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Aliases for ANKRD45 Gene

Aliases for ANKRD45 Gene

  • Ankyrin Repeat Domain 45 2 3 5
  • Cancer/Testis Antigen 117 2 3
  • Ankyrin Repeat Domain-Containing Protein 45 3
  • CT117 3

External Ids for ANKRD45 Gene

Previous GeneCards Identifiers for ANKRD45 Gene

  • GC01M170310
  • GC01M171844
  • GC01M144805

Summaries for ANKRD45 Gene

GeneCards Summary for ANKRD45 Gene

ANKRD45 (Ankyrin Repeat Domain 45) is a Protein Coding gene.

Additional gene information for ANKRD45 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD45 Gene

Genomics for ANKRD45 Gene

GeneHancer (GH) Regulatory Elements for ANKRD45 Gene

Promoters and enhancers for ANKRD45 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I173669 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.3 +35.4 35419 1.2 CTCF MXI1 RFX1 EBF1 BMI1 RELA CHAMP1 POLR2A RFX3 ZBTB33 GC01M173668 ANKRD45 LOC105371619
GH01I174158 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 17.6 -454.1 -454077 3.7 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B RABGAP1L LOC102724601 RC3H1 ANKRD45 GAS5 ZBTB37 RNU7-78P GC01M174104
GH01I174020 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 17.3 -317.0 -316998 3.9 HDGF SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 LOC105371620 RC3H1 ANKRD45 ZBTB37 GAS5 RC3H1-IT1
GH01I173861 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.3 -161.5 -161493 10.3 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZBTB37 GC01M174026 GC01M174027 GC01M174029 GC01M174030 GC01M174031 GC01M174033 GC01M174034 GC01M174035 GC01M174036
GH01I173714 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 -10.2 -10171 2.3 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC SSRP1 KLHL20 RC3H1 DARS2 GAS5 GAS5-AS1 ANKRD45 RPS27P7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANKRD45 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD45 gene promoter:

Genomic Locations for ANKRD45 Gene

Genomic Locations for ANKRD45 Gene
chr1:173,608,336-173,705,267
(GRCh38/hg38)
Size:
96,932 bases
Orientation:
Minus strand
chr1:173,577,475-173,639,001
(GRCh37/hg19)

Genomic View for ANKRD45 Gene

Genes around ANKRD45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD45 Gene

Proteins for ANKRD45 Gene

  • Protein details for ANKRD45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TZF3-ANR45_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 45
    Protein Accession:
    Q5TZF3
    Secondary Accessions:
    • A1A4G2
    • Q6ZST1

    Protein attributes for ANKRD45 Gene

    Size:
    282 amino acids
    Molecular mass:
    31810 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD45 Gene

Post-translational modifications for ANKRD45 Gene

No Post-translational modifications

Other Protein References for ANKRD45 Gene

No data available for DME Specific Peptides for ANKRD45 Gene

Domains & Families for ANKRD45 Gene

Gene Families for ANKRD45 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD45 Gene

Suggested Antigen Peptide Sequences for ANKRD45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD45: view

No data available for UniProtKB/Swiss-Prot for ANKRD45 Gene

Function for ANKRD45 Gene

Phenotypes From GWAS Catalog for ANKRD45 Gene

Gene Ontology (GO) - Molecular Function for ANKRD45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ANKRD45: view
genes like me logo Genes that share phenotypes with ANKRD45: view

Animal Model Products

CRISPR Products

miRNA for ANKRD45 Gene

miRTarBase miRNAs that target ANKRD45

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD45 Gene

Localization for ANKRD45 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD45 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 2
cytoskeleton 2
golgi apparatus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ANKRD45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with ANKRD45: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ANKRD45 Gene

Pathways & Interactions for ANKRD45 Gene

SuperPathways for ANKRD45 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ANKRD45: view

No data available for Pathways by source and SIGNOR curated interactions for ANKRD45 Gene

Drugs & Compounds for ANKRD45 Gene

No Compound Related Data Available

Transcripts for ANKRD45 Gene

mRNA/cDNA for ANKRD45 Gene

Unigene Clusters for ANKRD45 Gene

Ankyrin repeat domain 45:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD45 Gene

No ASD Table

Relevant External Links for ANKRD45 Gene

GeneLoc Exon Structure for
ANKRD45
ECgene alternative splicing isoforms for
ANKRD45

Expression for ANKRD45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD45 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD45 Gene

This gene is overexpressed in Testis (x9.4), Brain - Nucleus accumbens (basal ganglia) (x5.9), and Brain - Caudate (basal ganglia) (x5.7).

Protein differential expression in normal tissues from HIPED for ANKRD45 Gene

This gene is overexpressed in Monocytes (30.7), Testis (13.9), Prostate (13.8), and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD45 Gene



Protein tissue co-expression partners for ANKRD45 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD45 Gene:

ANKRD45

SOURCE GeneReport for Unigene cluster for ANKRD45 Gene:

Hs.130054

Evidence on tissue expression from TISSUES for ANKRD45 Gene

  • Lung(2.6)
genes like me logo Genes that share expression patterns with ANKRD45: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD45 Gene

Orthologs for ANKRD45 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANKRD45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD45 33 34
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia ANKRD45 33 34
  • 91.07 (n)
cow
(Bos Taurus)
Mammalia ANKRD45 33 34
  • 89.15 (n)
mouse
(Mus musculus)
Mammalia Ankrd45 33 16 34
  • 81.4 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd45 33
  • 80.84 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD45 34
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD45 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd45 33
  • 59.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18865 33
zebrafish
(Danio rerio)
Actinopterygii ankrd45 33 34
  • 55.01 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.7279 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
OneToOne
Species where no ortholog for ANKRD45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD45 Gene

ENSEMBL:
Gene Tree for ANKRD45 (if available)
TreeFam:
Gene Tree for ANKRD45 (if available)

Paralogs for ANKRD45 Gene

No data available for Paralogs for ANKRD45 Gene

Variants for ANKRD45 Gene

Sequence variations from dbSNP and Humsavar for ANKRD45 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000000710 -- 173,680,455(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000003492 -- 173,634,713(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000014316 -- 173,676,470(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000062888 -- 173,679,887(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000076873 -- 173,609,868(-) G/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Variation tolerance for ANKRD45 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANKRD45 Gene

Disorders for ANKRD45 Gene

Additional Disease Information for ANKRD45

No disorders were found for ANKRD45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD45 Gene

Publications for ANKRD45 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for ANKRD45 Gene

Sources for ANKRD45 Gene

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