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Aliases for ANKRD22 Gene

Aliases for ANKRD22 Gene

  • Ankyrin Repeat Domain 22 2 3 5

External Ids for ANKRD22 Gene

Previous GeneCards Identifiers for ANKRD22 Gene

  • GC10M090247
  • GC10M090572
  • GC10M084214

Summaries for ANKRD22 Gene

GeneCards Summary for ANKRD22 Gene

ANKRD22 (Ankyrin Repeat Domain 22) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD22 Gene

Genomics for ANKRD22 Gene

Regulatory Elements for ANKRD22 Gene

Enhancers for ANKRD22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F088840 1.5 FANTOM5 Ensembl ENCODE 55.5 +11.0 11016 1.9 ATF3 ZBTB33 REST YY1 ANKRD22 STAMBPL1 ACTA2-AS1 FAS LIPM IFIT3 IFIT2 LIPN
GH10F088857 1.4 FANTOM5 Ensembl ENCODE 35.9 -6.6 -6590 1.7 FOS ANKRD22 STAMBPL1 IFIT3 IFIT2 PTCD2P2
GH10F088853 0.4 FANTOM5 34.2 -1.3 -1337 0.4 MYC ANKRD22 IFIT3 IFIT2 PTCD2P2
GH10F088860 0.4 FANTOM5 28.3 -9.1 -9124 0.5 SCRT2 ANKRD22 ACTA2-AS1 FAS LIPM ENSG00000201548 LIPJ RNLS IFIT3 IFIT2 PTCD2P2
GH10F088837 0.4 FANTOM5 19.8 +14.1 14124 0.4 ZNF263 ANKRD22 ACTA2-AS1 STAMBPL1 LIPM LIPF IFIT3 IFIT2 LIPN
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ANKRD22 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001762613 1275 201 ATF2

Genomic Location for ANKRD22 Gene

Chromosome:
10
Start:
88,819,899 bp from pter
End:
88,851,975 bp from pter
Size:
32,077 bases
Orientation:
Minus strand

Genomic View for ANKRD22 Gene

Genes around ANKRD22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD22 Gene

Proteins for ANKRD22 Gene

  • Protein details for ANKRD22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYY1-ANR22_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 22
    Protein Accession:
    Q5VYY1
    Secondary Accessions:
    • B2R9Y7
    • Q8WU06

    Protein attributes for ANKRD22 Gene

    Size:
    191 amino acids
    Molecular mass:
    21849 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD22 Gene

Post-translational modifications for ANKRD22 Gene

No Post-translational modifications

Other Protein References for ANKRD22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD22 Gene

Domains & Families for ANKRD22 Gene

Gene Families for ANKRD22 Gene

Protein Domains for ANKRD22 Gene

Suggested Antigen Peptide Sequences for ANKRD22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VYY1

UniProtKB/Swiss-Prot:

ANR22_HUMAN :
  • Contains 4 ANK repeats.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with ANKRD22: view

Function for ANKRD22 Gene

Phenotypes for ANKRD22 Gene

genes like me logo Genes that share phenotypes with ANKRD22: view

Animal Model Products

miRNA for ANKRD22 Gene

miRTarBase miRNAs that target ANKRD22

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD22 Gene

Localization for ANKRD22 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD22 Gene COMPARTMENTS Subcellular localization image for ANKRD22 gene
Compartment Confidence
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD22 Gene

Pathways & Interactions for ANKRD22 Gene

SuperPathways for ANKRD22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD22 Gene

Transcripts for ANKRD22 Gene

mRNA/cDNA for ANKRD22 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD22 Gene

Ankyrin repeat domain 22:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD22 Gene

No ASD Table

Relevant External Links for ANKRD22 Gene

GeneLoc Exon Structure for
ANKRD22
ECgene alternative splicing isoforms for
ANKRD22

Expression for ANKRD22 Gene

mRNA expression in normal human tissues for ANKRD22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD22 Gene

This gene is overexpressed in Whole Blood (x8.5), Stomach (x8.4), Esophagus - Mucosa (x6.5), Skin - Not Sun Exposed (Suprapubic) (x5.6), and Skin - Sun Exposed (Lower leg) (x5.5).

Protein differential expression in normal tissues from HIPED for ANKRD22 Gene

This gene is overexpressed in Nasal epithelium (42.6) and Plasma (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD22 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANKRD22 Gene:

ANKRD22

SOURCE GeneReport for Unigene cluster for ANKRD22 Gene:

Hs.217484
genes like me logo Genes that share expression patterns with ANKRD22: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ANKRD22 Gene

Orthologs for ANKRD22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD22 34 35
  • 99.3 (n)
cow
(Bos Taurus)
Mammalia ANKRD22 34 35
  • 89.3 (n)
mouse
(Mus musculus)
Mammalia Ankrd22 34 16 35
  • 85.09 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd22 34
  • 84.39 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD22 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD22 34 35
  • 79.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD22 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD22 34 35
  • 68.42 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD22 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd22 34
  • 64.91 (n)
zebrafish
(Danio rerio)
Actinopterygii ankrd22 34 35
  • 57.94 (n)
Species where no ortholog for ANKRD22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD22 Gene

ENSEMBL:
Gene Tree for ANKRD22 (if available)
TreeFam:
Gene Tree for ANKRD22 (if available)

Paralogs for ANKRD22 Gene

No data available for Paralogs for ANKRD22 Gene

Variants for ANKRD22 Gene

Sequence variations from dbSNP and Humsavar for ANKRD22 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1029024 -- 88,828,778(-) AGATG(C/T)CATGG intron-variant
rs1029025 -- 88,828,404(-) CCAAT(A/G)CTATA intron-variant
rs10509556 -- 88,840,239(+) GAAGC(A/G)TCCAT intron-variant
rs10736363 -- 88,830,989(+) AGTCC(A/G)GTAAT intron-variant
rs10749596 -- 88,829,110(+) TCATG(C/T)GCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD22 Gene

Variant ID Type Subtype PubMed ID
esv3624139 CNV gain 21293372
esv3624140 CNV loss 21293372
esv3624141 CNV gain 21293372
nsv1043015 CNV gain 25217958
nsv551840 CNV gain 21841781
nsv7484 CNV insertion 18451855
nsv831941 CNV gain 17160897
nsv831942 CNV gain 17160897
nsv950991 CNV duplication 24416366

Variation tolerance for ANKRD22 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.77; 73.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD22 Gene

Human Gene Mutation Database (HGMD)
ANKRD22
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD22 Gene

Disorders for ANKRD22 Gene

Relevant External Links for ANKRD22

Genetic Association Database (GAD)
ANKRD22
Human Genome Epidemiology (HuGE) Navigator
ANKRD22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD22

No disorders were found for ANKRD22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD22 Gene

Publications for ANKRD22 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for ANKRD22 Gene

Sources for ANKRD22 Gene

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