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Aliases for ANKRD26 Gene

Aliases for ANKRD26 Gene

  • Ankyrin Repeat Domain 26 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 26 3
  • Thrombocytopenia 2 (Autosomal Dominant) 2
  • BA145E8.1 3
  • KIAA1074 4
  • THC2 3

External Ids for ANKRD26 Gene

Previous HGNC Symbols for ANKRD26 Gene

  • THC2

Previous GeneCards Identifiers for ANKRD26 Gene

  • GC10M027298
  • GC10M027297
  • GC10M027334
  • GC10M027280

Summaries for ANKRD26 Gene

Entrez Gene Summary for ANKRD26 Gene

  • This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ANKRD26 Gene

ANKRD26 (Ankyrin Repeat Domain 26) is a Protein Coding gene. Diseases associated with ANKRD26 include Thrombocytopenia 2 and Platelet Disorder, Familial, With Associated Myeloid Malignancy. GO annotations related to this gene include transferase activity and cofactor binding. An important paralog of this gene is ENSG00000266302.

Gene Wiki entry for ANKRD26 Gene

Additional gene information for ANKRD26 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD26 Gene

Genomics for ANKRD26 Gene

Regulatory Elements for ANKRD26 Gene

Enhancers for ANKRD26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H027152 1.4 ENCODE dbSUPER 19.9 -54.5 -54484 5 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MASTL ANKRD26 ENSG00000227932 FAM238C YME1L1 LRRC37A6P
GH10H026523 1.2 ENCODE dbSUPER 16.8 +576.3 576250 0 PKNOX1 INSM2 KLF17 FEZF1 ZEB1 GLIS2 ZNF302 ZNF366 ZNF350 KLF7 ANKRD26 GC10P026534 RNA5SP307
GH10H027238 1.8 FANTOM5 ENCODE dbSUPER 10.7 -141.0 -140999 5 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 MASTL YME1L1 ANKRD26 ABI1 ACBD5 RNU7-12P
GH10H026524 1.1 ENCODE dbSUPER 16.8 +575.8 575802 0 PKNOX1 JUN FEZF1 BRCA1 ZEB1 ZNF324 HIC1 ZNF302 ZNF366 ZNF350 ANKRD26 GC10P026534 RNA5SP307
GH10H027099 1.1 ENCODE 14.1 +0.0 39 2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF207 JUNB MASTL ANKRD26 FAM238C YME1L1 GC10M027087
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD26 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000025839 198 1801 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF207 KAT8

Genomic Location for ANKRD26 Gene

Chromosome:
10
Start:
26,966,584 bp from pter
End:
27,100,498 bp from pter
Size:
133,915 bases
Orientation:
Minus strand

Genomic View for ANKRD26 Gene

Genes around ANKRD26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD26 Gene

Proteins for ANKRD26 Gene

  • Protein details for ANKRD26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPS8-ANR26_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 26
    Protein Accession:
    Q9UPS8
    Secondary Accessions:
    • A6NH29
    • Q2TAZ3
    • Q6ZR14
    • Q9H1Q1
    • Q9NSK9
    • Q9NTD5
    • Q9NW69

    Protein attributes for ANKRD26 Gene

    Size:
    1709 amino acids
    Molecular mass:
    196324 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83026.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD26 Gene

Post-translational modifications for ANKRD26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD26 Gene

Domains & Families for ANKRD26 Gene

Gene Families for ANKRD26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD26 Gene

Suggested Antigen Peptide Sequences for ANKRD26 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD26: view

No data available for UniProtKB/Swiss-Prot for ANKRD26 Gene

Function for ANKRD26 Gene

Phenotypes From GWAS Catalog for ANKRD26 Gene

Gene Ontology (GO) - Molecular Function for ANKRD26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22666460
genes like me logo Genes that share ontologies with ANKRD26: view
genes like me logo Genes that share phenotypes with ANKRD26: view

Human Phenotype Ontology for ANKRD26 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD26 Gene

Localization for ANKRD26 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD26 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANKRD26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with ANKRD26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANKRD26 Gene

Pathways & Interactions for ANKRD26 Gene

SuperPathways for ANKRD26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045599 negative regulation of fat cell differentiation ISS --
genes like me logo Genes that share ontologies with ANKRD26: view

No data available for Pathways by source and SIGNOR curated interactions for ANKRD26 Gene

Drugs & Compounds for ANKRD26 Gene

No Compound Related Data Available

Transcripts for ANKRD26 Gene

Unigene Clusters for ANKRD26 Gene

Ankyrin repeat domain 26:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD26 Gene

No ASD Table

Relevant External Links for ANKRD26 Gene

GeneLoc Exon Structure for
ANKRD26
ECgene alternative splicing isoforms for
ANKRD26

Expression for ANKRD26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD26 Gene

Protein differential expression in normal tissues from HIPED for ANKRD26 Gene

This gene is overexpressed in Colon (12.9), Testis (12.2), Bone marrow stromal cell (9.9), and Prostate (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANKRD26 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANKRD26 Gene:

ANKRD26

SOURCE GeneReport for Unigene cluster for ANKRD26 Gene:

Hs.361041

Evidence on tissue expression from TISSUES for ANKRD26 Gene

  • Nervous system(4.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD26 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • integumentary
  • skeleton
Organs:
General:
  • blood
  • blood vessel
  • coagulation system
  • skin
genes like me logo Genes that share expression patterns with ANKRD26: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ANKRD26 Gene

Orthologs for ANKRD26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD26 33 34
  • 99.38 (n)
cow
(Bos Taurus)
Mammalia ANKRD26 33 34 34
  • 81.03 (n)
-- 34
  • 66 (a)
OneToMany
-- 34
  • 62 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
-- 34
  • 57 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
-- 34
  • 40 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ANKRD26 33
  • 76.73 (n)
-- 34
  • 63 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ankrd26 33 16 34
  • 73.14 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd26 33
  • 72.16 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 40 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 34 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 39 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ANKRD7 34
  • 28 (a)
OneToMany
Dr.26488 33
Species where no ortholog for ANKRD26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD26 Gene

ENSEMBL:
Gene Tree for ANKRD26 (if available)
TreeFam:
Gene Tree for ANKRD26 (if available)

Paralogs for ANKRD26 Gene

genes like me logo Genes that share paralogs with ANKRD26: view

Variants for ANKRD26 Gene

Sequence variations from dbSNP and Humsavar for ANKRD26 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs863223318 Pathogenic 27,100,460(-) CCGGA(A/G)GGAGA utr-variant-5-prime
rs10829158 Likely benign 27,004,415(+) ATTGA(A/G)GGTTC intron-variant, utr-variant-3-prime
rs10829163 Likely benign 27,028,911(+) TTTGA(C/T)TGTAA reference, missense, utr-variant-3-prime
rs11015449 Likely benign 27,004,686(+) TGAGG(G/T)ACATT intron-variant, utr-variant-3-prime
rs112091269 Likely benign 27,004,355(+) AACTC(-/A)CTGAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ANKRD26 Gene

Variant ID Type Subtype PubMed ID
esv2664616 CNV deletion 23128226
esv2670516 CNV deletion 23128226
esv3622707 CNV gain 21293372
nsv1116452 OTHER inversion 24896259
nsv1145435 CNV deletion 24896259
nsv510988 OTHER complex 20534489

Variation tolerance for ANKRD26 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.41; 88.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD26 Gene

Human Gene Mutation Database (HGMD)
ANKRD26
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD26 Gene

Disorders for ANKRD26 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ANKRD26 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
thrombocytopenia 2
  • thc2
platelet disorder, familial, with associated myeloid malignancy
  • familial platelet disorder with associated myeloid malignancy
myh-9 related disease
  • sebastian syndrome
thrombocytopenia
thrombocytopenia-absent radius syndrome
  • chromosome 1q21.1 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ANKRD26

Genetic Association Database (GAD)
ANKRD26
Human Genome Epidemiology (HuGE) Navigator
ANKRD26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD26
genes like me logo Genes that share disorders with ANKRD26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKRD26 Gene

Publications for ANKRD26 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 60
  2. Mutations in the 5' UTR of ANKRD26, the ankirin repeat domain 26 gene, cause an autosomal-dominant form of inherited thrombocytopenia, THC2. (PMID: 21211618) Pippucci T … Balduini CL (American journal of human genetics 2011) 2 3 60
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 60

Products for ANKRD26 Gene

Sources for ANKRD26 Gene

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