V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

ANKRD30A Gene

protein-coding GIFtS: 47

GC10P037454

ankyrin repeat domain 30A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
NY-BR-1 ^¹, ²
OTTHUMP00000019457 ^²

Descriptions
Serologically defined breast cancer antigen NY-BR-1 ^³
ankyrin repeat domain 30A ^²
breast cancer antigen NY-BR-1 ^²

External Ids
HGNC: 17234¹
Entrez Gene: 91074²
UniProtKB: Q9BXX3³
Ensembl: ENSG00000148513⁷

Search outside databases for aliases for ANKRD30A gene

Previous GC identifer: GC10P037419

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ANKRD30A gene

Entrez Gene cytogenetic band: 10p11.21 Ensembl cytogenetic band: 10p11.21 HGNC cytogenetic band: 10p11.21

ANKRD30A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P037454: (about GC identifiers)

Start:	37,454,791 bp from pter
End:	37,561,501 bp from pter
Size:	106,711 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_008705.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AN30A_HUMAN, Q9BXX3 (See protein sequence)

Recommended Name: Ankyrin repeat domain-containing protein 30A

Size: 1397 amino acids; 158835 Da

Secondary accessions: Q5W025

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_443723.2

ENSEMBL proteins:

ENSP00000363792 ENSP00000277669 ENSP00000354432

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NY-BR-1)
	Human Recombinant Proteins from Abnova (ANKRD30A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	11280766
GO:0005737	cytoplasm	IDA	18029348

About this table

Antibodies for ANKRD30A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ANKRD30A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (NY-BR-1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ANKRD30A

Assays for ANKRD30A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9BXX3

ProtoNet protein and cluster: Q9BXX3

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: AN30A_HUMAN, Q9BXX3

Similarity: Contains 6 ANK repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ANKRD30A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ANKRD30A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_052997

Applied Biosystems Silencer® siRNAs for ANKRD30A

Sigma-Aldrich siRNA for ANKRD30A

Sigma-Aldrich shRNA for ANKRD30A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_052997
Myc/DDK tagged cDNA clone in CMV expression vector: NM_052997
untagged cDNA clone in CMV expression vector: NM_052997

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_052997

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	NAS	11280766
GO:0005515	protein binding	NAS	11280766

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for ANKRD30A (ENSP00000363792³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ESR1	ENSP00000206249³	STRING (score=.866)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	NAS	11280766

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ANKRD30A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ANKRD30A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ANKRD30A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_052997

Sigma-Aldrich siRNA for ANKRD30A

Sigma-Aldrich shRNA for ANKRD30A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_052997

REFSEQ mRNAs for ANKRD30A gene:

NM_052997.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_052997

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_052997
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_052997
                                 untagged cDNA clone in CMV expression vector: NM_052997

Additional cDNA sequence: AF269087.1

5 DOTS entries:

DT.99948140 DT.75197678 DT.121234778 DT.121234781 DT.91744003

4 AceView cDNA sequences:

BF746340 BF746270 AI951118 BF328582

highest scoring ESTs for ANKRD30A:

AW170035 BX282243 NM_052997 AI951118 AW373574 BE061918 BF171216 BF328582 BF746270 BF746340

Unigene Cluster for ANKRD30A:

Ankyrin repeat domain 30A

Hs.373787 [show with all ESTs]

Unigene Representative Sequence: AF269087

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000374660 ENST00000277669 ENST00000361713

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ANKRD30A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ANKRD30A

¹ / ² / ³

2 probe-sets matching ANKRD30A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
223864_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF269087	0.60	0.78	0.69	1
223864_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATTTCTTCCT

SOURCE GeneReport for Unigene cluster: Hs.373787
UniProtKB/Swiss-Prot: AN30A_HUMAN, Q9BXX3
Tissue specificity: Mainly expressed in breast and testis. A very faint signal is detected in
placenta. Also expressed in many breast cancer cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ANKRD30A gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ANKRD30A¹	--	ankyrin repeat domain 30A	98.31(n) 96.19(a)	466043 XM_001143833.1 XP_001143833.1

About this table Species with no ortholog for ANKRD30A

ENSEMBL Gene Tree for ANKRD30A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ANKRD30A gene

ENSG00000215398² ENSG00000215409² NCRNA00164² ANKRD7² ENSG00000215512² ANKRD30B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/670 NCBI SNPs in ANKRD30A are shown (see all 670 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 37)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs1209750^1,2	A,C,F,H,O	37528695(+)	`AAGAAG/CGTTGA`	1	N/K	mis¹		12		EA NA EU WA	1054
--	rs1200875^1,2	C,F,H	37545198(-)	`TGTACG/ATTGTT`	1	C/R	mis¹ ese³		12		EU EA WA	1252
--	rs16937417^1,2	C,F,H	37487451(+)	`AGGCTA/GCCTGC`	1	T/A	mis¹		11		NA EU EA WA	978
--	rs1200876^1,2	F,H	37545147(-)	`ATGAAC/TTGTAT`	1	V/I	mis¹		3		EA WA	268
--	rs7908887^1,2	A,C	37453145(+)	`aaaaaA/Gaaaaa`	1	--	ng5¹ trp³		0	--	--	--	--
--	rs2944452^1,2	A,C	37453409(+)	`cgcccC/Ttgcac`	1	--	ng5¹		0	--	--	--	--
--	rs11011073^1,2	A	37561588(+)	`TGGTtA/Ttatat`	1	--	ng3¹		0	--	--	--	--
--	rs34042320^1,2	C	37461205(+)	`CATAAC/TGAAAA`	1	T/M	mis¹		0	--	--	--	--
--	rs11011045^1,2	H	37454439(+)	`CCTCAG/ACGGCA`	1	--	ng5¹		4		EU EA WA	418
--	rs12766884^1,2	H	37491592(+)	`TCCGGG/AGAAGC`	1	E/G	mis¹ ese³		4		EU EA WA	406

About this table

HapMap Linkage Disequilibrium images for ANKRD30A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 610856

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/14 PubMed articles for ANKRD30A gene (see all 14 ):

Identification of a tissue-specific putative transcription factor in breast tissue by serological screening of a breast cancer library. (PubMed id 11280766)^{2, 3, 4} Jaeger D.... Chen Y.-T. (2001)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
Distinct expression patterns of the immunogenic differentiation antigen NY-BR-1 in normal breast, testis and their malignant counterparts. (PubMed id 18041742)³ Theurillat J.P....Moch H. (2008)
A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)³ Melzer D....Ferrucci L. (2008)
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. (PubMed id 19043545)³ Gieger C....Suhre K. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)³ Barbe L....Andersson-Svahn H. (2008)
Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)³ Yang Q....O'Donnell C.J. (2007)
NY-BR-1 is a differentiation antigen of the mammary gland. (PubMed id 17536312)³ Jager D....Jungbluth A.A. (2007)
The differentiation antigen NY-BR-1 is a potential target for antibody-based therapies in breast cancer. (PubMed id 17330232)³ Seil I....Jager D. (2007)
Preferential nuclear and cytoplasmic NY-BR-1 protein expression in primary breast cancer and lymph node metastases. (PubMed id 16675566)³ Varga Z....Moch H. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 91074	HGNC: 17234	AceView: ANKRD30A	Ensembl:ENSG00000148513	euGenes: HUgn91074
ECgene: ANKRD30A	H-InvDB: ANKRD30A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ANKRD30A	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ANKRD30A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ANKRD30A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ANKRD30A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ANKRD30A		Antibodies for ANKRD30A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ANKRD30A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ANKRD30A)
	Search for Antibodies
	Chimera RNAi (ANKRD30A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (NY-BR-1)
	Antibodies (NY-BR-1)

Search OriGene for ANKRD30A

Search Tocris compounds for ANKRD30A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ANKRD30A

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ANKRD30A Gene at Home site.
Version 2.41.1
server5.xennexinc.com

ANKRD30A Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for ANKRD30A

Summaries
for ANKRD30A

Genomic Location
for ANKRD30A

Proteins
for ANKRD30A

Protein Domains/
Families
for ANKRD30A

Gene Function
for ANKRD30A

Pathways & Interactions
for ANKRD30A

Drugs & Compounds
for ANKRD30A

Transcripts
for ANKRD30A

Expression
for ANKRD30A

Orthologs
for ANKRD30A

Paralogs
for ANKRD30A

SNPs/Variants
for ANKRD30A

Disorders & Mutations
for ANKRD30A

Medical News
for ANKRD30A

Publications
for ANKRD30A

Search for ANKRD30A

Genome Databases showing ANKRD30A

Other Databases showing ANKRD30A

Specialized Databases showing ANKRD30A

Licensable Technologies
for ANKRD30A

Services
for ANKRD30A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ANKRD30A Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor ANKRD30A

Summariesfor ANKRD30A

Genomic Locationfor ANKRD30A

Proteinsfor ANKRD30A

Protein Domains/Familiesfor ANKRD30A

Gene Functionfor ANKRD30A

Pathways & Interactionsfor ANKRD30A

Drugs & Compoundsfor ANKRD30A

Transcriptsfor ANKRD30A

Expression for ANKRD30A

Orthologsfor ANKRD30A

Paralogsfor ANKRD30A

SNPs/Variantsfor ANKRD30A

Disorders & Mutationsfor ANKRD30A

Medical Newsfor ANKRD30A

Publicationsfor ANKRD30A

Search for ANKRD30A

Genome Databases showing ANKRD30A

Other Databases showing ANKRD30A

Specialized Databases showing ANKRD30A

Licensable Technologiesfor ANKRD30A

Servicesfor ANKRD30A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ANKRD30A

Summaries
for ANKRD30A

Genomic Location
for ANKRD30A

Proteins
for ANKRD30A

Protein Domains/
Families
for ANKRD30A

Gene Function
for ANKRD30A

Pathways & Interactions
for ANKRD30A

Drugs & Compounds
for ANKRD30A

Transcripts
for ANKRD30A

Expression
for ANKRD30A

Orthologs
for ANKRD30A

Paralogs
for ANKRD30A

SNPs/Variants
for ANKRD30A

Disorders & Mutations
for ANKRD30A

Medical News
for ANKRD30A

Publications
for ANKRD30A

Licensable Technologies
for ANKRD30A

Services
for ANKRD30A