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Aliases for ANKRD42 Gene

Aliases for ANKRD42 Gene

  • Ankyrin Repeat Domain 42 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 79 2 3
  • Ankyrin Repeat Domain-Containing Protein 42 3
  • Several Ankyrin Repeat Protein 3
  • PPP1R79 3
  • SARP 3

External Ids for ANKRD42 Gene

Previous GeneCards Identifiers for ANKRD42 Gene

  • GC11P082583
  • GC11P082904
  • GC11P079202

Summaries for ANKRD42 Gene

GeneCards Summary for ANKRD42 Gene

ANKRD42 (Ankyrin Repeat Domain 42) is a Protein Coding gene. GO annotations related to this gene include structural constituent of ribosome and NF-kappaB binding. An important paralog of this gene is ESPNL.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD42 Gene

Genomics for ANKRD42 Gene

Regulatory Elements for ANKRD42 Gene

Enhancers for ANKRD42 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G083155 1.4 ENCODE dbSUPER 13 -34.3 -34310 8.0 AGO1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PCF11 LOC100506282 ANKRD42 RAB30-AS1 RAB30 SNORA70E ENSG00000254522 ENSG00000254698 GC11P083158 ENSG00000254676
GH11G082899 1.7 FANTOM5 ENCODE dbSUPER 2.5 -292.8 -292784 3.8 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 DDIAS PRCP PCF11 ENSG00000254676 ANKRD42 RAB30 RPL7AP54
GH11G083472 0.5 ENCODE 4.4 +279.6 279583 2.0 AGO1 CEBPB EP300 ATF2 RBFOX2 CCDC90B ANKRD42 GC11M083456 GC11M083502
GH11G083206 0.5 FANTOM5 2.3 +13.4 13421 0.4 L3MBTL2 MNT LOC102724712 CCDC90B RAB30-AS1 RAB30 PCF11 ANKRD42 CKS1BP4 LOC100506282
GH11G083191 1.3 ENCODE dbSUPER 0.7 0.0 -14 4.3 HDGF PKNOX1 FOXA2 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 ANKRD42 PCF11-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD42 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD42 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042786 161 2601 HDGF PKNOX1 FOXA2 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1

Genomic Location for ANKRD42 Gene

Chromosome:
11
Start:
83,193,739 bp from pter
End:
83,260,694 bp from pter
Size:
66,956 bases
Orientation:
Plus strand

Genomic View for ANKRD42 Gene

Genes around ANKRD42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD42 Gene

Proteins for ANKRD42 Gene

  • Protein details for ANKRD42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9B4-ANR42_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 42
    Protein Accession:
    Q8N9B4
    Secondary Accessions:
    • Q49A49

    Protein attributes for ANKRD42 Gene

    Size:
    389 amino acids
    Molecular mass:
    43052 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD42 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD42 Gene

Post-translational modifications for ANKRD42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD42 Gene

Domains & Families for ANKRD42 Gene

Protein Domains for ANKRD42 Gene

Suggested Antigen Peptide Sequences for ANKRD42 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD42: view

No data available for UniProtKB/Swiss-Prot for ANKRD42 Gene

Function for ANKRD42 Gene

Phenotypes for ANKRD42 Gene

GenomeRNAi human phenotypes for ANKRD42:
genes like me logo Genes that share phenotypes with ANKRD42: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD42 Gene

Localization for ANKRD42 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD42 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ANKRD42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with ANKRD42: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANKRD42 Gene

Pathways & Interactions for ANKRD42 Gene

SuperPathways for ANKRD42 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
genes like me logo Genes that share ontologies with ANKRD42: view

No data available for Pathways by source and SIGNOR curated interactions for ANKRD42 Gene

Drugs & Compounds for ANKRD42 Gene

No Compound Related Data Available

Transcripts for ANKRD42 Gene

Unigene Clusters for ANKRD42 Gene

Ankyrin repeat domain 42:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD42 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2:
SP3: -
SP4: - -

Relevant External Links for ANKRD42 Gene

GeneLoc Exon Structure for
ANKRD42
ECgene alternative splicing isoforms for
ANKRD42

Expression for ANKRD42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD42 Gene

Protein differential expression in normal tissues from HIPED for ANKRD42 Gene

This gene is overexpressed in Pancreas (36.5) and Bone (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD42 Gene



Protein tissue co-expression partners for ANKRD42 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD42 Gene:

ANKRD42

SOURCE GeneReport for Unigene cluster for ANKRD42 Gene:

Hs.503438
genes like me logo Genes that share expression patterns with ANKRD42: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD42 Gene

Orthologs for ANKRD42 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANKRD42 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD42 34 35
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia ANKRD42 34 35
  • 89.01 (n)
dog
(Canis familiaris)
Mammalia ANKRD42 34 35
  • 87.63 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd42 34
  • 85.14 (n)
mouse
(Mus musculus)
Mammalia Ankrd42 34 16 35
  • 84.82 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD42 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD42 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD42 34 35
  • 68.96 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD42 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd42 34
  • 65.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9121 35
  • 11 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAS6 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7381 34
Species where no ortholog for ANKRD42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANKRD42 Gene

ENSEMBL:
Gene Tree for ANKRD42 (if available)
TreeFam:
Gene Tree for ANKRD42 (if available)

Paralogs for ANKRD42 Gene

Variants for ANKRD42 Gene

Sequence variations from dbSNP and Humsavar for ANKRD42 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000008295 -- 83,229,950(+) GGAGA(A/G)TGGGG intron-variant
rs1000169445 -- 83,207,771(+) TATTA(A/G)TCTCT intron-variant
rs1000224081 -- 83,248,585(+) ATCAT(C/T)ATGGA intron-variant, utr-variant-3-prime
rs1000248036 -- 83,255,824(+) TTGAC(C/T)CTCTT intron-variant
rs1000267114 -- 83,213,328(+) CCATC(A/G)TGGAA intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ANKRD42 Gene

Variant ID Type Subtype PubMed ID
esv33531 CNV loss 17666407
esv3627012 CNV gain 21293372
nsv972050 CNV duplication 23825009
nsv972051 CNV duplication 23825009

Variation tolerance for ANKRD42 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD42 Gene

Disorders for ANKRD42 Gene

Relevant External Links for ANKRD42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD42

No disorders were found for ANKRD42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD42 Gene

Publications for ANKRD42 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M. … da Cruz e Silva E.F. (Biochem. Pharmacol. 2011) 3 64
  4. SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein. (PMID: 17123353) Browne G.J. … da Cruz E Silva E.F. (Biochem. J. 2007) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ANKRD42 Gene

Sources for ANKRD42 Gene

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