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ANKRD24 Gene

protein-coding   GIFtS: 45
GCID: GC19P004183

Ankyrin Repeat Domain 24

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 241 2
Ankyrin Repeat Domain-Containing Protein 242
KIAA19813

External Ids:    HGNC: 294241   Entrez Gene: 1709612   Ensembl: ENSG000000898477   UniProtKB: Q8TF213   

Export aliases for ANKRD24 gene to outside databases

Previous GC identifers: GC19P004134 GC19P004135 GC19P003946


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD24 Gene:
ANKRD24 (ankyrin repeat domain 24) is a protein-coding gene. An important paralog of this gene is RAI14.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD24 gene promoter:
         HFH-3   Olf-1   LUN-1   MIF-1   Nkx2-5   FOXI1   HEN1   FOXJ2 (long isoform)   ARP-1   FOXJ2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ANKRD24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ANKRD24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD24 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P004183:  view genomic region     (about GC identifiers)

Start:
4,183,351 bp from pter      End:
4,224,811 bp from pter
Size:
41,461 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANR24_HUMAN, Q8TF21 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 24  
Size: 1146 amino acids; 124187 Da
Sequence caution: Sequence=AAC33490.1; Type=Erroneous gene model prediction; Sequence=AAD15479.1; Type=Erroneous
gene model prediction;
Secondary accessions: O75268 O95781
Alternative splicing: 2 isoforms:  Q8TF21-1   Q8TF21-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD24: NX_Q8TF21

Explore proteomics data for ANKRD24 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANKRD24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_597732.1  
    ENSEMBL proteins: 
     ENSP00000471252   ENSP00000470227   ENSP00000262970   ENSP00000471346   ENSP00000321731  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q8TF21

    ProtoNet protein and cluster: Q8TF21

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: ANR24_HUMAN, Q8TF21
    Similarity: Contains 5 ANK repeats


    Find genes that share domains with ANKRD24           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ANKRD24           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ANKRD24:
     Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ANKRD24

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD24
    Interactions:

        Search GeneGlobe Interaction Network for ANKRD24

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for ANKRD24 (Q8TF212, 3 ENSP000003217314) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UNC119Q134322, 3MINT-63317 I2D: score=4 
    LRIF1Q5T3J32, 3MINT-63319 I2D: score=3 
    PACSIN1Q9BY113, ENSP000002444584I2D: score=3 STRING: ENSP00000244458
    EEF1A1P681043I2D: score=3 
    RIF1Q5UIP03I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKRD24 (ANR24)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANKRD24 gene: 
    NM_133475.1  

    Unigene Cluster for ANKRD24:

    Ankyrin repeat domain 24
    Hs.197872  [show with all ESTs]
    Unigene Representative Sequence: NM_133475
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600132 ENST00000597689 ENST00000262970(uc002lzt.2) ENST00000595928
    ENST00000595096 ENST00000318934(uc010dtt.1 uc002lzs.2)
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      QuantiFast Probe-based Assays in human, mouse, rat ANKRD24

    Additional mRNA sequence: 

    AB075861.1 BC028236.1 

    3 DOTS entries:

    DT.95153534  DT.95194386  DT.121469935 

    5 AceView cDNA sequences:

    BX117359 BI769995 BU176951 AI632678 BM693112 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD24    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
    SP1:                    -                                                                                                                           
    SP2:                                                                                                                                                
    SP3:              -                                                                                                                                 


    ECgene alternative splicing isoforms for ANKRD24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKRD24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTTGGAGA
    ANKRD24 Expression
    About this image

    ANKRD24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKRD24 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.197872
        Custom PCR Arrays for ANKRD24
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ANKRD24 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankrd241 , 5 ankyrin repeat domain 241, 5 71.09(n)1
    67.49(a)1
      10 (39.72 cM)5
    706151  NM_027480.31  NP_081756.41 
     816285405 
    chicken
    (Gallus gallus)
    Aves ANKRD246
    ankyrin repeat domain 24
    42(a)
    1 ↔ 1
    28(2537314-2544234)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    18(a)
    many ↔ many
    AAWZ02038447(516-8292)
    zebrafish
    (Danio rerio)
    Actinopterygii ankrd246
    ankyrin repeat domain 24
    33(a)
    1 ↔ 1
    22(21680202-21714522) ENSDARG00000062103


    ENSEMBL Gene Tree for ANKRD24 (if available)
    TreeFam Gene Tree for ANKRD24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKRD24 gene
    RAI142  UACA2  ANKRD352  
    10 SIMAP similar genes for ANKRD24 using alignment to 3 protein entries:     ANR24_HUMAN (see all proteins):
    RAI14    UACA    ANKRD35    PPP1R12A    DKFZp564M063    ANKDD1A
    ANK2    GABPB1    PPP1R27    CDKN2C

    Find genes that share paralogs with ANKRD24           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKRD24 (see all 1168)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1417244021,2
    --4184748(+) GGCACC/TGGTGG 1 -- int10--------
    rs753442071,2
    F--4184790(+) GATGGG/AGGGCG 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1454563501,2
    --4184857(+) GGTGGA/GTGGAT 1 -- int10--------
    rs1452216951,2
    --4184895(+) TGGAGA/GGATGG 1 -- int10--------
    rs1169518921,2
    F--4184935(+) TCCATG/CGATGG 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1407518911,2
    C--4184968(+) GCACT-/GGTG  
            
    GGTGG
    1 -- int10--------
    rs1151693031,2
    C,F--4185008(+) GGGTGG/CGTGGA 1 -- int12Minor allele frequency- C:0.17WA EA 238
    rs2008488801,2
    --4185094(+) GCAGA-/TGGG  
            
    TGGAT
    1 -- int10--------
    rs1177945681,2
    F--4185097(+) GATGGG/ATGGAT 1 -- int11Minor allele frequency- A:0.11EA 120
    rs1809671131,2
    --4185105(+) GATGGA/GTGGAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for ANKRD24 (4183351 - 4224811 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ANKRD24 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717993CNV Deletion23290073
    esv2717992CNV Deletion23290073
    esv2717991CNV Deletion23290073
    esv2717994CNV Deletion23290073
    esv1448643CNV Deletion17803354
    nsv833716CNV Loss17160897
    nsv910816CNV Loss21882294
    nsv833717CNV Loss17160897
    nsv910818CNV Loss21882294
    nsv910783CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKRD24 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ANKRD24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    3. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    4. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 170961 HGNC: 29424 AceView: ANKRD24.1 Ensembl:ENSG00000089847 euGenes: HUgn170961
    ECgene: ANKRD24 H-InvDB: ANKRD24

    (According to HUGE)
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    HUGE: KIAA1981

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKRD24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKRD24 gene:
    Search GeneIP for patents involving ANKRD24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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