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Aliases for ANKRD34B Gene

Aliases for ANKRD34B Gene

  • Ankyrin Repeat Domain 34B 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 34B 3
  • Dendritic Phosphoprotein 58 KDa 3
  • Cytosolic Phosphoprotein DP58 3
  • DP58 3

External Ids for ANKRD34B Gene

Previous GeneCards Identifiers for ANKRD34B Gene

  • GC05M079888
  • GC05M075060

Summaries for ANKRD34B Gene

GeneCards Summary for ANKRD34B Gene

ANKRD34B (Ankyrin Repeat Domain 34B) is a Protein Coding gene. An important paralog of this gene is ANKRD34C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD34B Gene

Genomics for ANKRD34B Gene

Regulatory Elements for ANKRD34B Gene

Enhancers for ANKRD34B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F080607 0.7 ENCODE 11.9 -35.3 -35298 0.3 SOX13 ELF3 SAP130 ARID4B ZNF644 RARA MAFK HOMEZ CREM FOXA3 DHFR ANKRD34B DBIP2 GC05M080611
GH05F080606 0.3 FANTOM5 11.2 -34.0 -33993 0.0 ANKRD34B DBIP2 GC05M080611
GH05F080568 0.3 FANTOM5 7.6 +4.5 4543 0.1 ANKRD34B RPL7P24
GH05F080569 0.9 ENCODE 0.8 +2.5 2499 0.7 ZNF76 GLIS2 ZNF263 SP3 ZEB2 ZFP69B ZNF341 MXD3 GLIS1 ZBTB26 DHFR ANKRD34B RPL7P24
GH05F080573 0.3 FANTOM5 0.8 -0.7 -653 0.1 SPZ1 ANKRD34B DBIP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD34B on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKRD34B Gene

Chromosome:
5
Start:
80,556,755 bp from pter
End:
80,572,753 bp from pter
Size:
15,999 bases
Orientation:
Minus strand

Genomic View for ANKRD34B Gene

Genes around ANKRD34B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD34B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD34B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD34B Gene

Proteins for ANKRD34B Gene

  • Protein details for ANKRD34B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5PLL1-AN34B_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 34B
    Protein Accession:
    A5PLL1
    Secondary Accessions:
    • B2RPH1
    • Q68D79

    Protein attributes for ANKRD34B Gene

    Size:
    514 amino acids
    Molecular mass:
    56414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD34B Gene

Post-translational modifications for ANKRD34B Gene

Other Protein References for ANKRD34B Gene

No data available for DME Specific Peptides for ANKRD34B Gene

Domains & Families for ANKRD34B Gene

Gene Families for ANKRD34B Gene

Protein Domains for ANKRD34B Gene

Suggested Antigen Peptide Sequences for ANKRD34B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A5PLL1

UniProtKB/Swiss-Prot:

AN34B_HUMAN :
  • Belongs to the ANKRD34 family.
  • Contains 4 ANK repeats.
Family:
  • Belongs to the ANKRD34 family.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with ANKRD34B: view

Function for ANKRD34B Gene

genes like me logo Genes that share phenotypes with ANKRD34B: view

Animal Model Products

miRNA for ANKRD34B Gene

miRTarBase miRNAs that target ANKRD34B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD34B Gene

Localization for ANKRD34B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD34B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD34B gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for ANKRD34B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ANKRD34B: view

Pathways & Interactions for ANKRD34B Gene

SuperPathways for ANKRD34B Gene

No Data Available

Interacting Proteins for ANKRD34B Gene

Selected Interacting proteins: A5PLL1-AN34B_HUMAN for ANKRD34B Gene via IID

Symbol External ID(s) Details
MPP5

Gene Ontology (GO) - Biological Process for ANKRD34B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD34B Gene

Transcripts for ANKRD34B Gene

mRNA/cDNA for ANKRD34B Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD34B Gene

Ankyrin repeat domain 34B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD34B Gene

No ASD Table

Relevant External Links for ANKRD34B Gene

GeneLoc Exon Structure for
ANKRD34B
ECgene alternative splicing isoforms for
ANKRD34B

Expression for ANKRD34B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD34B Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD34B Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x14.9), Brain - Putamen (basal ganglia) (x12.8), and Brain - Caudate (basal ganglia) (x12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD34B Gene



Protein tissue co-expression partners for ANKRD34B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD34B Gene:

ANKRD34B

SOURCE GeneReport for Unigene cluster for ANKRD34B Gene:

Hs.519404
genes like me logo Genes that share expression patterns with ANKRD34B: view

Primer Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKRD34B Gene

Orthologs for ANKRD34B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD34B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD34B 34 35
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia ANKRD34B 34 35
  • 88.87 (n)
dog
(Canis familiaris)
Mammalia ANKRD34B 34 35
  • 88.07 (n)
mouse
(Mus musculus)
Mammalia Ankrd34b 34 16 35
  • 81.76 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd34b 34
  • 81.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD34B 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD34B 35
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 67 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd34b 34
  • 66.27 (n)
zebrafish
(Danio rerio)
Actinopterygii ankrd34bb 34 35
  • 56.91 (n)
ankrd34ba 35
  • 44 (a)
OneToMany
Species where no ortholog for ANKRD34B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD34B Gene

ENSEMBL:
Gene Tree for ANKRD34B (if available)
TreeFam:
Gene Tree for ANKRD34B (if available)

Paralogs for ANKRD34B Gene

Paralogs for ANKRD34B Gene

(2) SIMAP similar genes for ANKRD34B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD34B: view

Variants for ANKRD34B Gene

Sequence variations from dbSNP and Humsavar for ANKRD34B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10073069 -- 80,564,768(+) TGGCA(A/C)AATCT intron-variant, upstream-variant-2KB
rs111282764 -- 80,571,775(+) CTGGC(A/C)AACGT upstream-variant-2KB
rs111416395 -- 80,560,632(+) ACTCA(C/G)CCTGG intron-variant
rs111603222 -- 80,567,622(+) GTCTC(-/A)AAAAA intron-variant
rs112219447 -- 80,562,805(+) GTACC(C/T)GAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD34B Gene

Variant ID Type Subtype PubMed ID
nsv483112 CNV loss 15286789
esv3605577 CNV gain 21293372
esv3605576 CNV loss 21293372
esv3605573 CNV loss 21293372
esv3575862 CNV gain 25503493
esv3575860 CNV gain 25503493
dgv5707n100 CNV gain 25217958
dgv5706n100 CNV gain 25217958
dgv5705n100 CNV gain 25217958

Variation tolerance for ANKRD34B Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD34B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD34B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD34B Gene

Disorders for ANKRD34B Gene

Relevant External Links for ANKRD34B

Genetic Association Database (GAD)
ANKRD34B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD34B

No disorders were found for ANKRD34B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD34B Gene

Publications for ANKRD34B Gene

  1. A novel phosphoprotein is induced during bone marrow commitment to dendritic cells. (PMID: 15358210) Al-Shaibi N. … Ghosh S.K. (Biochem. Biophys. Res. Commun. 2004) 3 22 64
  2. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  3. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 46 64
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for ANKRD34B Gene

Sources for ANKRD34B Gene

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