34
  • 75.17 (n)
zebrafish
(Danio rerio)
Actinopterygii ankrd52a 34 35
  • 67.76 (n)
ANKRD52 (2 of 2) 35
  • 61 (a)
OneToMany
Dr.18831 34
fruit fly
(Drosophila melanogaster)
Insecta nompC 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for ANKRD52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD52 Gene

ENSEMBL:
Gene Tree for ANKRD52 (if available)
TreeFam:
Gene Tree for ANKRD52 (if available)

Paralogs for ANKRD52 Gene

(12) SIMAP similar genes for ANKRD52 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD52: view

Variants for ANKRD52 Gene

Sequence variations from dbSNP and Humsavar for ANKRD52 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs111313177 -- 56,241,824(+) CCCTC(C/T)TCACT utr-variant-3-prime
rs111320403 -- 56,252,288(+) CTACC(A/G)TTAGC reference, synonymous-codon
rs111378824 -- 56,238,401(+) GATGC(C/G/T)CACAG utr-variant-3-prime
rs111481799 -- 56,256,291(+) TCCAC(A/G)TGTGG intron-variant
rs111563777 -- 56,243,873(+) TGGAG(C/T)GGCCT intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ANKRD52 Gene

Variant ID Type Subtype PubMed ID
nsv952186 CNV deletion 24416366
nsv482992 CNV gain+loss 15286789
esv3381217 CNV duplication 20981092

Variation tolerance for ANKRD52 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD52 Gene

Disorders for ANKRD52 Gene

Relevant External Links for ANKRD52

Genetic Association Database (GAD)
ANKRD52
Human Genome Epidemiology (HuGE) Navigator
ANKRD52
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD52

No disorders were found for ANKRD52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD52 Gene

Publications for ANKRD52 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PMID: 18186651) Stefansson B. … Brautigan D.L. (Biochemistry 2008) 3 4 64
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ANKRD52 Gene

Sources for ANKRD52 Gene

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