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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKRD45 Gene

protein-coding   GIFtS: 38
GCID: GC01M173577

ankyrin repeat domain 45
  Search for ANKRD45
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ANKRD45    

Aliases
for ANKRD45 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ankyrin Repeat Domain 451 2
CT1171 2
FLJ452351
RP3-436N22.42
Ankyrin Repeat Domain-Containing Protein 452
Cancer/Testis Antigen 1172

External Ids:    HGNC: 247861   Entrez Gene: 3394162   Ensembl: ENSG000001838317   UniProtKB: Q5TZF33   

Export aliases for ANKRD45 gene to outside databases

Previous GC identifers: GC01M170310 GC01M171844 GC01M144805


Summaries
for ANKRD45 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for ANKRD45 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKRD45 gene promoter:
         E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANKRD45 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANKRD45

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q25.1

ANKRD45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD45 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M173577:  view genomic region     (about GC identifiers)

Start:
 173,577,475 bp from pter      End:
 173,639,001 bp from pter
Size:
 61,527 bases      Orientation:
 minus strand

Proteins
for ANKRD45 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ANR45_HUMAN, Q5TZF3 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 45  
Size: 282 amino acids; 31810 Da
Secondary accessions: A1A4G2 Q6ZST1
Alternative splicing: 2 isoforms:  Q5TZF3-1   Q5TZF3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD45: NX_Q5TZF3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5TZF3

    • ANKRD45 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_940895.1  
    ENSEMBL proteins: 
     ENSP00000331268  

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    Uscn Proteins for ANKRD45

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--


    ANKRD45 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ANKRD45 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ANKRD45 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q5TZF3

    ProtoNet protein and cluster: Q5TZF3

    UniProtKB/Swiss-Prot: ANR45_HUMAN, Q5TZF3
    Similarity: Contains 2 ANK repeats


    Function
    for ANKRD45 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: ANKRD45 3' UTR sequence
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--


    ANKRD45 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ANKRD45 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD45

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--


    ANKRD45 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ANKRD45 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ANKRD45
    Search CenterWatch for drugs/clinical trials and news about ANKRD45 / ANR45 

    Transcripts
    for ANKRD45 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for ANKRD45 gene: 
    NM_198493.2  

    Unigene Cluster for ANKRD45:

    Ankyrin repeat domain 45
    Hs.130054  [show with all ESTs]
    Unigene Representative Sequence: NM_198493
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333279(uc001gja.1) ENST00000367712(uc001gjb.4)

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    hsa-miR-3163 hsa-miR-502-5p hsa-miR-875-3p hsa-miR-765 hsa-miR-548aa hsa-miR-432 hsa-miR-373* hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmid: ANKRD45 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK127170.1 BC029866.2 BC094694.1 BC126353.1 BC126355.1 

    3 DOTS entries:

    DT.101980028  DT.95125140  DT.95186258 

    20 AceView cDNA sequences:

    BX092638 BM021478 BC029866 AA909581 AK127170 AV728969 AI017771 AW662914 
    AW297920 BI829303 BI827264 AV729474 BM021201 NM_198493 BI830529 BE464138 
    AI204272 AA902816 CD557840 BI914423 

    GeneLoc Exon Structure


    Expression
    for ANKRD45 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKRD45 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGAGGCTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ANKRD45 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ANKRD45 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANKRD45

    SOURCE GeneReport for Unigene cluster: Hs.130054
        SABiosciences Custom PCR Arrays for ANKRD45
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    In Situ
    Assay Products:     
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    Orthologs
    for ANKRD45 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANKRD45 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ankrd451 , 5 ankyrin repeat domain 451, 5 82.64(n)1
    81.25(a)1    		   1 (69.75 cM)5
    738441  NM_028664.11  NP_082940.11 
     1611426915 
    lizard
    (Anolis carolinensis)    		 Reptilia ANKRD456
    		 --
    		 52(a)
    		 1 ↔ 1
    		 4(71301613-71305991)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.188652 Xenopus laevis transcribed sequence with weak similarity more 70.78(n)    BX854467.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ankrd451 ankyrin repeat domain 45 55.56(n)
    46.46(a)    		   553808  NM_001020770.1  NP_001018606.1 
    barley
    (Hordeum vulgare)    		 Liliopsida Hv.72792 Transcribed sequences 70.31(n)    BE421120.1 


    ENSEMBL Gene Tree for ANKRD45 (if available)
    TreeFam Gene Tree for ANKRD45 (if available) 

    Paralogs
    for ANKRD45 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ANKRD45 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/807 NCBI SNPs in ANKRD45 are shown (see all 807)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1845314211,2
    		--173577018(+) AAATAC/TATCAA 1 -- ds50010--------
    rs1893803411,2
    		--173577079(+) AATAGG/TTTTAT 1 -- ds50010--------
    rs1930509421,2
    		--173577091(+) TTATAA/CTAAGG 1 -- ds50010--------
    rs1850828421,2
    		--173577422(+) GGAAAC/TGTAGC 1 -- ds50010--------
    rs798688771,2
    		F,--173577455(+) TTATTT/CGTTTT 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1903727021,2
    		--173577682(+) CAAACC/TGCTGA 1 -- ut310--------
    rs1423830481,2
    		--173577908(+) GGGTG-/GAGAGAG 1 -- ut310--------
    rs567831851,2
    		--173578023(+) GGAAGA/GGAGGG 1 -- ut310--------
    rs1445372851,2
    		--173578047(+) GGGAGA/GGGAAG 1 -- ut310--------
    rs1812346791,2
    		--173578359(+) TGTCAA/GCTGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ANKRD45 (173577475 - 173639001 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ANKRD45: --

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    Disorders / Diseases
    for ANKRD45 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for ANKRD45 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKRD45 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ANKRD45)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for ANKRD45 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ANKRD45 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339416 HGNC: 24786 AceView: FLJ45235 Ensembl:ENSG00000183831 euGenes: HUgn339416
    ECgene: ANKRD45 H-InvDB: ANKRD45

    Other Databases showing ANKRD45 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ANKRD45 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKRD45 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ANKRD45 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ANKRD45 gene:
    Search GeneIP for patents involving ANKRD45

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ANKRD45 gene

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    About This Section

     
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