Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANKRD28 Gene

Aliases for ANKRD28 Gene

  • Ankyrin Repeat Domain 28 2 3 5
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit ARS-A 3 4
  • Phosphatase Interactor Targeting Protein HnRNP K 3 4
  • Protein Phosphatase 6 Ankyrin Repeat Subunit A 2 3
  • Protein Phosphatase 1, Regulatory Subunit 65 2 3
  • Ankyrin Repeat Domain-Containing Protein 28 3 4
  • Phosphatase Interactor Targeting K Protein 2 3
  • PP6-ARS-A 3 4
  • PITK 3 4
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Ankyrin Repeat Subunit A 3
  • KIAA0379 4
  • PPP1R65 3

External Ids for ANKRD28 Gene

Previous GeneCards Identifiers for ANKRD28 Gene

  • GC03M015684
  • GC03M015700
  • GC03M015643

Summaries for ANKRD28 Gene

GeneCards Summary for ANKRD28 Gene

ANKRD28 (Ankyrin Repeat Domain 28) is a Protein Coding gene. Diseases associated with ANKRD28 include Urethra Adenocarcinoma and Urethra Clear Cell Adenocarcinoma. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. An important paralog of this gene is ENSG00000283224.

UniProtKB/Swiss-Prot for ANKRD28 Gene

  • Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD28 Gene

Genomics for ANKRD28 Gene

Regulatory Elements for ANKRD28 Gene

Enhancers for ANKRD28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F015501 1.3 FANTOM5 Ensembl 18.5 +358.4 358444 0.3 ZIC2 ZBTB20 ANKRD28 COLQ METTL6 EAF1 RNU6-1024P EAF1-AS1 CAPN7 COL6A4P1 LOC105376964 RN7SL110P
GH03F015792 1.4 FANTOM5 ENCODE 15.4 +62.1 62125 9.6 HDGF PKNOX1 ATF1 ARNT SIN3A FEZF1 ZNF2 ZNF121 CBX5 FOS ANKRD28 IMPDH1P8 MRPS25 EAF1 EAF1-AS1 METTL6 BTD DPH3 COLQ SH3BP5
GH03F015299 1.4 FANTOM5 Ensembl ENCODE 8.4 +559.1 559129 3.3 PKNOX1 INSM2 KLF17 ZBTB40 ZNF121 ZNF366 GATA2 RCOR1 ETV6 FOS SH3BP5 EAF1 EAF1-AS1 RNU6-454P CAPN7 RNU6-1024P COL6A4P1 ANKRD28 COLQ NR2C2
GH03F015817 0.2 Ensembl 8.1 +43.7 43671 0.2 CTCF GATA3 SMC3 ZBTB33 REST RAD21 DPH3 OXNAD1 ANKRD28 IMPDH1P8 GC03M015809
GH03F015780 1 Ensembl ENCODE 8 +77.1 77090 3.9 SMARCE1 ZNF146 RNF2 DPF2 NR3C1 YY1 ARID1B ZNF316 JUND ATF3 IMPDH1P8 ANKRD28 HACL1 EAF1-AS1 GC03M015809 LOC101927647
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ANKRD28 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001358493 -29 3201 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF416 FOS KLF13 SP3 SP5

Genomic Location for ANKRD28 Gene

Chromosome:
3
Start:
15,667,236 bp from pter
End:
15,859,771 bp from pter
Size:
192,536 bases
Orientation:
Minus strand

Genomic View for ANKRD28 Gene

Genes around ANKRD28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD28 Gene

Proteins for ANKRD28 Gene

  • Protein details for ANKRD28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15084-ANR28_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
    Protein Accession:
    O15084
    Secondary Accessions:
    • B4DES5
    • Q1WWL4
    • Q29RW6
    • Q3B857
    • Q6ULS0
    • Q6ZT57

    Protein attributes for ANKRD28 Gene

    Size:
    1053 amino acids
    Molecular mass:
    112966 Da
    Quaternary structure:
    • Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, PPP6R1 and PPP6R3.
    SequenceCaution:
    • Sequence=AAQ72374.1; Type=Frameshift; Positions=408; Evidence={ECO:0000305}; Sequence=BAA20833.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC86737.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD28 Gene

Post-translational modifications for ANKRD28 Gene

  • Ubiquitination at Lys 106
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for ANKRD28

No data available for DME Specific Peptides for ANKRD28 Gene

Domains & Families for ANKRD28 Gene

Protein Domains for ANKRD28 Gene

Graphical View of Domain Structure for InterPro Entry

O15084

UniProtKB/Swiss-Prot:

ANR28_HUMAN :
  • Contains 27 ANK repeats.
Similarity:
  • Contains 27 ANK repeats.
genes like me logo Genes that share domains with ANKRD28: view

Function for ANKRD28 Gene

Molecular function for ANKRD28 Gene

UniProtKB/Swiss-Prot Function:
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.

Gene Ontology (GO) - Molecular Function for ANKRD28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18186651
genes like me logo Genes that share ontologies with ANKRD28: view

Phenotypes for ANKRD28 Gene

genes like me logo Genes that share phenotypes with ANKRD28: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD28 Gene

Localization for ANKRD28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD28 Gene

Nucleus, nucleoplasm. Note=Seems to be excluded from nucleoli.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD28 Gene COMPARTMENTS Subcellular localization image for ANKRD28 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ANKRD28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANKRD28: view

Pathways & Interactions for ANKRD28 Gene

genes like me logo Genes that share pathways with ANKRD28: view

Gene Ontology (GO) - Biological Process for ANKRD28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with ANKRD28: view

No data available for SIGNOR curated interactions for ANKRD28 Gene

Transcripts for ANKRD28 Gene

Unigene Clusters for ANKRD28 Gene

Ankyrin repeat domain 28:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD28 Gene

No ASD Table

Relevant External Links for ANKRD28 Gene

GeneLoc Exon Structure for
ANKRD28
ECgene alternative splicing isoforms for
ANKRD28

Expression for ANKRD28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD28 Gene

This gene is overexpressed in Bone (30.2) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANKRD28 Gene



Protein tissue co-expression partners for ANKRD28 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD28 Gene:

ANKRD28

SOURCE GeneReport for Unigene cluster for ANKRD28 Gene:

Hs.335239
genes like me logo Genes that share expression patterns with ANKRD28: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKRD28 Gene

Orthologs for ANKRD28 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD28 34 35
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia ANKRD28 34 35
  • 95.53 (n)
mouse
(Mus musculus)
Mammalia Ankrd28 34 16 35
  • 92.34 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD28 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd28 34
  • 90.95 (n)
cow
(Bos Taurus)
Mammalia ANKRD28 34 35
  • 90.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD28 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD28 34 35
  • 84.76 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD28 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd28 34
  • 80.37 (n)
Str.11443 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11016 34
zebrafish
(Danio rerio)
Actinopterygii ankrd28b 34 35
  • 74.12 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8553 34
fruit fly
(Drosophila melanogaster)
Insecta nompC 35
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToMany
Species where no ortholog for ANKRD28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD28 Gene

ENSEMBL:
Gene Tree for ANKRD28 (if available)
TreeFam:
Gene Tree for ANKRD28 (if available)

Paralogs for ANKRD28 Gene

Pseudogenes.org Pseudogenes for ANKRD28 Gene

genes like me logo Genes that share paralogs with ANKRD28: view

Variants for ANKRD28 Gene

Sequence variations from dbSNP and Humsavar for ANKRD28 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10212448 -- 15,853,143(+) AAACA(C/T)TACTG intron-variant
rs10428224 -- 15,699,287(+) aaaaa(C/T)cctat intron-variant, upstream-variant-2KB
rs1046952 -- 15,667,890(-) ATCCA(A/G)GGTGT nc-transcript-variant, utr-variant-3-prime
rs1047358 -- 15,797,570(-) CCCCC(C/T)TTTTT intron-variant, nc-transcript-variant, utr-variant-5-prime
rs1047938 -- 15,669,222(-) ATAAT(C/T)AAAAG intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ANKRD28 Gene

Variant ID Type Subtype PubMed ID
dgv794n67 CNV loss 20364138
dgv8236n54 CNV loss 21841781
dgv8237n54 CNV loss 21841781
dgv8238n54 CNV loss 21841781
dgv8239n54 CNV loss 21841781
dgv8240n54 CNV loss 21841781
dgv8241n54 CNV loss 21841781
esv1000221 CNV insertion 20482838
esv1198390 CNV insertion 17803354
esv1552939 CNV insertion 17803354
esv23511 CNV gain 19812545
esv2481540 CNV deletion 19546169
esv2670116 CNV deletion 23128226
esv2724968 CNV deletion 23290073
esv3561518 CNV deletion 23714750
esv3595392 CNV loss 21293372
esv3595393 CNV loss 21293372
esv6914 CNV loss 19470904
nsv1072241 CNV deletion 25765185
nsv460453 CNV loss 19166990
nsv529014 CNV loss 19592680
nsv589781 CNV loss 21841781
nsv589812 CNV loss 21841781
nsv819661 CNV gain 19587683
nsv821318 CNV deletion 20802225

Variation tolerance for ANKRD28 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD28 Gene

Disorders for ANKRD28 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ANKRD28 Gene - From: DISEASES

Disorder Aliases PubMed IDs
urethra adenocarcinoma
  • adenocarcinoma of the urethra
urethra clear cell adenocarcinoma
  • clear cell adenocarcinoma of the urethra
urethral benign neoplasm
  • neoplasm of urethra
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ANKRD28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD28
genes like me logo Genes that share disorders with ANKRD28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKRD28 Gene

Publications for ANKRD28 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 64
  2. Regulation of focal adhesion and cell migration by ANKRD28-DOCK180 interaction. (PMID: 19458477) Kiyokawa E. … Matsuda M. (Cell Adh Migr 2009) 2 3 64
  3. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PMID: 18186651) Stefansson B. … Brautigan D.L. (Biochemistry 2008) 3 4 64
  4. PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K. (PMID: 16564677) Kwiek N.C. … Haystead T.A.J. (Cell. Signal. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ANKRD28 Gene

Sources for ANKRD28 Gene

Content
Loading form....