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Aliases for ANKRD35 Gene

Aliases for ANKRD35 Gene

  • Ankyrin Repeat Domain 35 2 3

External Ids for ANKRD35 Gene

Previous GeneCards Identifiers for ANKRD35 Gene

  • GC01P143039
  • GC01P144260
  • GC01P145549
  • GC01P119512

Summaries for ANKRD35 Gene

GeneCards Summary for ANKRD35 Gene

ANKRD35 (Ankyrin Repeat Domain 35) is a Protein Coding gene. An important paralog of this gene is UACA.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD35 Gene

Genomics for ANKRD35 Gene

Regulatory Elements for ANKRD35 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ANKRD35 Gene

145,866,560 bp from pter
145,885,866 bp from pter
19,307 bases
Minus strand

Genomic View for ANKRD35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD35 Gene

Proteins for ANKRD35 Gene

  • Protein details for ANKRD35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat domain-containing protein 35
    Protein Accession:
    Secondary Accessions:
    • A6NEU0
    • B4DL62
    • Q3MJ10
    • Q96LS3

    Protein attributes for ANKRD35 Gene

    1001 amino acids
    Molecular mass:
    109966 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71597.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD35 Gene


neXtProt entry for ANKRD35 Gene

Proteomics data for ANKRD35 Gene at MOPED

Post-translational modifications for ANKRD35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD35 Gene

Domains & Families for ANKRD35 Gene

Gene Families for ANKRD35 Gene

Protein Domains for ANKRD35 Gene

Suggested Antigen Peptide Sequences for ANKRD35 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 ANK repeats.
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with ANKRD35: view

Function for ANKRD35 Gene

Gene Ontology (GO) - Molecular Function for ANKRD35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ANKRD35: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKRD35

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD35 Gene

Localization for ANKRD35 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ANKRD35 Gene

Pathways & Interactions for ANKRD35 Gene

SuperPathways for ANKRD35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD35 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKRD35 Gene

Drugs & Compounds for ANKRD35 Gene

No Compound Related Data Available

Transcripts for ANKRD35 Gene

mRNA/cDNA for ANKRD35 Gene

Unigene Clusters for ANKRD35 Gene

Ankyrin repeat domain 35:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKRD35

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD35 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - -
SP2: - -
SP3: -

Relevant External Links for ANKRD35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRD35 Gene

mRNA expression in normal human tissues for ANKRD35 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD35 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x8.2) and Skin - Not Sun Exposed (Suprapubic) (x6.7).

Protein differential expression in normal tissues from HIPED for ANKRD35 Gene

This gene is overexpressed in Placenta (20.2), Liver (13.4), Cervix (9.6), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD35 Gene

SOURCE GeneReport for Unigene cluster for ANKRD35 Gene Hs.710624

genes like me logo Genes that share expression patterns with ANKRD35: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ANKRD35 Gene

Orthologs for ANKRD35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD35 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANKRD35 35
  • 86.13 (n)
  • 84.4 (a)
ANKRD35 36
  • 84 (a)
(Canis familiaris)
Mammalia ANKRD35 35
  • 85.4 (n)
  • 82.58 (a)
ANKRD35 36
  • 82 (a)
(Mus musculus)
Mammalia Ankrd35 35
  • 83.05 (n)
  • 82.61 (a)
Ankrd35 16
Ankrd35 36
  • 83 (a)
(Pan troglodytes)
Mammalia ANKRD35 35
  • 98.85 (n)
  • 98.01 (a)
ANKRD35 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ankrd35 35
  • 83.35 (n)
  • 82.41 (a)
(Monodelphis domestica)
Mammalia ANKRD35 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ANKRD35 36
  • 82 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
-- 36
  • 65 (a)
(Danio rerio)
Actinopterygii uaca 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for ANKRD35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD35 Gene

Gene Tree for ANKRD35 (if available)
Gene Tree for ANKRD35 (if available)

Paralogs for ANKRD35 Gene

Paralogs for ANKRD35 Gene

(8) SIMAP similar genes for ANKRD35 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD35: view

Variants for ANKRD35 Gene

Sequence variations from dbSNP and Humsavar for ANKRD35 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs41315701 - 145,872,994(-) GGCTC(A/C/G)AGGAG reference, missense
VAR_048278 -
VAR_033506 -
rs6670984 - 145,873,487(-) GGCCA(C/T)CCCAG reference, missense
rs781641321 -- 145,866,382(-) GCTGG(A/T)GTGCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ANKRD35 Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
dgv15n16 CNV Deletion 17901297
dgv46e201 CNV Deletion 23290073
esv2422428 CNV Duplication 17116639
dgv347n71 CNV Gain 21882294
nsv831370 CNV Gain 17160897
nsv831381 CNV Gain 17160897
nsv872232 CNV Gain 21882294
esv32826 CNV Gain 17666407

Variation tolerance for ANKRD35 Gene

Residual Variation Intolerance Score: 96.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.45; 92.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD35 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD35 Gene

Disorders for ANKRD35 Gene

Relevant External Links for ANKRD35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ANKRD35: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD35 Gene

Publications for ANKRD35 Gene

  1. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. (PMID: 25505242) Fernandez J. … Arhel N.J. (J. Biol. Chem. 2015) 67
  2. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 67
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 67
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for ANKRD35 Gene

Sources for ANKRD35 Gene

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