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ANKRD34C Gene

protein-coding   GIFtS: 33
GCID: GC15P079585

Ankyrin Repeat Domain 34C

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 34C1 2
Ankyrin Repeat Domain-Containing Protein 34C2

External Ids:    HGNC: 338881   Entrez Gene: 3906162   Ensembl: ENSG000002357117   UniProtKB: P0C6C13   

Export aliases for ANKRD34C gene to outside databases

Previous GC identifers: GC15P077372 GC15P056333


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD34C Gene:
ANKRD34C (ankyrin repeat domain 34C) is a protein-coding gene. An important paralog of this gene is ANKRD34A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD34C gene promoter:
         Max1   SREBP-1c   SREBP-1b   AREB6   NF-AT4   SREBP-1a   NF-AT2   NF-AT3   Zic3   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD34C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1

ANKRD34C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD34C gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P079585:  view genomic region     (about GC identifiers)

Start:
79,575,146 bp from pter      End:
79,590,581 bp from pter
Size:
15,436 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AN34C_HUMAN, P0C6C1 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 34C  
Size: 535 amino acids; 58256 Da
Secondary accessions: H3BNM1

Explore the universe of human proteins at neXtProt for ANKRD34C: NX_P0C6C1

Explore proteomics data for ANKRD34C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANKRD34C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001139813.1  
    ENSEMBL proteins: 
     ENSP00000454921   ENSP00000401089  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry P0C6C1

    ProtoNet protein and cluster: P0C6C1

    UniProtKB/Swiss-Prot: AN34C_HUMAN, P0C6C1
    Similarity: Belongs to the ANKRD34 family
    Similarity: Contains 4 ANK repeats


    Find genes that share domains with ANKRD34C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ANKRD34C           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ANKRD34C

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD34C
    Interactions:

        Search GeneGlobe Interaction Network for ANKRD34C

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ANKRD34C (AN34C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANKRD34C gene: 
    NM_001146341.1  

    Unigene Cluster for ANKRD34C:

    Ankyrin repeat domain 34C
    Hs.531231  [show with all ESTs]
    Unigene Representative Sequence: NM_001146341
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558647(uc021srm.1) ENST00000421388(uc002bet.3)
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    Additional mRNA sequence: 

    AK090665.1 AK127037.1 AL109678.1 

    2 DOTS entries:

    DT.40109559  DT.40109558 

    3 AceView cDNA sequences:

    AK090665 BX507873 AK127037 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKRD34C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ANKRD34C Expression
    About this image

    ANKRD34C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKRD34C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531231
        Custom PCR Arrays for ANKRD34C
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ANKRD34C gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankrd34c1 , 5 ankyrin repeat domain 34C1, 5 86.43(n)1
    90.43(a)1
      9 (47.24 cM)5
    3309981  NM_207260.21  NP_997143.11 
     897282495 
    chicken
    (Gallus gallus)
    Aves ANKRD34C1 ankyrin repeat domain 34C 65.09(n)
    66.12(a)
      415579  XM_413947.4  XP_413947.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5667431 ankyrin repeat domain-containing protein 34C-like 63.93(n)
    66.16(a)
      566743  XM_003200458.2  XP_003200506.1 


    ENSEMBL Gene Tree for ANKRD34C (if available)
    TreeFam Gene Tree for ANKRD34C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKRD34C gene
    ANKRD34A2  ANKRD34B2  
    2 SIMAP similar genes for ANKRD34C using alignment to 1 protein entry:     AN34C_HUMAN:
    ANKRD34B    ANKRD34A

    Find genes that share paralogs with ANKRD34C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKRD34C (see all 307)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1911781241,2
    --59612440(+) ATATGC/GCAACA 1 -- us2k10--------
    rs1511643461,2
    --79578312(+) AGCTTA/GAAAAA 1 -- int10--------
    rs1868366741,2
    --79578331(+) ATCTTC/TACTTT 1 -- int10--------
    rs1402309781,2
    C--79578344(+) GGGACA/CATAAA 1 -- int10--------
    rs1469220421,2
    C--79578362(+) AAGGAC/TATCAG 1 -- int10--------
    rs1923600701,2
    --79578450(+) ATATTC/TTAATC 1 -- int10--------
    rs1379309131,2
    --79578506(+) GCCACC/TATTAT 1 -- int10--------
    rs129162151,2
    C--79578579(+) GGGGTG/AGGGGG 1 -- int14Minor allele frequency- A:0.07NA CSA WA 242
    rs80430211,2
    C,F,A--79578590(+) TTGGCG/AGGTAG 1 -- int18Minor allele frequency- A:0.43NA WA EA 368
    rs1422252131,2
    C--79578625(+) AACCAA/GGCAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ANKRD34C (79575146 - 79590581 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ANKRD34C: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANKRD34C
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKRD34C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKRD34C gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ANKRD34C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390616 HGNC: 33888 AceView: LOC390616 Ensembl:ENSG00000235711 euGenes: HUgn390616
    ECgene: ANKRD34C H-InvDB: ANKRD34C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKRD34C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKRD34C gene:
    Search GeneIP for patents involving ANKRD34C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for ANKRD34C
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     Search ThermoFisher Antibodies for ANKRD34C
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANKRD34C
     Browse compounds at ApexBio
     Search Addgene for plasmids for ANKRD34C
      Search eBioscience for proteins for ANKRD34C
      Search eBioscience for elisas for ANKRD34C
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ANKRD34C
     antibodies-online antibodies for ANKRD34C (9 products)
     antibodies-online kits for ANKRD34C (4 products)
     antibodies-online peptides for ANKRD34C
     antibodies-online proteins for ANKRD34C
           
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