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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKRD26 Gene

protein-coding   GIFtS: 51
GCID: GC10M027280

ankyrin repeat domain 26

 Explore 2 diseases affiliated with
ANKRD26 via our new
 Human Malady Compendium 
Biological research products
for ANKRD26
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ankyrin Repeat Domain 261 2
KIAA10741 3 5
THC22
Ankyrin Repeat Domain-Containing Protein 262
BA145E8.11

External Ids:    HGNC: 291861   Entrez Gene: 228522   Ensembl: ENSG000001078907   OMIM: 6108555   UniProtKB: Q9UPS83   

Export aliases for ANKRD26 gene to outside databases

Previous GC identifers: GC10M027298 GC10M027297 GC10M027334 GC10M026961


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANKRD26:
This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions.
Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found
on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Dec 2011)

Gene Wiki entry for ANKRD26


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKRD26 gene promoter:
         Egr-1   CUTL1   E47   GATA-1   Meis-1b   Meis-1a   ZID   Hlf   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD26 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANKRD26

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12.1

ANKRD26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD26 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M027280:  view genomic region     (about GC identifiers)

Start:
27,280,843 bp from pter      End:
27,389,427 bp from pter
Size:
108,585 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANR26_HUMAN, Q9UPS8 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 26  
Size: 1709 amino acids; 196324 Da
Sequence caution: Sequence=BAA83026.2; Type=Erroneous initiation;
Secondary accessions: A6NH29 Q2TAZ3 Q6ZR14 Q9H1Q1 Q9NSK9 Q9NTD5 Q9NW69
Alternative splicing: 3 isoforms:  Q9UPS8-1   Q9UPS8-2   Q9UPS8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD26: NX_Q9UPS8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UPS8

  • ANKRD26 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001242982.1  NP_055730.2  

    ENSEMBL proteins: 
     ENSP00000394152   ENSP00000365255   ENSP00000405112   ENSP00000365238  

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    Uscn Proteins for ANKRD26

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--
    GO:0005884actin filament ----


    ANKRD26 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ANKRD26 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR021885 DUF3496
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q9UPS8

    ProtoNet protein and cluster: Q9UPS8

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: ANR26_HUMAN, Q9UPS8
    Similarity: Contains 5 ANK repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-miR-1253
    SwitchGear 3'UTR luciferase reporter plasmidANKRD26 3' UTR sequence
    Inhib. RNA
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    1 GenomeRNAi human phenotype for ANKRD26:
     Synthetic lethal with Ras 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ankrd26):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size  homeostasis/metabolism 
     renal/urinary system 

    ANKRD26 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD26

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for ANKRD26 (Q9UPS83 ENSP000003652554) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP4K4O958193I2D: score=1 
    CBX2ENSP000003087504STRING: ENSP00000308750
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019216regulation of lipid metabolic process ----
    GO:0019217regulation of fatty acid metabolic process ----
    GO:0040015negative regulation of multicellular organism growth ----
    GO:0046621negative regulation of organ growth ----
    GO:0060259regulation of feeding behavior ----


    ANKRD26 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANKRD26
    Search CenterWatch for drugs/clinical trials and news about ANKRD26 / ANR26 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANKRD26 gene (2 alternative transcripts): 
    NM_001256053.1  NM_014915.2  

    Unigene Cluster for ANKRD26:

    Ankyrin repeat domain 26
    Hs.361041  [show with all ESTs]
    Unigene Representative Sequence: NM_014915
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445828 ENST00000376087(uc001itg.2 uc009xku.1 uc001ith.2)
    ENST00000490015 ENST00000473304 ENST00000466890 ENST00000436985 ENST00000376070


    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ANKRD26:
    hsa-miR-1253
    SwitchGear 3'UTR luciferase reporter plasmidANKRD26 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKRD26 (see all 4)
    OriGene shRNA RFP: ANKRD26
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD26
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    Additional cDNA sequence: 

    AB028997.1 AK001137.1 AK128577.1 AL137351.1 AL162063.1 BC110646.1 BC130453.1 

    11 DOTS entries:

    DT.99989689  DT.408009  DT.95154865  DT.101970047  DT.75153471  DT.92423456  DT.40258759  DT.103376 
    DT.91924459  DT.95123741  DT.91663230 

    24/85 AceView cDNA sequences (see all 85):

    AB028997 BM463480 AI084496 H88735 BQ012478 H88734 AK001137 AW000914 
    BQ071543 CD675569 AI871874 BG527816 AL137351 AL162063 BM692701 BX353971 
    AK128577 AA826458 AA296607 BU734004 AI922499 BQ011407 CR624443 BF794181 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKRD26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAAAATATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ANKRD26 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANKRD26

    SOURCE GeneReport for Unigene cluster: Hs.361041
        SABiosciences Custom PCR Arrays for ANKRD26
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ANKRD26 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ANKRD261 ankyrin repeat domain 26 62.14(n)
    50.18(a)
      417764  XM_416008.3  XP_416008.3 
    lizard
    (Anolis carolinensis)
    Reptilia ANKRD626
    --
    34(a)
    1 → many
    GL344195.1(39104-48393)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420347462   -- 71.81(n)    142034746 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.264882 Danio rerio cDNA clone IMAGE6793503, partial cds 68.44(n)    BC053220.1 


    ENSEMBL Gene Tree for ANKRD26 (if available)
    TreeFam Gene Tree for ANKRD26 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANKRD26 gene
    POTEF2  POTEI2  ANKRD30A2  ANKRD362  ANKRD72  POTEB2  ANKRD30BL2  ANKRD20A32  
    POTEH2  ENSG000001552822  ANKRD30B2  ANKRD36C2  ENSG000002663022  POTEJ2  POTEC2  ANKRD20A22  
    POTEG2  ANKRD622  ANKRD18A2  ENSG000001882192  POTEM2  ANKRD20A12  LOC1009963312  CCDC144A2  
    POTED2  ANKRD20A42  ANKRD18B2  LOC1002889662  
    18/29 SIMAP similar genes for ANKRD26 using alignment to 4 protein entries:     ANR26_HUMAN (see all proteins) (see all similar genes):
    DKFZp781D1722    POTEA    ANKRD20A5P    ANKRD36BP1    ANKRD7    LOC254750
    MGC26718    POTEF    ANKRD19P    ANKRD30BL    LOC644249    ANKRD36
    POTEB    POTEM    SHANK2    ANKRD18A    NF2    EIF3L

    ANKRD26 for paralogs           About GeneDecksing


    5/21 Pseudogenes.org Pseudogenes for ANKRD26 (see all 21)
    PGOHUM00000238725 PGOHUM00000248306 PGOHUM00000248371 PGOHUM00000248560 PGOHUM00000262118


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1729 NCBI SNPs in ANKRD26 are shown (see all 1729    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11975861,2
    C,F,H,--26961056(+) ttggcC/Tagtaa 2 -- ds500116Minor allele frequency- T:0.03MN NS EA NA 1992
    rs758011811,2
    C,F,--26961233(+) CATAAA/GTGTCA 2 -- ds50011Minor allele frequency- G:0.08WA 118
    rs39455241,2
    C,H--26964038(+) CTGGCT/GACAGT 2 -- int16Minor allele frequency- G:0.00NS EA NA 422
    rs744267251,2
    --26964590(+) TCTGAT/CAAAAA 2 -- int11Minor allele frequency- C:0.01EA 120
    rs110154501,2
    C,F,H,--26965286(+) ATTCAT/CGTAAA 2 -- int19Minor allele frequency- C:0.16NS EA NA CSA WA 678
    rs618510361,2
    --26966694(+) AGGGAC/TACTTG 2 -- int11Minor allele frequency- T:0.50NA 2
    rs787687871,2
    --26966721(+) GTCTTC/TTGTGT 2 -- int10--------
    rs735963441,2
    C,--26967531(+) TGTAAC/TATAGT 2 -- int11Minor allele frequency- T:0.50WA 2
    rs590956921,2
    C,--26967761(+) AATTAA/GGGAAA 2 -- int12Minor allele frequency- G:0.02WA 120
    rs110154511,2
    F,--26968009(+) ctcctG/Aagctc 2 -- int11Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for ANKRD26 (27280843 - 27389427 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ANKRD26
         1 CNV: 39047
    Human Gene Mutation Database (HGMD): ANKRD26

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ANKRD26 for disorders           About GeneDecksing

    OMIM gene information: 610855    OMIM disorders: --

    2 diseases for ANKRD26:    About MalaCards
    thrombocytopenia    thrombocytopenia 2

    Human Genome Epidemiology (HuGE) Navigator: ANKRD26 (1 document)

    Export disorders for ANKRD26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKRD26 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with ANKRD26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    6. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    7. Mutations in ANKRD26 are responsible for a frequent f orm of inherited thrombocytopenia: analysis of 78 patients from 21 families. (PubMed id 21467542)1 Noris P....Savoia A. (2011)
    8. Mutations in the 5' UTR of ANKRD26, the ankirin repea t domain 26 gene, cause an autosomal-dominant form of inherited thrombocytopeni a, THC2. (PubMed id 21211618)1 Pippucci T....Balduini C.L. (2011)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22852 HGNC: 29186 AceView: ANKRD26 Ensembl:ENSG00000107890 euGenes: HUgn22852
    ECgene: ANKRD26 H-InvDB: ANKRD26

    (According to HUGE)
    About This Section
    HUGE: KIAA1074

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKRD26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANKRD26 gene:
    Search GeneIP for patents involving ANKRD26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    von Willebrand factor
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