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Aliases for ANKRD35 Gene

Aliases for ANKRD35 Gene

  • Ankyrin Repeat Domain 35 2 3 5

External Ids for ANKRD35 Gene

Previous GeneCards Identifiers for ANKRD35 Gene

  • GC01P143039
  • GC01P144260
  • GC01P145549
  • GC01P119512

Summaries for ANKRD35 Gene

GeneCards Summary for ANKRD35 Gene

ANKRD35 (Ankyrin Repeat Domain 35) is a Protein Coding gene. An important paralog of this gene is ANKRD24.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD35 Gene

Genomics for ANKRD35 Gene

Regulatory Elements for ANKRD35 Gene

Enhancers for ANKRD35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F145877 0.6 ENCODE 38.3 +7.8 7752 1.1 PKNOX1 JUN CEBPG RAD21 GATA3 CTBP1 HSF1 PRDM10 RCOR1 FOSL2 ANKRD35 POLR3C ITGA10 PEX11B TXNIP PIAS3
GH01F145879 0.4 ENCODE 26.1 +6.2 6178 0.9 RFX1 CEBPB ZEB2 CEBPG ZNF274 ZNF692 IKZF1 STAT2 HMBOX1 FOXJ2 ANKRD35 ITGA10 PEX11B TXNIP HFE2 PIAS3
GH01F145890 0.7 ENCODE 25.7 -6.4 -6442 3.6 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 ZNF143 FOS ANKRD35 TXNIP POLR3C ENSG00000244619
GH01F145932 0.8 Ensembl ENCODE 24.1 -46.9 -46889 1.5 HDAC1 ATF1 ARNT KLF17 CHAMP1 GATA2 SIRT6 ETV6 SMARCA5 ZBTB2 ANKRD35 LIX1L-AS1 RBM8A LIX1L
GH01F145917 0.6 ENCODE 23.4 -33.0 -32956 2.8 HDGF ATF1 ARNT ZFP64 ARID4B SIN3A GLI4 BRCA1 YY1 GLIS2 ANKRD35 HFE2 NOTCH2NL POLR3C LIX1L-AS1 PEX11B ITGA10
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ANKRD35 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001749640 -234 1001 KLF1 PKNOX1 SUZ12 SAP130 SIN3A ZNF384 FEZF1 SCRT2 KLF8 SP3

Genomic Location for ANKRD35 Gene

Chromosome:
1
Start:
145,866,560 bp from pter
End:
145,885,866 bp from pter
Size:
19,307 bases
Orientation:
Minus strand

Genomic View for ANKRD35 Gene

Genes around ANKRD35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD35 Gene

Proteins for ANKRD35 Gene

  • Protein details for ANKRD35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N283-ANR35_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 35
    Protein Accession:
    Q8N283
    Secondary Accessions:
    • A6NEU0
    • B4DL62
    • Q3MJ10
    • Q96LS3

    Protein attributes for ANKRD35 Gene

    Size:
    1001 amino acids
    Molecular mass:
    109966 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71597.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD35 Gene

Post-translational modifications for ANKRD35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD35 Gene

Domains & Families for ANKRD35 Gene

Gene Families for ANKRD35 Gene

Protein Domains for ANKRD35 Gene

Suggested Antigen Peptide Sequences for ANKRD35 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N283

UniProtKB/Swiss-Prot:

ANR35_HUMAN :
  • Contains 6 ANK repeats.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with ANKRD35: view

Function for ANKRD35 Gene

Phenotypes for ANKRD35 Gene

GenomeRNAi human phenotypes for ANKRD35:
genes like me logo Genes that share phenotypes with ANKRD35: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD35 Gene

Localization for ANKRD35 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD35 Gene COMPARTMENTS Subcellular localization image for ANKRD35 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
peroxisome 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD35 Gene

Pathways & Interactions for ANKRD35 Gene

SuperPathways for ANKRD35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD35 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD35 Gene

Transcripts for ANKRD35 Gene

mRNA/cDNA for ANKRD35 Gene

Unigene Clusters for ANKRD35 Gene

Ankyrin repeat domain 35:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD35 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for ANKRD35 Gene

GeneLoc Exon Structure for
ANKRD35
ECgene alternative splicing isoforms for
ANKRD35

Expression for ANKRD35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD35 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD35 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x8.2) and Skin - Not Sun Exposed (Suprapubic) (x6.7).

Protein differential expression in normal tissues from HIPED for ANKRD35 Gene

This gene is overexpressed in Placenta (20.2), Liver (13.4), Cervix (9.6), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD35 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANKRD35 Gene:

ANKRD35

SOURCE GeneReport for Unigene cluster for ANKRD35 Gene:

Hs.710624
genes like me logo Genes that share expression patterns with ANKRD35: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ANKRD35 Gene

Orthologs for ANKRD35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD35 34 35
  • 98.85 (n)
cow
(Bos Taurus)
Mammalia ANKRD35 34 35
  • 86.13 (n)
dog
(Canis familiaris)
Mammalia ANKRD35 34 35
  • 85.4 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd35 34
  • 83.35 (n)
mouse
(Mus musculus)
Mammalia Ankrd35 34 16 35
  • 83.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD35 35
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKRD35 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 65 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii uaca 35
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for ANKRD35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD35 Gene

ENSEMBL:
Gene Tree for ANKRD35 (if available)
TreeFam:
Gene Tree for ANKRD35 (if available)

Paralogs for ANKRD35 Gene

Paralogs for ANKRD35 Gene

(8) SIMAP similar genes for ANKRD35 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD35: view

Variants for ANKRD35 Gene

Sequence variations from dbSNP and Humsavar for ANKRD35 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10494240 -- 145,883,561(+) TAGAT(C/T)AGCTT intron-variant
rs10752823 -- 145,877,272(-) CTGGG(A/C)AACAG intron-variant
rs10752824 -- 145,871,121(-) AGAAA(A/G)AAAGC intron-variant
rs10752825 -- 145,870,854(-) GTAAT(A/C)CCAGC intron-variant
rs10797650 -- 145,874,605(-) GGACA(A/G)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD35 Gene

Variant ID Type Subtype PubMed ID
esv32826 CNV gain 17666407
esv3587420 CNV gain 21293372
nsv1005055 CNV loss 25217958
nsv831381 CNV gain 17160897
nsv946265 CNV duplication 23825009

Variation tolerance for ANKRD35 Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.45; 92.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD35 Gene

Disorders for ANKRD35 Gene

Relevant External Links for ANKRD35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD35

No disorders were found for ANKRD35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD35 Gene

Publications for ANKRD35 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. (PMID: 25505242) Fernandez J. … Arhel N.J. (J. Biol. Chem. 2015) 3 64
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64

Products for ANKRD35 Gene

Sources for ANKRD35 Gene

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