ANKRD46 Gene
protein-coding GIFtS: 44
GCID: GC08M101522
|
|
ankyrin repeat domain 46
| |
Aliases
for ANKRD46 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat Domain 461 2 | | Ankyrin Repeat Small Protein2 3 | | ANK-S2 3 | | GENX-1152792 | | Ankyrin Repeat Domain-Containing Protein 462 |
Export aliases for ANKRD46 gene to outside databasesPrevious GC identifers: GC08M101592 GC08M101602 GC08M096732 |
Summaries
for ANKRD46 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ANKRD46:
This gene encodes a protein containing multiple ankyrin repeats. Ankyrin domains function in protein-proteininteractions in a variety of cellular processes. Alternative splicing results in multiple transcript variants.(provided by RefSeq, Jun 2012)
|
Genomic Views
for ANKRD46 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKRD46 gene promoter:
AP-1 AML1a p300 RelA E4BP4 NF-kappaB c-Myb FOXO1a NF-kappaB1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKRD46
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD46 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q22.2 Ensembl cytogenetic band: 8q22.2 HGNC cytogenetic band: 8q22.3ANKRD46 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M101522: view genomic region
(about GC identifiers)
Start:
|
101,521,980 bp from pter |
End:
|
101,572,012 bp from pter |
Size:
|
50,033 bases |
Orientation:
|
minus strand |
|
Proteins
for ANKRD46 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANR46_HUMAN, Q86W74 (See
protein sequence)Recommended Name: Ankyrin repeat domain-containing protein 46 Size: 232 amino acids; 25967 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q6P9B7Alternative splicing: 2 isoforms: Q86W74-1 Q86W74-2 Explore the universe of human proteins at neXtProt for ANKRD46: NX_Q86W74
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86W74
ANKRD46 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001257306.1 NP_001257307.1 NP_001257308.1 NP_940683.1
ENSEMBL proteins: ENSP00000429015 ENSP00000335287 ENSP00000430056 ENSP00000428388 ENSP00000430827 ENSP00000351881 ENSP00000430357 ENSP00000430800 ENSP00000429647
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ANKRD46 for ontologies About GeneDecksing
ANKRD46 Antibody Products:
Assay Products for ANKRD46: |
Protein
Domains /
Families
for ANKRD46 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKRD46 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86W74ProtoNet protein and cluster: Q86W74 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ANR46_HUMAN, Q86W74Similarity: Contains 4 ANK repeats |
Function
for ANKRD46 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD46 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD46
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD46 |
|
Pathways & Interactions
for ANKRD46 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD46
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ANKRD46 (ENSP000003352874) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ANKRD46 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKRD46
Search CenterWatch for drugs/clinical trials and news about ANKRD46 / ANR46
|
Transcripts
for ANKRD46 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKRD46 gene (4 alternative transcripts): NM_001270377.1 NM_001270378.1 NM_001270379.1 NM_198401.3 Unigene Cluster for ANKRD46: Ankyrin repeat domain 46 Hs.744045 [show with all ESTs]Unigene Representative Sequence: NM_00127037811 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000520552(uc003yjm.3) ENST00000335659 ENST00000519597(uc003yjo.1 uc003yjp.1)
ENST00000520311(uc003yjn.1) ENST00000519316 ENST00000358990 ENST00000524072
ENST00000523000 ENST00000521345 ENST00000520713 ENST00000524319(uc003yjq.4)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD46
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AB077205.1 AK095235.1 AL832842.1 BC015811.1 BC035087.1 BC050396.1 BC060843.1 U79297.1 7 DOTS entries: DT.100767657 DT.316456 DT.95262635 DT.91684283 DT.91640713 DT.97837676 DT.121487472 24/194 AceView cDNA sequences (see all 194): BX434780 AL546194 F12804 BC060843 BM828907 BC050396 AI676209 BX440763 AW629831 AL561435 AA234889 F09828 AL832842 AI521506 AI091557 AI610986 AA843912 BU849608 CB989109 BM127539 AA253479 BM715651 U79297 CR623732
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD46 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | - | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ANKRD46
|
Expression
for ANKRD46 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKRD46 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCTTTATC
About this image
See ANKRD46 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD46
SOURCE GeneReport for Unigene cluster: Hs.744045
SABiosciences Custom PCR Arrays for ANKRD46
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD46
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD46 |
Orthologs
for ANKRD46 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ANKRD46 gene from 5/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ankrd461 , 5 |
ankyrin repeat domain 461, 5 |
87.72(n)1
97.81(a)1 |
|
15 (14.47 cM)5
688391 NM_175134.41 NP_780343.11
364776685 |
chicken
(Gallus gallus) |
Aves |
ANKRD461 |
ankyrin repeat domain 46 |
82.89(n)
99.12(a) |
|
426304 XM_423967.3 XP_423967.2 |
lizard
(Anolis carolinensis) |
Reptilia |
ANKRD466 |
-- |
91(a) |
1 ↔ 1 |
GL343394.1(108689-116665) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.88862 |
Xenopus laevis transcribed sequence with weak similarity more |
79.98(n) |
|
BJ029022.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.187232 |
Danio rerio hypothetical protein LOC157567-like protein more |
76.02(n) |
|
AY391435.1 |
ENSEMBL Gene Tree for ANKRD46 (if available)
TreeFam Gene Tree for ANKRD46 (if available) |
Paralogs
for ANKRD46 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKRD46 gene
- ANKRD392
18 SIMAP similar genes for ANKRD46 using alignment to 6 protein entries: ANR46_HUMAN (see all proteins):RAI14 PPP1R12A ANKFY1 GLS2 PPP1R12C INVS
ANKRD29 ANKRD44 ASB16 ASB8 TANC2 AGAP1
ANKRD54 ANKRD6 IkBa ANKS3 ILK PPP1R12B
ANKRD46 for paralogs About GeneDecksing
|
Genomic Variants
for ANKRD46 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKRD46 (101521980 - 101572012 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANKRD46: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD46 |
|
Disorders
/ Diseases
for ANKRD46 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ANKRD46 for disorders About GeneDecksing
2  diseases for ANKRD46: About MalaCardsduchenne muscular dystrophy muscular dystrophy
Export disorders for ANKRD46 gene to outside databases
|
Publications
for ANKRD46 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKRD46 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with ANKRD46) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Identification of genes with a correlation between cop y number and expression in gastric cancer. (PubMed id 22559327)1 Cheng L....Zhang Q. (2012)
- Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth. (PubMed id 21219636)1 Yan L.X....Shao J.Y. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Identification of genomic predictors of atrioventricu lar conduction: using electronic medical records as a tool for genome science. (PubMed id 21041692)1 Denny J.C....Roden D.M. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for ANKRD46 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANKRD46 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKRD46 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANKRD46 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKRD46 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANKRD46 gene:
Search GeneIP for patents involving ANKRD46
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKRD46 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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