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ANKRD42 Gene

protein-coding   GIFtS: 44
GCID: GC11P082904

Ankyrin Repeat Domain 42

  Search for ANKRD42
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 421 2
SARP2
Ankyrin Repeat Domain-Containing Protein 422
Several Ankyrin Repeat Protein2

External Ids:    HGNC: 267521   Entrez Gene: 3386992   Ensembl: ENSG000001374947   UniProtKB: Q8N9B43   

Export aliases for ANKRD42 gene to outside databases

Previous GC identifers: GC11P082583 GC11P079202


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD42 Gene:
ANKRD42 (ankyrin repeat domain 42) is a protein-coding gene. GO annotations related to this gene include NF-kappaB binding. An important paralog of this gene is ANKRD54.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD42 gene promoter:
         HOXA9B   HOXA9   Elk-1   Olf-1   Lmo2   POU2F1   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD42 promoter sequence
   Search Chromatin IP Primers for ANKRD42

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q14.1

ANKRD42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD42 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P082904:  view genomic region     (about GC identifiers)

Start:
82,904,781 bp from pter      End:
82,971,736 bp from pter
Size:
66,956 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ANR42_HUMAN, Q8N9B4 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 42  
Size: 389 amino acids; 43052 Da
Secondary accessions: Q49A49
Alternative splicing: 2 isoforms:  Q8N9B4-1   Q8N9B4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD42: NX_Q8N9B4

Explore proteomics data for ANKRD42 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANKRD42 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_872409.2  
    ENSEMBL proteins: 
     ENSP00000377049   ENSP00000432375   ENSP00000260047   ENSP00000433585   ENSP00000434666  
     ENSP00000377051   ENSP00000435790   ENSP00000435197  

    ANKRD42 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ANKRD42

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    LSBio Antibodies in human, mouse, rat for ANKRD42

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    Cloud-Clone Corp. CLIAs for ANKRD42


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    3 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR018247 EF_Hand_1_Ca_BS
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q8N9B4

    ProtoNet protein and cluster: Q8N9B4

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: ANR42_HUMAN, Q8N9B4
    Similarity: Contains 9 ANK repeats


    ANKRD42 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome ----
    GO:0005515protein binding ----
    GO:0051059NF-kappaB binding IEA--
         
    ANKRD42 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANKRD42
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    miRNA
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    miRTarBase miRNAs that target ANKRD42:
    hsa-mir-124-3p (MIRT022615)

    Block miRNA regulation of human, mouse, rat ANKRD42 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANKRD42 (see all 10):
    hsa-miR-219-1-3p hsa-miR-125a-5p hsa-miR-1197 hsa-miR-571 hsa-miR-767-3p hsa-miR-199a-5p hsa-miR-125b hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidANKRD42 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANKRD42

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ANKRD42 (NM_182603)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD42

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD42


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005840ribosome ----

    ANKRD42 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD42
    Interactions:

        Search GeneGlobe Interaction Network for ANKRD42

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation ----
    GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity ----
    GO:0051092positive regulation of NF-kappaB transcription factor activity IEA--
    GO:1900017positive regulation of cytokine production involved in inflammatory response IEA--

    ANKRD42 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKRD42 (ANR42)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANKRD42 gene: 
    NM_182603.2  

    Unigene Cluster for ANKRD42:

    Ankyrin repeat domain 42
    Hs.503438  [show with all ESTs]
    Unigene Representative Sequence: BC045621
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393389(uc009yvi.2) ENST00000528722 ENST00000260047(uc001paa.3 uc001pab.1)
    ENST00000526731 ENST00000531895 ENST00000393392(uc001ozz.1 uc010rsv.1)
    ENST00000533342 ENST00000531815 ENST00000528190
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ANKRD42 (see all 10):
    hsa-miR-219-1-3p hsa-miR-125a-5p hsa-miR-1197 hsa-miR-571 hsa-miR-767-3p hsa-miR-199a-5p hsa-miR-125b hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidANKRD42 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ANKRD42
    Predesigned siRNA for gene silencing in human, mouse, rat ANKRD42
    Clone
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    OriGene clones in human, mouse for ANKRD42 (see all 7)
    OriGene ORF clones in mouse, rat for ANKRD42
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANKRD42 (NM_182603)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANKRD42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD42
    Primer
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    OriGene qPCR primer pairs and template standards for ANKRD42
    OriGene qSTAR qPCR primer pairs in human, mouse for ANKRD42
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANKRD42
      QuantiTect SYBR Green Assays in human, mouse, rat ANKRD42
      QuantiFast Probe-based Assays in human, mouse, rat ANKRD42

    Additional mRNA sequence: 

    AK095193.1 AK310765.1 BC045621.1 BC062729.1 BC171752.1 BX648690.1 DQ508815.1 DQ508934.1 
    EF041819.1 

    11 DOTS entries:

    DT.402938  DT.99962747  DT.70103208  DT.100011831  DT.95149693  DT.100681214  DT.120721957  DT.92046372 
    DT.95198724  DT.95303781  DT.97781128 

    Selected AceView cDNA sequences (see all 61):

    CF126023 BU786313 AV727972 NM_182603 BX371413 AK095193 BM989261 CA417732 
    AI375415 N25812 AA665453 BQ712298 BF207726 AW592548 BU607968 BF508960 
    CK005378 BX648690 BM769762 BM979374 BU674837 BU622073 CB268217 BQ890069 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD42    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                -                       -     -     -                                 
    SP2:                                                                                                      
    SP3:                                                        -                                             
    SP4:              -     -                                                                                 


    ECgene alternative splicing isoforms for ANKRD42

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKRD42 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ANKRD42 Expression
    About this image

    ANKRD42 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKRD42 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.503438
        Custom PCR Arrays for ANKRD42
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD42

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ANKRD42 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankrd421 , 5 ankyrin repeat domain 421, 5 84.82(n)1
    83.2(a)1
      7 (51.52 cM)5
    738451  NM_028665.41  NP_082941.21 
     925817235 
    chicken
    (Gallus gallus)
    Aves ANKRD421 ankyrin repeat domain 42 68.96(n)
    66.76(a)
      772327  XM_004938898.1  XP_004938955.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANKRD426
    ankyrin repeat domain 42
    43(a)
    1 ↔ 1
    3(202046778-202074559)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ankrd421 ankyrin repeat domain 42 65.74(n)
    65.28(a)
      100498077  XM_004912190.1  XP_004912247.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG91216
    --
    11(a)
    1 → many
    2L(5047818-5050975)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAS66
    Proteasome-interacting protein involved in the ass...
    21(a)
    1 → many
    VII(953960-954646) YGR232W


    ENSEMBL Gene Tree for ANKRD42 (if available)
    TreeFam Gene Tree for ANKRD42 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKRD42 gene
    ANKRD542  PSMD102  ASB82  ASB72  
    Selected SIMAP similar genes for ANKRD42 using alignment to 8 protein entries:     ANR42_HUMAN (see all proteins) (see all similar genes):
    GPR75-ASB3    TNKS    CDKN2C    GABPB1    ANK2    ILK
    TANC2    CASKIN2    TRPA1    RAI14    DKFZp761E1322    MTPN
    PSMD10    FPGT-TNNI3K    ANKRD44    OSBPL1A    PPP1R12B    PPP1R12C

    ANKRD42 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKRD42 (see all 1156)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880966591,2
    --82906831(+) TTTCTA/GGTCTA 1 -- int10--------
    rs1929098181,2
    --82906889(+) TCTCTC/TTTTTT 1 -- int10--------
    rs71143641,2
    C--82906918(+) gtcttG/Tctctg 1 -- int10--------
    rs1853319681,2
    --82906973(+) ATCTCC/TGCCTT 1 -- int10--------
    rs1450608591,2
    C--82907038(+) GCCCAC/TCACCA 1 -- int10--------
    rs1875454451,2
    C--82907048(+) ACACCC/TGGCTA 1 -- int10--------
    rs1919796841,2
    C--82907149(+) AAAGTC/TCTGGG 1 -- int10--------
    rs1483133441,2
    --82907179(+) GCGCCC/TGGCCA 1 -- int10--------
    rs6063811,2
    C,F,O,H--82907249(+) ATTTAG/ACCTTG 1 -- int124Minor allele frequency- A:0.36NS EA NA WA CSA 2388
    rs1404578461,2
    C--82907268(+) GCCTTA/CCAGCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for ANKRD42 (82904781 - 82971736 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ANKRD42:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33531CNV Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANKRD42
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKRD42

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKRD42 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ANKRD42)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Identification of the human testis protein phosphatase 1 interactome. (PubMed id 21382349)1 Fardilha M....da Cruz e Silva E.F. (Biochem. Pharmacol. 2011)
    6. SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein. (PubMed id 17123353)1 Browne G.J.... da Cruz E Silva E.F. (Biochem. J. 2007)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 338699 HGNC: 26752 AceView: FLJ37874 Ensembl:ENSG00000137494 euGenes: HUgn338699
    ECgene: ANKRD42 H-InvDB: ANKRD42

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKRD42 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKRD42 gene:
    Search GeneIP for patents involving ANKRD42

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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