Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANKRD40 Gene

Aliases for ANKRD40 Gene

  • Ankyrin Repeat Domain 40 2 3 5

External Ids for ANKRD40 Gene

Previous GeneCards Identifiers for ANKRD40 Gene

  • GC17M046128
  • GC17M048770
  • GC17M044137

Summaries for ANKRD40 Gene

GeneCards Summary for ANKRD40 Gene

ANKRD40 (Ankyrin Repeat Domain 40) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD40 Gene

Genomics for ANKRD40 Gene

Regulatory Elements for ANKRD40 Gene

Enhancers for ANKRD40 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANKRD40 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD40 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANKRD40 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKRD40 Gene

50,693,190 bp from pter
50,707,924 bp from pter
14,735 bases
Minus strand

Genomic View for ANKRD40 Gene

Genes around ANKRD40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD40 Gene

Proteins for ANKRD40 Gene

  • Protein details for ANKRD40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat domain-containing protein 40
    Protein Accession:
    Secondary Accessions:
    • Q96E32

    Protein attributes for ANKRD40 Gene

    368 amino acids
    Molecular mass:
    41088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD40 Gene

Proteomics data for ANKRD40 Gene at MOPED

Post-translational modifications for ANKRD40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD40 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD40 Gene

Domains & Families for ANKRD40 Gene

Gene Families for ANKRD40 Gene

Protein Domains for ANKRD40 Gene

Suggested Antigen Peptide Sequences for ANKRD40 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 ANK repeats.
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with ANKRD40: view

Function for ANKRD40 Gene

Phenotypes for ANKRD40 Gene

genes like me logo Genes that share phenotypes with ANKRD40: view

Animal Model Products

CRISPR Products

miRNA for ANKRD40 Gene

miRTarBase miRNAs that target ANKRD40

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD40 Gene

Localization for ANKRD40 Gene

Subcellular locations from

Jensen Localization Image for ANKRD40 Gene COMPARTMENTS Subcellular localization image for ANKRD40 gene
Compartment Confidence
cytosol 4
golgi apparatus 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD40 Gene

Pathways & Interactions for ANKRD40 Gene

SuperPathways for ANKRD40 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD40 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKRD40 Gene

Drugs & Compounds for ANKRD40 Gene

No Compound Related Data Available

Transcripts for ANKRD40 Gene

mRNA/cDNA for ANKRD40 Gene

Unigene Clusters for ANKRD40 Gene

Ankyrin repeat domain 40:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD40 Gene

No ASD Table

Relevant External Links for ANKRD40 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRD40 Gene

mRNA expression in normal human tissues for ANKRD40 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD40 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.6).

Protein differential expression in normal tissues from HIPED for ANKRD40 Gene

This gene is overexpressed in Platelet (45.7) and Spleen (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKRD40 Gene

SOURCE GeneReport for Unigene cluster for ANKRD40 Gene Hs.463426

genes like me logo Genes that share expression patterns with ANKRD40: view

Protein tissue co-expression partners for ANKRD40 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ANKRD40 Gene

Orthologs for ANKRD40 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD40 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANKRD40 35
  • 92.97 (n)
  • 95.89 (a)
ANKRD40 36
  • 96 (a)
(Canis familiaris)
Mammalia ANKRD40 35
  • 91.03 (n)
  • 93.96 (a)
ANKRD40 36
  • 91 (a)
(Mus musculus)
Mammalia Ankrd40 35
  • 89.99 (n)
  • 93.39 (a)
Ankrd40 16
Ankrd40 36
  • 93 (a)
(Pan troglodytes)
Mammalia ANKRD40 35
  • 99.73 (n)
  • 99.46 (a)
ANKRD40 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ankrd40 35
  • 90.36 (n)
  • 93.39 (a)
(Monodelphis domestica)
Mammalia ANKRD40 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia ANKRD40 36
  • 68 (a)
(Gallus gallus)
Aves ANKRD40 36
  • 56 (a)
ANKRD40 35
  • 59.3 (n)
  • 58.14 (a)
(Anolis carolinensis)
Reptilia ANKRD40 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd40 35
  • 61.64 (n)
  • 58.58 (a)
(Danio rerio)
Actinopterygii LOC100005118 35
  • 60.42 (n)
  • 59.65 (a)
ankrd40 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea R31.2 36
  • 14 (a)
Species with no ortholog for ANKRD40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKRD40 Gene

Gene Tree for ANKRD40 (if available)
Gene Tree for ANKRD40 (if available)

Paralogs for ANKRD40 Gene Pseudogenes for ANKRD40 Gene

genes like me logo Genes that share paralogs with ANKRD40: view

No data available for Paralogs for ANKRD40 Gene

Variants for ANKRD40 Gene

Sequence variations from dbSNP and Humsavar for ANKRD40 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs8196 -- 50,693,598(-) GGGCA(C/T)GTTCT utr-variant-3-prime
rs9455 -- 50,693,774(-) TAAAA(A/C)AGTTA utr-variant-3-prime
rs14882 -- 50,693,258(-) TTTTT(C/T)TTTGT utr-variant-3-prime
rs1990333 -- 50,698,984(+) aaaat(A/C)caaaa intron-variant
rs2286650 -- 50,700,937(+) TAACT(C/T)AACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD40 Gene

Variant ID Type Subtype PubMed ID
dgv42n68 CNV Loss 17160897
nsv111922 CNV Loss 16902084
esv2716039 CNV Deletion 23290073
esv2242752 CNV Deletion 18987734

Variation tolerance for ANKRD40 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD40 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD40 Gene

Disorders for ANKRD40 Gene

Relevant External Links for ANKRD40

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANKRD40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD40 Gene

Publications for ANKRD40 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3

Products for ANKRD40 Gene

Sources for ANKRD40 Gene