ANKRD30A Gene
protein-coding GIFtS: 48
GCID: GC10P037414
|
|
ankyrin repeat domain 30A
| |
Aliases
for ANKRD30A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat Domain 30A1 2 | | NY-BR-11 2 | | Serologically Defined Breast Cancer Antigen NY-BR-12 3 | | Ankyrin Repeat Domain-Containing Protein 30A2 | | Breast Cancer Antigen NY-BR-12 |
Export aliases for ANKRD30A gene to outside databasesPrevious GC identifers: GC10P037419 GC10P037454 GC10P037134 |
Summaries
for ANKRD30A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ANKRD30A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKRD30A gene promoter:
Sox5 Pbx1a Pax-6 Nkx2-2 FOXD1 HNF-1A POU2F1 COMP1 POU2F1a HNF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKRD30A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD30A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p11.21 Ensembl cytogenetic band: 10p11.21 HGNC cytogenetic band: 10p11.21ANKRD30A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P037414: view genomic region
(about GC identifiers)
Start:
|
37,414,785 bp from pter |
End:
|
37,521,495 bp from pter |
Size:
|
106,711 bases |
Orientation:
|
plus strand |
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Proteins
for ANKRD30A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AN30A_HUMAN, Q9BXX3 (See
protein sequence)Recommended Name: Ankyrin repeat domain-containing protein 30A Size: 1397 amino acids; 158835 Da
Caution: It is uncertain whether Met-1 or Met-57 is the initiator
Sequence caution: Sequence=AAK27325.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAH71320.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI16567.1;Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5W025Explore the universe of human proteins at neXtProt for ANKRD30A: NX_Q9BXX3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXX3
ANKRD30A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_443723.2
ENSEMBL proteins: ENSP00000354432 ENSP00000363792
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
ANKRD30A for ontologies About GeneDecksing
ANKRD30A Antibody Products:
Assay Products for ANKRD30A: |
Protein
Domains /
Families
for ANKRD30A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKRD30A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BXX3ProtoNet protein and cluster: Q9BXX3 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: AN30A_HUMAN, Q9BXX3Similarity: Contains 6 ANK repeats |
Function
for ANKRD30A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD30A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD30A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD30A |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ANKRD30A for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for ANKRD30A:
|
Pathways & Interactions
for ANKRD30A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD30A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ANKRD30A (ENSP000003544324) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
NAS | 11280766 |
ANKRD30A for ontologies About GeneDecksing
|
Drugs & Compounds
for ANKRD30A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKRD30A
Search CenterWatch for drugs/clinical trials and news about ANKRD30A / AN30A
|
Transcripts
for ANKRD30A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKRD30A gene: NM_052997.2 Unigene Cluster for ANKRD30A: Ankyrin repeat domain 30A Hs.373787 [show with all ESTs]Unigene Representative Sequence: AF2690873 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361713(uc021ppc.1) ENST00000374660(uc001iza.1) ENST00000475522
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD30A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD30A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANKRD30A (NM_052997) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD30A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD30A |
Additional cDNA sequence: AF269087.1 5 DOTS entries: DT.99948140 DT.75197678 DT.121234778 DT.121234781 DT.91744003 4 AceView cDNA sequences: BF746340 BF746270 AI951118 BF328582
GeneLoc Exon Structure
|
Expression
for ANKRD30A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKRD30A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTCTTCCT
About this image
See ANKRD30A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD30A
SOURCE GeneReport for Unigene cluster: Hs.373787
UniProtKB/Swiss-Prot: AN30A_HUMAN, Q9BXX3Tissue specificity: Mainly expressed in breast and testis. A very faint signal is detected in placenta. Also expressedin many breast cancer cells
SABiosciences Custom PCR Arrays for ANKRD30A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD30A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ANKRD30A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD30A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD30A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD30A |
Orthologs
for ANKRD30A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ANKRD30A gene from 3/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ANKRD626 |
Uncharacterized protein |
22(a) |
1 → many |
1(26091172-26138404) |
lizard
(Anolis carolinensis) |
Reptilia |
ANKRD626 |
-- |
30(a) |
1 → many |
GL344195.1(39104-48393) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-272n13.36 |
si:ch211-272n13.3 |
10(a) |
1 → many |
25(3581527-3655709) |
ENSEMBL Gene Tree for ANKRD30A (if available)
TreeFam Gene Tree for ANKRD30A (if available) |
Paralogs
for ANKRD30A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKRD30A gene
- POTEF2 POTEI2 ANKRD362 ANKRD72 POTEB2 ANKRD30BL2 ANKRD20A32 POTEH2
- ENSG000001552822 ANKRD30B2 ENSG000002663022 ANKRD36C2 POTEJ2 POTEC2 ANKRD20A22 POTEG2
- ANKRD262 ANKRD622 ANKRD18A2 ENSG000001882192 POTEM2 ANKRD20A12 LOC1009963312 CCDC144A2
- POTED2 ANKRD20A42 ANKRD18B2 LOC1002889662
7 SIMAP similar genes for ANKRD30A using alignment to 2 protein entries: AN30A_HUMAN (see all proteins):PRED4 ANKRD19P ANKRD36BP1 ANKRD30BL DKFZp781D1722 ANKRD30B
POTEA
ANKRD30A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ANKRD30A
PGOHUM00000238762
|
Genomic Variants
for ANKRD30A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKRD30A (37414785 - 37521495 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 19 variations for ANKRD30A
15/17 CNVs (see all 17): 59623 85190 34874 58446 75175 30478 30479 85189 85187 70956 31715 85191 34875 70955 85192
1 Indel: 33218
1 Inversion: 37108 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD30A |
|
Disorders
/ Diseases
for ANKRD30A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ANKRD30A for disorders About GeneDecksing
OMIM gene information: 610856
OMIM disorders: --
4  diseases for ANKRD30A: About MalaCardsbreast cancer fainting gout alzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: ANKRD30A (2 documents)
Export disorders for ANKRD30A gene to outside databases
|
Publications
for ANKRD30A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKRD30A gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with ANKRD30A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a tissue-specific putative transcription factor in breast tissue by serological screening of a breast cancer library. (PubMed id 11280766)1, 2, 3 Jaeger D.... Chen Y.-T. (2001)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Distinct expression patterns of the immunogenic differentiation antigen NY-BR-1 in normal breast, testis and their malignant counterparts. (PubMed id 18041742)1 Theurillat J.P....Moch H. (2008)
- A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1 Melzer D....Ferrucci L. (2008)
- Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. (PubMed id 19043545)1 Gieger C....Suhre K. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)1 Yang Q....O'Donnell C.J. (2007)
- NY-BR-1 is a differentiation antigen of the mammary gland. (PubMed id 17536312)1 Jager D....Jungbluth A.A. (2007)
- The differentiation antigen NY-BR-1 is a potential target for antibody-based therapies in breast cancer. (PubMed id 17330232)1 Seil I....Jager D. (2007)
|
External Searches for ANKRD30A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANKRD30A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKRD30A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANKRD30A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ANKRD30A gene:
Search GeneIP for patents involving ANKRD30A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKRD30A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ANKRD30A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD30A |
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