ANKRD26 Gene
protein-coding GIFtS: 51
GCID: GC10M027280
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|
ankyrin repeat domain 26
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Aliases for ANKRD26 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ankyrin Repeat Domain 261 2 | | KIAA10741 3 5 | | THC22 | | Ankyrin Repeat Domain-Containing Protein 262 | | BA145E8.11 |
Export aliases for ANKRD26 gene to outside databasesPrevious GC identifers: GC10M027298 GC10M027297 GC10M027334 GC10M026961 |
Summaries for ANKRD26 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for ANKRD26: This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions.Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are foundon chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for thisgene. (provided by RefSeq, Dec 2011) Gene Wiki entry for ANKRD26
|
Genomic Views for ANKRD26 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ANKRD26 gene promoter: Egr-1 CUTL1 E47 GATA-1 Meis-1b Meis-1a ZID Hlf Meis-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKRD26
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD26 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p12.1 Ensembl cytogenetic band: 10p12.1 HGNC cytogenetic band: 10p12.1ANKRD26 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M027280: view genomic region
(about GC identifiers)
Start:
|
27,280,843 bp from pter |
End:
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27,389,427 bp from pter |
Size:
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108,585 bases |
Orientation:
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minus strand |
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Proteins for ANKRD26 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ANR26_HUMAN, Q9UPS8 (See
protein sequence)Recommended Name: Ankyrin repeat domain-containing protein 26 Size: 1709 amino acids; 196324 Da
Sequence caution: Sequence=BAA83026.2; Type=Erroneous initiation;
Secondary accessions: A6NH29 Q2TAZ3 Q6ZR14 Q9H1Q1 Q9NSK9 Q9NTD5 Q9NW69Alternative splicing: 3 isoforms: Q9UPS8-1 Q9UPS8-2 Q9UPS8-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ANKRD26: NX_Q9UPS8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UPS8 ANKRD26 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001242982.1 NP_055730.2 ENSEMBL proteins: ENSP00000394152 ENSP00000365255 ENSP00000405112 ENSP00000365238 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ANKRD26 for ontologies About GeneDecksing
ANKRD26 Antibody Products: Assay Products for ANKRD26: |
Protein
Domains / Families for ANKRD26 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKRD26 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UPS8ProtoNet protein and cluster: Q9UPS8 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ANR26_HUMAN, Q9UPS8Similarity: Contains 5 ANK repeats |
Function for ANKRD26 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD26 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD26 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ANKRD26 (NM_014915) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD26 |
1 GenomeRNAi human phenotype for ANKRD26: Animal Models: 6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ankrd26):
ANKRD26 for phenotypes About GeneDecksing
|
Pathways & Interactions for ANKRD26 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD26
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 3 Interacting proteins for ANKRD26 (Q9UPS83 ENSP000003652554) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019216 | regulation of lipid metabolic process |
-- | -- | | GO:0019217 | regulation of fatty acid metabolic process |
-- | -- | | GO:0040015 | negative regulation of multicellular organism growth |
-- | -- | | GO:0046621 | negative regulation of organ growth |
-- | -- | | GO:0060259 | regulation of feeding behavior |
-- | -- |
ANKRD26 for ontologies About GeneDecksing
|
Drugs & Compounds for ANKRD26 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ANKRD26 Search CenterWatch for drugs/clinical trials and news about ANKRD26 / ANR26 
|
Transcripts for ANKRD26 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ANKRD26 gene (2 alternative transcripts): NM_001256053.1 NM_014915.2 Unigene Cluster for ANKRD26: Ankyrin repeat domain 26 Hs.361041 [show with all ESTs]Unigene Representative Sequence: NM_0149157 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000445828 ENST00000376087(uc001itg.2 uc009xku.1 uc001ith.2) ENST00000490015 ENST00000473304 ENST00000466890 ENST00000436985 ENST00000376070
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD26 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD26 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ANKRD26 (NM_014915) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD26 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD26  |
Additional cDNA sequence: AB028997.1 AK001137.1 AK128577.1 AL137351.1 AL162063.1 BC110646.1 BC130453.1 11 DOTS entries: DT.99989689 DT.408009 DT.95154865 DT.101970047 DT.75153471 DT.92423456 DT.40258759 DT.103376 DT.91924459 DT.95123741 DT.91663230 24/85 AceView cDNA sequences (see all 85): AB028997 BM463480 AI084496 H88735 BQ012478 H88734 AK001137 AW000914 BQ071543 CD675569 AI871874 BG527816 AL137351 AL162063 BM692701 BX353971 AK128577 AA826458 AA296607 BU734004 AI922499 BQ011407 CR624443 BF794181 GeneLoc Exon Structure
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Expression for ANKRD26 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKRD26 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TAAAAATATT
About this image See ANKRD26 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ANKRD26
SOURCE GeneReport for Unigene cluster: Hs.361041 SABiosciences Custom PCR Arrays for ANKRD26
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD26 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANKRD26 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD26 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD26 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD26 |
Orthologs for ANKRD26 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ANKRD26 gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
ANKRD261 |
ankyrin repeat domain 26 |
62.14(n) 50.18(a) |
  |
417764 XM_416008.3 XP_416008.3 |
lizard (Anolis carolinensis) |
Reptilia |
ANKRD626 |
-- |
34(a) |
1 → many |
GL344195.1(39104-48393) |
tropical clawed frog (Xenopus tropicalis) |
Amphibia |
1420347462 |
-- |
71.81(n) |
  |
142034746 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.264882 |
Danio rerio cDNA clone IMAGE6793503, partial cds |
68.44(n) |
  |
BC053220.1 |
ENSEMBL Gene Tree for ANKRD26 (if available) TreeFam Gene Tree for ANKRD26 (if available)  |
Paralogs for ANKRD26 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ANKRD26 gene
- POTEF2 POTEI2 ANKRD30A2 ANKRD362 ANKRD72 POTEB2 ANKRD30BL2 ANKRD20A32
- POTEH2 ENSG000001552822 ANKRD30B2 ANKRD36C2 ENSG000002663022 POTEJ2 POTEC2 ANKRD20A22
- POTEG2 ANKRD622 ANKRD18A2 ENSG000001882192 POTEM2 ANKRD20A12 LOC1009963312 CCDC144A2
- POTED2 ANKRD20A42 ANKRD18B2 LOC1002889662
18/29 SIMAP similar genes for ANKRD26 using alignment to 4 protein entries: ANR26_HUMAN (see all proteins)
(see all similar genes):DKFZp781D1722 POTEA ANKRD20A5P ANKRD36BP1 ANKRD7 LOC254750 MGC26718 POTEF ANKRD19P ANKRD30BL LOC644249 ANKRD36 POTEB POTEM SHANK2 ANKRD18A NF2 EIF3L
ANKRD26 for paralogs About GeneDecksing
5/21 Pseudogenes.org Pseudogenes for ANKRD26 (see all 21) PGOHUM00000238725 PGOHUM00000248306 PGOHUM00000248371 PGOHUM00000248560 PGOHUM00000262118
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Genomic Variants for ANKRD26 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 10 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKRD26 (27280843 - 27389427 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for ANKRD26 1 CNV: 39047 Human Gene Mutation Database (HGMD): ANKRD26
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD26 |
|
Disorders
/ Diseases for ANKRD26 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ANKRD26 for disorders About GeneDecksing
OMIM gene information: 610855
OMIM disorders: --
2 diseases for ANKRD26: About MalaCardsthrombocytopenia thrombocytopenia 2 Human Genome Epidemiology (HuGE) Navigator: ANKRD26 (1 document) Export disorders for ANKRD26 gene to outside databases
|
Publications for ANKRD26 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKRD26 gene, integrated from 9 sources (see all 17): (articles sorted by number of sources associating them with ANKRD26) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- Mutations in ANKRD26 are responsible for a frequent f orm of inherited thrombocytopenia: analysis of 78 patients from 21 families. (PubMed id 21467542)1 Noris P....Savoia A. (2011)
- Mutations in the 5' UTR of ANKRD26, the ankirin repea t domain 26 gene, cause an autosomal-dominant form of inherited thrombocytopeni a, THC2. (PubMed id 21211618)1 Pippucci T....Balduini C.L. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
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External Searches for ANKRD26 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ANKRD26 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKRD26 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ANKRD26 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ANKRD26 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANKRD26 gene: Search GeneIP for patents involving ANKRD26
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ANKRD26 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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