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Aliases for ANKRD34A Gene

Aliases for ANKRD34A Gene

  • Ankyrin Repeat Domain 34A 2 3 5
  • Ankyrin Repeat Domain 34 2 3
  • ANKRD34 3 4
  • Ankyrin Repeat Domain-Containing Protein 34A 3

External Ids for ANKRD34A Gene

Previous HGNC Symbols for ANKRD34A Gene

  • ANKRD34

Previous GeneCards Identifiers for ANKRD34A Gene

  • GC01P144182
  • GC01P145470
  • GC01P119434

Summaries for ANKRD34A Gene

GeneCards Summary for ANKRD34A Gene

ANKRD34A (Ankyrin Repeat Domain 34A) is a Protein Coding gene. An important paralog of this gene is ANKRD34C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD34A Gene

Genomics for ANKRD34A Gene

Regulatory Elements for ANKRD34A Gene

Enhancers for ANKRD34A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F145990 1.6 FANTOM5 ENCODE 2 -30.8 -30752 10.5 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 LIX1L-AS1 NOTCH2NL POLR3C TXNIP HFE2 RBM8A PEX11B GNRHR2 CD160 ANKRD34A
GH01F145959 1.1 ENCODE 0.8 +2.2 2159 6.1 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 POLR3C LIX1L-AS1 RBM8A TXNIP PEX11B GNRHR2 NOTCH2NL LIX1L ANKRD34A ENSG00000278431
GH01F145976 1.6 FANTOM5 ENCODE 0.3 -17.4 -17395 10.0 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 POLR3C ANKRD35 NOTCH2NL HFE2 RBM8A LIX1L-AS1 PEX11B GNRHR2 LIX1L TXNIP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD34A on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD34A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000079648 -409 1601 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ELK1

Genomic Location for ANKRD34A Gene

Chromosome:
1
Start:
145,959,441 bp from pter
End:
145,964,591 bp from pter
Size:
5,151 bases
Orientation:
Minus strand

Genomic View for ANKRD34A Gene

Genes around ANKRD34A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD34A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD34A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD34A Gene

Proteins for ANKRD34A Gene

  • Protein details for ANKRD34A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YU3-AN34A_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 34A
    Protein Accession:
    Q69YU3
    Secondary Accessions:
    • B3KSU3

    Protein attributes for ANKRD34A Gene

    Size:
    496 amino acids
    Molecular mass:
    52636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD34A Gene

Post-translational modifications for ANKRD34A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD34A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD34A Gene

Domains & Families for ANKRD34A Gene

Gene Families for ANKRD34A Gene

Protein Domains for ANKRD34A Gene

Suggested Antigen Peptide Sequences for ANKRD34A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q69YU3

UniProtKB/Swiss-Prot:

AN34A_HUMAN :
  • Belongs to the ANKRD34 family.
  • Contains 4 ANK repeats.
Family:
  • Belongs to the ANKRD34 family.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with ANKRD34A: view

Function for ANKRD34A Gene

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD34A Gene

Localization for ANKRD34A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD34A gene
Compartment Confidence
nucleus 3
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD34A Gene

Pathways & Interactions for ANKRD34A Gene

SuperPathways for ANKRD34A Gene

No Data Available

Interacting Proteins for ANKRD34A Gene

Gene Ontology (GO) - Biological Process for ANKRD34A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD34A Gene

Transcripts for ANKRD34A Gene

mRNA/cDNA for ANKRD34A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD34A Gene

Ankyrin repeat domain 34A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD34A Gene

No ASD Table

Relevant External Links for ANKRD34A Gene

GeneLoc Exon Structure for
ANKRD34A
ECgene alternative splicing isoforms for
ANKRD34A

Expression for ANKRD34A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD34A Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD34A Gene

This gene is overexpressed in Brain - Cortex (x5.0), Brain - Frontal Cortex (BA9) (x4.9), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Protein differential expression in normal tissues from HIPED for ANKRD34A Gene

This gene is overexpressed in Frontal cortex (56.1) and Retina (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD34A Gene



Protein tissue co-expression partners for ANKRD34A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD34A Gene:

ANKRD34A

SOURCE GeneReport for Unigene cluster for ANKRD34A Gene:

Hs.620591
genes like me logo Genes that share expression patterns with ANKRD34A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ANKRD34A Gene

Orthologs for ANKRD34A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD34A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD34A 34
  • 98.56 (n)
cow
(Bos Taurus)
Mammalia ANKRD34A 34
  • 91.43 (n)
dog
(Canis familiaris)
Mammalia ANKRD34A 34
  • 90.93 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd34a 34
  • 89.63 (n)
mouse
(Mus musculus)
Mammalia Ankrd34a 34 16
  • 89.09 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd34a 34
  • 59.54 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC798097 34
  • 60.57 (n)
Species where no ortholog for ANKRD34A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD34A Gene

ENSEMBL:
Gene Tree for ANKRD34A (if available)
TreeFam:
Gene Tree for ANKRD34A (if available)

Paralogs for ANKRD34A Gene

Paralogs for ANKRD34A Gene

(2) SIMAP similar genes for ANKRD34A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANKRD34A: view

Variants for ANKRD34A Gene

Sequence variations from dbSNP and Humsavar for ANKRD34A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10910819 -- 145,962,056(-) CTTCA(C/G)TGCGG intron-variant
rs111540919 -- 145,962,300(-) GCTGC(C/T)TCCCT intron-variant
rs114238242 -- 145,959,175(+) TCCCT(C/T)CATCA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs115844564 -- 145,963,408(+) ATAAG(A/G)AATGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs115872596 -- 145,959,846(+) ACAGC(C/T)TATCA intron-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ANKRD34A Gene

Variant ID Type Subtype PubMed ID
esv33401 CNV gain 17666407
nsv1005055 CNV loss 25217958
nsv509457 CNV insertion 20534489
nsv8103 CNV gain 18304495
nsv831381 CNV gain 17160897

Variation tolerance for ANKRD34A Gene

Residual Variation Intolerance Score: 10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD34A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD34A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD34A Gene

Disorders for ANKRD34A Gene

Relevant External Links for ANKRD34A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD34A

No disorders were found for ANKRD34A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD34A Gene

Publications for ANKRD34A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64

Products for ANKRD34A Gene

Sources for ANKRD34A Gene

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