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Aliases for ANKRD24 Gene

Aliases for ANKRD24 Gene

  • Ankyrin Repeat Domain 24 2 3 5
  • KIAA1981 4

External Ids for ANKRD24 Gene

Previous GeneCards Identifiers for ANKRD24 Gene

  • GC19P004134
  • GC19P004135
  • GC19P003946

Summaries for ANKRD24 Gene

GeneCards Summary for ANKRD24 Gene

ANKRD24 (Ankyrin Repeat Domain 24) is a Protein Coding gene. An important paralog of this gene is RAI14.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD24 Gene

Genomics for ANKRD24 Gene

Regulatory Elements for ANKRD24 Gene

Enhancers for ANKRD24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F004142 1.4 Ensembl ENCODE 13.1 -36.1 -36052 8.0 PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 CACTIN ANKRD24 SIRT6 MAP2K2 FZR1 ENSG00000267030 FSD1 TMIGD2 ENSG00000267769 ENSG00000269318
GH19F004129 1.3 Ensembl ENCODE 12.4 -51.5 -51462 2.4 ATF1 PKNOX1 ARNT ARID4B SIN3A ZNF48 ZNF121 GATA2 ZNF548 FOS CACTIN CREB3L3 ANKRD24 SIRT6 CACTIN-AS1 APBA3 EEF2 FSD1 TMIGD2 ENSG00000269807
GH19F004204 1.2 Ensembl ENCODE 12.8 +22.3 22253 1.0 TBP PKNOX1 TBL1XR1 ZNF76 ZNF2 ZSCAN9 THRB RAD21 RFX5 SLC30A9 DPP9-AS1 ENSG00000267030 APBA3 ANKRD24 SIRT6 CREB3L3 ENSG00000267769 EBI3 CCDC94 CACTIN-AS1
GH19F004181 1.2 ENCODE 10 -0.7 -687 2.6 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SIRT6 LOC100287614 ENSG00000266959 LOC105372244 TICAM1 CACTIN ANKRD24 GC19M004146
GH19F003809 1.5 FANTOM5 Ensembl ENCODE 7.3 -370.2 -370225 6.4 HDGF HDAC1 ATF1 PKNOX1 NFRKB ZBTB40 ZNF121 ELK1 EGR1 ETV6 ZFR2 ATCAY ANKRD24 MATK MAP2K2 NFIC MFSD12 FZR1 ZBTB7A CCDC94
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD24 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042557 -125 1801 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for ANKRD24 Gene

Chromosome:
19
Start:
4,182,625 bp from pter
End:
4,224,814 bp from pter
Size:
42,190 bases
Orientation:
Plus strand

Genomic View for ANKRD24 Gene

Genes around ANKRD24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD24 Gene

Proteins for ANKRD24 Gene

  • Protein details for ANKRD24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF21-ANR24_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 24
    Protein Accession:
    Q8TF21
    Secondary Accessions:
    • O75268
    • O95781

    Protein attributes for ANKRD24 Gene

    Size:
    1146 amino acids
    Molecular mass:
    124187 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC33490.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAD15479.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD24 Gene

Post-translational modifications for ANKRD24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD24 Gene

Domains & Families for ANKRD24 Gene

Gene Families for ANKRD24 Gene

Protein Domains for ANKRD24 Gene

Suggested Antigen Peptide Sequences for ANKRD24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF21

UniProtKB/Swiss-Prot:

ANR24_HUMAN :
  • Contains 5 ANK repeats.
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with ANKRD24: view

Function for ANKRD24 Gene

Phenotypes for ANKRD24 Gene

GenomeRNAi human phenotypes for ANKRD24:
genes like me logo Genes that share phenotypes with ANKRD24: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD24 Gene

Localization for ANKRD24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD24 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD24 Gene

Pathways & Interactions for ANKRD24 Gene

SuperPathways for ANKRD24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD24 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD24 Gene

Transcripts for ANKRD24 Gene

mRNA/cDNA for ANKRD24 Gene

(12) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD24 Gene

Ankyrin repeat domain 24:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1: -
SP2:
SP3: -

Relevant External Links for ANKRD24 Gene

GeneLoc Exon Structure for
ANKRD24
ECgene alternative splicing isoforms for
ANKRD24

Expression for ANKRD24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD24 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD24 Gene

This gene is overexpressed in Brain - Cortex (x7.5), Brain - Frontal Cortex (BA9) (x6.4), and Brain - Anterior cingulate cortex (BA24) (x4.4).

Protein differential expression in normal tissues from HIPED for ANKRD24 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.9), Kidney (9.6), and Fetal gut (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD24 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANKRD24 Gene:

ANKRD24

SOURCE GeneReport for Unigene cluster for ANKRD24 Gene:

Hs.197872
genes like me logo Genes that share expression patterns with ANKRD24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ANKRD24 Gene

Orthologs for ANKRD24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD24 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD24 34 35
  • 83.76 (n)
cow
(Bos Taurus)
Mammalia ANKRD24 34 35
  • 83.58 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD24 35
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd24 34 16 35
  • 71.09 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909645 34
  • 66.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD24 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD24 35
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 18 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ankrd24 35
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToMany
Species where no ortholog for ANKRD24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD24 Gene

ENSEMBL:
Gene Tree for ANKRD24 (if available)
TreeFam:
Gene Tree for ANKRD24 (if available)

Paralogs for ANKRD24 Gene

Paralogs for ANKRD24 Gene

(10) SIMAP similar genes for ANKRD24 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ANKRD24: view

Variants for ANKRD24 Gene

Sequence variations from dbSNP and Humsavar for ANKRD24 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401182 -- 4,223,650(+) acctc(C/T)gcctc intron-variant
rs10402675 -- 4,209,921(+) AGCGG(C/G)AGGAG intron-variant, upstream-variant-2KB
rs10402917 -- 4,211,259(+) GGCGT(C/T)GTCAA intron-variant, reference, synonymous-codon
rs10405333 -- 4,220,715(+) acgcc(C/T)ggcta intron-variant
rs10408634 -- 4,212,149(+) GAGCC(A/G)AGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD24 Gene

Variant ID Type Subtype PubMed ID
nsv833718 CNV loss 17160897
nsv833717 CNV loss 17160897
nsv833716 CNV loss 17160897
nsv1121544 CNV deletion 24896259
esv3643490 CNV loss 21293372
esv32625 CNV gain 17666407
esv2717994 CNV deletion 23290073
esv2717993 CNV deletion 23290073
esv2717992 CNV deletion 23290073
esv2717991 CNV deletion 23290073
esv1448643 CNV deletion 17803354
dgv651e214 CNV gain 21293372
dgv216e215 CNV deletion 23714750

Variation tolerance for ANKRD24 Gene

Gene Damage Index Score: 9.79; 89.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD24 Gene

Disorders for ANKRD24 Gene

Relevant External Links for ANKRD24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD24

No disorders were found for ANKRD24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD24 Gene

Publications for ANKRD24 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3 64
  3. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3 64
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3 64
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64

Products for ANKRD24 Gene

Sources for ANKRD24 Gene

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