Aliases for ANKRD22 Gene
External Ids for ANKRD22 Gene
- HGNC: 28321
- Entrez Gene: 118932
- Ensembl: ENSG00000152766
- UniProtKB: Q5VYY1
Previous GeneCards Identifiers for ANKRD22 Gene
- GC10M090247
- GC10M090572
- GC10M084214
Summaries for ANKRD22 Gene
GeneCards Summary for ANKRD22 Gene
ANKRD22 (Ankyrin Repeat Domain 22) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD22 Gene
Genomics for ANKRD22 Gene
Regulatory Elements for ANKRD22 Gene
Enhancers for ANKRD22 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH10G088850 | 1.4 | FANTOM5 Ensembl ENCODE | 38.6 | -0.1 | -126 | 4.2 | SIX4 PKNOX1 MAX RFX5 CTBP1 NFYB EED FOSL2 FOS ZNF600 | ANKRD22 STAMBPL1 IFIT3 IFIT2 PTCD2P2 |
| GH10G088841 | 0.7 | FANTOM5 | 54.7 | +10.2 | 10242 | 0.3 | TAF1 MAX ZBTB33 REST GABPA YY1 | ANKRD22 STAMBPL1 ACTA2-AS1 LIPM IFIT3 IFIT2 |
| GH10G088857 | 0.7 | FANTOM5 ENCODE | 35.9 | -6.6 | -6590 | 1.7 | FOS | ANKRD22 STAMBPL1 IFIT3 IFIT2 PTCD2P2 |
| GH10G088840 | 1.1 | FANTOM5 Ensembl ENCODE | 20.8 | +11.2 | 11219 | 1.5 | JUND ATF3 TAF1 MAX ZBTB33 GABPA YY1 | ANKRD22 STAMBPL1 ACTA2-AS1 FAS LIPM IFIT3 IFIT2 LIPN |
| GH10G089241 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 12.5 | -390.5 | -390470 | 2.9 | FOXA2 FEZF1 RARA ETS1 RELB ETV6 IKZF2 CREM MXD4 JUNB | LIPA ANKRD22 ENSG00000232110 IFIT1B CH25H IFIT3 IFIT5 IFIT2 GC10P089210 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANKRD22 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ANKRD22 gene promoter:
Regulatory Element Products
Genomic Location for ANKRD22 Gene
- Chromosome:
- 10
- Start:
- 88,819,899 bp from pter
- End:
- 88,851,975 bp from pter
- Size:
- 32,077 bases
- Orientation:
- Minus strand
Genomic View for ANKRD22 Gene
Genes around ANKRD22 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q23.31 by Ensembl
- 10q23.31 by Entrez Gene
- 10q23.31 by HGNC
ANKRD22 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKRD22 Gene
Proteins for ANKRD22 Gene
-
Protein details for ANKRD22 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5VYY1-ANR22_HUMAN
- Recommended name:
- Ankyrin repeat domain-containing protein 22
- Protein Accession:
- Q5VYY1
- B2R9Y7
- Q8WU06
Protein attributes for ANKRD22 Gene
- Size:
- 191 amino acids
- Molecular mass:
- 21849 Da
- Quaternary structure:
- No Data Available
Protein Expression for ANKRD22 Gene
Post-translational modifications for ANKRD22 Gene
Other Protein References for ANKRD22 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ANKRD22
- Novus Biologicals Antibodies for ANKRD22
- Invitrogen Antibodies for ANKRD22
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Protein Products
-
OriGene Purified Proteins for ANKRD22
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- Search GeneTex for Proteins for ANKRD22
Assay Products
No data available for DME Specific Peptides for ANKRD22 Gene
Domains & Families for ANKRD22 Gene
Gene Families for ANKRD22 Gene
Protein Domains for ANKRD22 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANKRD22 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANKRD22 Gene
Function for ANKRD22 Gene
Phenotypes for ANKRD22 Gene
- GenomeRNAi human phenotypes for ANKRD22:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKRD22 gene
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CRISPR Products
-
OriGene CRISPR knockouts for ANKRD22
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD22
- GenScript: Design CRISPR guide RNA sequences for ANKRD22
miRNA for ANKRD22 Gene
- miRTarBase miRNAs that target ANKRD22
miRNA Products
- Search ViGene Biosciences for ANKRD22
Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANKRD22
-
ViGene Biosciences adenoviral particle packaged cDNA for ANKRD22 gene
-
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Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD22 Gene
Localization for ANKRD22 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD22 Gene
Pathways & Interactions for ANKRD22 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for ANKRD22 Gene
Transcripts for ANKRD22 Gene
mRNA/cDNA for ANKRD22 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (31) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANKRD22 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANKRD22
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD22
- GenScript: Design CRISPR guide RNA sequences for ANKRD22
miRNA Products
- Search ViGene Biosciences for ANKRD22
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANKRD22
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-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD22 gene
Clone Products
-
OriGene ORF clones in human for ANKRD22
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANKRD22
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD22
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for ANKRD22 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Ovary (Reproductive System)
- Mature Granulosa Cells Antral Follicle
mRNA differential expression in normal tissues according to GTEx for ANKRD22 Gene
This gene is overexpressed in Whole Blood (x8.5), Stomach (x8.4), Esophagus - Mucosa (x6.5), Skin - Not Sun Exposed (Suprapubic) (x5.6), and Skin - Sun Exposed (Lower leg) (x5.5).
This gene is overexpressed in Nasal epithelium (42.6) and Plasma (11.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD22 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANKRD22 Gene:
ANKRD22SOURCE GeneReport for Unigene cluster for ANKRD22 Gene:
Hs.217484Primer Products
-
OriGene qPCR primer pairs for ANKRD22
-
OriGene qPCR primer pairs and template standards for ANKRD22
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD22 Gene
Orthologs for ANKRD22 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANKRD22 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANKRD22 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ankrd22 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ankrd22 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANKRD22 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ANKRD22 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANKRD22 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANKRD22 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ANKRD22 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ankrd22 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ankrd22 34 35 |
|
- Species where no ortholog for ANKRD22 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANKRD22 Gene
No data available for Paralogs for ANKRD22 Gene
Variants for ANKRD22 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000057088 | -- | 88,834,174(+) | TTTGG(A/T)GTTCA | intron-variant | |
| rs1000127764 | -- | 88,823,897(+) | CATCA(A/G)TCTCT | intron-variant | |
| rs1000145390 | -- | 88,841,002(+) | ATGAA(C/T)GATAG | intron-variant | |
| rs1000184125 | -- | 88,850,031(+) | AGATT(C/T)TTCCA | intron-variant | |
| rs1000233901 | -- | 88,848,172(+) | TATAT(A/G)TGTAT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3624139 | CNV | gain | 21293372 |
| esv3624140 | CNV | loss | 21293372 |
| esv3624141 | CNV | gain | 21293372 |
| nsv1043015 | CNV | gain | 25217958 |
| nsv551840 | CNV | gain | 21841781 |
| nsv7484 | CNV | insertion | 18451855 |
| nsv831941 | CNV | gain | 17160897 |
| nsv831942 | CNV | gain | 17160897 |
| nsv950991 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.77;
73.51% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANKRD22 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD22 Gene
Disorders for ANKRD22 Gene
Relevant External Links for ANKRD22
No disorders were found for ANKRD22 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD22 Gene
Publications for ANKRD22 Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
Products for ANKRD22 Gene
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- Custom Antibody ServicesOriGene Antibodies for ANKRD22
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- OriGene qPCR primer pairs for ANKRD22
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- Novus Biologicals Antibodies for ANKRD22
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- ViGene Biosciences adenoviral particle packaged cDNA for ANKRD22 gene
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- VectorBuilder custom plasmid, inducible vectors for ANKRD22
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD22
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANKRD22 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
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- (141) ENCODE
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- (146) Cyagen
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- (151) CIViC
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer