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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKRD36B Gene

protein-coding   GIFtS: 40
GCID: GC02M098108

ankyrin repeat domain 36B

(Previous name: KIAA1641 )
(Previous symbol: KIAA1641)
 Explore 8 diseases affiliated with
ANKRD36B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ANKRD36B    

Aliases
for ANKRD36B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ankyrin Repeat Domain 36B1 2
KIAA16411 2
CLL-Associated Antigen KW-12 3
FLJ212811
Ankyrin Repeat Domain-Containing Protein 36B2
Melanoma-Associated Antigen2

External Ids:    HGNC: 293331   Entrez Gene: 577302   Ensembl: ENSG000001969127   UniProtKB: Q8N2N93   

Export aliases for ANKRD36B gene to outside databases

Previous GC identifer: GC02M097466


Summaries
for ANKRD36B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for ANKRD36B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_018913.1  NC_000002.11  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKRD36B gene promoter:
         HOXA9   HOXA9B   C/EBPbeta   Pbx1a   ATF-2   YY1   Meis-1a   MRF-2   Meis-1   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ANKRD36B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD36B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

ANKRD36B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD36B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M098108:  view genomic region     (about GC identifiers)

Start:
 98,108,978 bp from pter      End:
 98,206,428 bp from pter
Size:
 97,451 bases      Orientation:
 minus strand

Proteins
for ANKRD36B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AN36B_HUMAN, Q8N2N9 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 36B  
Size: 1353 amino acids; 153582 Da
Sequence caution: Sequence=AAI25133.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI25134.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAL99915.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB15039.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAB71081.1; Type=Erroneous initiation; Note=Translation N-terminally
extended;
Secondary accessions: Q08AK5 Q6IPR0 Q6PI49 Q8IZM7 Q8TDH6 Q96N30 Q9H759
Alternative splicing: 4 isoforms:  Q8N2N9-1   Q8N2N9-2   Q8N2N9-3   Q8N2N9-4   

Explore the universe of human proteins at neXtProt for ANKRD36B: NX_Q8N2N9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N2N9

    • ANKRD36B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079466.3  
    Human Recombinant Protein Products: 
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    Uscn Proteins for ANKRD36B


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    Protein Domains /
    Families
    for ANKRD36B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ANKRD36B for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q8N2N9

    ProtoNet protein and cluster: Q8N2N9

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: AN36B_HUMAN, Q8N2N9
    Similarity: Belongs to the ANKRD36 family
    Similarity: Contains 6 ANK repeats


    Function
    for ANKRD36B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for ANKRD36B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD36B

    Drugs & Compounds
    for ANKRD36B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANKRD36B
    Search CenterWatch for drugs/clinical trials and news about ANKRD36B / AN36B 

    Transcripts
    for ANKRD36B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ANKRD36B gene (2 alternative transcripts): 
    NM_025190.3  NM_020970.1  

    Unigene Cluster for ANKRD36B:

    Ankyrin repeat domain 36B
    Hs.532921  [show with all ESTs]
    Unigene Representative Sequence: NM_025190
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497329 ENST00000488634 ENST00000359901 ENST00000443455 ENST00000419390
    ENST00000377003(uc010yve.1 uc010fif.2) ENST00000258459(uc010yvc.1)
    ENST00000438709(uc010fid.1 uc002sxx.1) ENST00000447597(uc010yvd.1)


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    Inhib. RNA
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    OriGene siRNA: ANKRD36B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKRD36B
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD36B (see all 3)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD36B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD36B

    Additional cDNA sequence: 

    AF432208.1 AF432209.1 AK024934.1 AK056042.1 BC017427.1 BC031883.2 BC038460.1 BC044844.2 
    BC125132.1 BC125133.1 XR_112366.1 

    14 DOTS entries:

    DT.95369247  DT.305987  DT.95347420  DT.75117740  DT.95287589  DT.120937340  DT.121013063  DT.121013086 
    DT.40209136  DT.97839745  DT.120937419  DT.91697903  DT.120993082  DT.121013064 

    20 AceView cDNA sequences:

    AI951295 AI364625 AF543495 AL036373 AW383743 AK056042 BX478426 BC038460 
    AW383746 BF512258 AK090926 AF432208 AI884470 AI589943 BX499421 BM470429 
    AI004183 AA776913 AA347914 AA527528 

    GeneLoc Exon Structure


    Expression
    for ANKRD36B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKRD36B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATACTTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ANKRD36B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ANKRD36B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANKRD36B

    SOURCE GeneReport for Unigene cluster: Hs.532921
        SABiosciences Custom PCR Arrays for ANKRD36B
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD36B
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD36B

    Orthologs
    for ANKRD36B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for ANKRD36B (if available)
    TreeFam Gene Tree for ANKRD36B (if available) 

    Paralogs
    for ANKRD36B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ANKRD36B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1324 NCBI SNPs in ANKRD36B are shown (see all 1324)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2016017831,2
    		--98125797(+) AAAAA-/ATATATG 1 -- int10--------
    rs1837650051,2
    		--98126941(+) ATAAAC/TGCCAG 1 -- int10--------
    rs1999888761,2
    		C,F--98128150(+) GATGAG/ATGACT 2 /H syn11Minor allele frequency- A:0.01EU 257
    rs1998318291,2
    		C,F--98128172(+) CACATC/AGAGCA 2 /R /L mis11Minor allele frequency- A:0.01EU 250
    rs1504620501,2
    		C,F--98128194(+) ACAACG/CGTATG 2 /R /G mis11Minor allele frequency- C:0.01EU 257
    rs1493597071,2
    		C,F--98128195(+) CAACGG/ATATGA 2 /Y syn11Minor allele frequency- A:0.01EU 253
    rs1485390551,2
    		C,F--98128196(+) AACGGT/CATGAT 2 /Y /C mis11Minor allele frequency- C:0.01EU 255
    rs1495890171,2
    		C--98129428(+) TATTGA/C/TAGAAT 1 -- int10--------
    rs794444411,2
    		C--98129497(+) TAATTA/GTAGCT 1 -- int10--------
    rs1861747951,2
    		--98129504(+) AGCTAC/TAAATG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ANKRD36B (98108978 - 98206428 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 16 variations for ANKRD36B
         14 CNVs: 74179 35887 30983 74180 35889 3378 32337 7292 89828 30984 74177 2402 38784 35888
         2 Indels: 74178 33340

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    Disorders / Diseases
    for ANKRD36B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ANKRD36B for disorders           About GeneDecksing

    8 diseases for ANKRD36B:    About MalaCards
    acral lentiginous melanoma    melanoma    ocular melanoma    nodular melanoma
    bladder carcinoma    choroiditis    cerebritis    carcinoma

    4 Novoseek disease relationships for ANKRD36B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 78 62 1760821 (2), 11188931 (2), 15971113 (2), 8199106 (1) (see all 38)
    ocular melanoma 60.4 1 2203468 (1)
    mimicry 54.5 4 1933867 (1), 7829240 (1), 8361995 (1), 9816036 (1)
    tumors 26.1 4 1760821 (1), 16407841 (1), 1694058 (1), 15578703 (1)


    Export disorders for ANKRD36B gene to outside databases

    Publications
    for ANKRD36B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKRD36B gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with ANKRD36B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 3 Nagase T.... Ohara O. (2000)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107410)1 Wistow G.... Peterson K. (2002)
    8. Immunotherapy of melanoma: peptide mimics of a human high molecular weight-melanoma associated antigen. (PubMed id 11188931)9 Wang X....Ferrone S. (2000)
    9. Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic monoclonal antibodies MK2-23. Experimental studies and clinical trials in patients with malignant melanoma. (PubMed id 8361995)9 Ferrone S....Mittelman A. (1993)
    10. Regression of human melanoma xenografts in nude mice injected with methotrexate linked to monoclonal antibody 225.28 to human high molecular weight-melanoma associated antigen. (PubMed id 1760821)9 Ghose T....Mammen M. (1991)

    External Searches for ANKRD36B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ANKRD36B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57730 HGNC: 29333 AceView: KIAA1641.1 Ensembl:ENSG00000196912 euGenes: HUgn57730
    ECgene: ANKRD36B H-InvDB: ANKRD36B

    Other Databases showing ANKRD36B gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1641

    Specialized Databases showing ANKRD36B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKRD36B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ANKRD36B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ANKRD36B gene:
    Search GeneIP for patents involving ANKRD36B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ANKRD36B gene

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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    von Willebrand factor
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