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Aliases for ANKRD28 Gene

Aliases for ANKRD28 Gene

  • Ankyrin Repeat Domain 28 2 3 5
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit ARS-A 3 4
  • Phosphatase Interactor Targeting Protein HnRNP K 3 4
  • Protein Phosphatase 6 Ankyrin Repeat Subunit A 2 3
  • Protein Phosphatase 1, Regulatory Subunit 65 2 3
  • Ankyrin Repeat Domain-Containing Protein 28 3 4
  • Phosphatase Interactor Targeting K Protein 2 3
  • PP6-ARS-A 3 4
  • PITK 3 4
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Ankyrin Repeat Subunit A 3
  • KIAA0379 4
  • PPP1R65 3

External Ids for ANKRD28 Gene

Previous GeneCards Identifiers for ANKRD28 Gene

  • GC03M015684
  • GC03M015700
  • GC03M015643

Summaries for ANKRD28 Gene

GeneCards Summary for ANKRD28 Gene

ANKRD28 (Ankyrin Repeat Domain 28) is a Protein Coding gene. Diseases associated with ANKRD28 include Urethra Adenocarcinoma and Urethra Clear Cell Adenocarcinoma. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. An important paralog of this gene is ANKRD44.

UniProtKB/Swiss-Prot for ANKRD28 Gene

  • Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.

Additional gene information for ANKRD28 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD28 Gene

Genomics for ANKRD28 Gene

Regulatory Elements for ANKRD28 Gene

Enhancers for ANKRD28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H015792 2 FANTOM5 Ensembl ENCODE dbSUPER 15.4 +62.1 62125 9 HDGF PKNOX1 FOXA2 ATF1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF121 ANKRD28 IMPDH1P8 EAF1 EAF1-AS1 METTL6 BTD DPH3 COLQ SH3BP5 GC03M015809
GH03H015803 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.9 +54.3 54266 3 HDGF PKNOX1 ATF1 YBX1 TCF12 GATA2 ELK1 ZNF207 FOS ATF7 EAF1 SH3BP5 IMPDH1P8 ANKRD28 HACL1 DPH3 COLQ EAF1-AS1 GC03M015809 LOC101927647
GH03H015767 1.5 Ensembl ENCODE dbSUPER 8 +90.7 90716 3 FOXA2 ATF1 SIN3A YY1 ATF7 FOS RUNX3 DEK JUNB ZNF518A IMPDH1P8 ANKRD28 HACL1 EAF1-AS1 METTL6 LOC101927647 GC03M015809
GH03H016298 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -442.4 -442426 8 FOXA2 PKNOX1 ARNT YY1 TCF12 GATA2 FOS ATF7 RUNX3 NCOA1 DPH3 ENSG00000271964 OXNAD1 RFTN1 ANKRD28 PIR49727 THAP5P2
GH03H015644 1.4 Ensembl ENCODE dbSUPER 7.3 +212.5 212543 5 TBP PKNOX1 TBL1XR1 NFIB SIN3A BMI1 BATF SCRT2 FOS ATF7 CAPN7 COL6A4P1 EAF1 COLQ ANKRD28 BTD HACL1 IMPDH1P8 PIR61991
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD28 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000149116 71 2601 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF416 FOS SP3

Genomic Location for ANKRD28 Gene

Chromosome:
3
Start:
15,667,236 bp from pter
End:
15,859,771 bp from pter
Size:
192,536 bases
Orientation:
Minus strand

Genomic View for ANKRD28 Gene

Genes around ANKRD28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD28 Gene

Proteins for ANKRD28 Gene

  • Protein details for ANKRD28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15084-ANR28_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
    Protein Accession:
    O15084
    Secondary Accessions:
    • B4DES5
    • Q1WWL4
    • Q29RW6
    • Q3B857
    • Q6ULS0
    • Q6ZT57

    Protein attributes for ANKRD28 Gene

    Size:
    1053 amino acids
    Molecular mass:
    112966 Da
    Quaternary structure:
    • Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, PPP6R1 and PPP6R3.
    SequenceCaution:
    • Sequence=AAQ72374.1; Type=Frameshift; Positions=408; Evidence={ECO:0000305}; Sequence=BAA20833.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC86737.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD28 Gene

Post-translational modifications for ANKRD28 Gene

  • Ubiquitination at Lys106
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANKRD28 Gene

Domains & Families for ANKRD28 Gene

Protein Domains for ANKRD28 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD28: view

No data available for UniProtKB/Swiss-Prot for ANKRD28 Gene

Function for ANKRD28 Gene

Molecular function for ANKRD28 Gene

UniProtKB/Swiss-Prot Function:
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.

Phenotypes From GWAS Catalog for ANKRD28 Gene

Gene Ontology (GO) - Molecular Function for ANKRD28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18186651
genes like me logo Genes that share ontologies with ANKRD28: view

Phenotypes for ANKRD28 Gene

genes like me logo Genes that share phenotypes with ANKRD28: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD28 Gene

Localization for ANKRD28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD28 Gene

Nucleus, nucleoplasm. Note=Seems to be excluded from nucleoli.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD28 gene
Compartment Confidence
cytosol 5
nucleus 4
golgi apparatus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ANKRD28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANKRD28: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANKRD28 Gene

Pathways & Interactions for ANKRD28 Gene

genes like me logo Genes that share pathways with ANKRD28: view

Gene Ontology (GO) - Biological Process for ANKRD28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with ANKRD28: view

No data available for SIGNOR curated interactions for ANKRD28 Gene

Drugs & Compounds for ANKRD28 Gene

No Compound Related Data Available

Transcripts for ANKRD28 Gene

Unigene Clusters for ANKRD28 Gene

Ankyrin repeat domain 28:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD28 Gene

No ASD Table

Relevant External Links for ANKRD28 Gene

GeneLoc Exon Structure for
ANKRD28
ECgene alternative splicing isoforms for
ANKRD28

Expression for ANKRD28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD28 Gene

This gene is overexpressed in Bone (30.2) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANKRD28 Gene



Protein tissue co-expression partners for ANKRD28 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD28 Gene:

ANKRD28

SOURCE GeneReport for Unigene cluster for ANKRD28 Gene:

Hs.335239

Evidence on tissue expression from TISSUES for ANKRD28 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ANKRD28: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD28 Gene

Orthologs for ANKRD28 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD28 34 33
  • 99.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD28 33 34
  • 95.53 (n)
mouse
(Mus musculus)
Mammalia Ankrd28 16 34 33
  • 92.34 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD28 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd28 33
  • 90.95 (n)
cow
(Bos Taurus)
Mammalia ANKRD28 33 34
  • 90.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD28 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD28 33 34
  • 84.76 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD28 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd28 33
  • 80.37 (n)
Str.11443 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11016 33
zebrafish
(Danio rerio)
Actinopterygii ankrd28b 33 34
  • 74.12 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8553 33
fruit fly
(Drosophila melanogaster)
Insecta nompC 34
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToMany
Species where no ortholog for ANKRD28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD28 Gene

ENSEMBL:
Gene Tree for ANKRD28 (if available)
TreeFam:
Gene Tree for ANKRD28 (if available)

Paralogs for ANKRD28 Gene

Paralogs for ANKRD28 Gene

Pseudogenes.org Pseudogenes for ANKRD28 Gene

genes like me logo Genes that share paralogs with ANKRD28: view

Variants for ANKRD28 Gene

Sequence variations from dbSNP and Humsavar for ANKRD28 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000012218 -- 15,683,696(+) AACTT(C/T)GGCAT intron-variant
rs1000029822 -- 15,723,249(+) TCAGG(-/C)AAAGT intron-variant
rs1000030209 -- 15,783,096(+) GTCAT(C/G)AAAAT intron-variant
rs1000051937 -- 15,770,038(+) AACTT(-/AAAAA)AAAAA intron-variant
rs1000055938 -- 15,702,435(+) AGAAA(C/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD28 Gene

Variant ID Type Subtype PubMed ID
dgv794n67 CNV loss 20364138
dgv8236n54 CNV loss 21841781
dgv8237n54 CNV loss 21841781
dgv8238n54 CNV loss 21841781
dgv8239n54 CNV loss 21841781
dgv8240n54 CNV loss 21841781
dgv8241n54 CNV loss 21841781
esv1000221 CNV insertion 20482838
esv1198390 CNV insertion 17803354
esv1552939 CNV insertion 17803354
esv23511 CNV gain 19812545
esv2481540 CNV deletion 19546169
esv2670116 CNV deletion 23128226
esv2724968 CNV deletion 23290073
esv3561518 CNV deletion 23714750
esv3595392 CNV loss 21293372
esv3595393 CNV loss 21293372
esv6914 CNV loss 19470904
nsv1072241 CNV deletion 25765185
nsv460453 CNV loss 19166990
nsv529014 CNV loss 19592680
nsv589781 CNV loss 21841781
nsv589812 CNV loss 21841781
nsv819661 CNV gain 19587683
nsv821318 CNV deletion 20802225

Variation tolerance for ANKRD28 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD28 Gene

Disorders for ANKRD28 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ANKRD28 Gene - From: DISEASES

Disorder Aliases PubMed IDs
urethra adenocarcinoma
  • adenocarcinoma of the urethra
urethra clear cell adenocarcinoma
  • clear cell adenocarcinoma of the urethra
urethral benign neoplasm
  • neoplasm of urethra
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ANKRD28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD28
genes like me logo Genes that share disorders with ANKRD28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKRD28 Gene

Publications for ANKRD28 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 60
  2. Regulation of focal adhesion and cell migration by ANKRD28-DOCK180 interaction. (PMID: 19458477) Kiyokawa E … Matsuda M (Cell adhesion & migration 2009) 2 3 60
  3. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PMID: 18186651) Stefansson B … Brautigan DL (Biochemistry 2008) 3 4 60
  4. PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K. (PMID: 16564677) Kwiek NC … Haystead TA (Cellular signalling 2006) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for ANKRD28 Gene

Sources for ANKRD28 Gene

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