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Aliases for ANKRD28 Gene

Aliases for ANKRD28 Gene

  • Ankyrin Repeat Domain 28 2 3
  • PITK 3 4 6
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit ARS-A 3 4
  • Phosphatase Interactor Targeting Protein HnRNP K 3 4
  • Protein Phosphatase 6 Ankyrin Repeat Subunit A 2 3
  • Ankyrin Repeat Domain-Containing Protein 28 3 4
  • Phosphatase Interactor Targeting K Protein 2 3
  • PP6-ARS-A 3 4
  • KIAA0379 4 6
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Ankyrin Repeat Subunit A 3
  • Protein Phosphatase 1, Regulatory Subunit 65 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 65 2
  • PPP1R65 3

External Ids for ANKRD28 Gene

Previous GeneCards Identifiers for ANKRD28 Gene

  • GC03M015684
  • GC03M015700
  • GC03M015643

Summaries for ANKRD28 Gene

GeneCards Summary for ANKRD28 Gene

ANKRD28 (Ankyrin Repeat Domain 28) is a Protein Coding gene. An important paralog of this gene is ANKRD52.

UniProtKB/Swiss-Prot for ANKRD28 Gene

  • Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD28 Gene

Genomics for ANKRD28 Gene

Regulatory Elements for ANKRD28 Gene

Genomic Location for ANKRD28 Gene

Start:
15,667,236 bp from pter
End:
15,859,771 bp from pter
Size:
192,536 bases
Orientation:
Minus strand

Genomic View for ANKRD28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD28 Gene

Proteins for ANKRD28 Gene

  • Protein details for ANKRD28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15084-ANR28_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
    Protein Accession:
    O15084
    Secondary Accessions:
    • B4DES5
    • Q1WWL4
    • Q29RW6
    • Q3B857
    • Q6ULS0
    • Q6ZT57

    Protein attributes for ANKRD28 Gene

    Size:
    1053 amino acids
    Molecular mass:
    112966 Da
    Quaternary structure:
    • Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, PPP6R1 and PPP6R3.
    SequenceCaution:
    • Sequence=AAQ72374.1; Type=Frameshift; Positions=408; Evidence={ECO:0000305}; Sequence=BAA20833.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC86737.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD28 Gene

Proteomics data for ANKRD28 Gene at MOPED

Post-translational modifications for ANKRD28 Gene

  • Ubiquitination at Lys106
  • Modification sites at PhosphoSitePlus

Other Protein References for ANKRD28 Gene

No data available for DME Specific Peptides for ANKRD28 Gene

Domains for ANKRD28 Gene

Gene Families for ANKRD28 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • PPP6R :Serine/threonine phosphatases / Protein phosphatase 6, regulatory subunits

Protein Domains for ANKRD28 Gene

Graphical View of Domain Structure for InterPro Entry

O15084

UniProtKB/Swiss-Prot:

ANR28_HUMAN :
  • O15084
Similarity:
  • Contains 27 ANK repeats.
genes like me logo Genes that share domains with ANKRD28: view

Function for ANKRD28 Gene

Molecular function for ANKRD28 Gene

UniProtKB/Swiss-Prot Function: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.

Gene Ontology (GO) - Molecular Function for ANKRD28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18186651
genes like me logo Genes that share ontologies with ANKRD28: view

Animal Model Products

CRISPR Products

miRNA for ANKRD28 Gene

miRTarBase miRNAs that target ANKRD28

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKRD28

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANKRD28 Gene

Localization for ANKRD28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD28 Gene

Nucleus, nucleoplasm. Note=Seems to be excluded from nucleoli.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD28 Gene COMPARTMENTS Subcellular localization image for ANKRD28 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ANKRD28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IEA --
genes like me logo Genes that share ontologies with ANKRD28: view

Transcripts for ANKRD28 Gene

Unigene Clusters for ANKRD28 Gene

Ankyrin repeat domain 28:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKRD28

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ANKRD28

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD28 Gene

No ASD Table

Relevant External Links for ANKRD28 Gene

GeneLoc Exon Structure for
ANKRD28
ECgene alternative splicing isoforms for
ANKRD28

Expression for ANKRD28 Gene

mRNA expression in normal human tissues for ANKRD28 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKRD28 Gene

SOURCE GeneReport for Unigene cluster for ANKRD28 Gene Hs.335239

genes like me logo Genes that share expressions with ANKRD28: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKRD28 Gene

Orthologs for ANKRD28 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD28 35
  • 99.78 (n)
  • 99.91 (a)
ANKRD28 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD28 35
  • 90.88 (n)
  • 97.82 (a)
ANKRD28 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD28 35
  • 95.53 (n)
  • 99.04 (a)
ANKRD28 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd28 35
  • 92.34 (n)
  • 98.2 (a)
Ankrd28 16
Ankrd28 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKRD28 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD28 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd28 35
  • 90.95 (n)
  • 98.03 (a)
chicken
(Gallus gallus)
Aves ANKRD28 35
  • 84.76 (n)
  • 93.61 (a)
ANKRD28 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD28 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11016 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd28 35
  • 80.37 (n)
  • 90.98 (a)
Str.11443 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8553 35
zebrafish
(Danio rerio)
Actinopterygii ankrd28b 35
  • 74.12 (n)
  • 86.68 (a)
ankrd28b 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nompC 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for ANKRD28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD28 Gene

ENSEMBL:
Gene Tree for ANKRD28 (if available)
TreeFam:
Gene Tree for ANKRD28 (if available)

Paralogs for ANKRD28 Gene

Paralogs for ANKRD28 Gene

Pseudogenes.org Pseudogenes for ANKRD28 Gene

genes like me logo Genes that share paralogs with ANKRD28: view

Variants for ANKRD28 Gene

Sequence variations from dbSNP and Humsavar for ANKRD28 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs11921 -- 15,669,221(+) CCTTT(A/T)GATTA utr-variant-3-prime, intron-variant
rs712870 -- 15,668,504(+) ATTTC(C/T)GTAAA utr-variant-3-prime, intron-variant
rs721747 -- 15,845,226(-) TTGAA(A/G)AAATG intron-variant
rs924754 -- 15,714,708(+) TGTAA(A/T)CCTTA intron-variant
rs983600 -- 15,667,633(+) CTGGC(A/G)TAGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ANKRD28 Gene

Variant ID Type Subtype PubMed ID
nsv460453 CNV Loss 19166990
nsv529014 CNV Loss 19592680
esv1000221 CNV Insertion 20482838
esv1198390 CNV Insertion 17803354
esv1552939 CNV Insertion 17803354
esv2481540 CNV Deletion 19546169
nsv819661 CNV Gain 19587683
dgv794n67 CNV Loss 20364138
nsv821318 CNV Deletion 20802225
esv23511 CNV Gain 19812545
esv2670116 CNV Deletion 23128226
esv6914 CNV Loss 19470904
esv2724968 CNV Deletion 23290073

Relevant External Links for ANKRD28 Gene

HapMap Linkage Disequilibrium report
ANKRD28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD28 Gene

Disorders for ANKRD28 Gene

No disorders were found for ANKRD28 Gene.

No data available for UniProtKB/Swiss-Prot for ANKRD28 Gene

Publications for ANKRD28 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  3. PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K. (PMID: 16564677) Kwiek N.C. … Haystead T.A.J. (Cell. Signal. 2006) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PMID: 18186651) Stefansson B. … Brautigan D.L. (Biochemistry 2008) 3 4

Products for ANKRD28 Gene

Sources for ANKRD28 Gene

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