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Aliases for ANKRD33B Gene

Aliases for ANKRD33B Gene

  • Ankyrin Repeat Domain 33B 2 3 5

External Ids for ANKRD33B Gene

Previous GeneCards Identifiers for ANKRD33B Gene

  • GC05P010616

Summaries for ANKRD33B Gene

GeneCards Summary for ANKRD33B Gene

ANKRD33B (Ankyrin Repeat Domain 33B) is a Protein Coding gene. An important paralog of this gene is ANKRD33.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD33B Gene

Genomics for ANKRD33B Gene

Regulatory Elements for ANKRD33B Gene

Enhancers for ANKRD33B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F010606 1.2 FANTOM5 Ensembl ENCODE 14.7 +43.5 43526 2.7 HDGF PKNOX1 WRNIP1 SIN3A FEZF1 ZNF2 ZNF766 CBX5 ZNF263 JUNB ROPN1L-AS1 CTD-2154B17.1 ENSG00000248525 LOC105374648 ANKRD33B ANKRD33B-AS1 LOC389273 ROPN1L LINC01513 ENSG00000251196
GH05F010599 0.8 FANTOM5 Ensembl ENCODE 13.6 +37.0 37026 3.3 HDGF PKNOX1 SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF302 ZNF143 ZNF207 ANKRD33B ANKRD33B-AS1 GC05P010606 GC05P010586
GH05F010543 0.5 Ensembl 13.1 -20.3 -20323 0.4 ATF1 ARNT KLF17 FEZF1 ZNF121 ZNF366 KLF7 ZNF362 CEBPB ZEB2 ANKRD33B ROPN1L ROPN1L-AS1 ENSG00000280017 ENSG00000279450
GH05F010588 0.9 Ensembl ENCODE 13 +25.6 25622 3.5 HDGF PKNOX1 ARNT ZNF766 CBX5 KLF13 DEK JUNB REST KAT8 ANKRD33B ANKRD33B-AS1 ROPN1L ROPN1L-AS1 ENSG00000251196 GC05P010586 GC05P010606
GH05F010583 0.2 Ensembl 13 +20.5 20478 2.0 PKNOX1 FEZF1 BCL11B ZIC2 HIC1 ZNF335 ZNF121 SCRT2 ZNF280C TCF7L2 ANKRD33B ANKRD33B-AS1 ENSG00000251196 GC05M010581 GC05P010586
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ANKRD33B on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD33B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001867068 377 2601 HDGF SIN3A ZNF121 GLIS2 ELK1 ZNF207 KLF7 KLF13 ZNF263 SP3
ENSR00001275418 1977 201 SCRT1 ZSCAN5A KLF1 SP3 ZBTB8A RAD21 ZFHX2 RAD51 POLR2A ZNF341

Genomic Location for ANKRD33B Gene

Chromosome:
5
Start:
10,564,323 bp from pter
End:
10,657,816 bp from pter
Size:
93,494 bases
Orientation:
Plus strand

Genomic View for ANKRD33B Gene

Genes around ANKRD33B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD33B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD33B Gene

Proteins for ANKRD33B Gene

  • Protein details for ANKRD33B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCL7-AN33B_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 33B
    Protein Accession:
    A6NCL7

    Protein attributes for ANKRD33B Gene

    Size:
    494 amino acids
    Molecular mass:
    53975 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD33B Gene

Post-translational modifications for ANKRD33B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD33B Gene

No data available for DME Specific Peptides for ANKRD33B Gene

Domains & Families for ANKRD33B Gene

Gene Families for ANKRD33B Gene

Protein Domains for ANKRD33B Gene

Suggested Antigen Peptide Sequences for ANKRD33B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NCL7

UniProtKB/Swiss-Prot:

AN33B_HUMAN :
  • Contains 5 ANK repeats.
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with ANKRD33B: view

Function for ANKRD33B Gene

Phenotypes for ANKRD33B Gene

GenomeRNAi human phenotypes for ANKRD33B:
genes like me logo Genes that share phenotypes with ANKRD33B: view

Animal Model Products

miRNA for ANKRD33B Gene

miRTarBase miRNAs that target ANKRD33B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD33B Gene

Localization for ANKRD33B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD33B Gene COMPARTMENTS Subcellular localization image for ANKRD33B gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD33B Gene

Pathways & Interactions for ANKRD33B Gene

SuperPathways for ANKRD33B Gene

No Data Available

Interacting Proteins for ANKRD33B Gene

Gene Ontology (GO) - Biological Process for ANKRD33B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD33B Gene

Transcripts for ANKRD33B Gene

mRNA/cDNA for ANKRD33B Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD33B Gene

Ankyrin repeat domain 33B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD33B Gene

No ASD Table

Relevant External Links for ANKRD33B Gene

GeneLoc Exon Structure for
ANKRD33B
ECgene alternative splicing isoforms for
ANKRD33B

Expression for ANKRD33B Gene

mRNA expression in normal human tissues for ANKRD33B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD33B Gene

This gene is overexpressed in Heart (51.5) and Retina (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD33B Gene



Protein tissue co-expression partners for ANKRD33B Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD33B Gene:

ANKRD33B

SOURCE GeneReport for Unigene cluster for ANKRD33B Gene:

Hs.26039
genes like me logo Genes that share expression patterns with ANKRD33B: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKRD33B Gene

Orthologs for ANKRD33B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD33B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD33B 34 35
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia ANKRD33B 34 35
  • 83.92 (n)
cow
(Bos Taurus)
Mammalia ANKRD33B 34 35
  • 83.67 (n)
mouse
(Mus musculus)
Mammalia Ankrd33b 34 16 35
  • 78.28 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd33b 34
  • 77.48 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD33B 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD33B 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD33B 34 35
  • 63.69 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD33B 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494504 34
  • 54.16 (n)
zebrafish
(Danio rerio)
Actinopterygii ankrd33ba 34 35
  • 58.29 (n)
ankrd33bb 35
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
OneToMany
Species where no ortholog for ANKRD33B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD33B Gene

ENSEMBL:
Gene Tree for ANKRD33B (if available)
TreeFam:
Gene Tree for ANKRD33B (if available)

Paralogs for ANKRD33B Gene

Paralogs for ANKRD33B Gene

(1) SIMAP similar genes for ANKRD33B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD33B: view

Variants for ANKRD33B Gene

Sequence variations from dbSNP and Humsavar for ANKRD33B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10035299 -- 10,612,515(+) CAAAC(A/G)TTCCG intron-variant
rs10035875 -- 10,623,541(+) CCTCC(C/G)AAAGC intron-variant
rs10036234 -- 10,642,082(+) GTCAC(A/G)TCACT intron-variant
rs10039748 -- 10,621,301(+) tctgg(A/G)ctcta intron-variant
rs10040830 -- 10,640,154(+) TGTTA(C/G)CGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD33B Gene

Variant ID Type Subtype PubMed ID
dgv3036n106 CNV deletion 24896259
dgv349e215 CNV deletion 23714750
dgv931e201 CNV deletion 23290073
dgv9579n54 CNV loss 21841781
dgv9580n54 CNV loss 21841781
dgv9581n54 CNV loss 21841781
esv1001828 CNV gain 20482838
esv2302807 CNV deletion 18987734
esv2429278 CNV deletion 19546169
esv2570309 CNV deletion 19546169
esv25753 CNV loss 19812545
esv2729744 CNV deletion 23290073
esv2729745 CNV deletion 23290073
esv27558 CNV loss 19812545
esv29091 CNV gain+loss 19812545
esv3304412 CNV mobile element insertion 20981092
esv3400859 CNV insertion 20981092
esv3565521 CNV deletion 23714750
esv3604003 CNV loss 21293372
esv3604004 CNV loss 21293372
esv5335 CNV loss 18987735
esv5923 CNV loss 19470904
nsv1021311 CNV loss 25217958
nsv1073041 CNV deletion 25765185
nsv1074809 CNV deletion 25765185
nsv1140509 CNV deletion 24896259
nsv329316 CNV deletion 16902084
nsv329565 CNV deletion 16902084
nsv472473 CNV novel sequence insertion 20440878
nsv507230 OTHER sequence alteration 20534489
nsv511306 CNV loss 21212237
nsv513220 CNV loss 21212237
nsv513221 CNV loss 21212237
nsv597119 CNV loss 21841781
nsv597121 CNV loss 21841781
nsv597122 CNV gain 21841781
nsv597124 CNV gain 21841781
nsv597125 CNV loss 21841781
nsv597126 CNV loss 21841781
nsv597127 CNV loss 21841781
nsv597135 CNV loss 21841781
nsv597136 CNV loss 21841781
nsv597137 CNV loss 21841781
nsv597138 CNV gain 21841781
nsv956440 CNV deletion 24416366
nsv968139 CNV duplication 23825009

Variation tolerance for ANKRD33B Gene

Gene Damage Index Score: 3.38; 54.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD33B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD33B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD33B Gene

Disorders for ANKRD33B Gene

Relevant External Links for ANKRD33B

Genetic Association Database (GAD)
ANKRD33B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD33B

No disorders were found for ANKRD33B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD33B Gene

Publications for ANKRD33B Gene

  1. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 64
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for ANKRD33B Gene

Sources for ANKRD33B Gene

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