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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANKRD29 Gene

protein-coding GIFtS: 45
GCID: GC18M021178

ankyrin repeat domain 29

Explore 1 disease affiliated with
ANKRD29 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ankyrin Repeat Domain 29¹ ²
FLJ25053¹
Ankyrin Repeat Domain-Containing Protein 29²

External Ids:	HGNC: 27110¹	Entrez Gene: 147463²	Ensembl: ENSG00000154065⁷	UniProtKB: Q8N6D5³

Export aliases for ANKRD29 gene to outside databases

Previous GC identifers: GC18M019432 GC18M019434 GC18M018035

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_010966.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANKRD29 gene promoter:
Max1 USF1 AP-1 Olf-1 E4BP4 HNF-1A Evi-1 USF-1 HNF-1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANKRD29 promoter sequence

Search SABiosciences Chromatin IP Primers for ANKRD29

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD29

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q11.2 Ensembl cytogenetic band: 18q11.2 HGNC cytogenetic band: 18q11.2

ANKRD29 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD29 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M021178: view genomic region (about GC identifiers)

Start:	21,178,890 bp from pter	End:	21,242,849 bp from pter
Size:	63,960 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANR29_HUMAN, Q8N6D5 (See protein sequence)

Recommended Name: Ankyrin repeat domain-containing protein 29

Size: 301 amino acids; 32442 Da

Sequence caution: Sequence=BAC85555.1; Type=Miscellaneous discrepancy; Note=Intron retention;

Secondary accessions: B2R972 Q6ZWE8 Q96LU9

Alternative splicing: 2 isoforms: Q8N6D5-1 Q8N6D5-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD29: NX_Q8N6D5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N6D5

ANKRD29 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_775776.2

ENSEMBL proteins:

ENSP00000468354 ENSP00000323387 ENSP00000467890 ENSP00000465936 ENSP00000284207

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANKRD29 for domains About GeneDecksing

2 InterPro domains/families:

IPR020683 Ankyrin_rpt-contain_dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q8N6D5

ProtoNet protein and cluster: Q8N6D5

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: ANR29_HUMAN, Q8N6D5

Similarity: Contains 8 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD29

1 GenomeRNAi human phenotype for ANKRD29:

Increased G1 DNA content

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ANKRD29

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ANKRD29
Search CenterWatch for drugs/clinical trials and news about ANKRD29 / ANR29

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ANKRD29 gene:

NM_173505.2

Unigene Cluster for ANKRD29:

Ankyrin repeat domain 29

Hs.374774 [show with all ESTs]

Unigene Representative Sequence: NM_173505

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000592179 ENST00000591280 ENST00000322980(uc002kun.3 uc002kuo.3)

ENST00000587763 ENST00000591617 ENST00000586511 ENST00000586087 ENST00000585908

ENST00000284207

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		hsa-miR-142-5p hsa-miR-125a-5p hsa-miR-106a hsa-miR-340 hsa-miR-519a hsa-miR-132 hsa-miR-125b hsa-miR-93

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Additional cDNA sequence:

AK057782.1 AK313667.1 BC030622.1

7 DOTS entries:

DT.210085 DT.432603 DT.97784272 DT.100747956 DT.75125454 DT.92416210 DT.121083574

24/37 AceView cDNA sequences (see all 37):

Z38147 BM724880 AI287808 F10426 BM718056 CB120510 F06195 BM680506

BM703831 AK057782 BC030622 AI004988 AI439791 BM680115 NM_173505 AK123197

AI307802 AA680307 BG542870 BI666662 BF447329 BM972741 C04161 BG547193

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD29 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	^	8	^	9	^	10	^	11	^	12a	·	12b	·	12c	·	12d	·	12e	·	12f	·
SP1:									-		-										-		-		-						-		-						-
SP2:									-		-										-		-		-						-		-				-		-
SP3:															-						-		-		-						-		-						-
SP4:																																	-						-
SP5:																																	-				-		-

ExUns:	12g
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ANKRD29

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANKRD29 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ANKRD29 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ANKRD29 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD29

SOURCE GeneReport for Unigene cluster: Hs.374774

SABiosciences Custom PCR Arrays for ANKRD29

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANKRD29 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ANKRD29¹	ankyrin repeat domain 29	78.86(n) 89.26(a)		428523 XM_426077.3 XP_426077.3
lizard (Anolis carolinensis)	Reptilia	ANKRD29⁶	--	84(a)	1 ↔ 1	4(38174825-38194510)
African clawed frog (Xenopus laevis)	Amphibia	BJ030853.1²	--	72.62(n)		BJ030853.1
zebrafish (Danio rerio)	Actinopterygii	ankrd29¹	ankyrin repeat domain 29	68.16(n) 74.83(a)		553798 NM_001020760.1 NP_001018596.1
fruit fly (Drosophila melanogaster)	Insecta	CG3104¹	CG3104	54.2(n) 49.26(a)		33486 NM_134880.1 NP_608724.1
rice (Oryza sativa)	Liliopsida	--	ankyrin homolog precursor, putative, expressed	12(a)	1 ↔ 1	1(35479000-35481147)

ENSEMBL Gene Tree for ANKRD29 (if available)
TreeFam Gene Tree for ANKRD29 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANKRD29 gene

FEM1B² FEM1A² KIDINS220² FEM1C²

18/30 SIMAP similar genes for ANKRD29 using alignment to 4 protein entries: ANR29_HUMAN (see all proteins) (see all similar genes):

KIDINS220 FEM1B ANKRD17 PPP1R12A ASB3 CDKN2C

GABPB1 ANKRD50 DKFZp761E1322 MTPN RAI14 ANK1

ANK3 IkBa ANKDD1A ANKHD1 ANKK1 ANKRD44

ANKRD29 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs61517023^1,2	C,F,	--	21179547(+)	`TTGTAC/AAAATT`	1	--	int¹		3		WA CSA	122
rs186423463^1,2		--	21179615(+)	`TATATC/TTGGAT`	1	--	int¹		0	--	--	--	--
rs190923112^1,2		--	21179722(+)	`GAGTTG/TCTCAT`	1	--	int¹		0	--	--	--	--
rs182715480^1,2		--	21180136(+)	`TTCAAC/TAAACC`	1	--	ut3¹		0	--	--	--	--
rs8091017^1,2	C,F,H,	--	21180229(+)	`TTTATA/GTTCCT`	1	--	ut3¹		4		NS EA	418
rs138407991^1,2		--	21180356(+)	`ATACTC/TACTTA`	1	--	ut3¹		0	--	--	--	--
rs1652364^1,2	C,F,H,	--	21180363(+)	`CTTATG/AGAATA`	1	--	ut3¹ ese³		24		MN NA NS EA WA CSA	1670
rs188452682^1,2		--	21180434(+)	`TCTCGC/TGGTTT`	1	--	ut3¹		0	--	--	--	--
rs191275646^1,2		--	21180440(+)	`GGTTTA/GTAAGT`	1	--	ut3¹		0	--	--	--	--
rs7239909^1,2	C,F,A,H,	--	21180472(+)	`ACTGGT/CATTTT`	1	--	ut3¹ ese³		8		NS EA NA WA	678

HapMap Linkage Disequilibrium report for ANKRD29 (21178890 - 21242849 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ANKRD29
1 CNV: 47911

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD29

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ANKRD29 for disorders About GeneDecksing

1 disease for ANKRD29: About MalaCards

neuronitis

Human Genome Epidemiology (HuGE) Navigator: ANKRD29 (1 document)

Export disorders for ANKRD29 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ANKRD29 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANKRD29)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)² Nusbaum C.... Lander E.S. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 147463	HGNC: 27110	AceView: ANKRD29	Ensembl:ENSG00000154065	euGenes: HUgn147463
ECgene: ANKRD29	H-InvDB: ANKRD29

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANKRD29	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANKRD29 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ANKRD29 gene:
Search GeneIP for patents involving ANKRD29

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Hot genes Disease genes ANKRD29 gene at Home site.

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ANKRD29 Gene

ankyrin repeat domain 29

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ANKRD29 Gene

ankyrin repeat domain 29

Aliasesfor ANKRD29 gene

Summariesfor ANKRD29 gene

Genomic Viewsfor ANKRD29 gene

Proteinsfor ANKRD29 gene

Protein Domains /Familiesfor ANKRD29 gene

Functionfor ANKRD29 gene

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for ANKRD29 gene

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for ANKRD29 gene

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for ANKRD29 gene

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for ANKRD29 gene

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for ANKRD29 gene

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for ANKRD29 gene

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for ANKRD29 gene

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for ANKRD29 gene

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for ANKRD29 gene

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