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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANKRD35 Gene

protein-coding GIFtS: 46
GCID: GC01P145549

ankyrin repeat domain 35

Explore 4 diseases affiliated with
ANKRD35 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ankyrin Repeat Domain 35¹ ²
FLJ25124¹
Ankyrin Repeat Domain-Containing Protein 35²

External Ids:	HGNC: 26323¹	Entrez Gene: 148741²	Ensembl: ENSG00000198483⁷	UniProtKB: Q8N283³

Export aliases for ANKRD35 gene to outside databases

Previous GC identifers: GC01P143039 GC01P144260 GC01P119512

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167185.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANKRD35 gene promoter:
Bach1 TBP NF-1/L AML1a Pax-5 NCX/Ncx HTF GATA-2 SEF-1 (1)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANKRD35 promoter sequence

Search SABiosciences Chromatin IP Primers for ANKRD35

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD35

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21.1

ANKRD35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD35 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P145549: view genomic region (about GC identifiers)

Start:	145,549,209 bp from pter	End:	145,568,526 bp from pter
Size:	19,318 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANR35_HUMAN, Q8N283 (See protein sequence)

Recommended Name: Ankyrin repeat domain-containing protein 35

Size: 1001 amino acids; 109966 Da

Sequence caution: Sequence=BAB71597.1; Type=Erroneous initiation;

Secondary accessions: A6NEU0 Q3MJ10 Q96LS3

Explore the universe of human proteins at neXtProt for ANKRD35: NX_Q8N283

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N283

ANKRD35 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_653299.3

ENSEMBL proteins:

ENSP00000347802 ENSP00000442671

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANKRD35 for domains About GeneDecksing

2 InterPro domains/families:

IPR020683 Ankyrin_rpt-contain_dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q8N283

ProtoNet protein and cluster: Q8N283

UniProtKB/Swiss-Prot: ANR35_HUMAN, Q8N283

Similarity: Contains 6 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ANKRD35

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ANKRD35

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for ANKRD35 (Q8N283^{2, 3} ENSP00000347802⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VIM	P08670²^,³, ENSP00000224237⁴	MINT-8276982 I2D: score=2 STRING: ENSP00000224237
SUMO2	ENSP00000405965⁴	STRING: ENSP00000405965
JUNB	ENSP00000303315⁴	STRING: ENSP00000303315

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ANKRD35
Search CenterWatch for drugs/clinical trials and news about ANKRD35 / ANR35

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for ANKRD35 gene:

NM_144698.3

Unigene Cluster for ANKRD35:

Ankyrin repeat domain 35

Hs.710624 [show with all ESTs]

Unigene Representative Sequence: NM_144698

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000355594(uc010oyx.1 uc001eob.1) ENST00000544626

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Additional cDNA sequence:

AK057853.1 AK091120.1 AK294308.1 AK296861.1 BC101618.1 BC101620.1

2 DOTS entries:

DT.97790015 DT.121360650

24/41 AceView cDNA sequences (see all 41):

BM700206 BM978311 CR621087 AI969067 BQ636616 AW273207 AW245831 AK057853

BU683120 BQ009216 AI621064 BX398909 BM987645 AI953151 BM973074 AI968473

BQ638805 AI634073 AW590824 CA433679 BE796869 NM_144698 BF829251 CA427060

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD35 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	^	15
SP1:					-										-
SP2:											-				-
SP3:											-
SP4:

ECgene alternative splicing isoforms for ANKRD35

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANKRD35 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGCAGGACG

About this image

ANKRD35 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ANKRD35 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD35

SOURCE GeneReport for Unigene cluster: Hs.710624

SABiosciences Custom PCR Arrays for ANKRD35

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD35 gene from 1/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ANKRD24⁶ -- (see all 3)	--	65(a) 58(a) (see all 3)	1 ↔ many 1 ↔ many (see all 3)	GL344289.1(50799-51132) GL343236.1(24223-33022)

ENSEMBL Gene Tree for ANKRD35 (if available)
TreeFam Gene Tree for ANKRD35 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANKRD35 gene

UACA² RAI14² ANKRD24²

8 SIMAP similar genes for ANKRD35 using alignment to 2 protein entries: ANR35_HUMAN (see all proteins):

RAI14 UACA IkBa DKFZp761E1322 MTPN PSMD10

CDKN2C PPP1R12B

ANKRD35 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115446710^1,2	F	--	145547236(+)	`CCACCG/ACAGGG`	1	--	us2k¹		1		WA	118
rs187804728^1,2		--	145547249(+)	`CAAATA/GTGACA`	1	--	us2k¹		0	--	--	--	--
rs191111202^1,2		--	145547361(+)	`TGAGCC/TCAGGA`	1	--	us2k¹		0	--	--	--	--
rs146145600^1,2		--	145547416(+)	`AAATAG/TATGAA`	1	--	us2k¹		0	--	--	--	--
rs77221101^1,2	C	--	145547453(+)	`CTATCA/GTCCCA`	1	--	us2k¹		3		NA	6
rs6680260^1,2	C,F,A	--	145547656(+)	`CACTTG/AAGGTC`	1	--	us2k¹ tfbs³		4		NA WA	8
rs141913212^1,2		--	145547759(+)	`CCAGCC/TACTTG`	1	--	us2k¹		0	--	--	--	--
rs111544002^1,2	C	--	145547796(+)	`GACCGG/AGAAGG`	1	--	us2k¹		1		WA	2
rs12410298^1,2	C,F,H	--	145547963(+)	`GCAGCG/ATATGA`	1	--	us2k¹		27		NS EA NA WA CSA	2568
rs78741661^1,2	F	--	145548016(+)	`ACCCTG/TTAGGT`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for ANKRD35 (145549209 - 145568526 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ANKRD35
4 CNVs: 6782 48114 5199 53561

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ANKRD35 for disorders About GeneDecksing

4 diseases for ANKRD35: About MalaCards

chronic lymphocytic leukemia lymphocytic leukemia leukemia retinitis

Export disorders for ANKRD35 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ANKRD35 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANKRD35)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)¹ Golebiowski F....Hay R.T. (2009)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PubMed id 12107411)¹ Wistow G.... Peterson K. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 148741	HGNC: 26323	AceView: FLJ25124	Ensembl:ENSG00000198483	euGenes: HUgn148741
ECgene: ANKRD35	H-InvDB: ANKRD35

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANKRD35	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANKRD35 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ANKRD35 gene:
Search GeneIP for patents involving ANKRD35

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ANKRD35 gene at Home site.

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ANKRD35 Gene

ankyrin repeat domain 35

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ANKRD35 Gene

ankyrin repeat domain 35

Aliasesfor ANKRD35 gene

Summariesfor ANKRD35 gene

Genomic Viewsfor ANKRD35 gene

Proteinsfor ANKRD35 gene

Protein Domains /Familiesfor ANKRD35 gene

Functionfor ANKRD35 gene

Pathways & Interactionsfor ANKRD35 gene

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Expression for ANKRD35 gene

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for ANKRD35 gene

Genomic Views
for ANKRD35 gene

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for ANKRD35 gene

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Families
for ANKRD35 gene

Function
for ANKRD35 gene

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for ANKRD35 gene

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for ANKRD35 gene

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for ANKRD35 gene

Expression
for ANKRD35 gene

Orthologs
for ANKRD35 gene

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for ANKRD35 gene

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for ANKRD35 gene

Intellectual Property
for ANKRD35 gene

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for ANKRD35 gene