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Aliases for ANKRD45 Gene

Aliases for ANKRD45 Gene

  • Ankyrin Repeat Domain 45 2 3 5
  • Cancer/Testis Antigen 117 2 3
  • Ankyrin Repeat Domain-Containing Protein 45 3
  • CT117 3

External Ids for ANKRD45 Gene

Previous GeneCards Identifiers for ANKRD45 Gene

  • GC01M170310
  • GC01M171844
  • GC01M144805

Summaries for ANKRD45 Gene

GeneCards Summary for ANKRD45 Gene

ANKRD45 (Ankyrin Repeat Domain 45) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD45 Gene

Genomics for ANKRD45 Gene

Regulatory Elements for ANKRD45 Gene

Enhancers for ANKRD45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F173861 0.2 ENCODE 21.9 -161.5 -161493 10.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 TBX21 DARS2 GAS5-AS1 KLHL20 ANKRD45 GAS5 LOC730159 RC3H1 CENPL RNA5SP67 SERPINC1
GH01F174204 1.6 FANTOM5 Ensembl ENCODE 18.1 -500.3 -500259 3.0 HDGF ATF1 CREB3L1 CBX5 JUNB MEF2D ATF4 SMARCA4 PBX2 NBN RABGAP1L ANKRD45 KLHL20 RC3H1 GAS5 GAS5-AS1 GC01M174104 LOC102724601
GH01F174158 0.6 ENCODE 17.6 -454.1 -454077 3.7 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 KLF13 ZNF263 SP3 RABGAP1L ANKRD45 GAS5 RNU7-78P
GH01F173506 0.8 Ensembl ENCODE 17.5 +197.9 197910 1.8 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 KLHL20 GAS5 PRDX6 ANKRD45 ENSG00000238272 RC3H1 SUCO SLC9C2 PIR59510
GH01F174020 0.2 ENCODE 17.3 -317.0 -316999 3.9 HDGF ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FOS ANKRD45 KLHL20 GAS5 GAS5-AS1 RC3H1 RC3H1-IT1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ANKRD45 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ANKRD45 gene promoter:

Genomic Location for ANKRD45 Gene

Chromosome:
1
Start:
173,608,336 bp from pter
End:
173,705,267 bp from pter
Size:
96,932 bases
Orientation:
Minus strand

Genomic View for ANKRD45 Gene

Genes around ANKRD45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD45 Gene

Proteins for ANKRD45 Gene

  • Protein details for ANKRD45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TZF3-ANR45_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 45
    Protein Accession:
    Q5TZF3
    Secondary Accessions:
    • A1A4G2
    • Q6ZST1

    Protein attributes for ANKRD45 Gene

    Size:
    282 amino acids
    Molecular mass:
    31810 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD45 Gene

Post-translational modifications for ANKRD45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD45 Gene

No data available for DME Specific Peptides for ANKRD45 Gene

Domains & Families for ANKRD45 Gene

Gene Families for ANKRD45 Gene

Protein Domains for ANKRD45 Gene

Suggested Antigen Peptide Sequences for ANKRD45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TZF3

UniProtKB/Swiss-Prot:

ANR45_HUMAN :
  • Contains 2 ANK repeats.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with ANKRD45: view

Function for ANKRD45 Gene

Gene Ontology (GO) - Molecular Function for ANKRD45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ANKRD45: view
genes like me logo Genes that share phenotypes with ANKRD45: view

Animal Model Products

miRNA for ANKRD45 Gene

miRTarBase miRNAs that target ANKRD45

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD45 Gene

Localization for ANKRD45 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD45 Gene COMPARTMENTS Subcellular localization image for ANKRD45 gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 2
golgi apparatus 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ANKRD45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANKRD45: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANKRD45 Gene

Pathways & Interactions for ANKRD45 Gene

SuperPathways for ANKRD45 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0008150 biological_process ND --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ANKRD45: view

No data available for Pathways by source and SIGNOR curated interactions for ANKRD45 Gene

Transcripts for ANKRD45 Gene

mRNA/cDNA for ANKRD45 Gene

Unigene Clusters for ANKRD45 Gene

Ankyrin repeat domain 45:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD45 Gene

No ASD Table

Relevant External Links for ANKRD45 Gene

GeneLoc Exon Structure for
ANKRD45
ECgene alternative splicing isoforms for
ANKRD45

Expression for ANKRD45 Gene

mRNA expression in normal human tissues for ANKRD45 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD45 Gene

This gene is overexpressed in Testis (x9.4), Brain - Nucleus accumbens (basal ganglia) (x5.9), and Brain - Caudate (basal ganglia) (x5.7).

Protein differential expression in normal tissues from HIPED for ANKRD45 Gene

This gene is overexpressed in Monocytes (30.7), Testis (13.9), Prostate (13.8), and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD45 Gene



Protein tissue co-expression partners for ANKRD45 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD45 Gene:

ANKRD45

SOURCE GeneReport for Unigene cluster for ANKRD45 Gene:

Hs.130054
genes like me logo Genes that share expression patterns with ANKRD45: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ANKRD45 Gene

Orthologs for ANKRD45 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANKRD45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD45 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia ANKRD45 34 35
  • 91.07 (n)
cow
(Bos Taurus)
Mammalia ANKRD45 34 35
  • 89.15 (n)
mouse
(Mus musculus)
Mammalia Ankrd45 34 16 35
  • 81.4 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd45 34
  • 80.84 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD45 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD45 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd45 34
  • 59.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18865 34
zebrafish
(Danio rerio)
Actinopterygii ankrd45 34 35
  • 55.01 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.7279 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToOne
Species where no ortholog for ANKRD45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD45 Gene

ENSEMBL:
Gene Tree for ANKRD45 (if available)
TreeFam:
Gene Tree for ANKRD45 (if available)

Paralogs for ANKRD45 Gene

No data available for Paralogs for ANKRD45 Gene

Variants for ANKRD45 Gene

Sequence variations from dbSNP and Humsavar for ANKRD45 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157215 -- 173,691,465(+) ATTTT(A/C)TTTTT intron-variant
rs10157218 -- 173,691,307(+) ATTTC(C/T)CACCC intron-variant
rs10157371 -- 173,691,647(+) CAGGC(A/T)TGGTG intron-variant
rs10157384 -- 173,691,883(+) TATCC(C/T)TGACG intron-variant
rs10157684 -- 173,691,130(+) cacca(A/G)ggaaa intron-variant

Variation tolerance for ANKRD45 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANKRD45 Gene

Disorders for ANKRD45 Gene

Relevant External Links for ANKRD45

Genetic Association Database (GAD)
ANKRD45
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD45

No disorders were found for ANKRD45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD45 Gene

Publications for ANKRD45 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for ANKRD45 Gene

Sources for ANKRD45 Gene

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