ANKRD27 Gene
protein-coding GIFtS: 48
GCID: GC19M033087
|
|
ankyrin repeat domain 27 (VPS9 domain)
| |
Aliases
for ANKRD27 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat Domain 27 (VPS9 Domain)1 2 | | FLJ000401 | | VARP1 2 | | Ankyrin Repeat Domain-Containing Protein 272 | | VPS9 Domain-Containing Protein2 3 | | Vps9 Domain And Ankyrin-Repeat-Containing Protein2 | | DKFZp434L07181 | | VPS9-Ankyrin-Repeat Protein2 |
Export aliases for ANKRD27 gene to outside databasesPrevious GC identifers: GC00U913736 GC19M037751 GC19M037780 GC19M029590 |
Summaries
for ANKRD27 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ANR27_HUMAN, Q96NW4Function: May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity)
Gene Wiki entry for ANKRD27
|
Genomic Views
for ANKRD27 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKRD27 gene promoter:
Spz1 AML1a Sp1 p300 HNF-4alpha2 HNF-4alpha1 AREB6 Pax-3 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKRD27
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD27 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.11 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.12ANKRD27 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M033087: view genomic region
(about GC identifiers)
Start:
|
33,087,907 bp from pter |
End:
|
33,167,028 bp from pter |
Size:
|
79,122 bases |
Orientation:
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minus strand |
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Proteins
for ANKRD27 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANR27_HUMAN, Q96NW4 (See
protein sequence)Recommended Name: Ankyrin repeat domain-containing protein 27 Size: 1050 amino acids; 116984 Da
Subunit: Interacts with RAB21 and RAB5A, with a strong preference for RAB21 (By similarity)
Subcellular location: Cytoplasm. Note=Mainly localized to early endosomes in the perinuclear region (By similarity)
Sequence caution: Sequence=BAB70755.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for ANKRD27:4B93 (3D)
Secondary accessions: Q71MF5 Q86UC3 Q8ND80 Q9H0I4Explore the universe of human proteins at neXtProt for ANKRD27: NX_Q96NW4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96NW4
ANKRD27 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115515.2
ENSEMBL proteins: ENSP00000304292 ENSP00000464751 ENSP00000466138 ENSP00000467447 ENSP00000466905 ENSP00000464819
Human Recombinant Protein Products for ANKRD27:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ANKRD27 for ontologies About GeneDecksing
ANKRD27 Antibody Products:
Assay Products for ANKRD27: |
Protein
Domains /
Families
for ANKRD27 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKRD27 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96NW4ProtoNet protein and cluster: Q96NW4 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ANR27_HUMAN, Q96NW4Similarity: Contains 11 ANK repeatsSimilarity: Contains 1 VPS9 domain |
Function
for ANKRD27 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ANR27_HUMAN, Q96NW4Function: May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity) Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ANKRD27 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD27 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD27
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ANKRD27 (NM_032139) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD27 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD27 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD27 |
|
Pathways & Interactions
for ANKRD27 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANKRD27
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/10 Interacting proteins for ANKRD27 (Q96NW41, 2, 3 ENSP000003042924) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045022 | early endosome to late endosome transport |
IDA | 16525121 |
ANKRD27 for ontologies About GeneDecksing
|
Drugs & Compounds
for ANKRD27 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKRD27
Search CenterWatch for drugs/clinical trials and news about ANKRD27 / ANR27
|
Transcripts
for ANKRD27 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKRD27 gene: NM_032139.2 Unigene Cluster for ANKRD27: Ankyrin repeat domain 27 (VPS9 domain) Hs.59236 [show with all ESTs]Unigene Representative Sequence: AL1367849 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000306065(uc002ntn.1 uc002nto.1) ENST00000587667 ENST00000591100
ENST00000587352 ENST00000593232 ENST00000586463 ENST00000588700 ENST00000586693
ENST00000590519
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD27 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD27
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANKRD27 (NM_032139) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD27 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD27 |
Additional cDNA sequence: AF447882.1 AK054561.1 AL136784.1 AL834335.1 BC015552.1 BC045605.1 BC050529.1 9 DOTS entries: DT.215729 DT.100710631 DT.95373975 DT.91753996 DT.95360956 DT.100710418 DT.101972096 DT.95074549 DT.439762 24/181 AceView cDNA sequences (see all 181): AK054561 CF552747 BG577070 BU167120 BU625291 AL136784 BM976786 CD369706 AA635541 AL536944 AA218701 BQ015367 BQ440443 BM456760 BU429349 BM473365 BQ425621 BQ220451 AW161366 CA448155 BU153844 AA218700 NM_032139 CD642844
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD27 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29a | · | 29b |
|---|
|
| SP1: | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ANKRD27
|
Expression
for ANKRD27 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKRD27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTTGGAAA
About this image
See ANKRD27 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD27
SOURCE GeneReport for Unigene cluster: Hs.59236
SABiosciences Custom PCR Arrays for ANKRD27
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD27
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANKRD27 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD27 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD27 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD27 |
Orthologs
for ANKRD27 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ANKRD27 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for ANKRD27 (if available)
TreeFam Gene Tree for ANKRD27 (if available) |
Paralogs
for ANKRD27 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ANKRD27 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKRD27 (33087907 - 33167028 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANKRD27: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD27 |
|
Disorders
/ Diseases
for ANKRD27 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ANKRD27 for disorders About GeneDecksing
1  disease for ANKRD27: About MalaCardstetanus
Human Genome Epidemiology (HuGE) Navigator: ANKRD27 (3 documents)
Export disorders for ANKRD27 gene to outside databases
|
Publications
for ANKRD27 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKRD27 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with ANKRD27) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics. (PubMed id 16525121)1, 3 Zhang X....Chang Z. (2006)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation. (PubMed id 23104059)1 Schafer I.B....Owen D.J. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for ANKRD27 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANKRD27 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKRD27 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANKRD27 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKRD27 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANKRD27 gene:
Search GeneIP for patents involving ANKRD27
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKRD27 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD27 |
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