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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKRD37 Gene

protein-coding   GIFtS: 46
GCID: GC04P186317

ankyrin repeat domain 37
 Explore 3 diseases affiliated with
ANKRD37 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ANKRD37    

Aliases
for ANKRD37 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ankyrin Repeat Domain 371 2     Ankyrin Repeat Domain-Containing Protein 372
Lrp2bp1 2     Low Density Lipoprotein Receptor-Related Protein Binding Protein2
Low-Density Lipoprotein Receptor-Related Protein 2-Binding Protein2 3     LPR2BP3
HLrp2bp1     

External Ids:    HGNC: 295931   Entrez Gene: 3533222   Ensembl: ENSG000001863527   UniProtKB: Q7Z7133   

Export aliases for ANKRD37 gene to outside databases

Previous GC identifers: GC04P186693 GC04P186554 GC04P182071


Summaries
for ANKRD37 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for ANKRD37 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKRD37 gene promoter:
         CBF-C   YY1   POU2F1   CBF-B   CBF-A   POU2F1b   POU2F1a   CP1A   POU2F1c   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANKRD37 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANKRD37

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35.1

ANKRD37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD37 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P186317:  view genomic region     (about GC identifiers)

Start:
 186,317,175 bp from pter      End:
 186,321,782 bp from pter
Size:
 4,608 bases      Orientation:
 plus strand

Proteins
for ANKRD37 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ANR37_HUMAN, Q7Z713 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 37  
Size: 158 amino acids; 16872 Da
Subcellular location: Nucleus. Cytoplasm

Explore the universe of human proteins at neXtProt for ANKRD37: NX_Q7Z713

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z713

    • ANKRD37 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_859077.1  
    ENSEMBL proteins: 
     ENSP00000421529   ENSP00000335147   ENSP00000427192  

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    Uscn Proteins for ANKRD37

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    ANKRD37 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ANKRD37 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ANKRD37 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q7Z713

    ProtoNet protein and cluster: Q7Z713

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: ANR37_HUMAN, Q7Z713
    Similarity: Contains 3 ANK repeats


    Function
    for ANKRD37 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: ANKRD37 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    ANKRD37 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ANKRD37:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for ANKRD37 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD37

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ANKRD37 (ENSP000003351474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    FEM1BENSP000003072984STRING: ENSP00000307298
    About this table

    Drugs & Compounds
    for ANKRD37 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANKRD37
    Search CenterWatch for drugs/clinical trials and news about ANKRD37 / ANR37 

    Transcripts
    for ANKRD37 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for ANKRD37 gene: 
    NM_181726.2  

    Unigene Cluster for ANKRD37:

    Ankyrin repeat domain 37
    Hs.508154  [show with all ESTs]
    Unigene Representative Sequence: AK127395
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507479 ENST00000507753 ENST00000335174(uc003ixm.3) ENST00000511393(uc011cks.2)
    ENST00000511311 ENST00000506424

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    hsa-miR-1237 hsa-miR-412 hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmid: ANKRD37 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKRD37 (see all 7)
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    Clone
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    Additional cDNA sequence: 

    AK127395.1 AK303243.1 AY296056.1 BC088376.1 

    8 DOTS entries:

    DT.99928380  DT.100810742  DT.92440901  DT.97858856  DT.121224482  DT.100810754  DT.40129238  DT.121224610 

    24/107 AceView cDNA sequences (see all 107):

    AI937434 AW664874 AI216877 BM997127 AI797540 CA748553 AI375295 AI333984 
    AA961059 AA885898 W23609 AA886870 R81196 CA450084 AI950798 BQ575105 
    BM696704 BM716455 AA869002 BM987064 AI382103 AA934911 AW610097 CA391165 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD37    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6
    SP1:                                                                    -         
    SP2:                                                                              
    SP3:        -     -     -     -                                                   
    SP4:        -                                                                     
    SP5:                                            -                                 


    ECgene alternative splicing isoforms for ANKRD37

    Expression
    for ANKRD37 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKRD37 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTATAATAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ANKRD37 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANKRD37

    SOURCE GeneReport for Unigene cluster: Hs.508154

    UniProtKB/Swiss-Prot: ANR37_HUMAN, Q7Z713
    Tissue specificity: Mainly expressed in testis, small intestine, colon, blood leukocytes and in pancreatic
    adenocarcinoma cells

        SABiosciences Expression via Pathway-Focused PCR Array including ANKRD37: 
              Hypoxia Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for ANKRD37 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ANKRD37 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ankrd371 , 5 ankyrin repeat domain 371, 5 78.9(n)1
    77.22(a)1    		   8 (25.99 cM)5
    6548241  NM_001039562.11  NP_001034651.11 
     459969025 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.80332 Xenopus laevis transcribed sequence with strong similarity to protein refNP_286085.1 (E. coli) beta-D-galactosidase [Escherichia coli O157H7 EDL933] less 73.71(n)    BJ616822.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ankrd371 ankyrin repeat domain 37 58.13(n)
    53.6(a)    		   793783  NM_001145614.1  NP_001139086.1 


    ENSEMBL Gene Tree for ANKRD37 (if available)
    TreeFam Gene Tree for ANKRD37 (if available) 

    Paralogs
    for ANKRD37 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANKRD37 gene
    ANKRD102  
    1 SIMAP similar gene for ANKRD37 using alignment to 3 protein entries:     ANR37_HUMAN (see all proteins):
    ANKRD10

    ANKRD37 for paralogs           About GeneDecksing



    Genomic Variants
    for ANKRD37 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ANKRD37
         1 CNV: 3530
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ANKRD37

    Disorders / Diseases
    for ANKRD37 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ANKRD37 for disorders           About GeneDecksing

    3 diseases for ANKRD37:    About MalaCards
    hypoxia    adenocarcinoma    pancreatitis


    Export disorders for ANKRD37 gene to outside databases

    Publications
    for ANKRD37 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKRD37 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ANKRD37)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human gene containing 4 ankyrin repeat domains. (PubMed id 15809689)1, 2, 9 Li J....Mao Y. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    4. An integrative genomics approach identifies Hypoxia I nducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. (PubMed id 19491311)1 Benita Y....Xavier R.J. (2009)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for ANKRD37 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ANKRD37 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 353322 HGNC: 29593 AceView: Lrp2bp Ensembl:ENSG00000186352 euGenes: HUgn353322
    ECgene: ANKRD37 H-InvDB: ANKRD37

    Other Databases showing ANKRD37 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ANKRD37 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKRD37 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ANKRD37 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ANKRD37 gene:
    Search GeneIP for patents involving ANKRD37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ANKRD37 gene

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    Advanced Cell Diagnostics
    About This Section

     
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