Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANKRD23 Gene

Aliases for ANKRD23 Gene

  • Ankyrin Repeat Domain 23 2 3 5
  • Diabetes Related Ankyrin Repeat Protein 2 3
  • Muscle Ankyrin Repeat Protein 3 3 4
  • DARP 3 4
  • Ankyrin Repeat Domain-Containing Protein 23 3
  • Diabetes-Related Ankyrin Repeat Protein 4
  • MARP3 3

External Ids for ANKRD23 Gene

Previous GeneCards Identifiers for ANKRD23 Gene

  • GC02M096988
  • GC02M096925
  • GC02M097490
  • GC02M091464

Summaries for ANKRD23 Gene

Entrez Gene Summary for ANKRD23 Gene

  • This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induced during recovery following starvation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANKRD23 Gene

ANKRD23 (Ankyrin Repeat Domain 23) is a Protein Coding gene. GO annotations related to this gene include titin binding. An important paralog of this gene is ANKRD1.

UniProtKB/Swiss-Prot for ANKRD23 Gene

  • May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.

Gene Wiki entry for ANKRD23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD23 Gene

Genomics for ANKRD23 Gene

Regulatory Elements for ANKRD23 Gene

Enhancers for ANKRD23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F096905 1.1 Ensembl ENCODE 13 -49.3 -49286 2.5 KLF1 MAZ SP3 MNT ZIC2 NR2F2 ZFHX2 GLIS2 SCRT2 GLIS1 FAM178B SEMA4C ANKRD23 ANKRD39 SNRNP200 LOC101927053
GH02F096848 0.7 ENCODE 0.4 +9.5 9545 0.7 TFAP4 MXI1 SAP130 RAD21 RARA YY1 POLR2A SCRT2 NR2F6 TFE3 GC02P096839 ANKRD23
GH02F096847 0.2 ENCODE 0.4 +10.2 10156 0.2 ZNF316 SMARCA4 L3MBTL2 GC02P096839 ANKRD23
GH02F096842 1.1 ENCODE 0.4 +15.0 14996 0.2 ZNF263 POLR2A GLIS1 ZIC2 GC02P096839 ANKRD23
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ANKRD23 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000594823 34 2201 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for ANKRD23 Gene

Chromosome:
2
Start:
96,824,526 bp from pter
End:
96,857,934 bp from pter
Size:
33,409 bases
Orientation:
Minus strand

Genomic View for ANKRD23 Gene

Genes around ANKRD23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD23 Gene

Proteins for ANKRD23 Gene

  • Protein details for ANKRD23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SG2-ANR23_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 23
    Protein Accession:
    Q86SG2
    Secondary Accessions:
    • Q711K7
    • Q8NAJ7

    Protein attributes for ANKRD23 Gene

    Size:
    305 amino acids
    Molecular mass:
    34297 Da
    Quaternary structure:
    • Interacts with titin/TTN and MYPN.

    Alternative splice isoforms for ANKRD23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD23 Gene

Post-translational modifications for ANKRD23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD23 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD23 Gene

Domains & Families for ANKRD23 Gene

Gene Families for ANKRD23 Gene

Protein Domains for ANKRD23 Gene

Suggested Antigen Peptide Sequences for ANKRD23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86SG2

UniProtKB/Swiss-Prot:

ANR23_HUMAN :
  • Contains 4 ANK repeats.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with ANKRD23: view

Function for ANKRD23 Gene

Molecular function for ANKRD23 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.

Gene Ontology (GO) - Molecular Function for ANKRD23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031432 titin binding IPI 14583192
genes like me logo Genes that share ontologies with ANKRD23: view
genes like me logo Genes that share phenotypes with ANKRD23: view

Animal Models for ANKRD23 Gene

MGI Knock Outs for ANKRD23:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKRD23 Gene

Localization for ANKRD23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD23 Gene

Nucleus. Note=Sarcomeric I-band and some intercalated disks. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD23 Gene COMPARTMENTS Subcellular localization image for ANKRD23 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ANKRD23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0014704 intercalated disc IEA --
GO:0015629 actin cytoskeleton IDA --
GO:0030016 myofibril IEA --
genes like me logo Genes that share ontologies with ANKRD23: view

Pathways & Interactions for ANKRD23 Gene

SuperPathways for ANKRD23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009612 response to mechanical stimulus IEA --
genes like me logo Genes that share ontologies with ANKRD23: view

No data available for Pathways by source and SIGNOR curated interactions for ANKRD23 Gene

Transcripts for ANKRD23 Gene

Unigene Clusters for ANKRD23 Gene

Ankyrin repeat domain 23:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD23 Gene

No ASD Table

Relevant External Links for ANKRD23 Gene

GeneLoc Exon Structure for
ANKRD23
ECgene alternative splicing isoforms for
ANKRD23

Expression for ANKRD23 Gene

mRNA expression in normal human tissues for ANKRD23 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD23 Gene

This gene is overexpressed in Muscle - Skeletal (x28.9).

NURSA nuclear receptor signaling pathways regulating expression of ANKRD23 Gene:

ANKRD23

SOURCE GeneReport for Unigene cluster for ANKRD23 Gene:

Hs.643430

mRNA Expression by UniProt/SwissProt for ANKRD23 Gene:

Q86SG2-ANR23_HUMAN
Tissue specificity: Mainly expressed in heart, skeletal muscle and brown adipose tissues.
genes like me logo Genes that share expression patterns with ANKRD23: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ANKRD23 Gene

Orthologs for ANKRD23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD23 34 35
  • 99.56 (n)
mouse
(Mus musculus)
Mammalia Ankrd23 34 16 35
  • 86.12 (n)
dog
(Canis familiaris)
Mammalia ANKRD23 34
  • 85.53 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd23 34
  • 85.25 (n)
cow
(Bos Taurus)
Mammalia ANKRD23 34 35
  • 83.33 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD23 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD23 35
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gabpb1 35
  • 9 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for ANKRD23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD23 Gene

ENSEMBL:
Gene Tree for ANKRD23 (if available)
TreeFam:
Gene Tree for ANKRD23 (if available)

Paralogs for ANKRD23 Gene

Paralogs for ANKRD23 Gene

(3) SIMAP similar genes for ANKRD23 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANKRD23: view

Variants for ANKRD23 Gene

Sequence variations from dbSNP and Humsavar for ANKRD23 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs111422274 -- 96,842,362(+) TCTCT(A/C/G)ACTTT intron-variant
rs111492760 -- 96,845,411(+) CGCCT(C/T)AGCCT upstream-variant-2KB
rs111495538 -- 96,838,010(+) GTTGT(C/T)TTCTC utr-variant-3-prime
rs111988673 -- 96,838,108(+) GTGTG(C/T)GCCCC utr-variant-3-prime
rs112177754 -- 96,839,288(+) ACCCG(C/T)GCTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ANKRD23 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv526313 CNV loss 19592680

Variation tolerance for ANKRD23 Gene

Residual Variation Intolerance Score: 36.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD23 Gene

Disorders for ANKRD23 Gene

Relevant External Links for ANKRD23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD23

No disorders were found for ANKRD23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD23 Gene

Publications for ANKRD23 Gene

  1. Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals. (PMID: 12456686) Ikeda K. … Yokoyama M. (J. Biol. Chem. 2003) 2 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. (PMID: 15238456) Nagueh S.F. … Granzier H.L. (Circulation 2004) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ANKRD23 Gene

Sources for ANKRD23 Gene

Content
Loading form....