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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKRD22 Gene

protein-coding   GIFtS: 45
GCID: GC10M090572

Ankyrin Repeat Domain 22

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ankyrin Repeat Domain 221 2
Ankyrin Repeat Domain-Containing Protein 222

External Ids:    HGNC: 283211   Entrez Gene: 1189322   Ensembl: ENSG000001527667   UniProtKB: Q5VYY13   

Export aliases for ANKRD22 gene to outside databases

Previous GC identifers: GC10M090247 GC10M084214


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ANKRD22 Gene: 
ANKRD22 (ankyrin repeat domain 22) is a protein-coding gene. Diseases associated with ANKRD22 include alzheimer's disease, and gastric cancer.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKRD22 gene promoter:
         Nkx3-1   Nkx3-1 v1   Nkx2-5   RORalpha2   C/EBPalpha   NF-AT   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD22 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANKRD22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

ANKRD22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD22 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M090572:  view genomic region     (about GC identifiers)

Start:
90,579,656 bp from pter      End:
90,611,732 bp from pter
Size:
32,077 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANR22_HUMAN, Q5VYY1 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 22  
Size: 191 amino acids; 21849 Da
Secondary accessions: B2R9Y7 Q8WU06

Explore the universe of human proteins at neXtProt for ANKRD22: NX_Q5VYY1

Explore proteomics data for ANKRD22 at MOPED 

ANKRD22 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ANKRD22 Protein Expression

REFSEQ proteins: NP_653191.2  
ENSEMBL proteins: 
 ENSP00000360998  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ANKRD: Ankyrin repeat domain containing

2 InterPro protein domains:
 IPR020683 Ankyrin_rpt-contain_dom
 IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q5VYY1

ProtoNet protein and cluster: Q5VYY1

UniProtKB/Swiss-Prot: ANR22_HUMAN, Q5VYY1
Similarity: Contains 4 ANK repeats


ANKRD22 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
ANKRD22 for ontologies           About GeneDecksing


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SwitchGear 3'UTR luciferase reporter plasmidANKRD22 3' UTR sequence
Inhib. RNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD22

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for ANKRD22 (Q5VYY13 ENSP000003609984) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CITED4Q96RK13, ENSP000003617214I2D: score=1 STRING: ENSP00000361721
SS18L1O751773, ENSP000003330124I2D: score=1 STRING: ENSP00000333012
HDAC3ENSP000003029674STRING: ENSP00000302967
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ANKRD22 (ANR22)

Search CenterWatch for drugs/clinical trials and news about ANKRD22 / ANR22

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ANKRD22 gene: 
NM_144590.2  

Unigene Cluster for ANKRD22:

Ankyrin repeat domain 22
Hs.217484  [show with all ESTs]
Unigene Representative Sequence: NM_144590
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000371930(uc001kfj.4) ENST00000476963

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidANKRD22 3' UTR sequence
Inhib. RNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD22
Sirion Biotech Customized lentivirus for stable overexpression of ANKRD22 
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD22

Additional mRNA sequence: 

AK313969.1 BC021671.1 

6 DOTS entries:

DT.436140  DT.95133899  DT.306014  DT.91690704  DT.40246582  DT.121286034 

24/31 AceView cDNA sequences (see all 31):

AA976927 BM785517 AI651205 AI242329 AI660377 NM_144590 AA775676 CB128220 
BP342197 BP343758 BF326749 BM837388 BE841230 BU932881 BC021671 AW299505 
AW196074 AA306997 AA295175 BU596895 AW001485 CD693721 BE566554 BG539351 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANKRD22 expression in normal human tissues (normalized intensities)      ANKRD22 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAATGCCTTG
ANKRD22 Expression
About this image


ANKRD22 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Heart (Cardiovascular System)
         Human Cardiac Myocytes-adult (HCM-a)   
 
 Ovary (Reproductive System)
         Mature Granulosa Cells Antral Follicle
 
 Blood (Hematopoietic System)
         Granulocytes Peripheral Blood

See ANKRD22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD22

SOURCE GeneReport for Unigene cluster: Hs.217484
    SABiosciences Custom PCR Arrays for ANKRD22
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD22
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD22

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD22 gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ankrd221 , 5 ankyrin repeat domain 221, 5 85.09(n)1
86.84(a)1
  19 (29.33 cM)5
520241  NM_024204.61  NP_077166.41 
 341225495 
chicken
(Gallus gallus)
Aves ANKRD221 ankyrin repeat domain 22 68.61(n)
69.84(a)
  771419  XM_001234692.2  XP_001234693.1 
lizard
(Anolis carolinensis)
Reptilia ANKRD226
ankyrin repeat domain 22
67(a)
1 ↔ 1
GL343246.1(247602-272878)
zebrafish
(Danio rerio)
Actinopterygii ankrd221 ankyrin repeat domain 22 57.94(n)
51.83(a)
  393244  NM_200274.1  NP_956568.1 


ENSEMBL Gene Tree for ANKRD22 (if available)
TreeFam Gene Tree for ANKRD22 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/773 SNPs in ANKRD22 are shown (see all 773)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs22973071,2
C,F,H--90581404(-) AACTTA/CTTTTA 1 -- ut315Minor allele frequency- C:0.01EA NS 1886
rs1510174511,2
--90581517(+) CATACA/CAAGAG 1 -- ut310--------
rs1866806211,2
--90581603(+) ATTTAC/TTTCTA 1 -- ut310--------
rs799358601,2
C--90581746(+) ATAATA/GTTTTA 1 -- ut310--------
rs1907388461,2
--90581783(+) AACAAA/GCTTGG 1 -- ut310--------
rs792652181,2
C,F--90581784(+) ACAAGC/GTTGGC 1 -- ut311Minor allele frequency- G:0.03WA 118
rs760891881,2
F--90581833(+) TTAAAC/TGAACA 1 -- ut311Minor allele frequency- T:0.01EA 120
rs171133441,2
C,F,H--90581891(+) TAAACC/TGAAAT 1 -- ut3118Minor allele frequency- T:0.07NA NS EA 1998
rs1826630301,2
--90581971(+) TTGTCA/CATTTG 1 -- ut310--------
rs174373961,2
C,F--90582022(+) ATAGAT/CGTTTT 1 -- ut31 ese34Minor allele frequency- C:0.01NA 144

HapMap Linkage Disequilibrium report for ANKRD22 (90579656 - 90611732 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for ANKRD22:    About this table     
Variant IDTypeSubtypePubMed ID
nsv7484CNV Insertion18451855
nsv831942CNV Gain17160897
nsv831941CNV Gain17160897

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for ANKRD22:    About MalaCards
alzheimer's disease    gastric cancer


ANKRD22 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): ANKRD22
Human Genome Epidemiology (HuGE) Navigator: ANKRD22 (2 documents)

Export disorders for ANKRD22 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ANKRD22 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ANKRD22)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  6. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
  7. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
  8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  9. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (2007)
  10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 118932 HGNC: 28321 AceView: ANKRD22 Ensembl:ENSG00000152766 euGenes: HUgn118932
ECgene: ANKRD22 H-InvDB: ANKRD22

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ANKRD22 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ANKRD22 gene:
Search GeneIP for patents involving ANKRD22

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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