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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKRD36 Gene

protein-coding   GIFtS: 39
GCID: GC02P097782

Ankyrin Repeat Domain 36

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ankyrin Repeat Domain 361 2     ankyrin-related2
UNQ24302     ANKRD36A3
Ankyrin Repeat Domain-Containing Protein 362     KIAA16413
Ankyrin Repeat Domain-Containing Protein 36A2     

External Ids:    HGNC: 240791   Entrez Gene: 3752482   Ensembl: ENSG000001359767   UniProtKB: A6QL643   

Export aliases for ANKRD36 gene to outside databases

Previous GC identifers: GC02P097202 GC02P091738


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ANKRD36 Gene: 
ANKRD36 (ankyrin repeat domain 36) is a protein-coding gene. Diseases associated with ANKRD36 include neuronitis. An important paralog of this gene is POTEF.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKRD36 gene promoter:
         Pbx1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   CUTL1   POU3F2   MRF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD36 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANKRD36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

ANKRD36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD36 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P097782:  view genomic region     (about GC identifiers)

Start:
97,779,233 bp from pter      End:
97,930,258 bp from pter
Size:
151,026 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AN36A_HUMAN, A6QL64 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 36A  
Size: 1941 amino acids; 217465 Da
Sequence caution: Sequence=AAQ88934.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAQ88934.1; Type=Frameshift; Positions=5; Sequence=BAB13467.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
Secondary accessions: B4E3I8 Q6UX02 Q86X62 Q9HCD1
Alternative splicing: 4 isoforms:  A6QL64-1   A6QL64-3   A6QL64-4, Q6UX02-1   A6QL64-5, Q6UX02-2   

Explore the universe of human proteins at neXtProt for ANKRD36: NX_A6QL64

Explore proteomics data for ANKRD36 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6QL64

  • ANKRD36 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANKRD36 Protein Expression
    REFSEQ proteins: NP_001157787.1  
    ENSEMBL proteins: 
     ENSP00000419530   ENSP00000391950   ENSP00000349546  

    Human Recombinant Protein Products for ANKRD36: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry A6QL64

    ProtoNet protein and cluster: A6QL64

    UniProtKB/Swiss-Prot: AN36A_HUMAN, A6QL64
    Similarity: Belongs to the ANKRD36 family
    Similarity: Contains 6 ANK repeats


    ANKRD36 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ANKRD36 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ANKRD36 
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    miRNA
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ANKRD36 (NM_025190)
    Browse Sino Biological Human cDNA Clones
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD36

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANKRD36 (AN36A)

    Search CenterWatch for drugs/clinical trials and news about ANKRD36 / AN36A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANKRD36 gene (2 alternative transcripts): 
    NM_001164315.1  NM_198555.3  

    Unigene Cluster for ANKRD36:

    Ankyrin repeat domain 36
    Hs.541894  [show with all ESTs]
    Unigene Representative Sequence: NM_001164315
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461153(uc021vlk.1 uc010yuz.1 uc010fic.2 uc002sxo.2 uc002sxq.2 uc002sxp.3)
    ENST00000452478(uc002sxn.2) ENST00000421946(uc002sxr.1) ENST00000494336
    ENST00000420699(uc010yva.2) ENST00000357042(uc002sxt.1)
    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ANKRD36
    SwitchGear 3'UTR luciferase reporter plasmidANKRD36 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ANKRD36
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKRD36
    Clone
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    OriGene clones in human, mouse for ANKRD36 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANKRD36 (NM_025190)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANKRD36
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD36
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ANKRD36
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ANKRD36
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD36
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD36

    Additional mRNA sequence: 

    AF543495.1 AK090926.1 AK307629.1 AK316541.1 AY358571.1 BC046186.1 BC128262.1 BX647769.1 

    24/38 DOTS entries (see all 38):

    DT.305987  DT.97827404  DT.95369247  DT.100798631  DT.120937420  DT.120937341  DT.121013060  DT.102835270 
    DT.40209136  DT.70102521  DT.120937340  DT.100798621  DT.100798626  DT.75117740  DT.91971414  DT.97839745 
    DT.120937334  DT.120937419  DT.120937422  DT.120937424  DT.120937447  DT.121013080  DT.121013086  DT.40130353 

    24/42 AceView cDNA sequences (see all 42):

    BX090308 AI022794 AW614968 AA463221 BM452273 BU154721 BU662770 BC046186 
    BX508241 AA670278 AY358571 CD238562 BX647769 BM799695 AA463220 AW955793 
    BQ429040 C15980 BG260694 BF103611 BU570225 AA331577 AI191760 CD695800 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKRD36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ANKRD36 Expression
    About this image


    See ANKRD36 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANKRD36

    SOURCE GeneReport for Unigene cluster: Hs.541894
        SABiosciences Custom PCR Arrays for ANKRD36
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ANKRD36
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD36
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD36

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ANKRD36 gene from 4/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    (see all 7)
    --
    42(a)
    38(a)
    (see all 7)
    possible ortholog
    possible ortholog
    (see all 7)
    JH373864.1(4599-16595)
    2(18332785-18383893)
    chicken
    (Gallus gallus)
    Aves --
    --
    19(a)
    possible ortholog
    1(24064036-24111623)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    30(a)
    possible ortholog
    GL344195.1(38786-58936)
    zebrafish
    (Danio rerio)
    Actinopterygii ANKRD30B6
    ankyrin repeat domain 30B
    9(a)
    1 → many
    25(3581527-3655709)


    ENSEMBL Gene Tree for ANKRD36 (if available)
    TreeFam Gene Tree for ANKRD36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANKRD36 gene
    POTEF2  POTEI2  ANKRD30A2  POTEB22  ANKRD72  POTEB2  ANKRD30BL2  ANKRD20A32  
    POTEH2  ANKRD30B2  LOC6442492  ENSG000002663022  ANKRD36C2  POTEJ2  POTEC2  ANKRD20A22  
    ANKRD262  POTEG2  ANKRD622  ANKRD18A2  POTEM2  ANKRD20A12  CCDC144A2  POTEE2  
    POTED2  ANKRD20A42  ANKRD18B2  LOC1002889662  
    18/27 SIMAP similar genes for ANKRD36 using alignment to 4 protein entries:     AN36A_HUMAN (see all proteins) (see all similar genes):
    ANKRD36C    ANKRD36B    ANKRD36BP1    ANKRD20A5P    ANKRD30BL    ANKRD19P
    ANKRD26    LOC254750    ANKRD26P1    ANKRD7    POTEB    ANKRD62
    POTEC    POTEH    DKFZp781D1722    POTEE    POTEA    POTEF

    ANKRD36 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ANKRD36
    PGOHUM00000263084 PGOHUM00000240726 PGOHUM00000234100


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3534 SNPs in ANKRD36 are shown (see all 3534)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs709385081,2
    C--97777380(-) TTTTT-/TAGACG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs29240661,2
    --97778106(+) ATGGAA/GAAATC 1 -- us2k10--------
    rs40633921,2
    --97778491(-) GCGCCG/TGTTTT 1 -- us2k10--------
    rs39688531,2
    C--97778510(-) GCCACC/GGGGAT 1 -- us2k10--------
    rs23151531,2
    --97778532(-) ACCTGA/GCGCTT 1 -- us2k10--------
    rs38789881,2
    F--97779015(+) GAAGTG/CGGGCT 1 -- us2k11Minor allele frequency- C:0.07MN 184
    rs18145071,2
    A--97779382(+) CCGTGC/GACAGA 1 -- ut510--------
    rs23151511,2
    C,H--97779487(-) GCTTGC/TCGTCT 2 D G mis15Minor allele frequency- T:0.00NS EA EU 1727
    rs2022083771,2
    C--97779639(+) TCACGT/CATTAT 2 /H /Y mis11Minor allele frequency- C:0.00EU 1225
    rs18091141,2
    A--97780033(+) tgaggG/Tgtggg 1 -- int10--------

    HapMap Linkage Disequilibrium report for ANKRD36 (97779233 - 97930258 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/45 variations for ANKRD36 (see all 45):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675758CNV Deletion23128226
    nsv436306CNV Deletion17901297
    esv2720418CNV Deletion23290073
    esv2720416CNV Deletion23290073
    dgv650e201CNV Deletion23290073
    dgv720e199CNV Deletion23128226
    esv2660796CNV Deletion23128226
    esv2671652CNV Deletion23128226
    esv2720415CNV Deletion23290073
    esv2598149CNV Deletion19546169

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ANKRD36
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKRD36

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ANKRD36:    About MalaCards
    neuronitis    


    ANKRD36 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ANKRD36

    Export disorders for ANKRD36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKRD36 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ANKRD36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
    10. An 88-kDa protein of Plasmodium falciparum is related to the band-3-binding domain of human erythrocyte ankyrin. (PubMed id 1386021)9 Suetterlin B.W....Franklin R.M. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 375248 HGNC: 24079 AceView: UNQ2430 Ensembl:ENSG00000135976 euGenes: HUgn375248
    ECgene: ANKRD36 H-InvDB: ANKRD36

    (According to HUGE)
    About This Section
    HUGE: KIAA1641

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKRD36 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANKRD36 gene:
    Search GeneIP for patents involving ANKRD36

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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