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Aliases for ANKRD39 Gene

Aliases for ANKRD39 Gene

  • Ankyrin Repeat Domain 39 2 3 5

External Ids for ANKRD39 Gene

Previous GeneCards Identifiers for ANKRD39 Gene

  • GC02M096936
  • GC02M096865
  • GC02M097502
  • GC02M091473

Summaries for ANKRD39 Gene

GeneCards Summary for ANKRD39 Gene

ANKRD39 (Ankyrin Repeat Domain 39) is a Protein Coding gene. An important paralog of this gene is GABPB2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD39 Gene

Genomics for ANKRD39 Gene

Regulatory Elements for ANKRD39 Gene

Promoters for ANKRD39 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANKRD39 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKRD39 Gene

Chromosome:
2
Start:
96,836,611 bp from pter
End:
96,858,095 bp from pter
Size:
21,485 bases
Orientation:
Minus strand

Genomic View for ANKRD39 Gene

Genes around ANKRD39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD39 Gene

Proteins for ANKRD39 Gene

  • Protein details for ANKRD39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53RE8-ANR39_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 39
    Protein Accession:
    Q53RE8
    Secondary Accessions:
    • Q59FU2
    • Q8N5X5
    • Q9P0S5

    Protein attributes for ANKRD39 Gene

    Size:
    183 amino acids
    Molecular mass:
    19651 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF36120.1; Type=Frameshift; Positions=172; Evidence={ECO:0000305}; Sequence=BAD92604.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ANKRD39 Gene

Proteomics data for ANKRD39 Gene at MOPED

Post-translational modifications for ANKRD39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD39 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD39 Gene

Domains & Families for ANKRD39 Gene

Gene Families for ANKRD39 Gene

Protein Domains for ANKRD39 Gene

Suggested Antigen Peptide Sequences for ANKRD39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53RE8

UniProtKB/Swiss-Prot:

ANR39_HUMAN :
  • Belongs to the ANKRD39 family.
  • Contains 4 ANK repeats.
Family:
  • Belongs to the ANKRD39 family.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with ANKRD39: view

Function for ANKRD39 Gene

genes like me logo Genes that share phenotypes with ANKRD39: view

Animal Model Products

CRISPR Products

miRNA for ANKRD39 Gene

miRTarBase miRNAs that target ANKRD39

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD39 Gene

Localization for ANKRD39 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD39 Gene COMPARTMENTS Subcellular localization image for ANKRD39 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD39 Gene

Pathways & Interactions for ANKRD39 Gene

SuperPathways for ANKRD39 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD39 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD39 Gene

Drugs & Compounds for ANKRD39 Gene

No Compound Related Data Available

Transcripts for ANKRD39 Gene

mRNA/cDNA for ANKRD39 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(177) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD39 Gene

Ankyrin repeat domain 39:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD39 Gene

No ASD Table

Relevant External Links for ANKRD39 Gene

GeneLoc Exon Structure for
ANKRD39
ECgene alternative splicing isoforms for
ANKRD39

Expression for ANKRD39 Gene

mRNA expression in normal human tissues for ANKRD39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKRD39 Gene



SOURCE GeneReport for Unigene cluster for ANKRD39 Gene Hs.709507

genes like me logo Genes that share expression patterns with ANKRD39: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ANKRD39 Gene

Orthologs for ANKRD39 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD39 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANKRD39 35
  • 88.52 (n)
  • 91.8 (a)
ANKRD39 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD39 35
  • 87.07 (n)
  • 89.07 (a)
ANKRD39 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd39 35
  • 87.07 (n)
  • 90.16 (a)
Ankrd39 16
Ankrd39 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANKRD39 35
  • 99.82 (n)
  • 100 (a)
ANKRD39 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd39 35
  • 86.34 (n)
  • 88.52 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD39 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD39 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd39 35
  • 58.81 (n)
  • 58.05 (a)
Str.15021 35
zebrafish
(Danio rerio)
Actinopterygii ankrd39 35
  • 58.28 (n)
  • 58.94 (a)
ankrd39 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009205 35
  • 50.57 (n)
  • 47.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG44001 35
  • 55.35 (n)
  • 45.91 (a)
CG31919 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for ANKRD39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD39 Gene

ENSEMBL:
Gene Tree for ANKRD39 (if available)
TreeFam:
Gene Tree for ANKRD39 (if available)

Paralogs for ANKRD39 Gene

Paralogs for ANKRD39 Gene

(9) SIMAP similar genes for ANKRD39 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ANKRD39 Gene

genes like me logo Genes that share paralogs with ANKRD39: view

Variants for ANKRD39 Gene

Sequence variations from dbSNP and Humsavar for ANKRD39 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs17852947 - 96,853,472(+) CCGCG(C/T)GATTT reference, missense
rs4473423 -- 96,850,093(+) TCTTA(A/T)TAACT intron-variant
rs6576988 -- 96,850,206(+) AAATT(G/T)GAATC intron-variant
rs6753987 -- 96,856,083(+) TAAAA(C/T)TGGCT intron-variant
rs10188136 -- 96,850,693(+) aaaaa(A/C)aAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD39 Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
nsv874680 CNV Loss 21882294
nsv526313 CNV Loss 19592680
dgv4249n71 CNV Loss 21882294

Variation tolerance for ANKRD39 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD39 Gene

HapMap Linkage Disequilibrium report
ANKRD39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD39 Gene

Disorders for ANKRD39 Gene

Relevant External Links for ANKRD39

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD39

No disorders were found for ANKRD39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD39 Gene

Publications for ANKRD39 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for ANKRD39 Gene

Sources for ANKRD39 Gene

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