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ANKRD39 Gene

protein-coding   GIFtS: 42
GCID: GC02M097502

Ankyrin Repeat Domain 39

  Search for ANKRD39
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 391 2
Ankyrin Repeat Domain-Containing Protein 392

External Ids:    HGNC: 286401   Entrez Gene: 512392   Ensembl: ENSG000002133377   UniProtKB: Q53RE83   

Export aliases for ANKRD39 gene to outside databases

Previous GC identifers: GC02M096936 GC02M096865 GC02M096877 GC02M091473


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD39 Gene:
ANKRD39 (ankyrin repeat domain 39) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD39 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   STAT5B   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD39 promoter sequence
   Search Chromatin IP Primers for ANKRD39

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

ANKRD39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD39 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M097502:  view genomic region     (about GC identifiers)

Start:
97,502,348 bp from pter      End:
97,523,832 bp from pter
Size:
21,485 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANR39_HUMAN, Q53RE8 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 39  
Size: 183 amino acids; 19651 Da
Sequence caution: Sequence=AAF36120.1; Type=Frameshift; Positions=172; Sequence=BAD92604.1; Type=Erroneous
initiation;
Secondary accessions: Q59FU2 Q8N5X5 Q9P0S5

Explore the universe of human proteins at neXtProt for ANKRD39: NX_Q53RE8

Explore proteomics data for ANKRD39 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANKRD39 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057550.3  
    ENSEMBL proteins: 
     ENSP00000398321   ENSP00000377170  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q53RE8

    ProtoNet protein and cluster: Q53RE8

    UniProtKB/Swiss-Prot: ANR39_HUMAN, Q53RE8
    Similarity: Belongs to the ANKRD39 family
    Similarity: Contains 4 ANK repeats


    Find genes that share domains with ANKRD39           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ANKRD39           About GenesLikeMe


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidANKRD39 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular2
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with ANKRD39           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD39
    Interactions:

        Search GeneGlobe Interaction Network for ANKRD39

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ANKRD39 (ENSP000003771704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMA3ENSP000002164554STRING: ENSP00000216455
    PSMA2ENSP000002233214STRING: ENSP00000223321
    UBCENSP000003448184STRING: ENSP00000344818
    MLST8ENSP000003718884STRING: ENSP00000371888
    --ENSP000003153094STRING: ENSP00000315309
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with ANKRD39           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKRD39 (ANR39)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANKRD39 gene: 
    NM_016466.5  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000443120 ENST00000393537(uc002sxd.4)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ANKRD39
      QuantiFast Probe-based Assays in human, mouse, rat ANKRD39

    Selected AceView cDNA sequences (see all 177):

    NM_144994 BC038584 F26254 BF195943 F35527 AI160687 AI201519 AI784086 
    BF196315 BU753444 F26598 AJ574563 BF516553 F36126 AA309912 AJ315766 
    AA629636 BU626151 AI492173 BU176483 AI276572 CF529198 AA176735 AI289034 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKRD39 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTGGGCA
    ANKRD39 Expression
    About this image


    ANKRD39 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
    ANKRD39 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKRD39 Protein Expression
        Custom PCR Arrays for ANKRD39
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD39

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANKRD39 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankrd391 , 5 ankyrin repeat domain 391, 5 87.07(n)1
    90.16(a)1
      1 (15.32 cM)5
    1093461  NM_026241.31  NP_080517.11 
     365381735 
    lizard
    (Anolis carolinensis)
    Reptilia ANKRD396
    ankyrin repeat domain 39
    60(a)
    1 ↔ 1
    GL343484.1(471526-475371)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.150212 Transcribed sequence with weak similarity to protein more 75.47(n)    142008864 
    zebrafish
    (Danio rerio)
    Actinopterygii ankrd391 ankyrin repeat domain 39 58.28(n)
    58.94(a)
      100000333  NM_001113640.1  NP_001107112.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG440011 CG44001 55.35(n)
    45.91(a)
      326173  NM_164623.3  NP_723052.2 


    ENSEMBL Gene Tree for ANKRD39 (if available)
    TreeFam Gene Tree for ANKRD39 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKRD39 gene
    9 SIMAP similar genes for ANKRD39 using alignment to 1 protein entry:     ANR39_HUMAN:
    ANK2    PPP1R12A    NRARP    ZDHHC17    ANK1    ANKRD65
    DKFZp761E1322    MTPN    TNKS

    Find genes that share paralogs with ANKRD39           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ANKRD39
    PGOHUM00000243615


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKRD39 (see all 211)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1488459101,2
    C--97513242(+) AAAAG-/AAAAAA 1 -- ds50010--------
    rs1447258741,2
    --97513371(+) CACAGA/GTGCTC 1 -- ds50010--------
    rs1481516761,2
    --97513412(+) AAACAA/GATGAA 1 -- ds50010--------
    rs1419450941,2
    C--97513425(+) AGCACC/TTTTCT 1 -- ds50010--------
    rs1857481541,2
    --97513442(+) GGACCA/GTTGCA 1 -- ds50010--------
    rs1898267091,2
    --97513465(+) ATGGTA/GTGCGC 1 -- ds50010--------
    rs576666571,2
    C,F--97513523(+) GCCACG/ATGCCA 1 -- ds50014Minor allele frequency- A:0.14WA EA 242
    rs1819296071,2
    --97513553(+) TCCCAG/TTGCAC 1 -- ds50010--------
    rs1472866541,2
    --97513589(+) GAGGCA/GGGCCC 1 -- ds50010--------
    rs1847459441,2
    --97513665(+) AGGGCA/CTTCAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ANKRD39 (97502348 - 97523832 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ANKRD39:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv650e201CNV Deletion23290073
    dgv4249n71CNV Loss21882294
    nsv874680CNV Loss21882294
    nsv526313CNV Loss19592680
    nsv874677CNV Loss21882294
    esv5003CNV Complex18987735

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKRD39 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ANKRD39)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51239 HGNC: 28640 AceView: MGC41816andANKRD23 Ensembl:ENSG00000213337 euGenes: HUgn51239
    ECgene: ANKRD39 H-InvDB: ANKRD39

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKRD39 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKRD39 gene:
    Search GeneIP for patents involving ANKRD39

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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