ANKRD49 Gene
protein-coding GIFtS: 47
GCID: GC11P094227
|
|
ankyrin repeat domain 49
| |
Aliases
for ANKRD49 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat Domain 491 2 | | FGIF1 2 3 | | GBIF1 2 | | Fetal Globin-Inducing Factor2 3 | | FLJ201891 | | Ankyrin Repeat Domain-Containing Protein 492 |
Export aliases for ANKRD49 gene to outside databasesPrevious GC identifers: GC11P093867 GC11P090292 |
Summaries
for ANKRD49 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ANKRD49 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKRD49 gene promoter:
HOXA9B HOXA9 AML1a POU6F1 (c2) Meis-1b PPAR-gamma1 PPAR-gamma2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKRD49
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD49 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q21 Ensembl cytogenetic band: 11q21 HGNC cytogenetic band: 11q21ANKRD49 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P094227: view genomic region
(about GC identifiers)
Start:
|
94,226,795 bp from pter |
End:
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94,232,749 bp from pter |
Size:
|
5,955 bases |
Orientation:
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plus strand |
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Proteins
for ANKRD49 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANR49_HUMAN, Q8WVL7 (See
protein sequence)Recommended Name: Ankyrin repeat domain-containing protein 49 Size: 239 amino acids; 27290 Da
Secondary accessions: Q8NDF2 Q96JE5 Q9NXK7Explore the universe of human proteins at neXtProt for ANKRD49: NX_Q8WVL7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WVL7
ANKRD49 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060174.2
ENSEMBL proteins: ENSP00000440396 ENSP00000438506 ENSP00000444030 ENSP00000442449 ENSP00000441877 ENSP00000445597 ENSP00000446433 ENSP00000439200 ENSP00000303518
Human Recombinant Protein Products for ANKRD49:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
ANKRD49 for ontologies About GeneDecksing
ANKRD49 Antibody Products:
Assay Products for ANKRD49: |
Protein
Domains /
Families
for ANKRD49 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKRD49 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WVL7ProtoNet protein and cluster: Q8WVL7 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ANR49_HUMAN, Q8WVL7Similarity: Contains 4 ANK repeats |
Function
for ANKRD49 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for ANKRD49:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD49 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD49
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ANKRD49 (NM_017704) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD49 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD49 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD49 |
|
Pathways & Interactions
for ANKRD49 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD49
2 Interacting proteins for ANKRD49 (Q8WVL73) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045893 | positive regulation of transcription, DNA-dependent |
IDA | 11162141 |
ANKRD49 for ontologies About GeneDecksing
|
Drugs & Compounds
for ANKRD49 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKRD49
Search CenterWatch for drugs/clinical trials and news about ANKRD49 / ANR49
|
Transcripts
for ANKRD49 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKRD49 gene: NM_017704.2 Unigene Cluster for ANKRD49: Ankyrin repeat domain 49 Hs.29052 [show with all ESTs]Unigene Representative Sequence: AL83397711 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000544612(uc001pew.3) ENST00000540349 ENST00000534911 ENST00000535502
ENST00000545130 ENST00000544514 ENST00000544253(uc001pex.3) ENST00000541144
ENST00000302755 ENST00000539883 ENST00000538535(uc001pey.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD49 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD49
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANKRD49 (NM_017704) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD49 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD49 |
Additional cDNA sequence: AF025354.1 AK000196.1 AK000448.1 AK057696.1 AL833977.1 BC017798.1 7 DOTS entries: DT.101961674 DT.212411 DT.100020218 DT.100782064 DT.86852984 DT.120701070 DT.120812359 24/99 AceView cDNA sequences (see all 99): AI273656 AI824504 BF791893 AA811579 CR609043 AW194169 AI673304 AW273349 AI861888 AA768384 NM_017704 AA812179 CN481781 AK057696 BQ575085 AI698788 AA502756 CB216066 CA313383 AA768837 AA971763 BF328964 AL833977 AW665337
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD49 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f |
|---|
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| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ANKRD49
|
Expression
for ANKRD49 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKRD49 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACACAACTA
About this image
See ANKRD49 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD49
SOURCE GeneReport for Unigene cluster: Hs.29052
UniProtKB/Swiss-Prot: ANR49_HUMAN, Q8WVL7Tissue specificity: Widely expressed in fetus, at a high level in fetal liver, brain and lung
SABiosciences Custom PCR Arrays for ANKRD49
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD49
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANKRD49 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD49 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD49 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD49 |
Orthologs
for ANKRD49 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ANKRD49 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for ANKRD49 (if available)
TreeFam Gene Tree for ANKRD49 (if available) |
Paralogs
for ANKRD49 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKRD49 gene
6 SIMAP similar genes for ANKRD49 using alignment to 6 protein entries: ANR49_HUMAN (see all proteins):ANKRD44 ANKRD12 IkBa ANKRD29 PPP1R12A ANKRD54
ANKRD49 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for ANKRD49
PGOHUM00000256694 PGOHUM00000240539 PGOHUM00000235767 PGOHUM00000232972
|
Genomic Variants
for ANKRD49 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKRD49 (94226795 - 94232749 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ANKRD49
1 CNV: 85953
1 Indel: 58542 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD49 |
|
Disorders
/ Diseases
for ANKRD49 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ANKRD49 for disorders About MalaCards
ANKRD49 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: ANKRD49 (2 documents)
Export disorders for ANKRD49 gene to outside databases
|
Publications
for ANKRD49 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKRD49 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANKRD49) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a potential transcriptional activator of human gamma-globin genes. (PubMed id 11162141)1, 2, 3 Yang Y....Stamatoyannopoulos G. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- {gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice. (PubMed id 16131492)1, 9 Blau C.A....Peterson K.R. (2005)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay. (PubMed id 11371508)1 Pitts S.A....Byrd P.J. (2001)
|
External Searches for ANKRD49 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANKRD49 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKRD49 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANKRD49 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKRD49 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANKRD49 gene:
Search GeneIP for patents involving ANKRD49
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKRD49 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ANKRD49 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKRD49 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD49 | | | OriGene Protein Over-expression Lysate for ANKRD49 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ANKRD49 | | OriGene 3'-UTR Clone for ANKRD49 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD49 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD49 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ANKRD49 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ANKRD49 | | OriGene Custom Protein Services for ANKRD49 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANKRD49 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD49 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD49 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKRD49 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD49 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD49 |
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 | | | ANKRD49 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD49 |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD49 |
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