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Aliases for ANKRD46 Gene

Aliases for ANKRD46 Gene

  • Ankyrin Repeat Domain 46 2 3
  • Ankyrin Repeat Small Protein 3 4
  • ANK-S 3 4
  • GENX-115279 3

External Ids for ANKRD46 Gene

Previous GeneCards Identifiers for ANKRD46 Gene

  • GC08M101592
  • GC08M101602
  • GC08M101522
  • GC08M096732

Summaries for ANKRD46 Gene

Entrez Gene Summary for ANKRD46 Gene

  • This gene encodes a protein containing multiple ankyrin repeats. Ankyrin domains function in protein-protein interactions in a variety of cellular processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for ANKRD46 Gene

ANKRD46 (Ankyrin Repeat Domain 46) is a Protein Coding gene. An important paralog of this gene is ANKRD63.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD46 Gene

Genomics for ANKRD46 Gene

Regulatory Elements for ANKRD46 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ANKRD46 Gene

100,509,752 bp from pter
100,559,786 bp from pter
50,035 bases
Minus strand

Genomic View for ANKRD46 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD46 Gene

Proteins for ANKRD46 Gene

  • Protein details for ANKRD46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat domain-containing protein 46
    Protein Accession:
    Secondary Accessions:
    • Q6P9B7

    Protein attributes for ANKRD46 Gene

    232 amino acids
    Molecular mass:
    25967 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD46 Gene


neXtProt entry for ANKRD46 Gene

Proteomics data for ANKRD46 Gene at MOPED

Post-translational modifications for ANKRD46 Gene

  • Ubiquitination at Lys 137
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ANKRD46 Gene

Domains & Families for ANKRD46 Gene

Gene Families for ANKRD46 Gene

Protein Domains for ANKRD46 Gene

Suggested Antigen Peptide Sequences for ANKRD46 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 ANK repeats.
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with ANKRD46: view

Function for ANKRD46 Gene

Gene Ontology (GO) - Molecular Function for ANKRD46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ANKRD46: view

Phenotypes for ANKRD46 Gene

GenomeRNAi human phenotypes for ANKRD46:
genes like me logo Genes that share phenotypes with ANKRD46: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD46 Gene

Localization for ANKRD46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD46 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ANKRD46 Gene COMPARTMENTS Subcellular localization image for ANKRD46 gene
Compartment Confidence
endosome 1

Gene Ontology (GO) - Cellular Components for ANKRD46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANKRD46: view

Pathways & Interactions for ANKRD46 Gene

SuperPathways for ANKRD46 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD46 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKRD46 Gene

Drugs & Compounds for ANKRD46 Gene

No Compound Related Data Available

Transcripts for ANKRD46 Gene

Unigene Clusters for ANKRD46 Gene

Ankyrin repeat domain 46:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKRD46

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD46 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - -

Relevant External Links for ANKRD46 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRD46 Gene

mRNA expression in normal human tissues for ANKRD46 Gene

Protein differential expression in normal tissues from HIPED for ANKRD46 Gene

This gene is overexpressed in CD4 Tcells (31.2), Retina (14.8), Fetal testis (8.2), and Frontal cortex (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKRD46 Gene

SOURCE GeneReport for Unigene cluster for ANKRD46 Gene Hs.530199

genes like me logo Genes that share expression patterns with ANKRD46: view

Protein tissue co-expression partners for ANKRD46 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKRD46 Gene

Orthologs for ANKRD46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD46 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANKRD46 35
  • 91.08 (n)
  • 100 (a)
ANKRD46 36
  • 93 (a)
(Canis familiaris)
Mammalia ANKRD46 35
  • 92.69 (n)
  • 99.56 (a)
ANKRD46 36
  • 93 (a)
(Mus musculus)
Mammalia Ankrd46 35
  • 87.72 (n)
  • 97.81 (a)
Ankrd46 16
Ankrd46 36
  • 92 (a)
(Pan troglodytes)
Mammalia ANKRD46 35
  • 99.85 (n)
  • 100 (a)
ANKRD46 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Ankrd46 35
  • 87.28 (n)
  • 97.81 (a)
(Monodelphis domestica)
Mammalia ANKRD46 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia ANKRD46 36
  • 92 (a)
(Gallus gallus)
Aves ANKRD46 35
  • 82.89 (n)
  • 99.12 (a)
ANKRD46 36
  • 93 (a)
(Anolis carolinensis)
Reptilia ANKRD46 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd46 35
  • 78.07 (n)
  • 96.49 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8886 35
(Danio rerio)
Actinopterygii ankrd46b 35
  • 74.56 (n)
  • 87.72 (a)
Dr.18723 35
ankrd46a 36
  • 71 (a)
ankrd46b 36
  • 83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9304 35
Species with no ortholog for ANKRD46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD46 Gene

Gene Tree for ANKRD46 (if available)
Gene Tree for ANKRD46 (if available)

Paralogs for ANKRD46 Gene

Paralogs for ANKRD46 Gene

genes like me logo Genes that share paralogs with ANKRD46: view

Variants for ANKRD46 Gene

Sequence variations from dbSNP and Humsavar for ANKRD46 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs62515846 -- 100,555,014(+) CATCT(A/C)CAAAA intron-variant
rs62515845 -- 100,551,839(+) GTCTT(C/T)ATCAT intron-variant
rs62515844 -- 100,551,364(+) TGACC(C/G)TTTTG intron-variant
rs62515843 -- 100,548,528(+) GTACA(C/T)CTCCT intron-variant
rs62515842 -- 100,547,155(+) AAAGG(A/C)CATGA intron-variant

Variation tolerance for ANKRD46 Gene

Residual Variation Intolerance Score: 41.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD46 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANKRD46 Gene

Disorders for ANKRD46 Gene

Relevant External Links for ANKRD46

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ANKRD46: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD46 Gene

Publications for ANKRD46 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  3. Identification of genes with a correlation between copy number and expression in gastric cancer. (PMID: 22559327) Cheng L. … Zhang Q. (BMC Med Genomics 2012) 67
  4. Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth. (PMID: 21219636) Yan L.X. … Shao J.Y. (Breast Cancer Res. 2011) 67
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67

Products for ANKRD46 Gene

Sources for ANKRD46 Gene

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