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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKRD33B Gene

protein-coding   GIFtS: 34
GCID: GC05P010564

ankyrin repeat domain 33B

  Search for ANKRD33B
in our new
 Human Malady Compendium 
Biological research products
for ANKRD33B
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ankyrin Repeat Domain 33B1 2
Ankyrin Repeat Domain-Containing Protein 33B2
Ankyrin Repeat Domain-Containing Protein LOC6517462

External Ids:    HGNC: 352401   Entrez Gene: 6517462   Ensembl: ENSG000001642367   UniProtKB: A6NCL73   

Export aliases for ANKRD33B gene to outside databases

Previous GC identifer: GC05P010616


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKRD33B gene promoter:
         Egr-3   p53   CUTL1   AP-2gamma   Evi-1   Egr-4   E47   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ANKRD33B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD33B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.2   Ensembl cytogenetic band:  5p15.2   HGNC cytogenetic band: 5p15.2

ANKRD33B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD33B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P010564:  view genomic region     (about GC identifiers)

Start:
10,564,435 bp from pter      End:
10,657,928 bp from pter
Size:
93,494 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AN33B_HUMAN, A6NCL7 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 33B  
Size: 494 amino acids; 53975 Da

Explore the universe of human proteins at neXtProt for ANKRD33B: NX_A6NCL7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NCL7

  • ANKRD33B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001157912.1  
    ENSEMBL proteins: 
     ENSP00000422195   ENSP00000296657  

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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ANKRD33B for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry A6NCL7

    ProtoNet protein and cluster: A6NCL7

    UniProtKB/Swiss-Prot: AN33B_HUMAN, A6NCL7
    Similarity: Contains 5 ANK repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD33B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
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    Search CenterWatch for drugs/clinical trials and news about ANKRD33B / AN33B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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    About This Section

    REFSEQ mRNAs for ANKRD33B gene: 
    NM_001164440.1  

    Unigene Cluster for ANKRD33B:

    Ankyrin repeat domain 33B
    Hs.26039  [show with all ESTs]
    Unigene Representative Sequence: NM_001164440
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504806 ENST00000296657(uc021xwp.1)

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    Additional cDNA sequence: 

    AF056441.1 AK023999.1 BC018597.1 

    4 DOTS entries:

    DT.453028  DT.70104201  DT.120869541  DT.95358328 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKRD33B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ANKRD33B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primordial germ cell-like cells (Reconstitution of mo...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ANKRD33B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANKRD33B

    SOURCE GeneReport for Unigene cluster: Hs.26039
        SABiosciences Custom PCR Arrays for ANKRD33B
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ANKRD33B gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankrd33b1 , 5 ankyrin repeat domain 33B1, 5 78.08(n)1
    77.11(a)1
      15 (12.76 cM)5
    674341  NM_001164441.11  NP_001157913.11 
     312914805 
    chicken
    (Gallus gallus)
    Aves ANKRD33B1 ankyrin repeat domain 33B 62.92(n)
    58.9(a)
      420924  XM_419009.3  XP_419009.3 
    lizard
    (Anolis carolinensis)
    Reptilia ANKRD33B6
    --
    57(a)
    1 ↔ 1
    4(66473105-66509581)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5579051 ankyrin repeat domain-containing protein 33B-like 57.45(n)
    50.79(a)
      557905  XM_001919577.1  XP_001919612.1 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    17(a)
    1 → many
    Group1.26(99353-105343)


    ENSEMBL Gene Tree for ANKRD33B (if available)
    TreeFam Gene Tree for ANKRD33B (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANKRD33B gene
    ANKRD332  
    1 SIMAP similar gene for ANKRD33B using alignment to 2 protein entries:     AN33B_HUMAN (see all proteins):
    ANKRD33

    ANKRD33B for paralogs           About GeneDecksing


    5/14 Pseudogenes.org Pseudogenes for ANKRD33B (see all 14)
    PGOHUM00000242230 PGOHUM00000250360 PGOHUM00000250362 PGOHUM00000250367 PGOHUM00000250385


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1886 NCBI SNPs in ANKRD33B are shown (see all 1886    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857745691,2
    --10562519(+) CTCTCA/GGGGCC 1 -- us2k10--------
    rs760120191,2
    --10562550(+) TTGGTA/GACCCG 1 -- us2k10--------
    rs758319711,2
    --10562621(+) CAAACC/TCAACT 1 -- us2k10--------
    rs1482950551,2
    --10562646(+) CACTTA/GAAATT 1 -- us2k10--------
    rs778341051,2
    C,--10562784(+) GTTGCA/TGAAAG 1 -- us2k12Minor allele frequency- T:0.14CSA WA 120
    rs1898973981,2
    --10562915(+) CTGCAA/GATGCC 1 -- us2k10--------
    rs802115601,2
    F,--10563020(+) CGAGGG/ACTCGA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs8145811,2
    C,F,H,--10563045(+) TAAACC/GTGTCC 1 -- us2k123Minor allele frequency- G:0.05NS EA NA WA CSA 1757
    rs669822031,2
    C,--10563296(+) CCTGCG/TACGGG 1 -- us2k14Minor allele frequency- T:0.14NA WA 242
    rs1821161971,2
    --10563356(+) CTCACG/TACGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANKRD33B (10564435 - 10657928 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for ANKRD33B
         7 CNVs: 43306 64117 69003 69004 99058 6379 99057
         5 Indels: 69005 40733 46742 62347 12653

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKRD33B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ANKRD33B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 651746 HGNC: 35240 Ensembl:ENSG00000164236 euGenes: HUgn651746 ECgene: ANKRD33B
    H-InvDB: ANKRD33B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKRD33B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANKRD33B gene:
    Search GeneIP for patents involving ANKRD33B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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