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Aliases for ANKRD44 Gene

Aliases for ANKRD44 Gene

  • Ankyrin Repeat Domain 44 2 3
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit ARS-B 3 4
  • Protein Phosphatase 6 Ankyrin Repeat Subunit B 2 3
  • Ankyrin Repeat Domain-Containing Protein 44 3 4
  • PP6-ARS-B 3 4
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Ankyrin Repeat Subunit B 3

External Ids for ANKRD44 Gene

Summaries for ANKRD44 Gene

GeneCards Summary for ANKRD44 Gene

ANKRD44 (Ankyrin Repeat Domain 44) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ANKRD44 Gene

  • Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD44 Gene

Genomics for ANKRD44 Gene

Genomic Location for ANKRD44 Gene

Start:
196,967,017 bp from pter
End:
197,311,173 bp from pter
Size:
344,157 bases
Orientation:
Minus strand

Genomic View for ANKRD44 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD44 Gene

Regulatory Elements for ANKRD44 Gene

Proteins for ANKRD44 Gene

  • Protein details for ANKRD44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8A2-ANR44_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
    Protein Accession:
    Q8N8A2
    Secondary Accessions:
    • Q53SL9
    • Q6P480
    • Q86VL5
    • Q8IZ72
    • Q9UFA4

    Protein attributes for ANKRD44 Gene

    Size:
    993 amino acids
    Molecular mass:
    107603 Da
    Quaternary structure:
    • Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1.

    Alternative splice isoforms for ANKRD44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD44 Gene

Proteomics data for ANKRD44 Gene at MOPED

Post-translational modifications for ANKRD44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD44 Gene

Domains for ANKRD44 Gene

Gene Families for ANKRD44 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • PPP6R :Serine/threonine phosphatases / Protein phosphatase 6, regulatory subunits

Protein Domains for ANKRD44 Gene

UniProtKB/Swiss-Prot:

ANR44_HUMAN
Similarity:
  • Contains 28 ANK repeats.:
    • Q8N8A2
genes like me logo Genes that share domains with ANKRD44: view

Function for ANKRD44 Gene

Molecular function for ANKRD44 Gene

UniProtKB/Swiss-Prot Function: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates

Gene Ontology (GO) - Molecular Function for ANKRD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16555005
genes like me logo Genes that share ontologies with ANKRD44: view

miRNA for ANKRD44 Gene

miRTarBase miRNAs that target ANKRD44

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANKRD44 Gene

Localization for ANKRD44 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD44 Gene COMPARTMENTS Subcellular localization image for ANKRD44 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ANKRD44 Gene

Pathways for ANKRD44 Gene

SuperPathways for ANKRD44 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD44 Gene

None

No data available for Pathways by source for ANKRD44 Gene

Transcripts for ANKRD44 Gene

Unigene Clusters for ANKRD44 Gene

Ankyrin repeat domain 44:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD44 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^
SP1: - -
SP2: - - - - - - -
SP3:
SP4: - - - - - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1:
SP2:
SP3:
SP4:

Relevant External Links for ANKRD44 Gene

GeneLoc Exon Structure for
ANKRD44
ECgene alternative splicing isoforms for
ANKRD44

Expression for ANKRD44 Gene

mRNA expression in normal human tissues for ANKRD44 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD44 Gene

This gene is overexpressed in Whole Blood (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKRD44 Gene

SOURCE GeneReport for Unigene cluster for ANKRD44 Gene Hs.432706

genes like me logo Genes that share expressions with ANKRD44: view

Orthologs for ANKRD44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD44 36
  • 99.73 (n)
  • 99.7 (a)
cow
(Bos Taurus)
Mammalia ANKRD44 36
  • 92.06 (n)
  • 97.05 (a)
dog
(Canis familiaris)
Mammalia ANKRD44 36
  • 93.33 (n)
  • 97.68 (a)
mouse
(Mus musculus)
Mammalia Ankrd44 36
  • 89.33 (n)
  • 95.77 (a)
Ankrd44 16
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD44 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd44 36
  • 89.36 (n)
  • 95.47 (a)
chicken
(Gallus gallus)
Aves ANKRD44 36
  • 82.36 (n)
  • 90.4 (a)
zebrafish
(Danio rerio)
Actinopterygii ankrd44 36
  • 66.12 (n)
  • 71.49 (a)
Species with no ortholog for ANKRD44:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD44 Gene

ENSEMBL:
Gene Tree for ANKRD44 (if available)
TreeFam:
Gene Tree for ANKRD44 (if available)

Paralogs for ANKRD44 Gene

genes like me logo Genes that share paralogs with ANKRD44: view

No data available for Paralogs for ANKRD44 Gene

Variants for ANKRD44 Gene

Sequence variations from dbSNP and Humsavar for ANKRD44 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs715185 -- 196,990,428(+) CTTTA(C/T)TTAAA intron-variant, utr-variant-3-prime
rs730200 -- 197,023,766(+) GTAAC(A/T)TCCCC intron-variant
rs893401 -- 197,085,334(+) TGAGG(A/G)GGCTC intron-variant
rs893402 -- 197,086,891(+) ACATA(C/T)TAGAG intron-variant
rs920263 -- 197,059,447(+) ATATA(C/T)AACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD44 Gene

Variant ID Type Subtype PubMed ID
nsv834505 CNV Loss 17160897
nsv526549 CNV Loss 19592680
esv2721337 CNV Deletion 23290073
esv23521 CNV Gain 19812545
nsv215425 CNV Loss 16902084
esv2674646 CNV Deletion 23128226
esv22536 CNV Loss 19812545
nsv460015 CNV Gain 19166990

Relevant External Links for ANKRD44 Gene

HapMap Linkage Disequilibrium report
ANKRD44
Human Gene Mutation Database (HGMD)
ANKRD44

Disorders for ANKRD44 Gene

Relevant External Links for ANKRD44

Genetic Association Database (GAD)
ANKRD44
Human Genome Epidemiology (HuGE) Navigator
ANKRD44
genes like me logo Genes that share disorders with ANKRD44: view

No data available for UniProtKB/Swiss-Prot for ANKRD44 Gene

Publications for ANKRD44 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PMID: 18186651) Stefansson B. … Brautigan D.L. (Biochemistry 2008) 3 4
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 49

Products for ANKRD44 Gene

Sources for ANKRD44 Gene

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