Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANKRD46 Gene

Aliases for ANKRD46 Gene

  • Ankyrin Repeat Domain 46 2 3
  • Ankyrin Repeat Small Protein 3 4
  • ANK-S 3 4
  • Ankyrin Repeat Domain-Containing Protein 46 3
  • GENX-115279 3

External Ids for ANKRD46 Gene

Previous GeneCards Identifiers for ANKRD46 Gene

  • GC08M101592
  • GC08M101602
  • GC08M101522
  • GC08M096732

Summaries for ANKRD46 Gene

Entrez Gene Summary for ANKRD46 Gene

  • This gene encodes a protein containing multiple ankyrin repeats. Ankyrin domains function in protein-protein interactions in a variety of cellular processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for ANKRD46 Gene

ANKRD46 (Ankyrin Repeat Domain 46) is a Protein Coding gene. An important paralog of this gene is ANKRD63.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD46 Gene

Genomics for ANKRD46 Gene

Regulatory Elements for ANKRD46 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ANKRD46 Gene

Start:
100,509,752 bp from pter
End:
100,559,786 bp from pter
Size:
50,035 bases
Orientation:
Minus strand

Genomic View for ANKRD46 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD46 Gene

Proteins for ANKRD46 Gene

  • Protein details for ANKRD46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W74-ANR46_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 46
    Protein Accession:
    Q86W74
    Secondary Accessions:
    • Q6P9B7

    Protein attributes for ANKRD46 Gene

    Size:
    232 amino acids
    Molecular mass:
    25967 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD46 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD46 Gene

Proteomics data for ANKRD46 Gene at MOPED

Post-translational modifications for ANKRD46 Gene

  • Ubiquitination at Lys137
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANKRD46 Gene

Domains for ANKRD46 Gene

Gene Families for ANKRD46 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ANKRD46 Gene

Suggested Antigen Peptide Sequences for ANKRD46 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86W74

UniProtKB/Swiss-Prot:

ANR46_HUMAN :
  • Q86W74
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with ANKRD46: view

Function for ANKRD46 Gene

Gene Ontology (GO) - Molecular Function for ANKRD46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ANKRD46: view

Animal Model Products

CRISPR Products

miRNA for ANKRD46 Gene

miRTarBase miRNAs that target ANKRD46

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANKRD46 Gene

Localization for ANKRD46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD46 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD46 Gene COMPARTMENTS Subcellular localization image for ANKRD46 gene
Compartment Confidence
plasma membrane 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ANKRD46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANKRD46: view

Pathways for ANKRD46 Gene

SuperPathways for ANKRD46 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD46 Gene

None

No data available for Pathways by source for ANKRD46 Gene

Transcripts for ANKRD46 Gene

Unigene Clusters for ANKRD46 Gene

Ankyrin repeat domain 46:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKRD46

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ANKRD46

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD46 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - -
SP7:

Relevant External Links for ANKRD46 Gene

GeneLoc Exon Structure for
ANKRD46
ECgene alternative splicing isoforms for
ANKRD46

Expression for ANKRD46 Gene

mRNA expression in normal human tissues for ANKRD46 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKRD46 Gene

SOURCE GeneReport for Unigene cluster for ANKRD46 Gene Hs.530199

genes like me logo Genes that share expressions with ANKRD46: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKRD46 Gene

Orthologs for ANKRD46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD46 35
  • 99.85 (n)
  • 100 (a)
ANKRD46 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD46 35
  • 91.08 (n)
  • 100 (a)
ANKRD46 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD46 35
  • 92.69 (n)
  • 99.56 (a)
ANKRD46 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd46 35
  • 87.72 (n)
  • 97.81 (a)
Ankrd46 16
Ankrd46 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKRD46 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD46 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd46 35
  • 87.28 (n)
  • 97.81 (a)
chicken
(Gallus gallus)
Aves ANKRD46 35
  • 82.89 (n)
  • 99.12 (a)
ANKRD46 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD46 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8886 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd46 35
  • 78.07 (n)
  • 96.49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9304 35
zebrafish
(Danio rerio)
Actinopterygii ankrd46a 36
  • 71 (a)
OneToMany
ankrd46b 35
  • 74.56 (n)
  • 87.72 (a)
ankrd46b 36
  • 83 (a)
OneToMany
Dr.18723 35
Species with no ortholog for ANKRD46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD46 Gene

ENSEMBL:
Gene Tree for ANKRD46 (if available)
TreeFam:
Gene Tree for ANKRD46 (if available)

Paralogs for ANKRD46 Gene

Paralogs for ANKRD46 Gene

genes like me logo Genes that share paralogs with ANKRD46: view

Variants for ANKRD46 Gene

Sequence variations from dbSNP and Humsavar for ANKRD46 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs15989 -- 100,521,640(-) TTTCA(C/T)GTGCA utr-variant-3-prime, intron-variant
rs725551 -- 100,561,759(-) ttgac(A/C)tatgg upstream-variant-2KB
rs731082 -- 100,527,545(-) TGTGC(A/G)CATAA intron-variant
rs731083 -- 100,527,532(-) TTCTG(A/T)TAGCC intron-variant
rs933908 -- 100,526,979(+) TTTTC(C/T)TTCAC intron-variant

Relevant External Links for ANKRD46 Gene

HapMap Linkage Disequilibrium report
ANKRD46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANKRD46 Gene

Disorders for ANKRD46 Gene

No disorders were found for ANKRD46 Gene.

No data available for UniProtKB/Swiss-Prot for ANKRD46 Gene

Publications for ANKRD46 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Ankyrin repeat: a unique motif mediating protein-protein interactions. (PMID: 17176038) Li J. … Tsai M.D. (Biochemistry 2006) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. (PMID: 21041692) Denny J.C. … Roden D.M. (Circulation 2010) 3

Products for ANKRD46 Gene

Sources for ANKRD46 Gene

Back to Top

Content