Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANKRD26 Gene

Aliases for ANKRD26 Gene

  • Ankyrin Repeat Domain 26 2 3
  • KIAA1074 4 6
  • THC2 3 6
  • Ankyrin Repeat Domain-Containing Protein 26 3
  • Thrombocytopenia 2 (Autosomal Dominant) 2
  • BA145E8.1 3

External Ids for ANKRD26 Gene

Previous HGNC Symbols for ANKRD26 Gene

  • THC2

Previous GeneCards Identifiers for ANKRD26 Gene

  • GC10M027298
  • GC10M027297
  • GC10M027334
  • GC10M027280

Summaries for ANKRD26 Gene

Entrez Gene Summary for ANKRD26 Gene

  • This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ANKRD26 Gene

ANKRD26 (Ankyrin Repeat Domain 26) is a Protein Coding gene. Diseases associated with ANKRD26 include thrombocytopenia 2 and ankrd26-related thrombocytopenia 2. An important paralog of this gene is POTEJ.

Gene Wiki entry for ANKRD26 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD26 Gene

Genomics for ANKRD26 Gene

Regulatory Elements for ANKRD26 Gene

Genomic Location for ANKRD26 Gene

Start:
26,991,914 bp from pter
End:
27,100,498 bp from pter
Size:
108,585 bases
Orientation:
Minus strand

Genomic View for ANKRD26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD26 Gene

Proteins for ANKRD26 Gene

  • Protein details for ANKRD26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPS8-ANR26_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 26
    Protein Accession:
    Q9UPS8
    Secondary Accessions:
    • A6NH29
    • Q2TAZ3
    • Q6ZR14
    • Q9H1Q1
    • Q9NSK9
    • Q9NTD5
    • Q9NW69

    Protein attributes for ANKRD26 Gene

    Size:
    1709 amino acids
    Molecular mass:
    196324 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83026.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD26 Gene

Proteomics data for ANKRD26 Gene at MOPED

Post-translational modifications for ANKRD26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD26 Gene

No data available for DME Specific Peptides for ANKRD26 Gene

Domains for ANKRD26 Gene

Gene Families for ANKRD26 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ANKRD26 Gene

Suggested Antigen Peptide Sequences for ANKRD26 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPS8

UniProtKB/Swiss-Prot:

ANR26_HUMAN :
  • Q9UPS8
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with ANKRD26: view

Function for ANKRD26 Gene

Gene Ontology (GO) - Molecular Function for ANKRD26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0016740 transferase activity --
GO:0048037 cofactor binding --
genes like me logo Genes that share ontologies with ANKRD26: view
genes like me logo Genes that share phenotypes with ANKRD26: view

miRNA for ANKRD26 Gene

miRTarBase miRNAs that target ANKRD26

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANKRD26 Gene

Localization for ANKRD26 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD26 Gene COMPARTMENTS Subcellular localization image for ANKRD26 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ANKRD26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0005884 actin filament IEA --
genes like me logo Genes that share ontologies with ANKRD26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANKRD26 Gene

Pathways for ANKRD26 Gene

SuperPathways for ANKRD26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019216 regulation of lipid metabolic process --
GO:0019217 regulation of fatty acid metabolic process IEA --
GO:0040015 negative regulation of multicellular organism growth IEA --
GO:0042593 glucose homeostasis IEA --
GO:0045599 negative regulation of fat cell differentiation IEA --
genes like me logo Genes that share ontologies with ANKRD26: view

No data available for Pathways by source for ANKRD26 Gene

Transcripts for ANKRD26 Gene

Unigene Clusters for ANKRD26 Gene

Ankyrin repeat domain 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD26 Gene

No ASD Table

Relevant External Links for ANKRD26 Gene

GeneLoc Exon Structure for
ANKRD26
ECgene alternative splicing isoforms for
ANKRD26

Expression for ANKRD26 Gene

mRNA expression in normal human tissues for ANKRD26 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKRD26 Gene

SOURCE GeneReport for Unigene cluster for ANKRD26 Gene Hs.361041

genes like me logo Genes that share expressions with ANKRD26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKRD26 Gene

Orthologs for ANKRD26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD26 35
  • 99.38 (n)
  • 98.89 (a)
ANKRD26 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 61 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
ANKRD26 35
  • 81.03 (n)
  • 72.77 (a)
ANKRD26 36
  • 62 (a)
OneToMany
ANKRD26 36
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 63 (a)
ManyToMany
ANKRD26 35
  • 76.73 (n)
  • 64.21 (a)
mouse
(Mus musculus)
Mammalia Ankrd26 35
  • 73.14 (n)
  • 62.66 (a)
Ankrd26 16
Ankrd26 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ankrd26 35
  • 72.16 (n)
  • 63.01 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 34 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ANKRD7 36
  • 28 (a)
OneToMany
Dr.26488 35
Species with no ortholog for ANKRD26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD26 Gene

ENSEMBL:
Gene Tree for ANKRD26 (if available)
TreeFam:
Gene Tree for ANKRD26 (if available)

Paralogs for ANKRD26 Gene

genes like me logo Genes that share paralogs with ANKRD26: view

Variants for ANKRD26 Gene

Sequence variations from dbSNP and Humsavar for ANKRD26 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1004437 -- 27,004,869(+) AAtgt(A/G)ttaat utr-variant-3-prime, intron-variant
rs1197582 -- 27,036,198(+) CTGAG(A/C)ATATT intron-variant
rs1197583 -- 27,080,420(+) ACGTA(C/T)ATGCT intron-variant
rs1197584 -- 26,999,660(+) ACACC(C/T)TCACA intron-variant
rs1197586 -- 27,003,634(+) ttggc(C/T)agtaa downstream-variant-500B, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD26 Gene

Variant ID Type Subtype PubMed ID
nsv510988 CNV Complex 20534489
esv2664616 CNV Deletion 23128226
nsv894979 CNV Loss 21882294
esv2670516 CNV Deletion 23128226

Relevant External Links for ANKRD26 Gene

HapMap Linkage Disequilibrium report
ANKRD26
Human Gene Mutation Database (HGMD)
ANKRD26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD26 Gene

Disorders for ANKRD26 Gene

(1) OMIM Diseases for ANKRD26 Gene (610855)

Relevant External Links for ANKRD26

Genetic Association Database (GAD)
ANKRD26
Human Genome Epidemiology (HuGE) Navigator
ANKRD26
genes like me logo Genes that share disorders with ANKRD26: view

No data available for UniProtKB/Swiss-Prot for ANKRD26 Gene

Publications for ANKRD26 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for ANKRD26 Gene

Sources for ANKRD26 Gene

Back to Top

Content