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ANKRD45 Gene

protein-coding   GIFtS: 39
GCID: GC01M173577

Ankyrin Repeat Domain 45

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 451 2
Cancer/Testis Antigen 1171 2
CT1172
Ankyrin Repeat Domain-Containing Protein 452

External Ids:    HGNC: 247861   Entrez Gene: 3394162   Ensembl: ENSG000001838317   UniProtKB: Q5TZF33   

Export aliases for ANKRD45 gene to outside databases

Previous GC identifers: GC01M170310 GC01M171844 GC01M144805


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD45 Gene:
ANKRD45 (ankyrin repeat domain 45) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD45 gene promoter:
         E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD45 promoter sequence
   Search Chromatin IP Primers for ANKRD45

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q25.1

ANKRD45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD45 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M173577:  view genomic region     (about GC identifiers)

Start:
173,577,475 bp from pter      End:
173,639,001 bp from pter
Size:
61,527 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANR45_HUMAN, Q5TZF3 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 45  
Size: 282 amino acids; 31810 Da
Secondary accessions: A1A4G2 Q6ZST1
Alternative splicing: 2 isoforms:  Q5TZF3-1   Q5TZF3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD45: NX_Q5TZF3

Explore proteomics data for ANKRD45 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANKRD45 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940895.1  
    ENSEMBL proteins: 
     ENSP00000331268  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q5TZF3

    ProtoNet protein and cluster: Q5TZF3

    UniProtKB/Swiss-Prot: ANR45_HUMAN, Q5TZF3
    Similarity: Contains 2 ANK repeats


    Find genes that share domains with ANKRD45           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ANKRD45           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ANKRD45

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    plasma membrane2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with ANKRD45           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD45
    Interactions:

        Search GeneGlobe Interaction Network for ANKRD45

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANKRD45 (ENSP000003312684) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEC63ENSP000003579984STRING: ENSP00000357998
    MOGSENSP000002336164STRING: ENSP00000233616
    SPCS1ENSP000002330254STRING: ENSP00000233025
    CANXENSP000002474614STRING: ENSP00000247461
    CLGNENSP000003266994STRING: ENSP00000326699
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with ANKRD45           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKRD45 (ANR45)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANKRD45 gene: 
    NM_198493.2  

    Unigene Cluster for ANKRD45:

    Ankyrin repeat domain 45
    Hs.130054  [show with all ESTs]
    Unigene Representative Sequence: NM_198493
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333279(uc001gja.1) ENST00000367712(uc001gjb.4)
    miRNA
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    hsa-miR-3163 hsa-miR-502-5p hsa-miR-875-3p hsa-miR-765 hsa-miR-548aa hsa-miR-432 hsa-miR-373* hsa-miR-4275
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      QuantiFast Probe-based Assays in human, mouse, rat ANKRD45

    Additional mRNA sequence: 

    AK127170.1 BC029866.2 BC094694.1 BC126353.1 BC126355.1 

    3 DOTS entries:

    DT.101980028  DT.95125140  DT.95186258 

    20 AceView cDNA sequences:

    BX092638 BC029866 BM021478 BI829303 AI204272 AV729474 BI827264 BI830529 
    AA902816 AK127170 BE464138 NM_198493 AW662914 CD557840 BM021201 AI017771 
    AA909581 AW297920 AV728969 BI914423 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKRD45 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAGGCTTT
    ANKRD45 Expression
    About this image


    ANKRD45 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
    ANKRD45 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKRD45 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.130054
        Custom PCR Arrays for ANKRD45
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANKRD45 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankrd451 , 5 ankyrin repeat domain 451, 5 81.4(n)1
    79.75(a)1
      1 (69.75 cM)5
    738441  NM_028664.11  NP_082940.11 
     1611426915 
    lizard
    (Anolis carolinensis)
    Reptilia ANKRD456
    ankyrin repeat domain 45
    51(a)
    1 ↔ 1
    4(71295801-71310407)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.188652 Xenopus laevis transcribed sequence with weak similarity more 70.78(n)    BX854467.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ankrd451 ankyrin repeat domain 45 55.01(n)
    45.81(a)
      553808  NM_001020770.1  NP_001018606.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.72792 Transcribed sequences 70.31(n)    BE421120.1 


    ENSEMBL Gene Tree for ANKRD45 (if available)
    TreeFam Gene Tree for ANKRD45 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKRD45 (see all 952)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1845314211,2
    --173577018(+) AAATAC/TATCAA 1 -- ds50010--------
    rs1893803411,2
    --173577079(+) AATAGG/TTTTAT 1 -- ds50010--------
    rs1930509421,2
    --173577091(+) TTATAA/CTAAGG 1 -- ds50010--------
    rs1850828421,2
    --173577422(+) GGAAAC/TGTAGC 1 -- ds50010--------
    rs798688771,2
    F--173577455(+) TTATTT/CGTTTT 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1903727021,2
    C--173577682(+) CAAACC/TGCTGA 1 -- ut310--------
    rs1423830481,2
    C--173577908(+) GGGTG-/GAGAGAG 1 -- ut310--------
    rs567831851,2
    --173578023(+) GGAAGA/GGAGGG 1 -- ut310--------
    rs1445372851,2
    --173578047(+) GGGAGA/GGGAAG 1 -- ut310--------
    rs1812346791,2
    --173578359(+) TGTCAA/GCTGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ANKRD45 (173577475 - 173639001 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ANKRD45: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANKRD45
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKRD45

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ANKRD45           About GenesLikeMe

    Genetic Association Database (GAD): ANKRD45

    Export disorders for ANKRD45 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKRD45 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ANKRD45)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 339416 HGNC: 24786 AceView: FLJ45235 Ensembl:ENSG00000183831 euGenes: HUgn339416
    ECgene: ANKRD45 H-InvDB: ANKRD45

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKRD45 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKRD45 gene:
    Search GeneIP for patents involving ANKRD45

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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