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ANKRD28 Gene

protein-coding   GIFtS: 48
GCID: GC03M015708

Ankyrin Repeat Domain 28

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 281 2     PP6-ARS-A2 3
PITK2 3 5     KIAA03793 5
Phosphatase Interactor Targeting K Protein1 2     Protein Phosphatase 11
Protein Phosphatase 6 Ankyrin Repeat Subunit A1 2     Regulatory Subunit 651
Ankyrin Repeat Domain-Containing Protein 282 3     PPP1R652
Phosphatase Interactor Targeting Protein HnRNP K2 3     Protein Phosphatase 1, Regulatory Subunit 652
Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit ARS-A2 3     Serine/Threonine-Protein Phosphatase 6 Regulatory Ankyrin Repeat Subunit A2

External Ids:    HGNC: 290241   Entrez Gene: 232432   Ensembl: ENSG000002065607   OMIM: 6111225   UniProtKB: O150843   

Export aliases for ANKRD28 gene to outside databases

Previous GC identifers: GC03M015684 GC03M015700 GC03M015643


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD28 Gene:
ANKRD28 (ankyrin repeat domain 28) is a protein-coding gene. An important paralog of this gene is TNKS2.

UniProtKB/Swiss-Prot: ANR28_HUMAN, O15084
Function: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of
phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in
response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK
phosphorylation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD28 gene promoter:
         NF-1/L   NF-1   NRSF form 1   NRSF form 2   Nkx5-1   Gfi-1   C/EBPalpha   MZF-1   SRY   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD28 promoter sequence
   Search Chromatin IP Primers for ANKRD28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25.1

ANKRD28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD28 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M015708:  view genomic region     (about GC identifiers)

Start:
15,708,743 bp from pter      End:
15,901,278 bp from pter
Size:
192,536 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANR28_HUMAN, O15084 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A  
Size: 1053 amino acids; 112966 Da
Subunit: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic
subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit
(ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, PPP6R1 and PPP6R3
Sequence caution: Sequence=AAQ72374.1; Type=Frameshift; Positions=408; Sequence=BAA20833.2; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=BAC86737.1; Type=Miscellaneous discrepancy;
Note=Intron retention;
Secondary accessions: B4DES5 Q1WWL4 Q29RW6 Q3B857 Q6ULS0 Q6ZT57
Alternative promoter usage, Alternative splicing: 4 isoforms:  O15084-3   O15084-2   O15084-1   O15084-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD28: NX_O15084

Explore proteomics data for ANKRD28 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys106
  • Modification sites at PhosphoSitePlus

  • See ANKRD28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001182027.1  NP_001182028.1  NP_056014.2  

    ENSEMBL proteins: 
     ENSP00000382379   ENSP00000397341   ENSP00000394845   ENSP00000389489   ENSP00000373287  

    ANKRD28 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ANKRD28

     
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    antibodies-online antibodies for ANKRD28 (22 products) 

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    antibodies-online kits for ANKRD28 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP6R: Serine/threonine phosphatases / Protein phosphatase 6, regulatory subunits
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry O15084

    ProtoNet protein and cluster: O15084

    UniProtKB/Swiss-Prot: ANR28_HUMAN, O15084
    Similarity: Contains 27 ANK repeats


    Find genes that share domains with ANKRD28           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANR28_HUMAN, O15084
    Function: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of
    phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in
    response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK
    phosphorylation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18186651
         
    Find genes that share ontologies with ANKRD28           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ANKRD28

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANKRD28:
    hsa-mir-21-5p (MIRT030731), hsa-mir-132-3p (MIRT021749), hsa-mir-221-3p (MIRT046912)

    Block miRNA regulation of human, mouse, rat ANKRD28 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANKRD28 (see all 93):
    hsa-miR-323-3p hsa-miR-1321 hsa-miR-3938 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-138-2* hsa-miR-502-3p hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidANKRD28 3' UTR sequence
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANR28_HUMAN, O15084: Nucleus, nucleoplasm. Note=Seems to be excluded from nucleoli
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm IEA--

    Find genes that share ontologies with ANKRD28           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD28
    Interactions:

        GeneGlobe Interaction Network for ANKRD28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for ANKRD28 (O150841, 2, 3 ENSP000003823794) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DOCK1Q141851, 2, 3EBI-359567,EBI-446740 MINT-7231973 MINT-7232107 MINT-7231945 MINT-7232187 I2D: score=1 
    PPP6CO007431, 2, 3, ENSP000003921474EBI-359567,EBI-359751 MINT-8287516 I2D: score=2 STRING: ENSP00000392147
    PPP6R2O751701, 2, 3, ENSP000003790934EBI-359567,EBI-359739 MINT-8287516 I2D: score=1 STRING: ENSP00000379093
    NFKBIEO002212, 3MINT-47879 I2D: score=2 
    ZNF512BQ96KM62, 3MINT-60832 I2D: score=1 
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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKRD28 (ANR28)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANKRD28 gene (3 alternative transcripts): 
    NM_001195098.1  NM_001195099.1  NM_015199.3  

    Unigene Cluster for ANKRD28:

    Ankyrin repeat domain 28
    Hs.335239  [show with all ESTs]
    Unigene Representative Sequence: NM_001195098
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399451(uc003caj.1 uc003cak.1) ENST00000412318 ENST00000498713
    ENST00000497037 ENST00000479043 ENST00000451422 ENST00000463533 ENST00000498524(uc003cal.1 uc003cam.2)
    ENST00000462657 ENST00000492895 ENST00000476472 ENST00000460278(uc003cao.3)
    ENST00000439830 ENST00000461696 ENST00000383777(uc011avy.1 uc003cai.1 uc011avz.1 uc011awa.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ANKRD28 (see all 93):
    hsa-miR-323-3p hsa-miR-1321 hsa-miR-3938 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-138-2* hsa-miR-502-3p hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidANKRD28 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 3): ANKRD28 (NM_015199)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD28
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      QuantiTect SYBR Green Assays in human, mouse, rat ANKRD28
      Search QuantiFast Probe-based Assays in human, mouse, rat ANKRD28

    Additional mRNA sequence: 

    AK293770.1 AK295813.1 AK299540.1 AY367056.1 BC064513.1 BC080522.1 BC106948.2 BC113868.1 
    BC114476.1 

    19 DOTS entries:

    DT.100668050  DT.112744  DT.86837623  DT.101982579  DT.95345014  DT.100744915  DT.100883946  DT.95130096 
    DT.95355024  DT.100703469  DT.100883923  DT.120889047  DT.120889096  DT.120889098  DT.91934864  DT.91982044 
    DT.120635526  DT.91703200  DT.99927761 

    Selected AceView cDNA sequences (see all 262):

    CA435282 AA252910 BU678984 N25798 BM668497 BQ285951 BM453290 BQ023743 
    AW008105 AW075744 BF726843 AW614893 BU155960 AI560639 AA041551 AW262982 
    AU120833 AW469324 CA447952 BQ214314 BX101011 W23725 AI680673 AA724023 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKRD28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACATAGAAA
    ANKRD28 Expression
    About this image

    ANKRD28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKRD28 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.335239
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANKRD28 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankrd281 , 5 ankyrin repeat domain 281, 5 92.34(n)1
    98.2(a)1
      14 (19.40 cM)5
    1055221  NM_001024604.21  NP_001019775.11 
     317000155 
    chicken
    (Gallus gallus)
    Aves ANKRD281 ankyrin repeat domain 28 84.76(n)
    93.61(a)
      420640  XM_418739.4  XP_418739.3 
    lizard
    (Anolis carolinensis)
    Reptilia ANKRD286
    ankyrin repeat domain 28
    90(a)
    1 ↔ 1
    6(35268481-35325915)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.110162 Xenopus laevis transcribed sequence with weak similarity more 71.49(n)    BU916671.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BG737472.12   -- 79.67(n)    BG737472.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nompC6
    no mechanoreceptor potential C
    14(a)
    1 → many
    2L(5342321-5365760)


    ENSEMBL Gene Tree for ANKRD28 (if available)
    TreeFam Gene Tree for ANKRD28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKRD28 gene
    TNKS22  ANK32  ANK12  ANKRD522  TNKS2  ANKRD652  ANKFY12  ANKRD502  
    INVS2  ANK22  
    Selected SIMAP similar genes for ANKRD28 using alignment to 4 protein entries:     ANR28_HUMAN (see all proteins) (see all similar genes):
    LOC91526    ANKRD44    ANKRD52    GABPB1    NRARP    DKFZp761E1322
    MTPN    IkBa    ANKRD54    ANKRD20A5P    PSMD10    ANKDD1A
    ANKRD10    CDKN2D    ASB13    PPP1R12A    CDKN2C    DKFZp434B2328

    Find genes that share paralogs with ANKRD28           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ANKRD28
    PGOHUM00000240471


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKRD28 (see all 3871)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405324271,2
    --15708377(+) ATGACA/GCCTGT 3 -- ds50010--------
    rs1504618261,2
    C--15708510(+) AAGGAA/CAAGAT 3 -- ds50010--------
    rs1381828791,2
    --15708675(+) AAAAAA/GCTTGT 3 -- ds50010--------
    rs37327191,2
    C,F,H--15708803(-) AATTTT/CGGGGT 3 -- ut314Minor allele frequency- C:0.02NS EA 420
    rs98124811,2
    C,F,H--15708866(+) GTCTTG/CTTAAA 3 -- ut31 ese311Minor allele frequency- C:0.06NA NS EA WA 686
    rs1466557441,2
    --15708973(+) ATGTAC/TAAGTT 3 -- ut310--------
    rs9836001,2
    C,F,H--15709140(+) CTGGCA/GTAGTT 3 -- ut31 ese318Minor allele frequency- T:0.00EA NA MN NS 1978
    rs1414610811,2
    C--15709215(+) AAGCT-/GGGGGG 3 -- ut310--------
    rs1904291991,2
    --15709292(+) AACTAC/TCTTAA 3 -- ut310--------
    rs1390140651,2
    --15709314(+) ACAGCA/TTCATT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ANKRD28 (15708743 - 15901278 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ANKRD28 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821318CNV Deletion20802225
    esv2724968CNV Deletion23290073
    esv2481540CNV Deletion19546169
    esv2670116CNV Deletion23128226
    esv1198390CNV Insertion17803354
    esv1000221CNV Insertion20482838
    esv1552939CNV Insertion17803354
    dgv794n67CNV Loss20364138
    nsv529014CNV Loss19592680
    nsv460453CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611122    OMIM disorders: --


    Find genes that share disorders with ANKRD28           About GenesLikeMe


    Export disorders for ANKRD28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKRD28 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with ANKRD28)
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    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    2. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PubMed id 18186651)1, 2 Stefansson B.... Brautigan D.L. (Biochemistry 2008)
    3. PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K. (PubMed id 16564677)1, 2 Kwiek N.C.... Haystead T.A.J. (Cell. Signal. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    6. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23243 HGNC: 29024 AceView: ANKRD28 Ensembl:ENSG00000206560 euGenes: HUgn23243
    ECgene: ANKRD28 H-InvDB: ANKRD28

    (According to HUGE)
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    HUGE: KIAA0379

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKRD28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKRD28 gene:
    Search GeneIP for patents involving ANKRD28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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