ANKRD32 Gene
protein-coding GIFtS : 44
GCID: GC05 P094039
ankyrin repeat domain 32 (Previous name: BRCT domain containing 1 ) (Previous symbol: BRCTD1 )
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Aliasesfor ANKRD32 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ankyrin Repeat Domain 32 1 2 DKFZp564C04691 BRCTD11 2 3 DKFZp761C1211 BRCT Domain Containing 11 2 BRCTx2 BRCT Domain-Containing Protein 12 3 Ankyrin Repeat Domain-Containing Protein 322
Export aliases for ANKRD32 gene to outside databases Previous GC identifers: GC05P094089 GC05P089127
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Summariesfor ANKRD32 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor ANKRD32 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000005.9 NC_018916.1 NT_034772.6 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ANKRD32 gene promoter: Sox5 AML1a POU6F1 (c2) STAT5A HNF-3beta Evi-1 POU2F1a FOXJ2 (long isoform) HFH-1 FOXJ2 Other transcription factors Search SABiosciences Chromatin IP Primers for ANKRD32 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ANKRD32
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 5q15 Ensembl cytogenetic band: 5q15 HGNC cytogenetic band: 5q15 ANKRD32 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05P094039: view genomic region
(about GC identifiers )
Start:
93,954,052 bp from pter
End:
94,075,141 bp from pter
Size:
121,090 bases
Orientation:
plus strand
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Proteinsfor ANKRD32 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ANR32_HUMAN, Q9BQI6 (See
protein sequence )Recommended Name: Ankyrin repeat domain-containing protein 32 Size : 1058 amino acids; 121050 Da
Sequence caution : Sequence=AAH54885.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAH54885.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH70332.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH70332.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAI07572.1; Type=Erroneous initiation; Sequence=CAB66495.1; Type=Erroneous initiation;
Secondary accessions : Q3B7K4 Q6NSA5 Q6PHW9 Q9Y402Explore the universe of human proteins at neXtProt for ANKRD32: NX_Q9BQI6 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BQI6 ANKRD32 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_115666.2 ENSEMBL proteins: ENSP00000265140 ENSP00000424232 ENSP00000425022 ENSP00000430335 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
ANKRD32 for ontologies About GeneDecksing ANKRD32 Antibody Products: Assay Products for ANKRD32:
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Protein
Domains / Familiesfor ANKRD32 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ANKRD32 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9BQI6 ProtoNet protein and cluster: Q9BQI6
1 Blocks protein family : IPB002110 Ankyrin repeat signature UniProtKB/Swiss-Prot: ANR32_HUMAN, Q9BQI6 Similarity : Contains 3 ANK repeatsSimilarity : Contains 2 BRCT domains
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Functionfor ANKRD32 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD32 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD32 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANKRD32 (NM_032290 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD32 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANKRD32
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD32
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
-- --
ANKRD32 for ontologies About GeneDecksing Animal Models: Mouse knock-out Ankrd32 tm1Brd for ANKRD32 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Ankrd32) :
ANKRD32 for phenotypes About GeneDecksing
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Pathways & Interactionsfor ANKRD32 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD32 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)4 Interacting proteins for ANKRD32 (Q9BQI6 3 ENSP00000265140 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor ANKRD32 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ANKRD32 Search CenterWatch for drugs/clinical trials and news about ANKRD32 / ANR32
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Transcriptsfor ANKRD32 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ANKRD32 gene: NM_032290.3 Unigene Cluster for ANKRD32:
Ankyrin repeat domain 32 Hs.657315 [show with all ESTs ] Unigene Representative Sequence: NM_032290 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000265140 (uc011cul.1 uc003kkr.4 ) ENST00000508130 ENST00000508383 ENST00000504099 ENST00000466957 ENST00000450932 (uc003kks.3 ) ENST00000475916 ENST00000493934 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD32 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD32 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANKRD32 (NM_032290 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD32 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANKRD32
Additional cDNA sequence: AK297452.1 AK299080.1 AK309859.1 AL050298.1 AL136560.1 BC015315.2 BC054885.1 BC063674.1 BC070332.1 BC107571.1 CR533539.1 CR936768.1
9 DOTS entries : DT.75127977 DT.91710069
DT.120815413 DT.100641925 DT.120815478 DT.452476 DT.100671829 DT.95196191 DT.99970358 24/63 AceView cDNA sequences (see all 63 ):
AA807135 AA398186 BM757807 AI679532 CR533539 BC063674 BX362703 AA769230 NM_032290 AL135075 BM559149 AI679970 AL136560 CR607591 N63286 BQ774978 AA448724 BM467850 AW450638 BI260672 BF666900 BG388384 AI371994 BG709652 GeneLoc Exon Structure
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Expression for ANKRD32 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ANKRD32 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image ANKRD32 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Brain Cerebral Cortex Brain Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
See ANKRD32 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ANKRD32 SOURCE GeneReport for Unigene cluster: Hs.657315 SABiosciences Custom PCR Arrays for ANKRD32 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ANKRD32Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ANKRD32 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ANKRD32 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ANKRD32 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD32
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Orthologsfor ANKRD32 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for ANKRD32 gene from 3/11 species (see all 11 ) About this table
ENSEMBL Gene Tree for ANKRD32 (if available)TreeFam Gene Tree for ANKRD32 (if available)
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Paralogsfor ANKRD32 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ANKRD32 gene ANKRD11 2 BARD1 2 TONSL 2 ANKRD12 2 ANKRD31 2 1 SIMAP similar gene for ANKRD32 using alignment to 5 protein entries: ANR32_HUMAN (see all proteins ):PPP1R12A
ANKRD32 for paralogs About GeneDecksing
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Genomic Variantsfor ANKRD32 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 5 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ANKRD32 (93954052 - 94075141 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for ANKRD32 2 CNVs : 3561 23074 1 Indel : 60543
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ANKRD32
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Disorders
/ Diseasesfor ANKRD32 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor ANKRD32 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ANKRD32 gene integrated from 9 sources : (articles sorted by number of sources associating them with ANKRD32) Utopia : connect your pdf to the dynamic world of online information
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 1 , 2 Wiemann S.... Poustka A. (2001) RAD18-BRCTx interaction is required for efficient rep air of UV-induced DNA damage. (PubMed id 22036607) 1 Liu T....Huang J. (2012) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764) 1 Tatham M.H....Hay R.T. (2011) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336) 2 Cantin G.T....Yates J.R. III (2008) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) BRCTx is a novel, highly conserved RAD18-interacting protein. (PubMed id 15632077) 1 Adams D.J....Bradley A. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022) 2 Schmutz J.... Rubin E.M. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ANKRD32 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ANKRD32 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ANKRD32 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ANKRD32 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ANKRD32 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ANKRD32 gene: Search GeneIP for patents involving ANKRD32 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ANKRD32 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ANKRD32 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ANKRD32 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ANKRD32 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ANKRD32 OriGene 3'-UTR Clone for ANKRD32 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD32 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD32 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ANKRD32 OriGene Custom Protein Services for ANKRD32 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANKRD32 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ANKRD32 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ANKRD32 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ANKRD32 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ANKRD32 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ANKRD32
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ANKRD32 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD32
ThermoFisher Antibodies for ANKRD32
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANKRD32
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