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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANKRD24 Gene

protein-coding GIFtS: 45
GCID: GC19P004183

ankyrin repeat domain 24

Explore 3 diseases affiliated with
ANKRD24 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ankyrin Repeat Domain 24¹ ²
KIAA1981¹ ³
Ankyrin Repeat Domain-Containing Protein 24²

External Ids:	HGNC: 29424¹	Entrez Gene: 170961²	Ensembl: ENSG00000089847⁷	UniProtKB: Q8TF21³

Export aliases for ANKRD24 gene to outside databases

Previous GC identifers: GC19P004134 GC19P004135 GC19P003946

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011255.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANKRD24 gene promoter:
HFH-3 Olf-1 LUN-1 MIF-1 Nkx2-5 FOXI1 HEN1 FOXJ2 (long isoform) ARP-1 FOXJ2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ANKRD24

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD24

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

ANKRD24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD24 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P004183: view genomic region (about GC identifiers)

Start:	4,183,351 bp from pter	End:	4,224,811 bp from pter
Size:	41,461 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANR24_HUMAN, Q8TF21 (See protein sequence)

Recommended Name: Ankyrin repeat domain-containing protein 24

Size: 1146 amino acids; 124187 Da

Sequence caution: Sequence=AAC33490.1; Type=Erroneous gene model prediction; Sequence=AAD15479.1; Type=Erroneous gene

model prediction;

Secondary accessions: O75268 O95781

Alternative splicing: 2 isoforms: Q8TF21-1 Q8TF21-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD24: NX_Q8TF21

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TF21

ANKRD24 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_597732.1

ENSEMBL proteins:

ENSP00000321731 ENSP00000262970

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANKRD24 for domains About GeneDecksing

2 InterPro domains/families:

IPR020683 Ankyrin_rpt-contain_dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q8TF21

ProtoNet protein and cluster: Q8TF21

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: ANR24_HUMAN, Q8TF21

Similarity: Contains 5 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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1 GenomeRNAi human phenotype for ANKRD24:

Increased G1 DNA content

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ANKRD24

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

5/8 Interacting proteins for ANKRD24 (Q8TF21^{2, 3} ENSP00000321731⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UNC119	Q13432²^,³	MINT-63317 I2D: score=4
LRIF1	Q5T3J3²^,³	MINT-63319 I2D: score=3
PACSIN1	Q9BY11³, ENSP00000244458⁴	I2D: score=3 STRING: ENSP00000244458
EEF1A1	P68104³	I2D: score=3
RIF1	Q5UIP0³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for ANKRD24
Search CenterWatch for drugs/clinical trials and news about ANKRD24 / ANR24

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for ANKRD24 gene:

NM_133475.1

Unigene Cluster for ANKRD24:

Ankyrin repeat domain 24

Hs.197872 [show with all ESTs]

Unigene Representative Sequence: NM_133475

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000318934(uc010dtt.1 uc002lzs.2) ENST00000262970(uc002lzt.2)

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Additional cDNA sequence:

AB075861.1 BC028236.1

3 DOTS entries:

DT.95153534 DT.95194386 DT.121469935

5 AceView cDNA sequences:

BX117359 BI769995 BU176951 AI632678 BM693112

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD24 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24
SP1:							-
SP2:
SP3:					-

ECgene alternative splicing isoforms for ANKRD24

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANKRD24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACTTGGAGA

About this image

ANKRD24 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mesendoderm-like cells (Generation of mesend...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ANKRD24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD24

SOURCE GeneReport for Unigene cluster: Hs.197872

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD24 gene from 2/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ANKRD24¹	ankyrin repeat domain 24	57.19(n) 46.4(a)		428331 XM_425891.3 XP_425891.3
zebrafish (Danio rerio)	Actinopterygii	ankrd24¹	ankyrin repeat domain 24	49.25(n) 40.82(a)		565326 XM_688603.4 XP_693695.4

ENSEMBL Gene Tree for ANKRD24 (if available)
TreeFam Gene Tree for ANKRD24 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANKRD24 gene

UACA² RAI14² ANKRD35²

4 SIMAP similar genes for ANKRD24 using alignment to 3 protein entries: ANR24_HUMAN (see all proteins):

PPP1R12A DKFZp564M063 PPP1R27 CDKN2C

ANKRD24 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141724402^1,2		--	4184748(+)	`GGCACC/TGGTGG`	1	--	int¹		0	--	--	--	--
rs75344207^1,2		--	4184790(+)	`GATGGG/AGGGCG`	1	--	int¹		1		WA	118
rs145456350^1,2		--	4184857(+)	`GGTGGA/GTGGAT`	1	--	int¹		0	--	--	--	--
rs145221695^1,2		--	4184895(+)	`TGGAGA/GGATGG`	1	--	int¹		0	--	--	--	--
rs116951892^1,2		--	4184935(+)	`TCCATG/CGATGG`	1	--	int¹		1		NA	120
rs140751891^1,2	C,	--	4184968(+)	`GCACT-/GGTG GGTGG`	1	--	int¹		0	--	--	--	--
rs115169303^1,2	F,	--	4185008(+)	`GGGTGG/CGTGGA`	1	--	int¹		2		WA EA	238
rs200848880^1,2		--	4185094(+)	`GCAGA-/TGGG TGGAT`	1	--	int¹		0	--	--	--	--
rs117794568^1,2	F,	--	4185097(+)	`GATGGG/ATGGAT`	1	--	int¹		1		EA	120
rs180967113^1,2		--	4185105(+)	`GATGGA/GTGGAT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ANKRD24 (4183351 - 4224811 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for ANKRD24
4 CNVs: 5074 78044 7202 89044
4 Indels: 78043 78042 89043 89042

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ANKRD24 for disorders About GeneDecksing

3 diseases for ANKRD24: About MalaCards

chronic lymphocytic leukemia lymphocytic leukemia leukemia

Export disorders for ANKRD24 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ANKRD24 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANKRD24)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)^{1, 2, 3} Nagase T.... Ohara O. (2001)
A human MAP kinase interactome. (PubMed id 20936779)¹ Bandyopadhyay S....Ideker T. (2010)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 170961	HGNC: 29424	AceView: ANKRD24.1	Ensembl:ENSG00000089847	euGenes: HUgn170961
ECgene: ANKRD24	H-InvDB: ANKRD24

(According to HUGE)
About This Section

HUGE: KIAA1981

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANKRD24	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANKRD24 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ANKRD24 gene:
Search GeneIP for patents involving ANKRD24

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ANKRD24 gene at Home site.

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ANKRD24 Gene

ankyrin repeat domain 24

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Export list of displayed genes

ANKRD24 Gene

ankyrin repeat domain 24

Aliasesfor ANKRD24 gene

Summariesfor ANKRD24 gene

Genomic Viewsfor ANKRD24 gene

Proteinsfor ANKRD24 gene

Protein Domains /Familiesfor ANKRD24 gene

Functionfor ANKRD24 gene

Pathways & Interactionsfor ANKRD24 gene

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Transcriptsfor ANKRD24 gene

Expression for ANKRD24 gene

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Genomic Variantsfor ANKRD24 gene

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Genome Databases showing ANKRD24 gene

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Specialized Databases showing ANKRD24 gene

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for ANKRD24 gene

Summaries
for ANKRD24 gene

Genomic Views
for ANKRD24 gene

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for ANKRD24 gene

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Families
for ANKRD24 gene

Function
for ANKRD24 gene

Pathways & Interactions
for ANKRD24 gene

Drugs & Compounds
for ANKRD24 gene

Transcripts
for ANKRD24 gene

Expression
for ANKRD24 gene

Orthologs
for ANKRD24 gene

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for ANKRD24 gene

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for ANKRD24 gene

Disorders / Diseases
for ANKRD24 gene

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for ANKRD24 gene

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for ANKRD24 gene

Products
for ANKRD24 gene