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Aliases for ANKRD46 Gene

Aliases for ANKRD46 Gene

  • Ankyrin Repeat Domain 46 2 3 5
  • Ankyrin Repeat Small Protein 3 4
  • ANK-S 3 4
  • Ankyrin Repeat Domain-Containing Protein 46 3
  • GENX-115279 3

External Ids for ANKRD46 Gene

Previous GeneCards Identifiers for ANKRD46 Gene

  • GC08M101592
  • GC08M101602
  • GC08M101522
  • GC08M096732

Summaries for ANKRD46 Gene

Entrez Gene Summary for ANKRD46 Gene

  • This gene encodes a protein containing multiple ankyrin repeats. Ankyrin domains function in protein-protein interactions in a variety of cellular processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for ANKRD46 Gene

ANKRD46 (Ankyrin Repeat Domain 46) is a Protein Coding gene. An important paralog of this gene is ANKRD63.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD46 Gene

Genomics for ANKRD46 Gene

Regulatory Elements for ANKRD46 Gene

Enhancers for ANKRD46 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F100525 0.5 Ensembl ENCODE 15.2 +31.9 31860 4.5 HDGF PKNOX1 ATF1 MLX ZFP64 ARID4B SIN3A YY1 ZNF143 FOS ANKRD46 FBXO43 POLR2K ENSG00000253666 ENSG00000202310 SPAG1 ENSG00000253217 RNF19A RGS22 LOC105375674
GH08F100826 1 Ensembl ENCODE 10.5 -267.3 -267292 0.6 GTF2F1 CTCF TBL1XR1 WRNIP1 ZBTB40 RAD21 GATA3 ZNF143 SMC3 CREM MIR7705 PABPC1 ANKRD46 RNU4-83P RPS20P23
GH08F100824 0.8 ENCODE 10.5 -265.1 -265122 0.6 PKNOX1 SIN3A THRB RAD21 ZNF207 RCOR1 CEBPB ZNF592 ZNF217 MAFF POLR2K MIR7705 PABPC1 ANKRD46 ENSG00000271882 RNU4-83P RPS20P23
GH08F100487 1.4 FANTOM5 Ensembl ENCODE 10.4 +64.4 64414 16.6 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A YBX1 YY1 SLC30A9 ZNF207 RNF19A SPAG1 POLR2K ENSG00000202310 ANKRD46 ENSG00000253217 ENSG00000271882 RGS22 ENSG00000254364 YWHAZ
GH08F100212 1 ENCODE 10 +346.3 346302 2.1 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 GLIS2 FOS SP3 ZNF623 SPAG1 ENSG00000202310 ENSG00000253666 RGS22 ANKRD46 LOC105375669 ENSG00000199667
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ANKRD46 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD46 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001397643 486 1800 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for ANKRD46 Gene

Chromosome:
8
Start:
100,509,752 bp from pter
End:
100,559,786 bp from pter
Size:
50,035 bases
Orientation:
Minus strand

Genomic View for ANKRD46 Gene

Genes around ANKRD46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD46 Gene

Proteins for ANKRD46 Gene

  • Protein details for ANKRD46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W74-ANR46_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 46
    Protein Accession:
    Q86W74
    Secondary Accessions:
    • Q6P9B7

    Protein attributes for ANKRD46 Gene

    Size:
    232 amino acids
    Molecular mass:
    25967 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD46 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD46 Gene

Post-translational modifications for ANKRD46 Gene

  • Ubiquitination at Lys 137
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANKRD46 Gene

Domains & Families for ANKRD46 Gene

Gene Families for ANKRD46 Gene

Protein Domains for ANKRD46 Gene

Suggested Antigen Peptide Sequences for ANKRD46 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86W74

UniProtKB/Swiss-Prot:

ANR46_HUMAN :
  • Contains 4 ANK repeats.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with ANKRD46: view

Function for ANKRD46 Gene

genes like me logo Genes that share phenotypes with ANKRD46: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD46 Gene

Localization for ANKRD46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD46 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD46 Gene COMPARTMENTS Subcellular localization image for ANKRD46 gene
Compartment Confidence
plasma membrane 2
cytosol 1
endosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ANKRD46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANKRD46: view

Pathways & Interactions for ANKRD46 Gene

SuperPathways for ANKRD46 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD46 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD46 Gene

Transcripts for ANKRD46 Gene

Unigene Clusters for ANKRD46 Gene

Ankyrin repeat domain 46:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD46 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - -
SP7:

Relevant External Links for ANKRD46 Gene

GeneLoc Exon Structure for
ANKRD46
ECgene alternative splicing isoforms for
ANKRD46

Expression for ANKRD46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD46 Gene

Protein differential expression in normal tissues from HIPED for ANKRD46 Gene

This gene is overexpressed in CD4 Tcells (31.2), Retina (14.8), Fetal testis (8.2), and Frontal cortex (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANKRD46 Gene



Protein tissue co-expression partners for ANKRD46 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD46 Gene:

ANKRD46

SOURCE GeneReport for Unigene cluster for ANKRD46 Gene:

Hs.530199
genes like me logo Genes that share expression patterns with ANKRD46: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKRD46 Gene

Orthologs for ANKRD46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD46 34 35
  • 99.85 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD46 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD46 34 35
  • 92.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD46 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD46 34 35
  • 91.08 (n)
mouse
(Mus musculus)
Mammalia Ankrd46 34 16 35
  • 87.72 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd46 34
  • 87.28 (n)
chicken
(Gallus gallus)
Aves ANKRD46 34 35
  • 82.89 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD46 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd46 34
  • 78.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8886 34
zebrafish
(Danio rerio)
Actinopterygii ankrd46b 34 35
  • 74.56 (n)
ankrd46a 35
  • 71 (a)
OneToMany
Dr.18723 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9304 34
Species where no ortholog for ANKRD46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD46 Gene

ENSEMBL:
Gene Tree for ANKRD46 (if available)
TreeFam:
Gene Tree for ANKRD46 (if available)

Paralogs for ANKRD46 Gene

Paralogs for ANKRD46 Gene

genes like me logo Genes that share paralogs with ANKRD46: view

Variants for ANKRD46 Gene

Sequence variations from dbSNP and Humsavar for ANKRD46 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10090453 -- 100,514,372(+) TTTTT(A/T)AAAAA intron-variant
rs10093762 -- 100,514,765(+) CTCCC(A/G)AGTAG intron-variant
rs10102516 -- 100,517,462(+) CTGTT(A/G)TCAGC intron-variant
rs10103866 -- 100,535,396(+) ctgtg(C/T)accct intron-variant
rs10104673 -- 100,513,652(+) TGAAA(C/T)ATAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD46 Gene

Variant ID Type Subtype PubMed ID
esv2761451 CNV gain 21179565
esv3618190 CNV loss 21293372
esv3618191 CNV loss 21293372
esv3891450 CNV loss 25118596
nsv971689 CNV duplication 23825009

Variation tolerance for ANKRD46 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD46 Gene

Disorders for ANKRD46 Gene

Relevant External Links for ANKRD46

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD46

No disorders were found for ANKRD46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD46 Gene

Publications for ANKRD46 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  4. Identification of genes with a correlation between copy number and expression in gastric cancer. (PMID: 22559327) Cheng L. … Zhang Q. (BMC Med Genomics 2012) 3 64
  5. Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth. (PMID: 21219636) Yan L.X. … Shao J.Y. (Breast Cancer Res. 2011) 3 64

Products for ANKRD46 Gene

Sources for ANKRD46 Gene

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