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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANKRD34B Gene

protein-coding GIFtS: 39
GCID: GC05M079888

ankyrin repeat domain 34B

Search for ANKRD34B
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ankyrin Repeat Domain 34B¹ ²
DP58¹ ²
Ankyrin Repeat Domain-Containing Protein 34B²
Cytosolic Phosphoprotein DP58²
Dendritic Phosphoprotein 58 KDa²

External Ids:	HGNC: 33736¹	Entrez Gene: 340120²	Ensembl: ENSG00000189127⁷	UniProtKB: A5PLL1³

Export aliases for ANKRD34B gene to outside databases

Previous GC identifer: GC05M075060

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANKRD34B gene promoter:
AML1a MyoD NF-kappaB YY1 E47 HSF2 Hand1 Pax-4a NF-kappaB1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANKRD34B promoter sequence

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD34B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14.1 Ensembl cytogenetic band: 5q14.1 HGNC cytogenetic band: 5q14.1

ANKRD34B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD34B gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M079888: view genomic region (about GC identifiers)

Start:	79,852,574 bp from pter	End:	79,866,307 bp from pter
Size:	13,734 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: AN34B_HUMAN, A5PLL1 (See protein sequence)

Recommended Name: Ankyrin repeat domain-containing protein 34B

Size: 514 amino acids; 56414 Da

Subcellular location: Cytoplasm. Nucleus (By similarity)

Secondary accessions: B2RPH1 Q68D79

Explore the universe of human proteins at neXtProt for ANKRD34B: NX_A5PLL1

Post-translational modifications:

Phosphorylated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A5PLL1

ANKRD34B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001004441.2

ENSEMBL proteins:

ENSP00000339802 ENSP00000426198

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

ANKRD34B for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANKRD34B for domains About GeneDecksing

2 InterPro domains/families:

IPR020683 Ankyrin_rpt-contain_dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry A5PLL1

ProtoNet protein and cluster: A5PLL1

UniProtKB/Swiss-Prot: AN34B_HUMAN, A5PLL1

Similarity: Belongs to the ANKRD34 family

Similarity: Contains 4 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ANKRD34B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
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About This Section

REFSEQ mRNAs for ANKRD34B gene:

NM_001004441.2

Unigene Cluster for ANKRD34B:

Ankyrin repeat domain 34B

Hs.519404 [show with all ESTs]

Unigene Representative Sequence: NM_001004441

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000338682(uc010jam.3 uc003kgw.3 uc010jan.3) ENST00000508916

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Additional cDNA sequence:

BC137441.1 BC137442.1 BC142957.1 CR749535.1

1 DOTS entry:

DT.40305325

5 AceView cDNA sequences:

AA810833 BV191027 CR749535 NM_001004441 BI601141

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANKRD34B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTGAACAA

About this image

ANKRD34B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

N2/LSB induced-cells (Generation of midbra...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ANKRD34B Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.519404

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD34B gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ankrd34b^{1 , 5}	ankyrin repeat domain 34B^{1, 5}	81.76(n)¹ 82.48(a)¹		13 (47.68 cM)⁵ 218440¹ NM_175455.4¹ NP_780664.2¹ 92425896⁵
chicken (Gallus gallus)	Aves	ANKRD34B¹	ankyrin repeat domain 34B	67.32(n) 63.39(a)		431626 XM_429178.1 XP_429178.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	65(a) 65(a)	many → 1 many → 1	AAWZ02039579(1856-3358) GL344451.1(12476-13978)
zebrafish (Danio rerio)	Actinopterygii	LOC565548¹	similar to LOC495946 protein	56.73(n) 56(a)		565548 NM_001098183.1 NP_001091653.1

ENSEMBL Gene Tree for ANKRD34B (if available)
TreeFam Gene Tree for ANKRD34B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANKRD34B gene

ANKRD34C² ANKRD34A²

2 SIMAP similar genes for ANKRD34B using alignment to 2 protein entries: AN34B_HUMAN (see all proteins):

ANKRD34C ANKRD34A

ANKRD34B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs62366865^1,2		--	79852145(+)	`CTAGAG/AATGGA`	1	--	int¹		1		NA	2
rs189057983^1,2		--	79852226(+)	`AAGTGC/TTGGGA`	1	--	int¹		0	--	--	--	--
rs192054080^1,2		--	79852237(+)	`TTACAA/GGCGTG`	1	--	int¹		0	--	--	--	--
rs115677755^1,2	F,	--	79852428(+)	`ATATCT/CTTTTC`	1	--	int¹		1		WA	118
rs6453521^1,2	C,F,A,H,	--	79852478(+)	`AGTTTT/GCTATT`	1	--	int¹		18		NS EA WA NA CSA	2105
rs184606099^1,2		--	79852984(+)	`GTCTGA/GTTTAT`	1	--	ut3¹		0	--	--	--	--
rs77782083^1,2	C,F,	--	79853000(+)	`GTTGTT/GAAGCT`	1	--	ut3¹		1		WA	118
rs60500964^1,2	C,	--	79853055(+)	`AGTTAT/AATAGA`	1	--	ut3¹		1		WA	2
rs141716753^1,2		--	79853064(+)	`GATGAC/TATAAT`	1	--	ut3¹		0	--	--	--	--
rs146033419^1,2		--	79853077(+)	`TTACTA/TTATAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ANKRD34B (79852574 - 79866307 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ANKRD34B
1 CNV: 0065

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ANKRD34B gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANKRD34B)

Utopia: connect your pdf to the dynamic
world of online information

A novel phosphoprotein is induced during bone marrow commitment to dendritic cells. (PubMed id 15358210)^{1, 9} Al-Shaibi N. and Ghosh S.K. (2004)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)² Schmutz J.... Rubin E.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 340120	HGNC: 33736	AceView: DP58	Ensembl:ENSG00000189127	euGenes: HUgn340120
ECgene: ANKRD34B	H-InvDB: ANKRD34B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANKRD34B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANKRD34B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ANKRD34B gene:
Search GeneIP for patents involving ANKRD34B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ANKRD34B Gene

ankyrin repeat domain 34B

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for ANKRD34B gene

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ANKRD34B Gene

ankyrin repeat domain 34B

Aliasesfor ANKRD34B gene

Summariesfor ANKRD34B gene

Genomic Viewsfor ANKRD34B gene

Proteinsfor ANKRD34B gene

Protein Domains /Familiesfor ANKRD34B gene

Functionfor ANKRD34B gene

Pathways & Interactionsfor ANKRD34B gene

Drugs & Compoundsfor ANKRD34B gene

Transcriptsfor ANKRD34B gene

Expression for ANKRD34B gene

Orthologsfor ANKRD34B gene

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Genomic Variantsfor ANKRD34B gene

Disorders / Diseasesfor ANKRD34B gene

Publicationsfor ANKRD34B gene

External Searches for ANKRD34B gene

Genome Databases showing ANKRD34B gene

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Specialized Databases showing ANKRD34B gene

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Aliases
for ANKRD34B gene

Summaries
for ANKRD34B gene

Genomic Views
for ANKRD34B gene

Proteins
for ANKRD34B gene

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Families
for ANKRD34B gene

Function
for ANKRD34B gene

Pathways & Interactions
for ANKRD34B gene

Drugs & Compounds
for ANKRD34B gene

Transcripts
for ANKRD34B gene

Expression
for ANKRD34B gene

Orthologs
for ANKRD34B gene

Paralogs
for ANKRD34B gene

Genomic Variants
for ANKRD34B gene

Disorders / Diseases
for ANKRD34B gene

Publications
for ANKRD34B gene

Intellectual Property
for ANKRD34B gene

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for ANKRD34B gene