ANKRD36 Gene
protein-coding GIFtS: 39
GCID: GC02P097782
|
|
ankyrin repeat domain 36
| |
Aliases
for ANKRD36 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat Domain 361 2 | | Ankyrin-Related1 | | UNQ24301 2 | | ANKRD36A3 | | Ankyrin Repeat Domain-Containing Protein 362 | | KIAA16413 | | Ankyrin Repeat Domain-Containing Protein 36A2 | | |
Export aliases for ANKRD36 gene to outside databasesPrevious GC identifers: GC02P097202 GC02P091738 |
Summaries
for ANKRD36 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ANKRD36 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022171.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKRD36 gene promoter:
Pbx1a POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) CUTL1 POU3F2 MRF-2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKRD36
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD36 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.2ANKRD36 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P097782: view genomic region
(about GC identifiers)
Start:
|
97,779,233 bp from pter |
End:
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97,930,258 bp from pter |
Size:
|
151,026 bases |
Orientation:
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plus strand |
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Proteins
for ANKRD36 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AN36A_HUMAN, A6QL64 (See
protein sequence)Recommended Name: Ankyrin repeat domain-containing protein 36A Size: 1941 amino acids; 217465 Da
Sequence caution: Sequence=AAQ88934.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAQ88934.1; Type=Frameshift; Positions=5; Sequence=BAB13467.1; Type=Erroneous initiation; Note=TranslationN-terminally shortened;
Secondary accessions: B4E3I8 Q6UX02 Q86X62 Q9HCD1Alternative splicing: 4 isoforms: A6QL64-1 A6QL64-3 A6QL64-4, Q6UX02-1 A6QL64-5, Q6UX02-2 Explore the universe of human proteins at neXtProt for ANKRD36: NX_A6QL64
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6QL64
ANKRD36 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001157787.1
ENSEMBL proteins: ENSP00000419530 ENSP00000391950 ENSP00000349546
Human Recombinant Protein Products:
ANKRD36 Antibody Products:
Assay Products for ANKRD36: |
Protein
Domains /
Families
for ANKRD36 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKRD36 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6QL64ProtoNet protein and cluster: A6QL64 UniProtKB/Swiss-Prot: AN36A_HUMAN, A6QL64Similarity: Belongs to the ANKRD36 familySimilarity: Contains 6 ANK repeats |
Function
for ANKRD36 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD36
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD36
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD36 |
|
Pathways & Interactions
for ANKRD36 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD36
|
Drugs & Compounds
for ANKRD36 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKRD36
Search CenterWatch for drugs/clinical trials and news about ANKRD36 / AN36A
|
Transcripts
for ANKRD36 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKRD36 gene (2 alternative transcripts): NM_001164315.1 NM_198555.3 Unigene Cluster for ANKRD36: Ankyrin repeat domain 36 Hs.541894 [show with all ESTs]Unigene Representative Sequence: NM_0011643156 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000461153(uc021vlk.1 uc010yuz.1 uc010fic.2 uc002sxo.2 uc002sxq.2 uc002sxp.3)
ENST00000452478(uc002sxn.2) ENST00000421946(uc002sxr.1) ENST00000494336
ENST00000420699(uc010yva.2) ENST00000357042(uc002sxt.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD36
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD36
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANKRD36 (NM_025190) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD36 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD36 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD36
Browse OriGene validated miRNA SYBR primer pairs
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Additional cDNA sequence: AF543495.1 AK090926.1 AK307629.1 AK316541.1 AY358571.1 BC046186.1 BC128262.1 BX647769.1 24/39 DOTS entries (see all 39): DT.305987 DT.97827404 DT.95369247 DT.100798631 DT.120937420 DT.120937341 DT.121013060 DT.102835270 DT.40209136 DT.70102521 DT.120937340 DT.100798621 DT.100798626 DT.75117740 DT.91971414 DT.97839745 DT.120937334 DT.120937419 DT.120937422 DT.120937424 DT.120937447 DT.121013080 DT.121013086 DT.40130353 24/42 AceView cDNA sequences (see all 42): BX090308 BU154721 CD238562 BX508241 BM799695 AA463221 BC046186 AY358571 BX647769 BM452273 AA670278 AW614968 AI022794 BU662770 BG260694 AW955793 AA463220 C15980 BU570225 AI191760 AA331577 BQ429040 BF103611 BQ435565
GeneLoc Exon Structure
|
Expression
for ANKRD36 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKRD36 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ANKRD36 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD36
SOURCE GeneReport for Unigene cluster: Hs.541894
SABiosciences Custom PCR Arrays for ANKRD36
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD36
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ANKRD36 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD36 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD36 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD36 |
Orthologs
for ANKRD36 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ANKRD36 gene from 3/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ANKRD626 |
Uncharacterized protein |
26(a) |
1 → many |
1(26091172-26138404) |
lizard
(Anolis carolinensis) |
Reptilia |
ANKRD626 |
-- |
35(a) |
1 → many |
GL344195.1(39104-48393) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-272n13.36 |
si:ch211-272n13.3 |
11(a) |
1 → many |
25(3581527-3655709) |
ENSEMBL Gene Tree for ANKRD36 (if available)
TreeFam Gene Tree for ANKRD36 (if available) |
Paralogs
for ANKRD36 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKRD36 gene
- POTEF2 POTEI2 ANKRD30A2 ANKRD72 POTEB2 ANKRD30BL2 ANKRD20A32 POTEH2
- ENSG000001552822 ANKRD30B2 ENSG000002663022 ANKRD36C2 POTEJ2 POTEC2 ANKRD20A22 POTEG2
- ANKRD262 ANKRD622 ANKRD18A2 ENSG000001882192 POTEM2 ANKRD20A12 LOC1009963312 CCDC144A2
- POTED2 ANKRD20A42 ANKRD18B2 LOC1002889662
18/27 SIMAP similar genes for ANKRD36 using alignment to 4 protein entries: AN36A_HUMAN (see all proteins)
(see all similar genes):ANKRD36C ANKRD36B ANKRD36BP1 ANKRD20A5P ANKRD30BL ANKRD19P
ANKRD26 LOC254750 ANKRD26P1 ANKRD7 POTEB ANKRD62
POTEC POTEH DKFZp781D1722 POTEE POTEA POTEF
ANKRD36 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for ANKRD36
PGOHUM00000263084 PGOHUM00000240726 PGOHUM00000234100
|
Genomic Variants
for ANKRD36 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKRD36 (97779233 - 97930258 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 23 variations for ANKRD36
15/23 CNVs (see all 23): 74175 30982 32336 5990 74173 50605 74174 89828 7290 22810 38898 32335 61798 97917 61799 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD36 |
|
Disorders
/ Diseases
for ANKRD36 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ANKRD36 for disorders About GeneDecksing
1  disease for ANKRD36: About MalaCardsneuronitis
Export disorders for ANKRD36 gene to outside databases
|
Publications
for ANKRD36 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKRD36 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ANKRD36) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
- An 88-kDa protein of Plasmodium falciparum is related to the band-3-binding domain of human erythrocyte ankyrin. (PubMed id 1386021)9 Suetterlin B.W....Franklin R.M. (1992)
|
External Searches for ANKRD36 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANKRD36 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKRD36 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ANKRD36 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKRD36 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANKRD36 gene:
Search GeneIP for patents involving ANKRD36
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKRD36 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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