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ANKRD20A4 Gene

protein-coding   GIFtS: 33
GCID: GC09P069381

Ankyrin Repeat Domain 20 Family, Member A4

  Search for ANKRD20A4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 20 Family, Member A41 2
Ankyrin Repeat Domain-Containing Protein 20A42

External Ids:    HGNC: 319821   Entrez Gene: 7287472   Ensembl: ENSG000001720147   UniProtKB: Q4UJ753   

Export aliases for ANKRD20A4 gene to outside databases

Previous GC identifers: GC09U900751 GC09P068672 GC09M039336


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD20A4 Gene:
ANKRD20A4 (ankyrin repeat domain 20 family, member A4) is a protein-coding gene. An important paralog of this gene is POTEF.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_078070.4  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD20A4 gene promoter:
         TBP   CUTL1   YY1   Evi-1   POU2F1   POU2F1b   POU2F1a   POU2F1c   TGIF   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD20A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.11   Ensembl cytogenetic band:  9q21.11   HGNC cytogenetic band: 9q21.11

ANKRD20A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD20A4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P069381:  view genomic region     (about GC identifiers)

Start:
69,381,812 bp from pter      End:
69,425,560 bp from pter
Size:
43,749 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: A20A4_HUMAN, Q4UJ75 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 20A4  
Size: 823 amino acids; 94149 Da

Explore the universe of human proteins at neXtProt for ANKRD20A4: NX_Q4UJ75

Explore proteomics data for ANKRD20A4 at MOPED


See ANKRD20A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001092275.1  
ENSEMBL proteins: 
 ENSP00000349891  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ANKRD: Ankyrin repeat domain containing

2 InterPro protein domains:
 IPR002110 Ankyrin_rpt
 IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry Q4UJ75

ProtoNet protein and cluster: Q4UJ75

UniProtKB/Swiss-Prot: A20A4_HUMAN, Q4UJ75
Similarity: Contains 5 ANK repeats


ANKRD20A4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
ANKRD20A4 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD20A4
Interactions:

    Search GeneGlobe Interaction Network for ANKRD20A4

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ANKRD20A4 (A20A4)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ANKRD20A4 gene: 
NM_001098805.1  

Unigene Cluster for ANKRD20A4:

Ankyrin repeat domain 20 family, member A4
Hs.645502  [show with all ESTs]
Unigene Representative Sequence: NM_001098805
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000357336(uc004afn.3) ENST00000427650(uc010mnw.1)
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Additional mRNA sequence: AK307323.1 

2 DOTS entries:

DT.121164867  DT.95241138 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ANKRD20A4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTAAGACCAT
ANKRD20A4 Expression
About this image

ANKRD20A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ANKRD20A4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.645502
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ANKRD20A4 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
18(a)
1 → many
1(24064036-24111623)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
41(a)
many ↔ many
GL344195.1(38786-58936)
zebrafish
(Danio rerio)
Actinopterygii ANKRD76
ankyrin repeat domain 7
9(a)
1 → many
25(3581527-3655709) ENSDARG00000013015
        Species with no ortholog for ANKRD20A4

ENSEMBL Gene Tree for ANKRD20A4 (if available)
TreeFam Gene Tree for ANKRD20A4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ANKRD20A4 gene
ANKRD20A21 2  ANKRD20A11 2  ANKRD20A31 2  POTEF2  POTEI2  ANKRD30A2  POTEB22  ANKRD362  
ANKRD72  POTEB2  ANKRD30BL2  POTEH2  ANKRD30B2  LOC6442492  ENSG000002663022  ANKRD36C2  
POTEJ2  POTEC2  ANKRD262  POTEG2  ANKRD622  ANKRD18A2  POTEM2  CCDC144A2  
POTED2  POTEE2  ANKRD18B2  LOC1002889662  
Selected SIMAP similar genes for ANKRD20A4 using alignment to 1 protein entry:     A20A4_HUMAN(see all similar genes):
ANKRD20A1    ANKRD20A2    ANKRD20A3    ANKRD20A8P    ANKRD19P    ANKRD30BL
MGC26718    DKFZp781D1722    ANKRD36BP1    PRED4    POTEG    POTEH
ANKRD62    ANKRD18B    ANKRD18A    POTEA    PSMD10    POTED

ANKRD20A4 for paralogs           About GeneDecksing


4 Pseudogenes.org Pseudogenes for ANKRD20A4
PGOHUM00000248293 PGOHUM00000248335 PGOHUM00000235008 PGOHUM00000239030


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ANKRD20A4 (see all 586)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs284095301,2
F--69291914(-) TAATTT/GTATTT 1 -- us2k11Minor allele frequency- G:0.25NA 4
rs2001489371,2
C--69291940(-) GACAC-/TTATCAT 1 -- us2k10--------
rs2002918541,2
C--69291963(-) GTTCAC/TTCACT 1 -- us2k10--------
rs1919395421,2
--69292059(-) CAGAGG/TCTTCC 1 -- us2k10--------
rs286518021,2
C,F--69292079(-) TTCCAC/G/TTCAGT 1 -- us2k15NA CSA 12
rs1136687831,2
--69292100(-) AACACA/C/G/
        
TTTTC
1 -- us2k11CSA 2
rs3746235841,2
C--69292134(-) GAATGC/TCATCA 1 -- us2k10--------
rs1835411091,2
--69292199(-) CTTGAA/GTTATT 1 -- us2k10--------
rs357793871,2
C--69292202(+) AACTCAA/-GAGAA 1 -- us2k11Minor allele frequency- -:0.50NA 2
rs2020969131,2
C--69292202(-) TCTCTC/TGAGTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ANKRD20A4 (69381812 - 69425560 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for ANKRD20A4:    About this table    
Variant IDTypeSubtypePubMed ID
dgv135n16CNV Deletion17901297
esv33449CNV Loss17666407
nsv893398CNV Loss21882294
essv17250CNV CNV17122850
dgv2381e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ANKRD20A4 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ANKRD20A4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
  2. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (Nature 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 728747 HGNC: 31982 Ensembl:ENSG00000172014 euGenes: HUgn728747 ECgene: ANKRD20A4
H-InvDB: ANKRD20A4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ANKRD20A4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ANKRD20A4 gene:
Search GeneIP for patents involving ANKRD20A4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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