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ANKRD22 Gene

protein-coding   GIFtS: 46
GCID: GC10M090572

Ankyrin Repeat Domain 22

  Search for ANKRD22
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 221 2
Ankyrin Repeat Domain-Containing Protein 222

External Ids:    HGNC: 283211   Entrez Gene: 1189322   Ensembl: ENSG000001527667   UniProtKB: Q5VYY13   

Export aliases for ANKRD22 gene to outside databases

Previous GC identifers: GC10M090247 GC10M084214


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD22 Gene:
ANKRD22 (ankyrin repeat domain 22) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD22 gene promoter:
         Nkx3-1   Nkx3-1 v1   Nkx2-5   RORalpha2   C/EBPalpha   NF-AT   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD22 promoter sequence
   Search Chromatin IP Primers for ANKRD22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

ANKRD22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD22 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M090572:  view genomic region     (about GC identifiers)

Start:
90,579,656 bp from pter      End:
90,611,732 bp from pter
Size:
32,077 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANR22_HUMAN, Q5VYY1 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 22  
Size: 191 amino acids; 21849 Da
Secondary accessions: B2R9Y7 Q8WU06

Explore the universe of human proteins at neXtProt for ANKRD22: NX_Q5VYY1

Explore proteomics data for ANKRD22 at MOPED


See ANKRD22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_653191.2  
ENSEMBL proteins: 
 ENSP00000360998  

ANKRD22 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ANKRD: Ankyrin repeat domain containing

2 InterPro protein domains:
 IPR002110 Ankyrin_rpt
 IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry Q5VYY1

ProtoNet protein and cluster: Q5VYY1

UniProtKB/Swiss-Prot: ANR22_HUMAN, Q5VYY1
Similarity: Contains 4 ANK repeats


Find genes that share domains with ANKRD22           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with ANKRD22           About GenesLikeMe


Animal Models:
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miRNA
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miRTarBase miRNAs that target ANKRD22:
hsa-mir-335-5p (MIRT019025)

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Selected qRT-PCR Assays for microRNAs that regulate ANKRD22 (see all 16):
hsa-miR-548w hsa-miR-548j hsa-miR-3650 hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y
SwitchGear 3'UTR luciferase reporter plasmidANKRD22 3' UTR sequence
Inhib. RNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD22

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD22


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
cytoskeleton1
endoplasmic reticulum1
extracellular1
nucleus1
peroxisome1
plasma membrane1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD22
Interactions:

    Search GeneGlobe Interaction Network for ANKRD22

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for ANKRD22 (Q5VYY13 ENSP000003609984) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SS18L1O751773, ENSP000003330124I2D: score=1 STRING: ENSP00000333012
CITED4Q96RK13I2D: score=1 
HDAC3ENSP000003029674STRING: ENSP00000302967
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ANKRD22 (ANR22)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ANKRD22 gene: 
NM_144590.2  

Unigene Cluster for ANKRD22:

Ankyrin repeat domain 22
Hs.217484  [show with all ESTs]
Unigene Representative Sequence: NM_144590
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000371930(uc001kfj.4) ENST00000476963
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate ANKRD22 (see all 16):
hsa-miR-548w hsa-miR-548j hsa-miR-3650 hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y
SwitchGear 3'UTR luciferase reporter plasmidANKRD22 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat ANKRD22
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  QuantiFast Probe-based Assays in human, mouse, rat ANKRD22

Additional mRNA sequence: 

AK313969.1 BC021671.1 

6 DOTS entries:

DT.436140  DT.95133899  DT.306014  DT.91690704  DT.40246582  DT.121286034 

Selected AceView cDNA sequences (see all 31):

BM785517 AA976927 AI651205 AI242329 CB128220 BF326749 AA775676 BC021671 
BE841230 BP343758 NM_144590 BU932881 AI660377 BM837388 BP342197 AW196074 
BU596895 AA306997 AA295175 AW299505 AW001485 CD707983 BE566554 BG539351 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ANKRD22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAATGCCTTG
ANKRD22 Expression
About this image


ANKRD22 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 2 entries
         Granulocytes Peripheral Blood
 
 Ovary (Reproductive System)
         Mature Granulosa Cells Antral Follicle
ANKRD22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ANKRD22 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.217484
    Custom PCR Arrays for ANKRD22
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD22

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ANKRD22 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ankrd221 , 5 ankyrin repeat domain 221, 5 85.09(n)1
86.84(a)1
  19 (29.33 cM)5
520241  NM_024204.61  NP_077166.41 
 341225495 
chicken
(Gallus gallus)
Aves ANKRD221 ankyrin repeat domain 22 68.42(n)
69.47(a)
  771419  NM_001277405.1  NP_001264334.1 
lizard
(Anolis carolinensis)
Reptilia ANKRD226
ankyrin repeat domain 22
67(a)
1 ↔ 1
GL343246.1(247602-272878)
tropical clawed frog
(Xenopus tropicalis)
Amphibia ankrd221 ankyrin repeat domain 22 64.91(n)
63.68(a)
  100127758  NM_001113090.1  NP_001106561.1 
zebrafish
(Danio rerio)
Actinopterygii ankrd221 ankyrin repeat domain 22 57.94(n)
51.83(a)
  393244  NM_200274.1  NP_956568.1 


ENSEMBL Gene Tree for ANKRD22 (if available)
TreeFam Gene Tree for ANKRD22 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ANKRD22 (see all 773)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs22973071,2
C,F,H--90581404(-) AACTTA/CTTTTA 1 -- ut315Minor allele frequency- C:0.01EA NS 1886
rs1510174511,2
--90581517(+) CATACA/CAAGAG 1 -- ut310--------
rs1866806211,2
--90581603(+) ATTTAC/TTTCTA 1 -- ut310--------
rs799358601,2
C--90581746(+) ATAATA/GTTTTA 1 -- ut310--------
rs1907388461,2
--90581783(+) AACAAA/GCTTGG 1 -- ut310--------
rs792652181,2
C,F--90581784(+) ACAAGC/GTTGGC 1 -- ut311Minor allele frequency- G:0.03WA 118
rs760891881,2
F--90581833(+) TTAAAC/TGAACA 1 -- ut311Minor allele frequency- T:0.01EA 120
rs171133441,2
C,F,H--90581891(+) TAAACC/TGAAAT 1 -- ut3118Minor allele frequency- T:0.07NA NS EA 1998
rs1826630301,2
--90581971(+) TTGTCA/CATTTG 1 -- ut310--------
rs174373961,2
C,F--90582022(+) ATAGAT/CGTTTT 1 -- ut31 ese34Minor allele frequency- C:0.01NA 144

HapMap Linkage Disequilibrium report for ANKRD22 (90579656 - 90611732 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for ANKRD22:    About this table    
Variant IDTypeSubtypePubMed ID
nsv7484CNV Insertion18451855
nsv831942CNV Gain17160897
nsv831941CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ANKRD22
DNA2.0 Custom Variant and Variant Library Synthesis for ANKRD22

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with ANKRD22           About GenesLikeMe

Genetic Association Database (GAD): ANKRD22
Human Genome Epidemiology (HuGE) Navigator: ANKRD22 (2 documents)

Export disorders for ANKRD22 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ANKRD22 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with ANKRD22)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
  7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  8. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
  9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  10. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 118932 HGNC: 28321 AceView: ANKRD22 Ensembl:ENSG00000152766 euGenes: HUgn118932
ECgene: ANKRD22 H-InvDB: ANKRD22

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ANKRD22 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ANKRD22 gene:
Search GeneIP for patents involving ANKRD22

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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