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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANKRD22 Gene

protein-coding GIFtS: 41
GCID: GC10M090572

ankyrin repeat domain 22

Explore 1 disease affiliated with
ANKRD22 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ankyrin Repeat Domain 22¹ ²
MGC22805¹
Ankyrin Repeat Domain-Containing Protein 22²

External Ids:	HGNC: 28321¹	Entrez Gene: 118932²	Ensembl: ENSG00000152766⁷	UniProtKB: Q5VYY1³

Export aliases for ANKRD22 gene to outside databases

Previous GC identifers: GC10M090247 GC10M084214

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANKRD22 gene promoter:
Nkx3-1 Nkx3-1 v1 Nkx2-5 RORalpha2 C/EBPalpha NF-AT NF-AT4 NF-AT2 NF-AT3 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANKRD22 promoter sequence

Search SABiosciences Chromatin IP Primers for ANKRD22

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD22

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31 Ensembl cytogenetic band: 10q23.31 HGNC chromosome: 10

ANKRD22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD22 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M090572: view genomic region (about GC identifiers)

Start:	90,579,656 bp from pter	End:	90,611,732 bp from pter
Size:	32,077 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANR22_HUMAN, Q5VYY1 (See protein sequence)

Recommended Name: Ankyrin repeat domain-containing protein 22

Size: 191 amino acids; 21849 Da

Secondary accessions: B2R9Y7 Q8WU06

Explore the universe of human proteins at neXtProt for ANKRD22: NX_Q5VYY1

ANKRD22 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_653191.2

ENSEMBL proteins:

ENSP00000360998

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANKRD22 for domains About GeneDecksing

2 InterPro domains/families:

IPR020683 Ankyrin_rpt-contain_dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q5VYY1

ProtoNet protein and cluster: Q5VYY1

UniProtKB/Swiss-Prot: ANR22_HUMAN, Q5VYY1

Similarity: Contains 4 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ANKRD22

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ANKRD22

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for ANKRD22 (Q5VYY1³ ENSP00000360998⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CITED4	Q96RK1³, ENSP00000361721⁴	I2D: score=1 STRING: ENSP00000361721
SS18L1	O75177³, ENSP00000333012⁴	I2D: score=1 STRING: ENSP00000333012
HDAC3	ENSP00000302967⁴	STRING: ENSP00000302967

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ANKRD22
Search CenterWatch for drugs/clinical trials and news about ANKRD22 / ANR22

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for ANKRD22 gene:

NM_144590.2

Unigene Cluster for ANKRD22:

Ankyrin repeat domain 22

Hs.217484 [show with all ESTs]

Unigene Representative Sequence: NM_144590

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371930(uc001kfj.4) ENST00000476963

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Additional cDNA sequence:

AK313969.1 BC021671.1

6 DOTS entries:

DT.436140 DT.95133899 DT.306014 DT.91690704 DT.40246582 DT.121286034

24/31 AceView cDNA sequences (see all 31):

AA976927 BM785517 AI242329 AI651205 BC021671 BF326749 BP342197 AA775676

BM837388 CB128220 BP343758 BE841230 NM_144590 AI660377 BU932881 AW299505

BU596895 AA295175 AA306997 AW196074 CD707983 BG539351 AI698467 AW001485

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANKRD22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATGCCTTG

About this image

ANKRD22 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Mature Granulosa Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ANKRD22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD22

SOURCE GeneReport for Unigene cluster: Hs.217484

SABiosciences Custom PCR Arrays for ANKRD22

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD22 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ankrd22^{1 , 5}	ankyrin repeat domain 22^{1, 5}	85.09(n)¹ 86.84(a)¹		19 (29.33 cM)⁵ 52024¹ NM_024204.6¹ NP_077166.4¹ 34122549⁵
chicken (Gallus gallus)	Aves	ANKRD22¹	ankyrin repeat domain 22	68.61(n) 69.84(a)		771419 XM_001234692.2 XP_001234693.1
lizard (Anolis carolinensis)	Reptilia	ANKRD22⁶	--	65(a)	1 ↔ 1	GL343246.1(262194-270327)
zebrafish (Danio rerio)	Actinopterygii	ankrd22¹	ankyrin repeat domain 22	57.94(n) 51.83(a)		393244 NM_200274.1 NP_956568.1

ENSEMBL Gene Tree for ANKRD22 (if available)
TreeFam Gene Tree for ANKRD22 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191597484^1,2		--	90579216(+)	`CAGAGC/TATCTA`	2	--	ds500¹ int¹		0	--	--	--	--
rs184890184^1,2		--	90579322(+)	`TCAGCC/TGGCTA`	2	--	ds500¹ int¹		0	--	--	--	--
rs77793193^1,2	F	--	90579323(+)	`CAGCCG/AGCTAG`	2	--	ds500¹ int¹		1		EA	120
rs17113317^1,2	C	--	90579340(+)	`TCTACT/CAACAC`	2	--	ds500¹ int¹		4		NA WA	260
rs113248953^1,2		--	90579357(+)	`AATACG/CGAAAG`	2	--	ds500¹ int¹		1		CSA	2
rs193258872^1,2		--	90579370(+)	`CCCAGC/GTATTA`	2	--	ds500¹ int¹		0	--	--	--	--
rs149693932^1,2		--	90579399(+)	`TTTGGC/TGGGGA`	2	--	ds500¹ int¹		0	--	--	--	--
rs185066495^1,2		--	90579427(+)	`TTGGAA/GCAGGT`	2	--	ds500¹ int¹		0	--	--	--	--
rs190306743^1,2		--	90579507(+)	`CAAGCC/TGGGTC`	2	--	int¹ ds500¹		0	--	--	--	--
rs3910679^1,2	C,F,A,H	--	90579609(-)	`CATGAA/GAGAAG`	2	--	ds500¹ int¹		34		NS EA NA WA CSA	2993

HapMap Linkage Disequilibrium report for ANKRD22 (90579656 - 90611732 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ANKRD22
1 CNV: 4707

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ANKRD22 for disorders About GeneDecksing

1 disease for ANKRD22: About MalaCards

alzheimer's disease

Human Genome Epidemiology (HuGE) Navigator: ANKRD22 (2 documents)

Export disorders for ANKRD22 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ANKRD22 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ANKRD22)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)¹ Grupe A....Goate A. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Transcriptome analysis of human gastric cancer. (PubMed id 16341674)¹ Oh J.H....Kim N.S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 118932	HGNC: 28321	AceView: ANKRD22	Ensembl:ENSG00000152766	euGenes: HUgn118932
ECgene: ANKRD22	H-InvDB: ANKRD22

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANKRD22	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANKRD22 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ANKRD22 gene:
Search GeneIP for patents involving ANKRD22

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ANKRD22 gene at Home site.

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ANKRD22 Gene

ankyrin repeat domain 22

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ANKRD22 Gene

ankyrin repeat domain 22

Aliasesfor ANKRD22 gene

Summariesfor ANKRD22 gene

Genomic Viewsfor ANKRD22 gene

Proteinsfor ANKRD22 gene

Protein Domains /Familiesfor ANKRD22 gene

Functionfor ANKRD22 gene

Pathways & Interactionsfor ANKRD22 gene

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Expression for ANKRD22 gene

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for ANKRD22 gene

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for ANKRD22 gene

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for ANKRD22 gene

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for ANKRD22 gene

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