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Aliases for ANKRD31 Gene

Aliases for ANKRD31 Gene

  • Ankyrin Repeat Domain 31 2 3 5

External Ids for ANKRD31 Gene

Previous GeneCards Identifiers for ANKRD31 Gene

  • GC05M074460
  • GC05M074399
  • GC05M074477
  • GC05M074364
  • GC05M069568

Summaries for ANKRD31 Gene

GeneCards Summary for ANKRD31 Gene

ANKRD31 (Ankyrin Repeat Domain 31) is a Protein Coding gene. An important paralog of this gene is BCOR.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD31 Gene

Genomics for ANKRD31 Gene

Regulatory Elements for ANKRD31 Gene

Enhancers for ANKRD31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F075057 1.3 FANTOM5 Ensembl ENCODE 16.5 +177.5 177471 4.6 PKNOX1 FEZF1 REST ZNF843 ATF2 ZNF664 GATA3 POLR2A MYNN PBX2 GCNT4 ANKRD31 ANKDD1B FAM169A LINC01336 PIR55798
GH05F074953 1.2 Ensembl ENCODE 10.8 +280.4 280368 6.1 PKNOX1 ARID4B ZNF48 SLC30A9 FOS MIER2 REST PPARG KAT8 MIER3 GCNT4 ANKRD31 LOC105379040 GC05M074981
GH05F074947 1.1 Ensembl ENCODE 11.4 +287.7 287716 4.3 ELF3 RARA CREM MIXL1 PPARG KAT8 SREBF1 CEBPA DRAP1 SOX13 ANKRD31 GCNT4 POC5 LOC105379040 GC05M074981
GH05F075049 1 ENCODE 12.1 +183.4 183413 7.1 ARID4B ZNF48 ZNF2 GLIS2 DEK SP3 MIER2 REST KAT8 MIER3 GCNT4 ANKRD31 LINC01336 PIR55798
GH05F074934 1 Ensembl ENCODE 10.9 +301.6 301555 1.3 CTCF JUN CEBPG RAD21 YY1 ZNF316 FOS MAFK MIXL1 GATAD2A GCNT4 ANKRD31 RNU6-1330P RPL39P21 LOC105379040
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD31 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001283059 -113 1600 ATF1 CREB3L1 MLX WRNIP1 ARID4B SIN3A ZNF48 ZNF2 YY1 GLIS2

Genomic Location for ANKRD31 Gene

Chromosome:
5
Start:
75,068,275 bp from pter
End:
75,236,887 bp from pter
Size:
168,613 bases
Orientation:
Minus strand

Genomic View for ANKRD31 Gene

Genes around ANKRD31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD31 Gene

Proteins for ANKRD31 Gene

  • Protein details for ANKRD31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7Z5-ANR31_HUMAN
    Recommended name:
    Putative ankyrin repeat domain-containing protein 31
    Protein Accession:
    Q8N7Z5

    Protein attributes for ANKRD31 Gene

    Size:
    1873 amino acids
    Molecular mass:
    210816 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD31 Gene

Post-translational modifications for ANKRD31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD31 Gene

Domains & Families for ANKRD31 Gene

Gene Families for ANKRD31 Gene

Protein Domains for ANKRD31 Gene

Suggested Antigen Peptide Sequences for ANKRD31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7Z5

UniProtKB/Swiss-Prot:

ANR31_HUMAN :
  • Contains 6 ANK repeats.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with ANKRD31: view

Function for ANKRD31 Gene

genes like me logo Genes that share phenotypes with ANKRD31: view

Animal Model Products

miRNA for ANKRD31 Gene

miRTarBase miRNAs that target ANKRD31

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD31 Gene

Localization for ANKRD31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD31 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD31 Gene

Pathways & Interactions for ANKRD31 Gene

SuperPathways for ANKRD31 Gene

No Data Available

Interacting Proteins for ANKRD31 Gene

Gene Ontology (GO) - Biological Process for ANKRD31 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD31 Gene

Transcripts for ANKRD31 Gene

mRNA/cDNA for ANKRD31 Gene

(12) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD31 Gene

Ankyrin repeat domain 31:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD31 Gene

No ASD Table

Relevant External Links for ANKRD31 Gene

GeneLoc Exon Structure for
ANKRD31
ECgene alternative splicing isoforms for
ANKRD31

Expression for ANKRD31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD31 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD31 Gene

This gene is overexpressed in Testis (x19.9).

Protein differential expression in normal tissues from HIPED for ANKRD31 Gene

This gene is overexpressed in Platelet (30.2), Gallbladder (16.9), Blymphocyte (14.2), and Kidney (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD31 Gene



Protein tissue co-expression partners for ANKRD31 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD31 Gene:

ANKRD31

SOURCE GeneReport for Unigene cluster for ANKRD31 Gene:

Hs.482533
genes like me logo Genes that share expression patterns with ANKRD31: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ANKRD31 Gene

Orthologs for ANKRD31 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANKRD31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD31 34 35
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia ANKRD31 34 35
  • 82.49 (n)
cow
(Bos Taurus)
Mammalia ANKRD31 34 35
  • 80.59 (n)
mouse
(Mus musculus)
Mammalia Ankrd31 34 16
  • 73.1 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD31 35
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD31 35
  • 22 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD31 35
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD31 35
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ankrd31 35
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOS4 35
  • 12 (a)
OneToMany
Species where no ortholog for ANKRD31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD31 Gene

ENSEMBL:
Gene Tree for ANKRD31 (if available)
TreeFam:
Gene Tree for ANKRD31 (if available)

Paralogs for ANKRD31 Gene

Paralogs for ANKRD31 Gene

(4) SIMAP similar genes for ANKRD31 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ANKRD31: view

Variants for ANKRD31 Gene

Sequence variations from dbSNP and Humsavar for ANKRD31 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs567553089 Likely benign 75,195,905(+) CTTTA(C/T)GATCA intron-variant, upstream-variant-2KB, reference, missense
rs10025741 -- 75,133,765(+) tggaa(A/C/G)taaag intron-variant
rs10025843 -- 75,133,883(+) actac(A/C/G/T)tggaa intron-variant
rs10028077 -- 75,134,151(+) gcaag(A/G)aataa intron-variant
rs10028145 -- 75,134,052(+) cccac(A/C)agaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD31 Gene

Variant ID Type Subtype PubMed ID
nsv509073 CNV insertion 20534489
nsv4880 CNV insertion 18451855
nsv4879 CNV insertion 18451855
nsv327808 CNV deletion 16902084
esv3605442 CNV loss 21293372
esv2759350 CNV loss 17122850

Variation tolerance for ANKRD31 Gene

Gene Damage Index Score: 10.83; 91.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD31 Gene

Disorders for ANKRD31 Gene

Relevant External Links for ANKRD31

Genetic Association Database (GAD)
ANKRD31
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD31

No disorders were found for ANKRD31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD31 Gene

Publications for ANKRD31 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). (PMID: 22952603) Hart A.B. … Palmer A.A. (PLoS ONE 2012) 3 64
  3. Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13. (PMID: 18802019) Burkhardt R. … Breslow J.L. (Arterioscler. Thromb. Vasc. Biol. 2008) 46 64
  4. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 46 64
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 64

Products for ANKRD31 Gene

Sources for ANKRD31 Gene

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