ANKRD40 Gene
protein-coding GIFtS: 44
GCID: GC17M048770
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ankyrin repeat domain 40
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Aliases
for ANKRD40 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat Domain 401 2 | | MGC153961 | | Ankyrin Repeat Domain-Containing Protein 402 |
Export aliases for ANKRD40 gene to outside databasesPrevious GC identifers: GC17M046128 GC17M044137 |
Summaries
for ANKRD40 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ANKRD40 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKRD40 gene promoter:
AML1a Tal-1 AP-1 MAZR RREB-1 AP-4 Tal-1beta E47 Pax-3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKRD40
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD40 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.33 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21.33ANKRD40 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M048770: view genomic region
(about GC identifiers)
Start:
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48,770,551 bp from pter |
End:
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48,785,285 bp from pter |
Size:
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14,735 bases |
Orientation:
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minus strand |
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Proteins
for ANKRD40 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANR40_HUMAN, Q6AI12 (See
protein sequence)Recommended Name: Ankyrin repeat domain-containing protein 40 Size: 368 amino acids; 41088 Da
Secondary accessions: Q96E32Explore the universe of human proteins at neXtProt for ANKRD40: NX_Q6AI12
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6AI12
ANKRD40 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_443087.1
ENSEMBL proteins: ENSP00000285243 ENSP00000468442
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
ANKRD40 for ontologies About GeneDecksing
ANKRD40 Antibody Products:
Assay Products for ANKRD40: |
Protein
Domains /
Families
for ANKRD40 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKRD40 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6AI12ProtoNet protein and cluster: Q6AI12 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ANR40_HUMAN, Q6AI12Similarity: Contains 2 ANK repeats |
Function
for ANKRD40 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD40 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD40
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ANKRD40 (NM_052855) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD40 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD40 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD40 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
ANKRD40 for ontologies About GeneDecksing
|
Pathways & Interactions
for ANKRD40 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD40
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for ANKRD40 (Q6AI123 ENSP000002852434) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
ANKRD40 for ontologies About GeneDecksing
|
Drugs & Compounds
for ANKRD40 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKRD40
Search CenterWatch for drugs/clinical trials and news about ANKRD40 / ANR40
|
Transcripts
for ANKRD40 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKRD40 gene: NM_052855.3 Unigene Cluster for ANKRD40: Ankyrin repeat domain 40 Hs.463426 [show with all ESTs]Unigene Representative Sequence: NM_0528553 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000285243(uc002iso.3) ENST00000513072 ENST00000507114
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD40 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD40
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANKRD40 (NM_052855) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD40 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD40 |
Additional cDNA sequence: AK054795.1 AK314010.1 BC005853.2 BC012978.2 CR627413.1 EU164539.1 5 DOTS entries: DT.70104038 DT.451538 DT.91762859 DT.91752494 DT.91762863 24/166 AceView cDNA sequences (see all 166): CA421013 BQ214356 BU633588 AI126526 BF512547 BQ272388 BU634235 AI620376 BM792759 CB853848 CR620109 BM773421 BM740925 BM772462 AA489651 BC005853 BM773434 CR616806 BM665118 AI129203 BU177977 BF686024 BM753043 BQ019246
GeneLoc Exon Structure
|
Expression
for ANKRD40 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKRD40 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTCACACT
About this image
See ANKRD40 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD40
SOURCE GeneReport for Unigene cluster: Hs.463426
SABiosciences Custom PCR Arrays for ANKRD40
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD40
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANKRD40 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD40 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD40 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD40 |
Orthologs
for ANKRD40 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ANKRD40 gene from 7/17 species (see all 17) About this table
ENSEMBL Gene Tree for ANKRD40 (if available)
TreeFam Gene Tree for ANKRD40 (if available) |
Paralogs
for ANKRD40 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKRD40 gene
ANKRD40 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ANKRD40
PGOHUM00000237106
|
Genomic Variants
for ANKRD40 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKRD40 (48770551 - 48785285 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ANKRD40
1 Indel: 11888 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD40 |
|
Disorders
/ Diseases
for ANKRD40 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ANKRD40 for disorders About MalaCards
ANKRD40 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: ANKRD40 (3 documents)
Export disorders for ANKRD40 gene to outside databases
|
Publications
for ANKRD40 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKRD40 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ANKRD40) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Proteomic dissection of the von Hippel-Lindau (VHL) i nteractome. (PubMed id 21942715)1 Lai Y....Shiio Y. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for ANKRD40 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANKRD40 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKRD40 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANKRD40 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKRD40 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANKRD40 gene:
Search GeneIP for patents involving ANKRD40
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKRD40 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ANKRD40 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKRD40 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD40 | | | OriGene Protein Over-expression Lysate for ANKRD40 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ANKRD40 | | OriGene 3'-UTR Clone for ANKRD40 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD40 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD40 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ANKRD40 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANKRD40 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD40 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD40 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKRD40 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD40 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD40 |
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| | | | Search Tocris compounds for ANKRD40 |
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 | | | ANKRD40 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD40 |
|  |  |  | | | | Search ThermoFisher Antibodies for ANKRD40 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD40 |
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