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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANKRD42 Gene

protein-coding GIFtS: 43
GCID: GC11P082904

ankyrin repeat domain 42

Search for ANKRD42
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ankyrin Repeat Domain 42¹ ²
SARP¹ ²
FLJ37874¹
Ankyrin Repeat Domain-Containing Protein 42²
Several Ankyrin Repeat Protein²

External Ids:	HGNC: 26752¹	Entrez Gene: 338699²	Ensembl: ENSG00000137494⁷	UniProtKB: Q8N9B4³

Export aliases for ANKRD42 gene to outside databases

Previous GC identifers: GC11P082583 GC11P079202

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANKRD42 gene promoter:
HOXA9B HOXA9 Elk-1 Olf-1 Lmo2 POU2F1 POU2F1b POU2F1a POU2F1c
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANKRD42 promoter sequence

Search SABiosciences Chromatin IP Primers for ANKRD42

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD42

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q14.1

ANKRD42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD42 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P082904: view genomic region (about GC identifiers)

Start:	82,904,781 bp from pter	End:	82,971,736 bp from pter
Size:	66,956 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANR42_HUMAN, Q8N9B4 (See protein sequence)

Recommended Name: Ankyrin repeat domain-containing protein 42

Size: 389 amino acids; 43052 Da

Secondary accessions: Q49A49

Alternative splicing: 2 isoforms: Q8N9B4-1 Q8N9B4-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD42: NX_Q8N9B4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N9B4

ANKRD42 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_872409.2

ENSEMBL proteins:

ENSP00000377049 ENSP00000432375 ENSP00000260047 ENSP00000433585 ENSP00000434666

ENSP00000377051 ENSP00000435790 ENSP00000435197

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ANKRD42 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANKRD42 for domains About GeneDecksing

3 InterPro domains/families:

IPR018247 EF_Hand_1_Ca_BS

IPR020683 Ankyrin_rpt-contain_dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q8N9B4

ProtoNet protein and cluster: Q8N9B4

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: ANR42_HUMAN, Q8N9B4

Similarity: Contains 9 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0051059	NF-kappaB binding	IEA	--

ANKRD42 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ANKRD42

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	--	--
GO:0051092	positive regulation of NF-kappaB transcription factor activity	IEA	--
GO:1900017	positive regulation of cytokine production involved in inflammatory response	IEA	--

ANKRD42 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about ANKRD42 / ANR42

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ANKRD42 gene:

NM_182603.2

Unigene Cluster for ANKRD42:

Ankyrin repeat domain 42

Hs.503438 [show with all ESTs]

Unigene Representative Sequence: BC045621

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000393389(uc009yvi.2) ENST00000528722 ENST00000260047(uc001paa.3 uc001pab.1)

ENST00000526731 ENST00000531895 ENST00000393392(uc001ozz.1 uc010rsv.1)

ENST00000533342 ENST00000531815 ENST00000528190

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		hsa-miR-219-1-3p hsa-miR-125a-5p hsa-miR-1197 hsa-miR-571 hsa-miR-767-3p hsa-miR-199a-5p hsa-miR-125b hsa-miR-3613-3p

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Additional cDNA sequence:

AK095193.1 AK310765.1 BC045621.1 BC062729.1 BC171752.1 BX648690.1 DQ508815.1 DQ508934.1

EF041819.1

11 DOTS entries:

DT.402938 DT.99962747 DT.70103208 DT.100011831 DT.95149693 DT.100681214 DT.120721957 DT.92046372

DT.95198724 DT.95303781 DT.97781128

24/61 AceView cDNA sequences (see all 61):

AK095193 AV727972 CF126023 BX371413 BM989261 BU786313 NM_182603 CB268217

AW592548 BQ712298 BU622073 CK005378 BG171404 BM979374 BM769762 BU853711

BF207726 AI915636 N25812 BX648690 AA665453 BX099159 BU674837 BC062729

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD42 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11	^	12
SP1:											-								-		-		-
SP2:
SP3:																			-
SP4:					-		-

ECgene alternative splicing isoforms for ANKRD42

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANKRD42 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ANKRD42 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for ANKRD42

SOURCE GeneReport for Unigene cluster: Hs.503438

SABiosciences Custom PCR Arrays for ANKRD42

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ANKRD42 gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ANKRD42¹	ankyrin repeat domain 42	69.06(n) 66.09(a)		772327 XM_001235478.2 XP_001235479.2
lizard (Anolis carolinensis)	Reptilia	ANKRD42⁶	--	42(a)	1 ↔ 1	3(202049658-202065484)
zebrafish (Danio rerio)	Actinopterygii	AL929287.2⁶	--	4(a)	possible ortholog	6(27044770-27046272)
honey bee (Apis mellifera)	Insecta	--	--	5(a)	possible ortholog	GroupUn.1449(14818-20088)

ENSEMBL Gene Tree for ANKRD42 (if available)
TreeFam Gene Tree for ANKRD42 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANKRD42 gene

ESPNL² ESPN²

18/28 SIMAP similar genes for ANKRD42 using alignment to 8 protein entries: ANR42_HUMAN (see all proteins) (see all similar genes):

ASB3 TNKS CDKN2C GABPB1 ANK2 ILK

TANC2 CASKIN2 TRPA1 RAI14 DKFZp761E1322 MTPN

PSMD10 ANKRD44 OSBPL1A PPP1R12B PPP1R12C ANK1

ANKRD42 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12576804^1,2	C,F,H	--	79200889(+)	`TTGATC/ACCTTT`	1	--	nc-transcript-varianttfbs³		5	NS EA NA	424
rs12295103^1,2	C,F,A,H	--	79201043(+)	`TTTTTT/CCCCTT`	1	--	nc-transcript-varianttfbs³ trp³		5	NS EA WA	530
rs2231731^1,2	C,F,H	--	79201195(-)	`ATCTAC/TTGAGT`	1	--	nc-transcript-variant		12	NS EA NA WA	1448
rs2231730^1,2	H	--	79201211(-)	`TAATAT/CTACAA`	1	--	nc-transcript-variant		3	NS EA	300
rs2231728^1,2	F,H	--	79201409(-)	`TTCAGG/AAATAA`	1	--	int¹ tfbs³		5	NS EA	496
rs2231727^1,2	C,H	--	79201895(-)	`GGAAAT/GTTGTT`	1	--	int¹		5	NS EA NA	422
rs2231726^1,2	F,H	--	79202186(-)	`CGGCCC/AACGCT`	1	--	us2k¹		4	NS EA	418
rs2231725^1,2	H	--	79202263(-)	`TGGCTG/TGAGAG`	1	--	us2k¹		4	NS EA	420
rs11549134^1,2	F	--	79202368(+)	`GACGGT/CGGCCG`	1	--	us2k¹		1	WA	118
rs80191020^1,2	C	--	79202738(+)	`AAGACC/TGAGGC`	1	--	us2k¹		1	WA	2

HapMap Linkage Disequilibrium report for ANKRD42 (82904781 - 82971736 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ANKRD42
1 CNV: 6945

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD42

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ANKRD42 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANKRD42)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)¹ Altun M....Kessler B.M. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein. (PubMed id 17123353)¹ Browne G.J.... da Cruz E Silva E.F. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 338699	HGNC: 26752	AceView: FLJ37874	Ensembl:ENSG00000137494	euGenes: HUgn338699
ECgene: ANKRD42	H-InvDB: ANKRD42

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANKRD42	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANKRD42 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ANKRD42 gene:
Search GeneIP for patents involving ANKRD42

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANKRD42
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	GenScript Custom Purified and Recombinant Proteins Services for ANKRD42		GenScript cDNA clones with any tag delivered in your preferred vector for ANKRD42
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD42

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD42

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ANKRD42

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ANKRD42 gene at Home site.

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ANKRD42 Gene

ankyrin repeat domain 42

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ANKRD42 Gene

ankyrin repeat domain 42

Aliasesfor ANKRD42 gene

Summariesfor ANKRD42 gene

Genomic Viewsfor ANKRD42 gene

Proteinsfor ANKRD42 gene

Protein Domains /Familiesfor ANKRD42 gene

Functionfor ANKRD42 gene

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Expression for ANKRD42 gene

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for ANKRD42 gene

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for ANKRD42 gene

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for ANKRD42 gene

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Families
for ANKRD42 gene

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for ANKRD42 gene

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for ANKRD42 gene

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for ANKRD42 gene

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for ANKRD42 gene

Expression
for ANKRD42 gene

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for ANKRD42 gene

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