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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKRD45 Gene

protein-coding   GIFtS: 38
GCID: GC01M173577

Ankyrin Repeat Domain 45

  Search for ANKRD45
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ankyrin Repeat Domain 451 2
Cancer/Testis Antigen 1171 2
CT1172
RP3-436N22.42
Ankyrin Repeat Domain-Containing Protein 452

External Ids:    HGNC: 247861   Entrez Gene: 3394162   Ensembl: ENSG000001838317   UniProtKB: Q5TZF33   

Export aliases for ANKRD45 gene to outside databases

Previous GC identifers: GC01M170310 GC01M171844 GC01M144805


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ANKRD45 Gene: 
ANKRD45 (ankyrin repeat domain 45) is a protein-coding gene. GO annotations related to this gene include molecular_function.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKRD45 gene promoter:
         E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD45 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANKRD45

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q25.1

ANKRD45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD45 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M173577:  view genomic region     (about GC identifiers)

Start:
173,577,475 bp from pter      End:
173,639,001 bp from pter
Size:
61,527 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANR45_HUMAN, Q5TZF3 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 45  
Size: 282 amino acids; 31810 Da
Secondary accessions: A1A4G2 Q6ZST1
Alternative splicing: 2 isoforms:  Q5TZF3-1   Q5TZF3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD45: NX_Q5TZF3

Explore proteomics data for ANKRD45 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TZF3

  • ANKRD45 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANKRD45 Protein Expression
    REFSEQ proteins: NP_940895.1  
    ENSEMBL proteins: 
     ENSP00000331268  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    ANKRD45 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q5TZF3

    ProtoNet protein and cluster: Q5TZF3

    UniProtKB/Swiss-Prot: ANR45_HUMAN, Q5TZF3
    Similarity: Contains 2 ANK repeats


    ANKRD45 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    ANKRD45 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD45

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    ANKRD45 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANKRD45 (ANR45)

    Search CenterWatch for drugs/clinical trials and news about ANKRD45 / ANR45

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANKRD45 gene: 
    NM_198493.2  

    Unigene Cluster for ANKRD45:

    Ankyrin repeat domain 45
    Hs.130054  [show with all ESTs]
    Unigene Representative Sequence: NM_198493
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333279(uc001gja.1) ENST00000367712(uc001gjb.4)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidANKRD45 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK127170.1 BC029866.2 BC094694.1 BC126353.1 BC126355.1 

    3 DOTS entries:

    DT.101980028  DT.95125140  DT.95186258 

    20 AceView cDNA sequences:

    BM021478 BX092638 BC029866 AI204272 NM_198493 AI017771 BI830529 AW297920 
    AA902816 BI827264 AK127170 BM021201 AW662914 BE464138 CD557840 AV728969 
    AV729474 BI829303 AA909581 BI914423 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKRD45 expression in normal human tissues (normalized intensities)      ANKRD45 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAGGCTTT
    ANKRD45 Expression
    About this image


    ANKRD45 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Testis (Reproductive System)

    See ANKRD45 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANKRD45

    SOURCE GeneReport for Unigene cluster: Hs.130054
        SABiosciences Custom PCR Arrays for ANKRD45
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD45

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANKRD45 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankrd451 , 5 ankyrin repeat domain 451, 5 82.64(n)1
    81.25(a)1
      1 (69.75 cM)5
    738441  NM_028664.11  NP_082940.11 
     1611426915 
    lizard
    (Anolis carolinensis)
    Reptilia ANKRD456
    ankyrin repeat domain 45
    50(a)
    1 ↔ 1
    4(71295801-71310407)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.188652 Xenopus laevis transcribed sequence with weak similarity more 70.78(n)    BX854467.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ankrd451 ankyrin repeat domain 45 55.56(n)
    46.46(a)
      553808  NM_001020770.1  NP_001018606.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.72792 Transcribed sequences 70.31(n)    BE421120.1 


    ENSEMBL Gene Tree for ANKRD45 (if available)
    TreeFam Gene Tree for ANKRD45 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/952 SNPs in ANKRD45 are shown (see all 952)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1845314211,2
    --173577018(+) AAATAC/TATCAA 1 -- ds50010--------
    rs1893803411,2
    --173577079(+) AATAGG/TTTTAT 1 -- ds50010--------
    rs1930509421,2
    --173577091(+) TTATAA/CTAAGG 1 -- ds50010--------
    rs1850828421,2
    --173577422(+) GGAAAC/TGTAGC 1 -- ds50010--------
    rs798688771,2
    F--173577455(+) TTATTT/CGTTTT 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1903727021,2
    C--173577682(+) CAAACC/TGCTGA 1 -- ut310--------
    rs1423830481,2
    C--173577908(+) GGGTG-/GAGAGAG 1 -- ut310--------
    rs567831851,2
    --173578023(+) GGAAGA/GGAGGG 1 -- ut310--------
    rs1445372851,2
    --173578047(+) GGGAGA/GGGAAG 1 -- ut310--------
    rs1812346791,2
    --173578359(+) TGTCAA/GCTGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ANKRD45 (173577475 - 173639001 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ANKRD45: --
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ANKRD45 for disorders           About MalaCards

    ANKRD45 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ANKRD45

    Export disorders for ANKRD45 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKRD45 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ANKRD45)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339416 HGNC: 24786 AceView: FLJ45235 Ensembl:ENSG00000183831 euGenes: HUgn339416
    ECgene: ANKRD45 H-InvDB: ANKRD45

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKRD45 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANKRD45 gene:
    Search GeneIP for patents involving ANKRD45

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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