Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANKRD52 Gene

Aliases for ANKRD52 Gene

  • Ankyrin Repeat Domain 52 2 3 5
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit ARS-C 3 4
  • Protein Phosphatase 6 Ankyrin Repeat Subunit C 2 3
  • Ankyrin Repeat Domain-Containing Protein 52 3 4
  • PP6-ARS-C 3 4
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Ankyrin Repeat Subunit C 3
  • Ankyrin Repeat Domain 33 3
  • CVWG5837 3
  • ANKRD33 3

External Ids for ANKRD52 Gene

Previous GeneCards Identifiers for ANKRD52 Gene

  • GC12M054920
  • GC12U900660
  • GC12M056631
  • GC12M053670

Summaries for ANKRD52 Gene

GeneCards Summary for ANKRD52 Gene

ANKRD52 (Ankyrin Repeat Domain 52) is a Protein Coding gene. An important paralog of this gene is ANKRD28.

UniProtKB/Swiss-Prot for ANKRD52 Gene

  • Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD52 Gene

Genomics for ANKRD52 Gene

Regulatory Elements for ANKRD52 Gene

Enhancers for ANKRD52 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G057109 1.5 ENCODE dbSUPER 83.2 -852.9 -852863 3.8 CREB3L1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 MCM3 NEMP1 SMARCC2 ENSG00000257740 ANKRD52 BAZ2A NAB2 ENSG00000224713 CTDSP2 LOC283387 RN7SL809P
GH12G056718 1.5 ENCODE dbSUPER 74.4 -464.2 -464168 8.9 CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF263 MCM3 NEMP1 SMARCC2 BAZ2A ENSG00000257740 ANKRD52 TMEM198B ENSG00000224713 NAB2 RN7SL809P STAT2
GH12G056220 1.4 ENCODE dbSUPER 46 +35.5 35510 5.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 NEMP1 PHC1P1 ANKRD52 BAZ2A SMARCC2 STAT2 RN7SL809P ENSG00000257740 RBMS2 NAB2
GH12G056266 1.2 ENCODE 46.1 -8.8 -8803 2.0 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 NEMP1 PHC1P1 ANKRD52 SMARCC2 BAZ2A RN7SL809P ENSG00000257740 ENSG00000257303 RBMS2 STAT2
GH12G055826 1 FANTOM5 45.7 +432.2 432213 0.2 ZNF493 ZFP64 INSM2 ZEB1 ZNF366 ZNF354C KLF7 ZNF202 ZNF680 ZNF654 ANKRD52 PHC1P1 SMARCC2 STAT2 BAZ2A RN7SL809P ENSG00000257740 ENSG00000258199 RBMS2 RNU6-343P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD52 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD52 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052495 191 1601 HDGF ATF1 ZNF133 ARID4B SIN3A DMAP1 GLI4 ZNF48 ZNF121 GLIS2

Genomic Location for ANKRD52 Gene

Chromosome:
12
Start:
56,237,807 bp from pter
End:
56,258,391 bp from pter
Size:
20,585 bases
Orientation:
Minus strand

Genomic View for ANKRD52 Gene

Genes around ANKRD52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD52 Gene

Proteins for ANKRD52 Gene

  • Protein details for ANKRD52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NB46-ANR52_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
    Protein Accession:
    Q8NB46
    Secondary Accessions:
    • A6NE79
    • B1Q2K2

    Protein attributes for ANKRD52 Gene

    Size:
    1076 amino acids
    Molecular mass:
    115077 Da
    Quaternary structure:
    • Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1.

neXtProt entry for ANKRD52 Gene

Post-translational modifications for ANKRD52 Gene

  • Ubiquitination at posLast=337337
  • Modification sites at PhosphoSitePlus

Other Protein References for ANKRD52 Gene

No data available for DME Specific Peptides for ANKRD52 Gene

Domains & Families for ANKRD52 Gene

Protein Domains for ANKRD52 Gene

Suggested Antigen Peptide Sequences for ANKRD52 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD52: view

No data available for UniProtKB/Swiss-Prot for ANKRD52 Gene

Function for ANKRD52 Gene

Molecular function for ANKRD52 Gene

UniProtKB/Swiss-Prot Function:
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

Gene Ontology (GO) - Molecular Function for ANKRD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18186651
genes like me logo Genes that share ontologies with ANKRD52: view

Animal Model Products

CRISPR Products

miRNA for ANKRD52 Gene

miRTarBase miRNAs that target ANKRD52

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD52 Gene

Localization for ANKRD52 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD52 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD52 Gene

Pathways & Interactions for ANKRD52 Gene

SuperPathways for ANKRD52 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD52 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD52 Gene

Transcripts for ANKRD52 Gene

mRNA/cDNA for ANKRD52 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD52 Gene

Ankyrin repeat domain 52:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD52 Gene

No ASD Table

Relevant External Links for ANKRD52 Gene

GeneLoc Exon Structure for
ANKRD52
ECgene alternative splicing isoforms for
ANKRD52

Expression for ANKRD52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD52 Gene

This gene is overexpressed in Lung (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD52 Gene



Protein tissue co-expression partners for ANKRD52 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD52 Gene:

ANKRD52

SOURCE GeneReport for Unigene cluster for ANKRD52 Gene:

Hs.524506

Evidence on tissue expression from TISSUES for ANKRD52 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with ANKRD52: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD52 Gene

Orthologs for ANKRD52 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD52 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia ANKRD52 34 35
  • 94.73 (n)
cow
(Bos Taurus)
Mammalia ANKRD52 34 35
  • 94.64 (n)
mouse
(Mus musculus)
Mammalia Ankrd52 34 16 35
  • 93.18 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd52 34
  • 93.06 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 62 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 18 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ANKRD52 34 35
  • 79.93 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD52 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd52 34
  • 75.17 (n)
zebrafish
(Danio rerio)
Actinopterygii ankrd52a 34 35
  • 67.76 (n)
ANKRD52 (2 of 2) 35
  • 61 (a)
OneToMany
Dr.18831 34
fruit fly
(Drosophila melanogaster)
Insecta nompC 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for ANKRD52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD52 Gene

ENSEMBL:
Gene Tree for ANKRD52 (if available)
TreeFam:
Gene Tree for ANKRD52 (if available)

Paralogs for ANKRD52 Gene

(12) SIMAP similar genes for ANKRD52 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD52: view

Variants for ANKRD52 Gene

Sequence variations from dbSNP and Humsavar for ANKRD52 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000156605 -- 56,249,079(+) CCCCT(C/G)TGGCT intron-variant
rs1000393735 -- 56,245,525(+) CCCTT(A/G)AAGTC reference, synonymous-codon
rs1000789373 -- 56,240,517(+) CCTCC(C/T)CGCCC utr-variant-3-prime
rs1000827861 -- 56,245,915(+) TTTCA(C/G)CACGT intron-variant
rs1000883162 -- 56,244,632(+) CCTTC(A/C)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD52 Gene

Variant ID Type Subtype PubMed ID
esv3381217 CNV duplication 20981092
nsv482992 CNV gain+loss 15286789
nsv952186 CNV deletion 24416366

Variation tolerance for ANKRD52 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD52 Gene

Disorders for ANKRD52 Gene

Relevant External Links for ANKRD52

Genetic Association Database (GAD)
ANKRD52
Human Genome Epidemiology (HuGE) Navigator
ANKRD52
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD52

No disorders were found for ANKRD52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD52 Gene

Publications for ANKRD52 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PMID: 18186651) Stefansson B. … Brautigan D.L. (Biochemistry 2008) 3 4 64
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ANKRD52 Gene

Sources for ANKRD52 Gene

Content
Loading form....